amphotericin b liposome / Generic mfg. - LARVOL DELTA

Disseminated Histoplasmosis Mimicking Cytomegalovirus Disease in a Liver Transplant Recipient With Hemophagocytic Lymphohistiocytosis (ACG 2026) - "Empiric antimicrobials and intravenous ganciclovir were started for presumed CMV colitis...Dexamethasone was initiated...Liposomal amphotericin B was started; however, her course was complicated by renal failure and bilateral subarachnoid hemorrhage...Bone marrow and liver biopsy, Histoplasma antigen testing, and molecular diagnostics were critical in establishing the diagnosis. This case highlights the need for a broad differential when evaluating HLH in transplant recipients."

Clinical • Anorexia • Cytomegalovirus Infection • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatitis C • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Malaria • Neutropenia • Rare Diseases • Renal Disease • Respiratory Diseases • Solid Tumor • Subarachnoid Hemorrhage • Transplantation

Colonic EBV-Associated Smooth Muscle Tumor Concurrent With Disseminated Histoplasmosis in Advanced AIDS (ACG 2026) - "In addition, disseminated histoplasmosis was treated by four weeks of liposomal amphotericin B, followed by itraconazole maintenance therapy. Targeted immunohistochemistry with EBV ISH is essential for diagnosis, particularly when concurrent opportunistic infections are present. Figure: Figure 1: Colonoscopy findings: large nodular masses in the ascending colon and cecum with normal terminal ileum."

Metastases • Colorectal Cancer • Cough • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Leiomyosarcoma • Oncology • Respiratory Diseases • Sarcoma • Solid Tumor • CALD • CD4

Fatal Angioinvasive Gastrointestinal Mucormycosis Following One Week of Autologous Hematopoietic Stem Cell Transplantation (ACG 2026) - "Liposomal amphotericin B and isavuconazole were initiated. Figure: Figure 1 A-B. Large cratered ulcers in the duodenum (1A) and duodenum (1B) Figure: Figure 2 A-C: Atypical circumferential ulceration in the cecum and proximal ascending colon"

Bone Marrow Transplantation • Cytomegalovirus Infection • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Neutropenia • Peptic Ulcer • Pulmonary Disease • Respiratory Diseases • Transplantation

Seronegative Disseminated Aspergillosis Mimicking Multiorgan Malignancy: When Culture Trumps Serology (ACG 2026) - "Urine Histoplasma antigen returned positive, and liposomal amphotericin B was initiated for presumed histoplasmosis...Voriconazole was initiated, achieving near-complete resolution on repeat PET-CT...Figure: FDG PET-CT demonstrating intensely avid circumferential sigmoid wall thickening with exophytic necrotic component and adjacent FDG-avid pelvic lesion, mimicking disseminated colorectal malignancy. Figure: Whole body FDG PET-CT showing multiorgan FDG-avid lesions involving sigmoid colon, lung, and breast, mimicking disseminated malignancy."

Colorectal Cancer • Cough • Endocrine Disorders • Gastrointestinal Disorder • Infectious Disease • Nephrology • Oncology • Renal Disease • Respiratory Diseases

Recurrent Small Bowel Perforation Due to Gastrointestinal Mucormycosis in a Young Immunocompetent Woman: A Fatal Case Illustrating a Diagnostic Imperative (ACG 2026) - "E chinocandins are ineffective against Mucorales ; prompt initiation of liposomal amphotericin B combined with surgical debridement remains the cornerstone of therapy. GI-m should be suspected in any patient with rapid deterioration and necrotizing GI disease"

Clinical • Acute Kidney Injury • Cardiovascular • Diabetes • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Infectious Disease • Inflammatory Bowel Disease • Metabolic Disorders • Nephrology • Pulmonary Disease • Renal Disease • Septic Shock

Disseminated Cryptococcosis in a Patient With Decompensated Cirrhosis and Hepatorenal Syndrome-Acute Kidney Injury: A Complicated Treatment Course in an HIV-Negative Host (ACG 2026) - "Induction with liposomal amphotericin B and flucytosine was initiated but complicated by severe nephrotoxicity (creatinine peak 3.34 mg/dL)...Fluconazole plus flucytosine may offer better efficacy, though unstudied in cirrhosis...The start and end of the first amphotericin challenge is indicated by the red diamond and red circle, respectively. The start and end of the amphotericin rechallenge is indicated by the orange diamond and orange circle, respectively."

Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Fibrosis • Heart Failure • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Nephrology • Renal Disease

Hidden Beneath an Ulcer: Invasive Mucormycosis Presenting as a Large Anastomotic Ulcer (ACG 2026) - "A 6-week course of liposomal amphotericin B and posaconazole (later transitioned to isavuconazole) was initiated, alongside pantoprazole 40 mg twice daily, and famotidine. Early biopsy with fungal staining is critical, as mucormycosis carries high mortality risk without prompt initiation of antifungal therapy and surgical intervention when possible. Gastrointestinal mucormycosis can be successfully managed medically with early recognition and a multidisciplinary approach."

Endocrine Disorders • Gastrointestinal Disorder • Infectious Disease • Peptic Ulcer • Pneumonia • Respiratory Diseases • Septic Shock

Not All Ulcers Are Created Equal: Disseminated Gastric Mucormycosis After Liver Transplantation (ACG 2026) - "Therapy was escalated to liposomal amphotericin B with adjunctive azole treatment...Mycophenolate mofetil was held, and tacrolimus was monitored because of azole interaction...Management depends on recognizing these findings as connected manifestations of invasive mucormycosis, stabilizing hemorrhage, confirming dissemination, initiating amphotericin-based therapy, reducing immunosuppression when feasible, and pursuing source control. Figure: Figure 1: Mucor ulcer at gastric lesser curvature Figure: Figure 2: Patient pathology results showing invasive gastric mucor infection"

Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Nephrology • Peptic Ulcer • Renal Disease • Transplantation

Disseminated Histoplasmosis Mimicking Decompensated Cryptogenic Cirrhosis With Portal Hypertension (ACG 2026) - "Case Description/ A 68-year-old woman with rheumatoid arthritis previously treated with abatacept, methotrexate, and hydroxychloroquine and presumed cryptogenic cirrhosis was admitted with markedly elevated liver enzymes and a right frontoparietal subdural hematoma after a ground-level fall...Liposomal amphotericin B was initiated, complicated by SIRS requiring ICU care, then transitioned to oral itraconazole...Figure: Figure 1. Axial CT abdomen demonstrating scattered, small to moderate volume ascites."

Cardiovascular • CNS Disorders • Fibrosis • Gastrointestinal Disorder • Hepatology • Immunology • Infectious Disease • Inflammatory Arthritis • Neuroendocrine Tumor • Portal Hypertension • Rheumatoid Arthritis • Solid Tumor • CHGA

Invasive Mucormycosis Resulting in Tracheoesophageal Fistula After Acute Liver Failure Treated With Plasma Exchange (ACG 2026) - "He was treated with N-acetylcysteine, multiple PLEX sessions, and continuous renal replacement therapy...Liposomal amphotericin B was started...Figure: Approx. 2cm non-bleeding perforation in the middle third of the esophagus consistent with tracheoesophageal fistula"

Addiction (Opioid and Alcohol) • Anorexia • Cardiovascular • CNS Disorders • Gastrointestinal Disorder • Hepatology • Infectious Disease • Liver Failure • Respiratory Diseases • Thrombosis

Hickamâs Dictum: Disseminated Histoplasmosis and CMV Masquerading as an Ileocecal Mass (ACG 2026) - "Empirical treatment with budesonide yielded no improvement...The patient was initiated on liposomal amphotericin B, and valganciclovir was added for treatment of CMV colitis due to persistent fevers...(B) Grocottâs methenamine silver (GMS) staining highlights numerous oval yeasts with occasional narrow-based budding, morphologically consistent with Histoplasma capsulatum. (C) CMV immunohistochemical staining demonstrates a positive cell within the granulation tissue."

Anorexia • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Human Immunodeficiency Virus • Immunology • Infectious Disease

Mucormycosis Peritonitis in a Patient With Decompensated Alcohol-Associated Cirrhosis (ACG 2026) - "Prednisone was discontinued; ceftriaxone was initiated for spontaneous bacterial peritonitis...Antimicrobials were broadened to vancomycin, meropenem and micafungin...Liposomal amphotericin B was initiated then transitioned to posaconazole...Clinicians should maintain a high index of suspicion for invasive mold infection in cirrhosis patients with refractory secBP despite broad-spectrum antimicrobial therapy. Figure: Figure 1A: Ultrasound of Complex Ascites on Day 3 of Hospitalization Figure: Figure 1B: Ultrasound of Complex Ascites on Day 3 of Hospitalization"

Clinical • CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Inflammation • Renal Disease • Septic Shock

Disseminated Histoplasmosis Masquerading as Decompensated Cirrhosis Diagnosed by Endoscopic Ultrasound-Guided Liver Biopsy (ACG 2026) - "The patient received liposomal amphotericin B followed by prolonged itraconazole therapy. This case highlights the importance of reconsidering the diagnosis when presumed cirrhosis is accompanied by unexplained liver injury and underscores the diagnostic utility of EUS-guided liver biopsy in patients with atypical liver disease. Figure: Computed tomography demonstrating ascites and imaging findings initially concerning for chronic liver disease and portal hypertension"

Biopsy • Autoimmune Hepatitis • Cardiovascular • Fibrosis • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Portal Hypertension • Rheumatoid Arthritis • Thrombocytopenia

Gastric Mucormycosis Following Cardiac Arrest in a Chronic Khat Chew (ACG 2026) - "Liposomal Amphotericin B at 8 mg/kg/day was started without surgical intervention...(2A) Repeat EGD after one month showing a well-healed 25 mm gastric scar with no residual mass. (2B) CT abdomen showing a collapsed stomach without perigastric fat stranding or lymphadenopathy"

Cardiovascular • CNS Disorders • Diabetes • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

A Case of Adalimumab-Associated Disseminated Histoplasmosis and Acute Liver Injury (ACG 2026) - "We describe a patient with rheumatoid arthritis, treated with adalimumab and methotrexate, who subsequently developed disseminated histoplasmosis (DH) complicated by acute hepatitis and Hemophagocytic Lymphohistiocytosis (HLH)...TNF-a therapy was discontinued, and she received two weeks of intravenous liposomal amphotericin B before transitioning to 12 months of oral itraconazole...Histoplasma capsulatum can remain dormant for years to decades, leading to reactivation even after remote exposure or in patients living outside classic endemic areas. This case highlights DH as a cause of acute hepatitis and underscores secondary HLH as a serious complication, where prompt identification of the trigger and timely therapy remain essential."

Clinical • Dyslipidemia • Gastroenterology • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatology • Hypertriglyceridemia • Immunology • Infectious Disease • Inflammatory Arthritis • Liver Failure • Metabolic Disorders • Pulmonary Embolism • Rare Diseases • Respiratory Diseases • Rheumatoid Arthritis • IL2

Colonic Mucormycosis Presenting as Gastrointestinal Bleeding in Critically Ill Patient With Cardiogenic Shock (ACG 2026) - "Liposomal amphotericin B was initiated empirically, with fungal PCR later identifying Rhizopus species...Mucosal lesion identified during colonoscopy Figure: Figure 2. Tissue invasive fungal organisms highlighted on Grocott's methanamine silver (GMS) stain of colectomy specimen"

Clinical • Acute Kidney Injury • Cardiovascular • Colorectal Cancer • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Primary Immunodeficiency • Renal Disease

Migratory Pulmonary Infiltrates Mimicking Malignancy, Tuberculosis, and Sarcoidosis in an Apparently Immunocompetent Adult: A Case of Tissue-Proven Invasive Fungal Disease Due to a Non-marneffeiPenicillium Species. (PubMed, J Fungi (Basel)) - "Liposomal amphotericin B followed by oral voriconazole produced near-complete radiological resolution. Attribution to Penicillium rests on recovery of the mold from the surgical tissue itself; identification nevertheless remained at genus level, because molecular identification, susceptibility testing, and fungal biomarkers were unavailable, and invasion of lung parenchyma was never demonstrated histologically. Migratory infiltrates should prompt reconsideration of fixed diagnoses; repeated mold recovery with tissue-invasive hyphae and treatment response warrants reassessment rather than dismissal as contamination."

Journal • Asthma • Chronic Cough • Cough • Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Sarcoidosis • Tuberculosis

Transferrin Enhances Antifungal Therapy and Improves Survival in Experimental Mucormycosis. (PubMed, J Fungi (Basel)) - "Checkerboard assays demonstrated synergistic interactions between transferrin and liposomal amphotericin B (LAMB), with fractional inhibitory concentration index values below 0.5 for all tested species. In a neutropenic murine model of pulmonary mucormycosis, transferrin enhanced the therapeutic efficacy of both LAMB and isavuconazole (ISAV), resulting in improved survival compared with antifungal monotherapy. Collectively, these findings provide preclinical evidence that transferrin modulates pathogenic determinants associated with mucormycosis and enhances the efficacy of current antifungal therapies, supporting further investigation of transferrin as a potential host-directed adjunctive treatment."

Journal • Infectious Disease • HSPA5

Treatment and outcome of chronic disseminated candidiasis in the era of antifungal prophylaxis: a retrospective multicentre cohort of 111 patients. (PubMed, EClinicalMedicine) - P | "Caspofungin (36.9%, 41/111) and liposomal amphotericin B (23/111; 20.7%) were the most frequently first-line agents for antifungal treatment...This study received no dedicated external funding. FungiScope® receives unrestricted grants for registry maintenance and infrastructure from Basilea Pharmaceutica, Melinta Therapeutics LLC, Mundipharma Ltd., and Pfizer Inc, which had no role in the study design, conduct analysis, interpretation, manuscript preparation, or the decision to submit for publication."

Journal • Retrospective data • Candidiasis • Hematological Disorders • Hematological Malignancies • Neutropenia • Oncology

Liposomal amphotericin B-associated electrolyte abnormalities among adult patients in a tertiary hospital. (PubMed, IJID Reg) - "Patients with cancer present with lower baseline electrolytes and are at compounded risk. These findings reinforce the need for structured electrolyte monitoring protocols and early supplementation strategies in all patients receiving L-AMB, particularly those with malignancy or receiving higher drug doses."

Journal • Infectious Disease • Oncology • Septic Shock

From breath to block: Disseminated invasive aspergillosis presenting with pulmonary, ocular, myocardial and cerebral involvement, and high-grade atrioventricular block during acalabrutinib therapy for chronic lymphocytic leukaemia. (PubMed, IDCases) - "The patient was treated initially with intravenous liposomal amphotericin B, before transition to oral isavuconazole following multidisciplinary specialist review. He was eventually palliated due to poor predicted prognosis, and subsequently died. This case highlights the importance of recognising disseminated invasive aspergillosis in patients receiving BTK inhibitor therapy, appreciating that ocular involvement commonly represents haematogenous dissemination rather than the primary site of infection, and considering early multidisciplinary assessment with prompt antifungal therapy when cardiac or central nervous system involvement is suspected."

Journal • Chronic Lymphocytic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Ocular Inflammation • Oncology • Ophthalmology • Pulmonary Disease • Respiratory Diseases • Uveitis

Pulmonary Mucormycosis Without Rhinocerebral Involvement: A Case Report. (PubMed, Cureus) - "The patient was treated with meropenem and liposomal amphotericin B and was transferred to a tertiary-care facility for surgical evaluation and debridement. PM should be considered in patients with poorly controlled diabetes who develop pneumonia or cavitary disease, even in the absence of classic rhinocerebral involvement. This case underscores the need for prompt identification of PM, antifungal therapy, and early surgical intervention to improve outcomes."

Journal • Cough • Diabetes • Fatigue • Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Pneumonia • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

Aerosolized antifungal therapy in pulmonary fungal disease: pharmacology, drug delivery and emerging clinical applications. (PubMed, Front Med (Lausanne)) - "Among currently available formulations, liposomal amphotericin B has the most extensive clinical experience for inhaled administration, supported by favorable pulmonary retention, respiratory tolerability, and compatibility with contemporary nebulization technologies...For pulmonary mucormycosis, cryptococcosis, Pneumocystis jirovecii pneumonia, and endemic mycoses, current evidence is insufficient to support routine inhaled antifungal therapy. This Mini Review summarizes current evidence on aerosolized antifungal formulations, pulmonary pharmacology, nebulization technologies, and disease-specific clinical applications, while highlighting current limitations and priorities for future translational and clinical research."

Journal • Review • Dermatology • Hematological Disorders • Infectious Disease • Neutropenia • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation

Post-Traumatic Primary Cutaneous Cryptococcosis Presenting as a Chronic Refractory Forearm Ulcer with Polymicrobial Coinfection: An mNGS-Assisted Case Report and Literature Review. (PubMed, Clin Cosmet Investig Dermatol) - "Liposomal amphotericin B was discontinued because of acute kidney injury, and subsequent fluconazole plus flucytosine treatment resulted in reduced exudation, granulation tissue formation, and partial ulcer healing. PCC should be considered in chronic post-traumatic ulcers, with systematic evaluation for extracutaneous involvement before establishing a primary cutaneous diagnosis."

Journal • Acute Kidney Injury • Diabetes • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

A trial of amphotericin B or voriconazole followed by oral triazoles for non-HIV-associated talaromycosis in South China (ERS 2026) - " In this prospective controlled trial, we randomly assigned 98 HIV-negative adults with talaromycosis to receive either intravenous amphotericin B/amphotericin B liposomes or intravenous voriconazole as initial induction therapy, followed by maintenance treatment with oral voriconazole or itraconazole, with a total treatment course not less than 36 weeks. Amphotericin B and voriconazole had similar clinical resolution times and cure rates in the treatment of HIV-negative talaromycosis. voriconazole was associated with a lower risk of severe laboratory adverse events."

Cough • Infectious Disease • Respiratory Diseases