amphotericin b liposome / Generic mfg. - LARVOL DELTA

Assessment of Clinical Guideline Use in the Prevention, Diagnosis, and Treatment of Cryptococcal Meningitis Among Health Care Providers in Ethiopia. (PubMed, Open Forum Infect Dis) - "Among antifungals, fluconazole was the most available, with 21/44 (48%) pharmacists and 49/202 (24%) HCWs reporting it as always in stock. Liposomal amphotericin B (L-Amb) was reported as available by only 7/44 (16%) pharmacists and 44/202 (22%) HCWs. The most significant barriers to guideline implementation were insufficient policy support and challenges in integrating guidelines into electronic health records, as reported by 152/202 (75.2%) and 143/202 (70.8%) HCWs, respectively. There are substantial gaps in CM care, highlighting the importance of improving resource allocation, technical assistance, additional training, and financial support."

Clinical guideline • Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease

Para-KDL in HIV co-infection: case report of a rare visceral-cutaneous leishmaniasis syndrome. (PubMed, AIDS Res Ther) - "The co-existence of active VL and PKDL can make diagnosis difficult, potentially leading to misdiagnosis and treatment, particularly in immunocompromised patients. The simultaneous occurrence of VL and PKDL-like skin lesions requires heightened clinical suspicion, especially in endemic regions. Delayed or misdiagnosed cases may lead to significant morbidity. Further research is needed to understand the pathophysiology, immune response, and optimal treatment strategies for para-KDL in HIV-infected individuals."

Journal • Dermatology • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Psychiatry

Novel use of hyperbaric oxygen treatment for treatment-resistant disseminated Saksenaea and Fusarium in a patient on extracorporeal membrane oxygenation (ECMO): a case report. (PubMed, Diving Hyperb Med) - "Treatment strategies included repeated and extensive surgical debridement (inferior orbital region to carotid sheath in the neck, to a depth of buccal mucosa and zygomatic bone in the cheek), antifungal agents including intravenous (IV) liposomal amphotericin B and voriconazole, and IV immunoglobulin and granulocyte colony stimulating factor. Local and systemic disease control was achieved within several days of commencing HBOT, and after a prolonged period of rehabilitation and reconstruction, the patient was discharged home. We conclude that HBOT may have an important role in the management of angioinvasive fungal disease."

Journal • Infectious Disease • Septic Shock

Metagenomic next-generation sequencing diagnoses Talaromyces marneffei infections: case report and review. (PubMed, J Infect Dev Ctries) - "Previous studies have found that T. marneffei infections are concentrated in patients with acquired immunodeficiency syndrome due to HIV infection, and in anti-IFN-γ antibody-positive patients. However, infections are increasing in individuals who are not immunosuppressed and are often misdiagnosed and underdiagnosed during the initial course of the disease. Therefore, clinicians should be aware that mNGS is an effective technique for detecting T. marneffei infection in non-endemic areas where they encounter non-HIV infected patients. This case report aims to raise the awareness of physicians regarding this rare disease in non-endemic areas and non-HIV patients."

Biomarker • Journal • Next-generation sequencing • Review • Cough • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Tuberculosis • IFNG

Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant Aspergillus isolates. (PubMed, Antimicrob Agents Chemother) - "We evaluated the efficacy of EL219 compared to liposomal amphotericin B (LAMB) in vitro using the Clinical Laboratory and Standards Institute M38 methodology and in immunosuppressed murine models of IPA caused by A. fumigatus, A. lentulus, and A. calidoustus...EL219 also resulted in >5-log fungal burden reductions in A. fumigatus-infected lungs. EL219 demonstrated broad-spectrum efficacy, improved survival, and reduced lung fungal burden, supporting its potential as a novel therapy for IPA."

Journal • Preclinical • Infectious Disease • Pulmonary Disease • Respiratory Diseases

ENDONASAL LEISHMANIASIS IN A FROZEN SECTION BIOPSY SPECIMEN. (PubMed, Acta Clin Croat) - "She received liposomal amphotericin B which led to prompt amelioration of the lesion. As shown in the present case, clinical presentation of leishmaniasis is unspecific and can mimic many other conditions, especially in the setting of concomitant immunosuppressive and anti-inflammatory treatment. It is important to be aware of this entity in order to treat such patients properly."

Journal • Immunology • Infectious Disease • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Diagnosis and Management of Visceral Leishmaniasis in Children: A French Retrospective Study. (PubMed, Open Forum Infect Dis) - "All the patients were treated with liposomal amphotericin B (chemical name, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;2-aminoguanidine)...The combination of blood and bone marrow PCR optimizes the diagnosis. Standardization of therapeutic regimens and follow-up is necessary."

Journal • Retrospective data • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Pediatrics • Rare Diseases

Cryptococcosis in kidney transplant recipients: Pathogenesis, clinical challenges, and evolving therapeutic strategies. (PubMed, Transplant Rev (Orlando)) - "The adoption of rapid cryptococcal antigen lateral flow assays, broader access to liposomal amphotericin B, and individualized adjustments of immunosuppression have improved outcomes; however, challenges persist, including relapse, drug toxicities, and immune reconstitution inflammatory syndrome. We summarize current evidence and outline priorities for research and clinical practice, aiming to support timely diagnosis and optimized, phase-based antifungal strategies in this high-risk population."

Journal • Review • Infectious Disease • Transplantation

Visceral Leishmaniasis as a Cause or Mimicker of Hemophagocytic Lymphohistiocytosis: Diagnostic Challenges and HLH-04 Criteria Limits. (PubMed, Pediatr Infect Dis J) - "VL is a neglected disease with a challenging diagnosis due to its strong resemblance to HLH. Although both conditions share overlapping clinical and laboratory findings, they have distinct pathogenic mechanisms. The HLH-04 criteria show limitations in distinguishing these conditions. While anemia and elevated ferritin might be more specific biomarkers for HLH, additional invasive tests, like bone marrow aspiration, are often essential due to the subtle symptoms and difficult diagnosis between the 2 conditions."

Journal • Dyslipidemia • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hypertriglyceridemia • Immunology • Infectious Disease • Influenza • Leukopenia • Pain • Pediatrics • Rare Diseases • Respiratory Diseases • Thrombocytopenia

Human Bioequivalence Study of Amphotericin B Liposome for Injection (clinicaltrials.gov) - P=N/A | N=42 | Completed | Sponsor: Sichuan Huiyu Pharmaceutical Co., Ltd | Recruiting ➔ Completed

Trial completion • Febrile Neutropenia • Infectious Disease

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post-Kala-Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing. (PubMed, Clin Pharmacol Ther) - "This study highlights the importance of understanding the bidirectional interactions between LAmB pharmacokinetics and parasite infection for interpreting systemic exposure and optimizing treatment approaches. If confirmed in clinical trials, reduced LAmB dosing strategies could enable more rational and cost-effective management of PKDL and other dermal leishmaniases."

Journal • PK/PD data • Infectious Disease

Optimizing Drug Therapy in ECMO-Supported Critically Ill Adults: A Narrative Review and Clinical Guide. (PubMed, Pharmacy (Basel)) - "Hydrophilic, low-protein-bound agents such as β-lactams, aminoglycosides, fluconazole, and caspofungin generally showed minimal ECMO-specific PK alterations, with dose adjustment mainly driven by renal function. Conversely, lipophilic and highly protein-bound drugs including fentanyl, midazolam, propofol, voriconazole, and liposomal amphotericin B exhibited substantial circuit adsorption and variability, often requiring higher loading doses, prolonged infusions, and rigorous therapeutic drug monitoring. No ECMO-specific data were identified for certain neuromuscular blockers, antivirals, and electrolytes. Overall, individualized dosing guided by therapeutic drug monitoring (TDM), organ function, and validated PK principles remains essential to optimize therapy in this complex population."

Journal • Review • Critical care • Pediatrics • Respiratory Diseases

Central nervous system cryptococcosis with brain stem hemorrhage during chemotherapy for pediatric acute myeloblastic leukemia patient. (PubMed, J Infect Chemother) - "She received a combination of liposomal amphotericin B for six weeks and 5-fluorocytosine for four weeks as induction therapy, followed by maintenance therapy with fluconazole for 12 months. When a central nervous system (CNS) infection occurs during neutropenia, abnormalities in the CSF examination are less likely to be detected. Multiplex genetic testing of CSF may be considered a useful diagnostic adjunct in immunocompromised patients with neurologic symptoms."

Journal • Acute Myelogenous Leukemia • Cardiovascular • CNS Disorders • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Pain • Pediatrics

Bad to the bone: Candida (Candidozyma) auris vertebral osteomyelitis treated with combination antifungal therapy followed by a novel long-acting echinocandin. (PubMed, ASM Case Rep) - "Initial treatment included dual antifungal therapy with liposomal amphotericin B and micafungin, selected based on in vitro susceptibility and preclinical synergy data. It also demonstrates the feasibility of using rezafungin as an option for long-term outpatient management. Given the limited clinical experience with combination therapy and rezafungin use, further data are needed to inform standardized treatment approaches."

Journal • CNS Disorders • Infectious Disease • Inflammation • Migraine • Pain

Verruconis gallopava: an isavuconazonium foe. (PubMed, ASM Case Rep) - "His symptoms persisted, and he was transitioned to liposomal amphotericin B and eventually oral posaconazole (POS) with clinical and radiographic resolution of his presenting syndrome. Transitioning to POS led to clinical improvement, suggesting its potential as a treatment option. Further experience is needed to establish optimal therapeutic strategies for this rare but serious infection."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases • Transplantation

Breaking the mold: a case of invasive Medicopsis romeroi pulmonary infection with innovative granulocyte treatment strategy. (PubMed, ASM Case Rep) - "The nodules progressed despite a combination of posaconazole, isavuconazole, terbinafine, and liposomal amphotericin B. A course of HLA-compatible granulocytes was initiated, resulting in stabilization of the infection. This is a rare case of M. romeroi causing an invasive fungal infection of a visceral organ, the second documented M. romeroi infection in a CGD patient, and a report of a novel treatment regimen for this pathogen."

Journal • CNS Disorders • Immunology • Infectious Disease • Primary Immunodeficiency • Respiratory Diseases • Ventriculomegaly

Single high-dose liposomal amphotericin B plus B/F/TAF for AIDS-associated talaromycosis in China: a multicentre randomised controlled trial protocol. (PubMed, BMJ Open) - P=N/A | "This multicentre, randomised controlled phase II clinical trial compares the efficacy and safety of single high-dose L-AMB (10 mg/kg), followed by itraconazole capsule 200 mg every 12 hours for the remaining 13 days of induction therapy, versus AmBD (0.5 mg/kg/day for 14 days) as induction therapy for AIDS-associated talaromycosis in PLWH adults with microbiologically confirmed diagnosis. ClinicalTrials. gov NCT06926569."

Clinical protocol • Journal • Human Immunodeficiency Virus • Infectious Disease • CD4

Pulmonary Mucormycosis with Endobronchial Involvement Complicated by Pleural Effusion. (PubMed, J Clin Pract Res) - "Without requiring surgical resection, the patient was successfully treated with intravenous antifungal medication, along with intrabronchial and intrapleural liposomal amphotericin B. Pulmonary mucormycosis requires prompt diagnosis and treatment. Close monitoring of such infections may minimize the need for invasive procedures and lower mortality, particularly when endobronchial involvement accompanied by effusion is present."

Journal • Pleural effusion • CNS Disorders • Diabetes • Infectious Disease • Metabolic Disorders • Respiratory Diseases

Development of propylated starch-based nanoparticles for Amphotericin B delivery. (PubMed, Int J Pharm) - "To circumvent the toxicity-related constraints associated with Amphotericin B, AmBisome®, a liposomal formulation of Amphotericin B, is commercially available...Furthermore, stability studies confirmed that Amphotericin B loaded PDASNPs were stable for 3 months at 4 0C. This study suggests that PDASNPs may serve as a nanocarrier for the delivery of Amphotericin B."

