Epistatus (midazolam oromucosal solution) / Veriton Pharma - LARVOL DELTA

"Class 2 @MHRAmedicines Recall: Epistatus (Midazolam) 10mg/mL Oromucosal Solution (Multi Dose Bottles)- Torbay Pharmaceuticals https://t.co/qQuGmIAUkB" (@PSNCNews)

Nasal Fentanyl and Buccal Midazolam for Dying Patients (clinicaltrials.gov) - P4; N=20; Recruiting; Sponsor: Gloucestershire Hospitals NHS Foundation Trust; Initiation date: Apr 2014 ➔ Jan 2017; Trial primary completion date: Apr 2015 ➔ Jan 2018

Trial initiation date • Trial primary completion date • Biosimilar • Oncology • Pain

Non-intravenous rescue medications for pediatric status epilepticus. A cost-effectiveness analysis (AES 2017) - "To quantify the cost-effectiveness of rescue medications for pediatric status epilepticus: rectal diazepam, nasal midazolam, buccal midazolam, intramuscular midazolam, and nasal lorazepam. For pediatric status epilepticus, buccal midazolam and nasal midazolam are the most cost-effective non-intravenous rescue medications in the USA. Rectal diazepam is not a cost-effective alternative and this conclusion remains extremely robust to wide variations of the input parameters."

Clinical • HEOR • CNS Disorders • Epilepsy

Development and evaluation of an anti-epileptic oral fast-dissolving film with enhanced dissolution and in vivo permeation. (PubMed, Curr Drug Deliv) - "The pharmacokinetic parameters of midazolam oral film in comparison to coarse midazolam suspension exhibited significant increase in AUC, Cmax, and a good decrease in Tmax. The overall results showed the enhanced in vivo orotransmucosal absorption of poorly water-soluble drugs via the insertion of drugs nanosuspension in buccal films."

Journal • Preclinical • Biosimilar • CNS Disorders • Epilepsy

The effect of status epilepticus on autonomic regulation of the heart and its functional capabilities in different postictal periods (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The high degree of seizure activity of the brain in the ES predetermines prolonged postictal disorders of the AR heart, which reduce its functional capabilities and increase the risk of life-threatening arrhythmias."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Epilepsy

Buccal Midazolam Solution for the Management of Prolonged Acute Convulsive Seizures: A Cost Analysis. (PubMed, Pharmacoecon Open) - "The availability of single-unit Epistatus allows for greater flexibility in prescribing. Physicians should attempt to categorise patients according to past PACS frequency with low PACS patients being prescribed single unit Epistatus (with/without spare loading) and 4-pack Buccolam reserved for patients in whom a high volume of usage is anticipated."

HEOR • Journal

A randomized controlled trial of oral chloral hydrate vs intranasal dexmedetomidine plus buccal midazolam for auditory brainstem response testing in children. (PubMed, Paediatr Anaesth) - "Intranasal dexmedetomidine plus buccal midazolam was associated with higher sedation success with deeper level of sedation, with similar discharge time and adverse event rate when compared to chloral hydrate."

Clinical • Journal

Can giving medication up the nose and through the lining of the mouth control symptoms as effectively as injections for people approaching the end of life? – Pilot Study (clinicaltrialsregister.eu) - P4; N=20; