ipratropium bromide / Generic mfg. - LARVOL DELTA

Chronic Nonallergic Rhinosinusitis Associated With Military Burn Pit Exposure. (PubMed, Cureus) - "He was treated with fluticasone and ipratropium intranasal sprays, oral antihistamines, and saline sinus irrigations...He required a course of prednisone and intermittent courses of budesonide sinus irrigations. At the one-year follow-up, he had an excellent treatment response on intranasal sprays and intermittent budesonide sinus irrigations. Enhanced awareness of the impact of toxic exposures on previously deployed individuals' health may help improve their quality of life."

Journal • Allergic Rhinitis • Allergy • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Comparison of nebulized long-acting muscarinic antagonist (LAMA) revefenacin to short acting muscarinic antagonist (SAMA) ipratropium in COPD patients with acute respiratory failure requiring mechanical ventilation (ERS 2025) - No abstract available

Clinical • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Effects of aerosol inhalation of budesonide and ipratropium bromide on postoperative respiratory function in children with obstructive sleep apnea syndrome (OSAS) : a single-center randomized controlled study (ChiCTR) - P=N/A | N=485 | Completed | Sponsor: Fujian Children’s Hospital; Fujian Children's Hospital

New trial • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

A clinical study on the combination of bencycloquidium bromide and montelukast in the treatment of moderate to severe allergic rhinitis. (PubMed, Medicine (Baltimore)) - "The combination of BCQB and MNT had a greater overall effect, compared to MNT monotherapy in improving nasal symptoms such as nasal congestion and rhinorrhea, as well as quality of life in the treatment of (M/S)AR."

Clinical • Journal • Allergic Rhinitis • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Otorhinolaryngology

Anti-MDA-5 Associated Dermatomyositis With Interstitial Lung Disease: A Case Report (ATS 2025) - "Initial management involved hydroxychloroquine, Moxifloxacin, and nebulization with ipratropium bromide and beclomethasone, but the regimen was adjusted to include high-dose IV Solumedrol, Tofacitinib, and plasmapheresis...Standard treatment for dermatomyositis involves corticosteroids, with steroid-sparing agents (e.g., methotrexate) to manage side effects. A Japanese study demonstrated improved outcomes with "triple therapy" (glucocorticoids, tacrolimus, cyclophosphamide), achieving 89% six-month survival...Conclusions CADM is a rare form of dermatomyositis with minimal or absent muscle symptoms, making early detection challenging. Patients are at high risk for interstitial lung disease, so timely diagnosis is crucial to manage complications and reduce morbidity and mortality."

Case report • Clinical • Alopecia • Cough • Dermatology • Dermatomyositis • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Lupus • Musculoskeletal Pain • Myositis • Pulmonary Disease • Respiratory Diseases • Rheumatology • Rosacea • IFIH1

Inhalers or nebulisation of salbutamol in childhood asthma exacerbations in emergency departments. (PubMed, Respir Med) - "The study suggests that salbutamol via pMDI with a holding chamber is as effective as nebulisation for treating mild to moderate childhood asthma exacerbations. This approach results in fewer hospitalisations, reduced side effects, and shorter PED visits. Educating patients on pMDI use and efficacy could further decrease emergency visits for asthma exacerbation."

Journal • Asthma • Immunology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Substrate-specific inhibition of organic cation transporter 1 revealed using a multisubstrate drug cocktail. (PubMed, Drug Metab Dispos) - "Here, we describe a multisubstrate drug cocktail that allows for the simultaneous testing of drug-drug interactions using 8 different victim drugs: fenoterol, salbutamol, sumatriptan, zolmitriptan, ipratropium, trospium, methylnaltrexone, and metformin...Group 1 comprised verapamil, quinidine, fenoterol, and ipratropium, and group 2 comprised metformin, sumatriptan, and trimethoprim...Here, we demonstrate this for organic cation transporter 1 (OCT1, SLC22A1) and presents a drug cocktail designed to identify varying inhibitory potencies in vitro and prevent false-negative drug-drug interaction results during early drug development. This approach can be extended to other polyspecific drug transporters."