Journal

Severe Saprochaete capitata fungemia presenting as micafungin breakthrough hepatosplenic lesions in an immunocompromised patient: case report. (PubMed, ASM Case Rep) - "Saprochaete capitata (S. While there is a lack of evidence to guide optimal treatment, the organism appears to exhibit resistance to echinocandins. Expert opinion favors voriconazole as empiric treatment with the addition of intravenous liposomal amphotericin B for severe infections."

Journal • CNS Disorders • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Myelodysplastic Syndrome • Oncology • Schizophrenia

Mycetohabitans rhizoxinica bacteremia in the setting of invasive fungal disease in an immunocompromised patient. (PubMed, ASM Case Rep) - "His surgical treatments included sinus debridement and a near total right pneumonectomy, and his antimicrobial treatment included 10 days of cefepime for his bacteremia, 4 weeks of liposomal amphotericin B, 4 weeks of micafungin following his pneumonectomy, and approximately 12 months of posaconazole. This case highlights the association of M. rhizoxinica with Rhizopus spp., wherein the isolation of M. rhizoxinica led to a high index of suspicion of Rhizopus infection in an immunocompromised patient who developed bacteremia with a slow-growing, oxidase positive, gram-negative bacteria not able to be identified by traditional identification methods."

Journal • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Otorhinolaryngology • Pneumonia • Respiratory Diseases • Sinusitis

Invasive fusariosis after CD19 chimeric antigen receptor T-cell therapy. (PubMed, ASM Case Rep) - "She developed grade 1 cytokine release syndrome (CRS) and grade 3 immune effector cell-associated neurotoxicity syndrome (ICANS), requiring dexamethasone and anakinra. Treatment with liposomal amphotericin B, voriconazole, and terbinafine followed by voriconazole and terbinafine led to clinical improvement. Though rare, healthcare providers should maintain an index of suspicion for Fusarium infections in recipients of cellular therapies with risk factors."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Rare Diseases

Disseminated Magnusiomyces clavatus (Geotrichum clavatum) infection following allogenic stem cell transplantation: a case report. (PubMed, ASM Case Rep) - "The patient was treated with voriconazole, as well as liposomal amphotericin B, along with granulocyte transfusion. The patient died from persistent fungemia, refractory septic shock, and multiorgan failure 20 days after the infection was first diagnosed. We subsequently discuss the epidemiological, clinical, and therapeutic features of this severe fungal infection and present a review of currently available literature."

Journal • Bone Marrow Transplantation • Hematological Disorders • Infectious Disease • Myelofibrosis • Neutropenia • Septic Shock • Transplantation

An Atypical Presentation of Culture-Negative Cryptococcal Meningitis in an Immunocompetent Host With Prior Stroke: A Case Report. (PubMed, Case Rep Infect Dis) - "She was treated with intravenous liposomal amphotericin B and oral flucytosine induction, followed by oral fluconazole consolidation and maintenance...Culture negativity complicates the determination of optimal treatment duration. This case also highlights the utility of the lateral flow assay (LFA) in diagnosing cryptococcal meningitis."

Journal • Cardiovascular • CNS Disorders • Infectious Disease • Ventriculomegaly

Pharmacogenetics and Pharmacokinetics of Posaconazole in Patients with Acute Myeloid Leukemia: Useful Tools for Antifungal Stewardship (ASH 2023) - "According to EORTC criteria, two patients (10%) had a probable IFI on day 14, and antifungal therapy with liposomal amphotericin B was started [3]...Isavuconazonium or posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia... Twenty patients were included: 9 were women (45%) with a median age of 67 years old (±10. 5) and a median Charlson Comorbidity Index of 5 (±1. 3)."

Biomarker • Clinical • PK/PD data • Acute Myelogenous Leukemia • Dermatology • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Oncology • ABCB1 • ABCC2 • ABCG2 • CYP24A1 • SLCO1B3 • UGT1A1 • UGT1A3