amphotericin b liposome / Generic mfg. - LARVOL DELTA

Disseminated Papulopustular Candidiasis in an Immunocompetent adult: A case report. (PubMed, IDCases) - "The patient was initiated on intravenous liposomal amphotericin B, administered systemically, intradermally, and intravitreally, in combination with posaconazole. This case highlights disseminated papulopustular candidiasis as an uncommon initial manifestation of invasive Candida infection. Prompt recognition and the institution of aggressive antifungal therapy are essential to optimize clinical outcomes."

Journal • Candidiasis • Genetic Disorders • Infectious Disease • Ocular Inflammation • Retinal Disorders • Uveitis

Successful use of isavuconazole as secondary prophylaxis of cryptococcal meningitis in a person living with HIV and AIDS: a case report. (PubMed, Ther Adv Infect Dis) - "Induction therapy with liposomal amphotericin B (4 mg/kg/day) plus fluconazole (800 mg/day) was prolonged to 10 weeks because flucytosine was initially unavailable; intravenous flucytosine (25 mg/kg q6h) was introduced when accessible. Maintenance fluconazole (800 mg/day) was continued, and antiretroviral therapy (ART) with dolutegravir plus emtricitabine/tenofovir disoproxil was initiated after 8 weeks...Isavuconazole's pharmacokinetic profile, oral availability, and limited antiretroviral drug-drug interactions supported its use as extended secondary prophylaxis in this setting, although limited access in low- and middle-income countries remains a concern. This case highlights isavuconazole as a potential alternative prophylactic strategy when fluconazole is ineffective or not tolerated."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • CD4

In Vitro, In Silico, and Scanning Electron Microscopy Study of Anti-leishmanial Efficacy of New Synthetic 3-Imidazolyl Flavan Fxime on Leishmania tropica. (PubMed, Infect Disord Drug Targets) - "The results demonstrated notable anti-leishmanial effects of IFO against Leishmania tropica, suggesting it may be considered a potent therapeutic agent."

Journal • Preclinical • Dermatology • Infectious Disease

Safety and efficacy of echinocandin antifungal agents in Candida albicans endophthalmitis. (PubMed, Antimicrob Agents Chemother) - "To evaluate the safety and efficacy of echinocandins (rezafungin, RZF; anidulafungin, AFG) in Candida albicans (C...At 48 h post-infection, rabbits received intravitreal injections of liposomal amphotericin B (L-AmB, 10 μg), voriconazole (VCZ, 50 μg), RZF (35 μg), AFG (35 μg), or saline (control)...In vivo, RZF/AFG reduced clinical and histopathological scores, fungal burden, and TNF-α levels, performing similarly to traditional drugs. RZF and AFG demonstrate potent antifungal activity against C. albicans comparable to conventional drugs, along with significant anti-inflammatory effects and acceptable safety profiles."

Journal • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • IL1B • TNFA

Immunocompetent but Not Immune: A Prolonged Course of Cryptococcal Meningitis. (PubMed, Cureus) - "She was treated with liposomal amphotericin B and flucytosine and later transitioned to high-dose fluconazole due to medication intolerance. This case highlights the potential for CM in immunocompetent hosts with protracted culture positivity despite guideline-directed antifungal therapy. Early recognition of antifungal intolerance, aggressive ICP management, and timely surgical intervention may be critical for optimizing outcomes in such complex cases."

Journal • CNS Disorders • Epilepsy • Infectious Disease • Pain

Successful Outcome of Rhino-Orbital-Cerebral Mucormycosis With Extensive Intracranial Disease in a Patient With Poorly Controlled Diabetes. (PubMed, Perm J) - "This included high-dose liposomal amphotericin B, targeted serial endoscopic debridements of extracranial disease, and adjunctive therapies comprising iron chelation (deferasirox), hyperbaric oxygen, and combination antifungal therapy with caspofungin and posaconazole. Despite the inability to achieve complete surgical clearance, this regimen halted disease progression and resulted in clinical and radiological regression. This case illustrated that a coordinated, multimodal approach utilizing aggressive medical management can achieve favorable outcomes in select patients with otherwise inoperable, extensive intracranial mucormycosis."

Journal • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Thrombosis

New 2030 Global Targets for Histoplasmosis from International Society for Human and Animal Mycology (ISHAM) 2025 Histoplasmosis Working Group. (PubMed, Emerg Infect Dis) - "The group highlighted persistent diagnostic delays, underuse of antigen testing, and poor access to liposomal amphotericin B and itraconazole. Innovations such as lateral flow assays and molecular tools were discussed, alongside the need for biobanks and validated diagnostic algorithms. A global 90-90-90 target for histoplasmosis by 2030 was proposed to improve diagnosis, treatment, and survival."

Journal • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Respiratory Diseases

Breakthrough probable invasive aspergillosis with cutaneous involvement in a neutropenic child with relapsed pre-B ALL under liposomal amphotericin-B prophylaxis (ESCMID Global 2026) - No abstract available

Clinical • Respiratory Diseases

Safety profile of liposomal amphotericin B in invasive Candidozyma auris infection: a multi-centre real-world cohort (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Infectious Disease

Real-world use, clinical characteristics and outcomes of liposomal amphotericin B for invasive Candidozyma auris infection: a multi-centre cohort (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Infectious Disease

Comedication patterns in the haemato-oncology setting suggest manageable renal safety profile of liposomal amphotericin B in the real-world setting (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Oncology

Use of DOOR and Win-Ratio Analysis in a Secondary Evaluation of a Histoplasmosis Clinical Trial. (PubMed, Open Forum Infect Dis) - "We applied DOOR and Win-Ratio analyses to a phase II trial comparing single high-dose vs standard liposomal amphotericin B for HIV-associated histoplasmosis. No clear differences were observed, supporting feasibility and informing design of future phase III trials."

Journal • Human Immunodeficiency Virus • Infectious Disease

Physicochemical compatibility and stability of ketamine co-administered with selected supportive care drugs and parenteral nutrition in pediatric oncology. (PubMed, Explor Res Clin Soc Pharm) - "No additional physical incompatibility occurred., but amoxicillin incompatibility was confirmed. Ketamine is safe to co-administer with AmBisome®, cyclizine, hydromorphone, Intralipid®, magnesium sulfate, metoclopramide, micafungin, potassium dihydrogen phosphate, sodium dihydrogen phosphate and vancomycin. Our findings are significant for improving pain management in vulnerable patients simultaneously administered the tested drugs with ketamine."

Journal • Anesthesia • Oncology • Pain • Pediatrics

Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis. (PubMed, Cureus) - "He was receiving immunosuppressive therapy with TAC, mycophenolate mofetil, and methylprednisolone...He received induction therapy with liposomal amphotericin B and flucytosine for approximately 10 weeks, but persistent intracranial hypertension required placement of a ventriculoperitoneal shunt...To our knowledge, reports describing more than 12 months of ISCZ therapy for cryptococcal infection are limited. This case highlights its potential as a maintenance option in transplant recipients, particularly when fluconazole or voriconazole are not suitable due to drug-drug interactions with TAC."

Journal • Cardiovascular • CNS Disorders • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hypertension • Infectious Disease • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation

A Rare Case of Central Nervous System Mucormycosis Following Deep Brain Stimulation Implantation (SCCM 2026) - "Immediate antifungal therapy with liposomal amphotericin B and isavuconazole was initiated alongside antibiotics. Early mNGS-based CSF testing enables timely diagnosis and facilitates the early initiation of amphotericin B–based antifungal therapy with close toxicity monitoring. Heightened awareness of this rare but lethal complication is essential for prompt intervention and improved prognosis."

Clinical • Cardiovascular • CNS Disorders • Infectious Disease • Movement Disorders • Otorhinolaryngology • Parkinson's Disease • Respiratory Diseases • Sinusitis • Vascular Neurology

Rare Case of Candida auris Pericarditis in an ESRD Patient With History of Endocarditis (SCCM 2026) - "The patient was initially started on micafungin, but due to lack of clinical response, therapy was switched to liposomal amphotericin B while awaiting susceptibility results. This case underscores the need to consider fungal etiologies in high-risk ICU patients with pericardial effusion and highlights C. auris as an emerging critical care threat that requires enhanced surveillance and infection control measures.Sources: (Ruiz-Gaitán et al., JMM Case Rep 2018). (Chowdhary et al., PLoS Pathog, 2016; CDC, 2024)."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Glomerulonephritis • Hematological Disorders • IgA Nephropathy • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus • Ulcerative Colitis

Rare Fungal ARDS: Saprochaete capitata in a Patient Without Classical Risk Factors (SCCM 2026) - "Liposomal amphotericin B was started...Co-infection with MDR organisms further complicates care, limiting therapy and worsening outcomes. Mortality from S. capitata remains high, underscoring the need for awareness, early diagnostics, and targeted management strategies in the ICU."

Clinical • Acute Respiratory Distress Syndrome • Asthma • Cardiovascular • Coronary Artery Disease • Hematological Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Neutropenia • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

The Rising Cost of ICU Drugs (SCCM 2026) - "The top six most expensive ICU drugs based on average monthly cost were albumin, vasopressin, propofol, dexmedetomidine, treprostinil, and amphotericin-B liposome. The overall inpatient drug cost, ICU drug cost, and ICU drug cost per ICU patient day rose by 51%, 43%, and 55% respectively from FY 2012 - 2023. The overall inpatient drug cost, ICU drug cost, and ICU drug cost per ICU patient day rose by 51%, 43%, and 55% respectively from FY 2012 - 2023. Despite these increases, the percentage of ICU drug cost relative the overall inpatient drug cost trended downward in the same period. This suggests that the increase in cost of non-ICU drugs outpaced that of ICU drugs to an extent that resulted in a net decrease in the percentage of ICU drug cost."

Mood Disorders

Disseminated Mucormycosis with Characteristic Gastric Ulcers and Extensive Intravascular Invasion after ABO-Incompatible Living-Donor Liver Transplantation: A Case Report. (PubMed, Surg Case Rep) - "This case represents a breakthrough mucormycosis infection that developed despite antifungal prophylaxis. The disease manifested as characteristic gastric ulcerations and extensive vascular invasion, leading to fatal outcomes despite liposomal amphotericin B therapy. Necrotic gastric ulcers and positive gastric juice cultures provide critical diagnostic clues. In highly immunosuppressed liver transplant recipients, atypical gastric findings should raise suspicion for mucormycosis, and early systemic evaluation is essential to improve otherwise poor prognoses."

Journal • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Peptic Ulcer • Septic Shock • Transplantation

THREE VALVES, ONE FUNGUS, AND ZERO POSITIVE CULTURES: A CASE OF HISTOPLASMOSIS ENDOCARDITIS (ACC 2026) - "Decision-Making: Initially, the patient was treated empirically for culture-negative endocarditis with ceftriaxone and doxycycline...He was treated with liposomal amphotericin B but was deemed a poor surgical candidate... In patients presenting with culture-negative endocarditis, Histoplasma Capsulatum should be included early in the differential diagnosis, especially in patients with prosthetic valves and nonspecific symptoms. When the pathogen remains elusive despite testing, diagnostics like the Karius test, which can identify over 1500 pathogens, can be invaluable."