Journal • SLC22A1

T-RECS: Treating Respiratory Emergencies in Children Study (clinicaltrials.gov) - P2 | N=44 | Completed | Sponsor: Oregon Health and Science University | Recruiting ➔ Completed | N=150 ➔ 44 | Trial completion date: Sep 2025 ➔ Mar 2025

Enrollment change • Trial completion • Trial completion date • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Direct-to-consumer customized nasal sprays for allergy relief: A market overview (COSM 2025) - "Both share three active ingredients: triamcinolone, ipratropium, and oxymetazoline, but differ in the antihistamine included—Allermi uses azelastine, while Nectar uses olopatadine. Allermi and Nectar are currently the only DTC sellers of customized allergy-relief IN sprays. Both emphasize convenience, transparent pricing, and customized spray formulations, with ongoing provider support. Nectar further positions the customized IN spray as a bridge to SLIT."

Allergy • Immunology

Timely Administration of IV Magnesium Sulfate in Patients with a Moderate Asthma Exacerbation. (PAS 2025) - "Most pediatric EDs across the country have protocols and algorithms in place to treat status asthmaticus which include bronchodilators, ipratropium, and systemic steroids as first line therapy...Enrolled patients will have their clinical course reviewed and data obtained to evaluate the objective measures described above. We are actively enrolling patients."

Clinical • Asthma • Immunology • Pediatrics • Respiratory Diseases

A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Children's Hospital and Institute of Child Health, Multan

New P4 trial • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

A Randomized Controlled Trial on the Efficacy of Combined Nebulized Inhalation of Heparin, Acetylcysteine, Budesonide, and Ipratropium Bromide in Accelerating Resolution of Influenza Pneumonia (ChiCTR) - P=N/A | N=100 | Recruiting | Sponsor: Army Medical Center (Daping hospital), Army Medical University; Army Medical Center (Daping hospital), Army Medical University

New trial • Infectious Disease • Influenza • Pneumonia • Respiratory Diseases

Treatment of allergic rhinitis and allergic conjunctivitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparison table: Some nasal sprays for seasonal allergic rhinitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation

Evaluating the Use of Inhaled Budesonide and Ipratropium Bromide Combination in Patients at High Risk of Acute Respiratory Distress Syndrome Development: A Randomized Controlled Trial. (PubMed, Pharmaceuticals (Basel)) - " The administration of inhaled budesonide and ipratropium bromide improved oxygenation, as assessed by the S/F ratio, and significantly reduced the rate of ARDS development and the requirement of MV versus the control group. Larger multi-center trials including diverse patient populations are needed to validate these results."

Journal • Acute Respiratory Distress Syndrome • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases

Unilateral mydriasis: an unexpected effect of ipratropium bromide inhalation-a brief report. (PubMed, Eur J Pediatr) - "This case underscores the importance of recognizing the side effects of medications, particularly in young patients with complex medical conditions."

Journal • Brain Cancer • Bronchopulmonary Dysplasia • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Oncology • Ophthalmology • Pediatrics • Pulmonary Disease • Respiratory Diseases • Solid Tumor

TRANSIENT ANISOCORIA DUE TO SUBCUTANEOUS EMPHYSEMA IN A CHILD WITH STATUS ASTHMATICUS (SCCM 2025) - "Despite various ventilation strategies and maximal medical management with continuous albuterol, steroids, aminophylline, magnesium, ketamine, epinephrine and sevoflurane, the decision was made to provide VV ECMO support due to continued hypercarbia and rising lactate...A complete review did not reveal any parasympathetic agent (i.e. ipratropium bromide) at the outside hospital that could have inadvertently affected pupillary exam...Trauma, inflammation or irritation to neck and lung apex area including pneumomediastinum have been reported to cause anisocoria due to proximity of the superior cervical ganglion. We believe the most likely cause of unilateral mydriasis was severe emphysema in the cervical region and/or mediastinum."

Clinical • Asthma • Immunology • Inflammation • Mood Disorders • Ophthalmology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Unilateral Mydriasis in Helicopter Emergency Medical Services: A Case of Ophthalmic Ipratropium Exposure in Pediatric Asthmatic Cardiac Arrest Prompting Cerebral Herniation Prophylaxis. (PubMed, Air Med J) - "This case emphasizes the importance of understanding and recognizing pharmacologic causes, such as muscarinic receptor antagonism, in the differential diagnosis of mydriasis. It also underscores the need for continuous reassessment during transport and the potential for cognitive biases to influence decision-making."

