PA83-FhCMB / iBio - LARVOL DELTA

Safety and immunogenicity of a plant-derived recombinant protective antigen (rPA)-based vaccine against Bacillus anthracis: A Phase 1 dose-escalation study in healthy adults. (PubMed, Vaccine) - P1 | "This is the first study demonstrating a plant-derived subunit anthrax vaccine's safety and immunogenicity in healthy adults. The results support further clinical investigation of the PA83-FhCMB vaccine. ClinicalTrials.gov identifier. NCT02239172."

Journal • P1 data

Transient expression of an anthrax decoy protein in Nicotiana benthamiana: The impacts of N-glycosylation on protein expression, stability and function (ACS-Sp 2019) - "The toxin neutralization potency of CMG2-Fc variants was tested in a cell-based assay, where the EC50 values for APO and Agly variants were lower than for the ER-retained variant. The possible causes of EC50 differences were investigated through molecular simulation and protein thermostability studies."

Transient expression of an anthrax decoy protein in Nicotiana benthamiana: The impacts of N-glycosylation on protein expression, stability and function (ACS-Sp 2019) - "The toxin neutralization potency of CMG2-Fc variants was tested in a cell-based assay, where the EC50 values for APO and Agly variants were lower than for the ER-retained variant. The possible causes of EC50 differences were investigated through molecular simulation and protein thermostability studies."