Delatestryl (testosterone enanthate) / Endo - LARVOL DELTA

Testosterone therapy in boys with constitutional delay of growth and puberty: a PubMed-based systematic review and exploratory meta-analysis. (PubMed, Clin Exp Pediatr) - "Across formulations (intramuscular testosterone enanthate or cypionate, depot ester mixtures, oral testosterone undecanoate, and transdermal gel), the literature consistently showed greater short-term height velocity and more rapid pubertal progression in treated boys without a clinically meaningful adverse effect on near-adult height when conservative regimens were used. Testosterone therapy in boys with CDGP was associated with faster short-term growth and pubertal maturation, and long-term data did not show a detrimental effect on near-adult height when conservative time-limited regimens were used. The quantitative evidence base is small and methodologically heterogeneous, and modern multicenter randomized trials incorporating validated patient-reported outcomes and long-term follow-ups are necessary."

Journal • Retrospective data • CNS Disorders • Endocrine Disorders • Pediatrics

Testosterone treatment for micropenis in partial androgen insensitivity syndrome. (PubMed, JCEM Case Rep) - "During treatment, luteinizing hormone secretion was suppressed, with trough levels falling below the limit of detection, consistent with androgen-mediated negative feedback. Luteinizing hormone levels during mini-puberty in response to testosterone treatment, supporting testosterone therapy in patients with PAIS."

Journal

Decoding the association of polycystic ovary syndrome with metabolic-associated fatty liver: insights into CK18 and LC3II/ATG7/P62 autophagy axis and adjunct therapeutics of metformin and levothyroxine. (PubMed, RSC Med Chem) - "metformin and levothyroxine synergistically improve PCOS-related MAFLD by restoring autophagy and metabolic-endocrine balance. System-level and docking analyses support autophagy regulation as a key therapeutic mechanism, highlighting the potential role of levothyroxine in modulating autophagy."

Journal • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Polycystic Ovary Syndrome • ATG7 • KRT18 • KRT18 • MAP1LC3B • NOS2 • SQSTM1

Co-administration of Bone Marrow-derived Mesenchymal Stem Cells and Royal Jelly Improved Ovarian Tissue Function in PCOS Rats via the Regulation of Inflammation and Angiogenesis. (PubMed, Int J Fertil Steril) - "The expression levels of BMP15 and GDF9 proteins were significantly reduced in PCOS rats compared to the control group (P<0.0001), while in the PCOS+RJ+BM-MSCs group, the expression of BMP15 (P<0.001) and GDF9 (P<0.0001) proteins increased compared to the PCOS group. RJ and BM-MSCs may restore ovarian function by regulating inflammation, angiogenesis, and oocyte quality."

Journal • Preclinical • Inflammation • Oncology • Polycystic Ovary Syndrome • IL6 • TNFA

Post-COVID-19 subacute painless thyroiditis: a case report in an anabolic androgenic steroid user. (PubMed, BMC Infect Dis) - "This case highlights the need to consider subacute thyroiditis in patients with unexplained thyrotoxicosis after COVID-19, especially when confounding factors, such as anabolic steroid use, are present."

Journal • Developmental Disorders • Endocrine Disorders • Immunology • Infectious Disease • Musculoskeletal Pain • Novel Coronavirus Disease • Pain • Respiratory Diseases

MRI findings of pelvic organs in transmen, who presented with vaginal bleeding after taking muscularization hormone (ESUR 2025) - "The masculinization hormone has affected the diffuse enlargement of the clitoris in our study, which is in concurrence with the study of A. Dimakopoulou (21) reported the enlargement of the size of the clitoris after 3-4 months after the masculinization hormone supplement as an exogenous androgen effect on the gland and can range from 4-5 cm in length and might stop growing after 2-3 cycles from negative feedback to the pituitary gland. In our study, we are the first to report the normal measurement of clitoris crus, hood, and gland in three dimensions, and morphological changes seen as wider than tall appearance in transmen, using the high-resolution MRI in the Asian population and reported the enlargement of the gland, diffusely."

Acne Vulgaris • Endometrial Cancer • Gynecology • Ovarian Cancer • Polycystic Ovary Syndrome • Solid Tumor • Uterine Leiomyoma • Women's Health • AR

A Preclinical Model of Testosterone Exposure in Female Mice Recapitulates the Human Phenotype (ENDO 2025) - "These findings indicate, through detailed reproductive phenotyping, that exogenous T exposure in postpubertal female mice recapitulates the human phenotype of increased body weight, lack of menstrual cyclicity and clitoromegaly. The sex steroid responsive adipokines, leptin and adiponectin, decreased to levels similar to male mice. This translational model can serve to help understand mechanisms of action of T on the neuroendocrine control of reproduction in humans, as well as the metabolic consequences of T therapy."

Preclinical • CCL2 • IL6 • LEP • RETN

Sex steroid priming prior to growth hormone stimulation testing in peripubertal adolescents with short stature? (ESPE-ESE 2025) - "For priming, sex steroids were delivered; testosterone enanthate 100mg IM 5-7 days before GHST for boys and estradiol valerate 1-2mg PO 3 days before GHST (glucagon or clonidine) for girls. In our cohort of peripubertal adolescents with short stature sex steroid priming prior to growth hormone stimulation testing failed to reveal statistically significant difference in growth hormone secretion."

Endocrine Disorders • Growth Hormone Deficiency

Sex differences in the Protein Kinase A signaling of chronic postsurgical pain sensitization is medi (IASP 2024) - "We then pharmacologically or surgically activated or inhibited ARs with 4 experiments: 1) in female mice, we administered testosterone enanthate (TE, 0.45 mg/kg, subcutaneous) or vehicle (sesame oil) for two weeks (n = 5-8); 2) in female mice, we spinally administered TE (10 µg, intrathecal) or vehicle (cremophore: ethanol: saline – 1:1:8) (n = 6-8); 3) in male mice, we administered flutamide (50 mg/kg, subcutaneous) to block AR (n = 6-12); 4) male mice received orchiectomy (surgical removal of testes) or sham surgery (n = 6-8). After each of these interventions, we administered vehicle, PKA inhibitor H89 (10 nmol, i.t.), and/or KOR antagonist LY2456302 (10 µg, i.t.) in a 2×2 design in both male and female mice... We found that pharmacological or surgical interruption of AR prevented the ability of a PKA inhibitor to prevent pain reinstatement in male mice, whereas pharmacological activation of AR recruited the ability of PKA to prevent reinstatement in..."

Immunology • Pain • AR • ER

Sex Differences of Neutrophil Extracellular Traps on Lipopolysaccharide-Stimulated Human Neutrophils. (PubMed, Surg Infect (Larchmt)) - "In females, endogenous gender hormones may promote NETs during infection. Sex differences in neutrophils may need to be considered in organ damage owing to NETs excess such as sepsis."

Journal • Infectious Disease • Septic Shock

Masculinizing Hormone Therapy and Gynecological Neoplasm: a Single Institution Cohort (ENDO 2024) - "Among a cohort of TM who received MHT for 32 months, there is no evidence of precancerous or malignant pathology of the endometrium, ovaries, and fallopian tubes. Most of them had thin endometrium with cystic ovaries. One TM showed LSIL with squamous metaplasia of the cervix."

Clinical • Colorectal Cancer • Gynecologic Cancers • Gynecology • Oncology • Uterine Leiomyoma

Delayed Diagnosis of Kallmann Syndrome: Journey from Patient to Advocate (ENDO 2024) - "This case highlights the importance of patient activation and advocacy for rare diseases. Partnerships between patients, expert clinicians, and researchers are critical for advancing science and developing more person-centered approaches to care that are responsive to patient priorities.Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins."

Clinical • Otorhinolaryngology • Rare Diseases

Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs. (PubMed, Animals (Basel)) - "The puppies were physically followed up until puberty when ovulation was tested by serum progesterone. The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium."

Journal

Challenges in Diagnosis and Treatment of Male Hypogonadism. (PubMed, Acta Med Indones) - "Moreover, administering hypogonadism therapy involves numerous considerations influenced by various patient factors and the potential for adverse effects. This poses a challenge for physicians to provide targeted hypogonadism therapy with minimal complications."

Journal • Breast Cancer • CNS Disorders • Developmental Disorders • Endocrine Disorders • Genito-urinary Cancer • Hepatology • Immunology • Infectious Disease • Nephrology • Oncology • Osteoporosis • Prostate Cancer • Psychiatry • Renal Disease • Rheumatology • Solid Tumor

Simultaneous detection of testosterone, nandrolone, and boldenone esters in dried blood spots for doping control in sports by liquid chromatography-tandem mass spectrometry. (PubMed, Drug Test Anal) - "Polymer and cellulose papers were used to collect blood from their upper arms and fingertips, respectively, and testosterone enanthate was identified and detectable at both blood-collection sites for up to 144 and 216 h, respectively. Furthermore, testosterone enanthate was detectable in the DBS samples stored under refrigeration after 6 months, indicating the stable nature of DBS."

Journal

Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation. (PubMed, Psychopharmacology (Berl)) - "Exogeneous testosterone enanthate (200 mg/week) during severe energy restriction did not reliably alter the measures of cognition. Study limitations include the relatively small sample size compared to many studies of acute testosterone administration. The findings are specific to healthy males experiencing severe energy deficit and should not be generalized to effects of other doses, formulations, or acute administration of endogenous testosterone or studies conducted with larger samples using tests of cognitive function designed to detect specific effects of testosterone."

Journal • Fatigue

Efficacy of Transdermal Dihydrotestosterone and Testosterone Enanthate for Penile Augmentation in Patients With Idiopathic Micropenis: A Comparative Randomized Study. (PubMed, Clin Med Insights Endocrinol Diabetes) - "In the present study, we demonstrated the superiority of transdermal DHT compared to injectable exogenous testosterone in the treatment of idiopathic micropenis. According to the age subgroups, there was no significant difference between the 2 treatments in each age group."

Journal

GENDER DYSPHORIA IN A PATIENT WITH OVOTESTICULAR DISORDER OF SEX DEVELOPMENT (ENDO 2023) - "OT-DSD is an uncommon condition, raising issues of gender assignment that are dependent on factors such as age at diagnosis, phenotype, internal structures and reproductive potential. Scarce data exists on long-term outcomes in OT-DSD, including the frequency of gender dysphoria in these patients. Gender identity is an important factor to consider on long-term follow-up of OT-DSD patients.*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation."

Clinical • CNS Disorders • Pediatrics • Psychiatry

The management of age-related oxidative stress in male hypogonadism associated with non-communicable chronic disease (Fertility 2023) - " In this narrative review, we discuss the approaches for clinical management of NCDs associated hypogonadic men, including testosterone replacement therapy (TRT), metformin, weight management, and antioxidant supplementation. The relationship between ageing, oxidative stress, male hypogonadism, and NCDs in males is complex. Although TRT may be beneficial, alternative therapeutic approaches require consideration. Weight loss, through nutritional and lifestyle interventions, and the use of nutritional and phytomedicinal antioxidants, may provide novel therapeutic options in the management of age-related NCDs in males by alleviating oxidative stress and improving steroidogenesis."

Cardiovascular • Diabetes • Endocrine Disorders • Genetic Disorders • Genito-urinary Cancer • Metabolic Disorders • Obesity • Oncology • Prostate Cancer • Sexual Disorders • Solid Tumor • Type 2 Diabetes Mellitus

Testicular sperm extraction in a patient with a new pathogenic NR5A1 (SF-1) variant : p.Phe70Serfs*5 (ESPE 2022) - "He was treated by triptorelin for central precocious puberty from 9.5 years old to 11 years old. We report a case with a new NR5A1 variant. The fertility preservation protocol proposed at the young age before parental project did not allow any sperm retrieval."

Clinical • Endocrine Disorders • Nephrology • Renal Disease • Turners Syndrome

Testosterone Undecanoate Administration Prevents Declines in Fat-Free Mass but not Physical Performance During Simulated Multi-Stressor Military Operations. (PubMed, J Appl Physiol (1985)) - "Administering testosterone undecanoate before a simulated military operation protected FFM but did not prevent decrements in physical performance."

Journal • Endocrine Disorders

BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals. (PubMed, Cell Prolif) - "Our findings reveal the critical roles of BAG6 exon24 in testosterone biosynthesis and male fertility, which provides new insights into the regulation of spermatogenesis and pathogenesis of subfertility in mammals."

IO biomarker • Journal • Infertility • BAG1 • BCL2

Slipped capital femoral epiphysis with hypopituitarism in adults: A case report and literature review. (PubMed, Medicine (Baltimore)) - "When treating adults with SCFE, clinicians must be alert to endocrine disorders. Comprehensive imaging evaluation is crucial for the accurate diagnosis and selection of an appropriate treatment."

Clinical • Journal • Review • Endocrine Disorders • Musculoskeletal Diseases • Orthopedics • Pain • Pediatrics • IGF1

[VIRTUAL] A comparison between Androstanolone and Testosterone Enanthate for penile augmentation in patients with idiopathic micropenis (ESPE 2021) - "The diagnosis of micropenis is purely clinical, based on the measurement of penile size. It is a simple symptom that can hide complex pathologies. Early management of micropenis is recommended to avoid sometimes dramatic complications, and androstanolone seems to be the most effective treatment without side effects."

Clinical

Cardiovascular Properties of the Androgen-Induced PCOS Model in Rats: The Role of Oxidative Stress. (PubMed, Oxid Med Cell Longev) - "Increased levels of O in CVE indicated the cardiotoxic effects in the rat PCOS model. The mentioned alterations of oxidative stress parameters in the blood, CVE, and heart could be recommended as potential contributors underlying the development of CV risk in PCOS women."

Journal • Preclinical • Cardiovascular • Endocrine Disorders • Polycystic Ovary Syndrome • CAT