DN-30 / Institute for Cancer Research and Treatment - LARVOL DELTA

Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers. (PubMed, Int J Mol Sci) - "These observations provide an association between the elevated CypD expression and increased mitoflash activities in hindlimb muscles in an amyotrophic lateral sclerosis (ALS) mouse model previously observed. More importantly, feeding the mice with sodium butyrate reversed the CypD-associated mitoflash phenotypes and protected against ectopic upregulation of CypD, unveiling a novel molecular mechanism underlying butyrate mediated alleviation of ALS progression in the mouse model."

Journal • Preclinical • Amyotrophic Lateral Sclerosis • CNS Disorders • PPIF

"@QuangDn93015295 @ProfDavidNutt @Dishasatra" (@nxhemn)

A Low-Frequency Pulsed Magnetic Field Reduces Neuropathic Pain by Regulating NaV and NaV Sodium Channels at the Transcriptional Level in Diabetic Rats. (PubMed, Bioelectromagnetics) - "Consequently, it may be deduced that 10 Hz PMF application reduces pain by modulating certain VGSCs at the transcriptional level."

Journal • Preclinical • Diabetes • Diabetic Neuropathy • Metabolic Disorders • Neuralgia • Pain • Peripheral Neuropathic Pain • PCR

Transcriptome analysis reveals the encystment-related lncRNA expression profile and coexpressed mRNAs in Pseudourostyla cristata. (PubMed, Sci Rep) - "These lncRNAs can regulate a variety of physiological activities that are essential for encystment, including autophagy, protein degradation, the intracellular calcium concentration, microtubule-associated dynein and microtubule interactions, and cell proliferation inhibition. These findings provide the first insight into the potentially functional lncRNAs and their coexpressed mRNAs involved in the dormancy of ciliated protozoa and contribute new evidence for understanding the molecular mechanisms regulating encystment."

Journal • Targeted Protein Degradation

Exercise-related blood pressure response is related to autonomic modulation in young adults: A new extension study. (PubMed, Technol Health Care) - "These observations represented a new insight into the cardiovascular regulation at post-exercise, which could contribute to physical exercise areas in the future."

Clinical • Journal • Cardiovascular

A receptor-antibody hybrid hampering MET-driven metastatic spread. (PubMed, J Exp Clin Cancer Res) - "These results provide a strategy to treat metastatic dissemination driven by the HGF/MET axis."

Journal • CNS Disorders • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Psychiatry • Solid Tumor • Transplantation

Targeting the MET oncogene by concomitant inhibition of receptor and ligand by an antibody-decoy strategy (AACR 2018) - "... To test this hypothesis we combined an anti-MET antibody (MvDN30), characterized by the property of inducing shedding (i.e. removal of MET from the cell surface), with a decoy (i.e. the soluble extracellular domain of the MET receptor) endowed with HGF-sequestering ability... The data reported indicate that vertical targeting of the MET/HGF axis results in powerful inhibition of ligand-dependent MET activation, providing proof of concept in favor of combined targeted therapy of MET expedience."

Colorectal Cancer • Pancreatic Cancer

Gene expression profiling of proximal and distal renal tubules in Atlantic salmon (Salmo salar) acclimated to fresh water and seawater. (PubMed, Am J Physiol Renal Physiol) - "Expression of aqp1aa, aqp3a1, aqp10b1, ncc, nhe3, cftr, sglt1, slc41a1, fxyd12a, cldn3a, cldn3b, cldn3c, cldn10b, cldn10e, cldn28a and cldn30c were higher in SW- than in FW-acclimated salmon, whereas the opposite was the case for aqp1ab, slc26a6C and fxyd2. The data shows distinct segmental distribution of transport genes and a significant regulation of tubular transcripts when kidney function is modulated during salinity transitions."

Journal • Psychiatry • Renal Disease

Continuous Intravenous Inotropes as a Bridge to Myocardial Recovery (HEART FAILURE 2018) - "In select patients unsuitable or reluctant to undergo advanced interventions, extended use of inotropic therapy may facilitate application of disease modifying therapy and represent a bridge to recovery. Prospective investigations are needed. Age Sex Initial EF/EDD Etiology Onset of HF Inotrope type Inotrope duration HF Tx Indication Final EF/EDD 66 F 10%/6.6cm ChemoTx 12/2014 Milrinone 11 m Bisoprolol 5, spironolactone 25, digoxin 0.125, ivabradine 2.5 bid Palliation 55%/4.3cm 52 M 22%/6.7cm CAD 07/2014 Milrinone 14 m Carvedilol 6.25 bid, ISDN 30 tid, valsartan 80, spironolactone 25 BTT 55%/4.8cm 66 F 15%/6.9cm Idiopathic vs ethanol 01/2014 Milrinone 12 m Metoprolol XR 75, spironolactone 25, hydralazine 75 tid, ISDN 60 tid BTT 60%/3.4cm Baseline demographics, therapies and outcomes of 3 advanced HF patients on chronic milrinone therapy"

Biosimilar • Cardiovascular • Heart Failure

Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody. (PubMed, Cancers (Basel)) - "The other acts as a hepatocyte growth factor (HGF)-mimetic, protecting normal cells from doxorubicin-induced apoptosis. Thus, by engineering the same receptor antibody, it is possible to generate molecules enhancing or inhibiting apoptosis either to kill cancer cells or to protect healthy tissues from the injuries of chemotherapy."

Journal • HGF

Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody-'decoy' strategy. (PubMed, Int J Cancer) - "In a preclinical model, built by orthotopic transplantation of a human pancreatic carcinoma in SCID mice engineered to express human HGF, concomitant treatment with antibody and decoy significantly reduces metastatic spread. The data reported indicate that vertical targeting of the MET/HGF axis results in powerful inhibition of ligand-dependent MET activation, providing proof of concept in favor of combined target therapy of MET 'expedience'."

Journal

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. (PubMed, Br J Cancer) - "These data show that in MET-amplified cancers, treatment with MET inhibitors counteracts the induction of PD-1 ligands by Interferon-γ. Thus, therapeutic use of anti-MET drugs may provide additional clinical benefit over and above the intended inhibition of the target oncogene."

IO Biomarker • Journal

De novo transcriptome analysis of gene responses to pest feeding in leaves of Panax ginseng C. A. Meyer. (PubMed, Mol Med Rep) - "WRYK and AP have been suggested to promote the activity of antioxidant peroxidase. Collectively, the findings from the present study suggested that a MAPK‑WRKY‑OPR/AP‑peroxidase signaling pathway may be a potentially important mechanism underlying defense responses against pests in ginseng plants."

Journal

Development of decellularized meniscus extracellular matrix and gelatin/chitosan scaffolds for meniscus tissue engineering. (PubMed, Biomed Mater Eng) - "This study developed a composite scaffold using DMECM and G/C, and demonstrated that it might be suitable for meniscal tissue engineering application."

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