Cardiovascular • Coronary Artery Disease • Infectious Disease

ACUTE COCCIDIOIDAL PERICARDITIS PRESENTING WITH CARDIAC TAMPONADE IN AN IMMUNOCOMPETENT TRAVELER COMPLICATED BY ACUTE PAROXYSMAL ATRIAL FIBRILLATION AND ACUTE KIDNEY INJURY (ACC 2026) - "We prioritized hemodynamic rescue via urgent pericardiocentesis, initiated liposomal amphotericin B (stopped with AKI), and transitioned to fluconazole. Patient stabilized, reverted to sinus rhythm, renal function recovered, and the effusion resolved (no tamponade by day 10). He was discharged on azole therapy; follow-up echocardiography was normal and chest CT showed resolution of pericardial fluid with stable pulmonary nodules."

Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Hypotension • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases

Prosthetic valve endocarditis caused by a very rare black mold, Exophiala dermatitidis. (PubMed, Indian J Thorac Cardiovasc Surg) - "Despite sterile blood cultures, intraoperative findings of black, friable vegetations prompted empirical antifungal therapy. Nanopore sequencing rapidly identified Exophiala dermatitidis, facilitating targeted dual antifungal treatment with voriconazole and liposomal amphotericin B. This case highlights the importance of early surgical intervention, molecular diagnostics, and combination antifungal therapy in managing fungal PVE caused by E. dermatitidis, emphasizing the need for heightened clinical suspicion and multidisciplinary approaches for improved patient outcomes."

Journal • Cardiovascular • Infectious Disease • Pulmonary Disease

Mucocutaneous Leishmaniasis Associated with Adalimumab Therapy: A Case Report from an Endemic Region (AAD 2026) - "We report the case of a 40-year-old woman with severe hidradenitis suppurativa and Crohn's disease treated with adalimumab and azathioprine...The patient was treated with liposomal amphotericin B, showing progressive clinical improvement until near-complete resolution of lesions. This case underscores the need to suspect leishmaniasis in patients receiving tumor necrosis factor inhibitors in endemic regions. Diagnosis should integrate clinical and histopathological findings, with PCR representing a key tool due to its high sensitivity and specificity when initial tests are inconclusive."

Case report • Clinical • Crohn's disease • Dermatology • Dermatopathology • Gastroenterology • Hematological Disorders • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammatory Bowel Disease

A Fatal Encounter of Endemic Mycoses: Concomitant Histoplasmosis and Paracoccidioidomycosis. (AAD 2026) - "Despite the early initiation of liposomal amphotericin B, the patient's condition worsened, leading to respiratory failure and death due to extensive pulmonary involvement. This case underscores the importance of considering endemic systemic mycoses in patients with risk factors or immunocompromised conditions. This case would be the fifth case reported of concomitant disseminated histoplasmosis and paracoccidioidomycosis, contributing valuable evidence to the clinical literature in this topic."

Dermatology • Infectious Disease • Respiratory Diseases

Fusarium on the Surface: Cutaneous Clues to a Deadly Disseminated Infection (AAD 2026) - "Patient History: Here we present a 68-year-old man with past medical history of acute myeloid leukemia (AML) treated with an allogeneic stem cell transplant, chronic hepatic graft-versus-host disease (GVHD), and cutaneous and pulmonary mucormycosis, which had been successfully managed for two years with posaconazole, who was admitted for chemotherapy with cladribine, cytarabine, and venetoclax...Treatment: Management included surgical nasal sinus debridement and near-total ethmoidectomy, in addition to aggressive systemic antifungal therapy with voriconazole, liposomal amphotericin B, micafungin, and oral terbinafine. Supportive treatment included meropenem and filgrastim to address concurrent neutropenia... In immunocompromised patients with hematologic malignancies, dermatologists should have a low threshold to perform biopsies and tissue cultures on even non-specific skin findings. Prompt dermatologic evaluation, biopsy, and tissue culture are essential for early..."

Acute Myelogenous Leukemia • Graft versus Host Disease • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Leukemia • Liver Failure • Neutropenia • Otorhinolaryngology