Journal • Asthma • Cardiovascular • Immunology • Ophthalmology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Long-acting muscarinic antagonists (LAMA) in asthma: What is the best strategy? (PubMed, Respir Med Res) - "However, eosinophil levels do not seem to predict the efficacy of LAMA. The role and long-term benefits of LAMA combined with biologic therapy in severe asthma remain uncertain, with more clinical data needed."

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Lupin secures US FDA approval for generic version of Atrovent nasal spray (CNBC-TV18) - "Drug firm Lupin Ltd on Monday (February 10) said it has received approval from the United States Food and Drug Administration (FDA) for its abbreviated new drug application (ANDA) for ipratropium bromide nasal solution (nasal spray), 0.03% (21 mcg/spray), to market a generic equivalent of Atrovent nasal spray, 0.03%, of Boehringer Ingelheim Pharmaceuticals, Inc...The product will be manufactured at Lupin’s Pithampur facility in India. Ipratropium bromide nasal solution (nasal spray), 0.03% is indicated for the symptomatic relief of rhinorrhea associated with allergic and nonallergic perennial rhinitis in adults and children aged six years and older....According to IQVIA MAT December 2024, ipratropium bromide nasal solution, 0.03% (RLD Atrovent) had estimated annual sales of $22 million in the US."

ANDA • Sales • Allergic Rhinitis

Ecofriendly colorimetric set-up coupled with mathematical filtration strategy for simultaneous determination of ipratropium and fenoterol in their novel anti-asthmatic metered dose inhaler. (PubMed, BMC Chem) - "Using cutting-edge software metric tools, namely the analytical greenness (AGREE), and complementary green analytical procedure index (ComplexGAPI), the greenness profile of the suggested method was clearly evaluated. The method also conformed well to the recently published blueness (BAGI tool) and whiteness (RGB12 tool) concepts."

Journal • Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

BUDIPRA-ARDS: A Combination of an Inhaled Budesonide and Ipratropium in Patients at Risk of Developing ARDS (clinicaltrials.gov) - P1/2 | N=119 | Completed | Sponsor: Damanhour University | Active, not recruiting ➔ Completed | N=60 ➔ 119

Enrollment change • Trial completion • Acute Respiratory Distress Syndrome • Pulmonary Disease • Respiratory Diseases

A Rare Case of Endotracheal Metastases in Head and Neck Squamous Cell Carcinoma: A Case Report and Literature Review. (PubMed, Cureus) - "Pulmonary function tests confirmed a diagnosis of chronic obstructive pulmonary disease (COPD), and bronchodilator therapy with ipratropium was initiated...The patient underwent concurrent chemotherapy with cisplatin for seven weeks and radiation therapy targeted at the larynx and bilateral neck lymph nodes...This case underscores the complexities in diagnosing head and neck squamous cell carcinoma (HNSCC) with atypical metastatic presentations. It highlights the necessity of an integrated approach for timely diagnosis and expeditious treatment."

Journal • Chronic Cough • Chronic Obstructive Pulmonary Disease • Cough • Gastrointestinal Disorder • Head and Neck Cancer • Immunology • Laryngeal Cancer • Oncology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

A randomized controlled study of four drugs combined with aerosol inhalation of heparin, acetylcysteine, budesonide and ipratropium bromide in promoting the absorption of COVID-19 pneumonia (ChiCTR) - P=N/A | N=74 | Recruiting | Sponsor: Army Medical Center (Daping hospital), Army Medical University; Army Medical Center (Daping hospital), Army Medical University | N=334 ➔ 74

Enrollment change • Infectious Disease • Novel Coronavirus Disease • Pneumonia

Nebulised high-dose corticosteroids as add-on therapy for adults with asthma exacerbation: a randomised controlled trial. (PubMed, Emerg Med J) - "HDICS may be useful as an add-on therapy to standard treatment for asthma exacerbation in adults to reduce ED stay."

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases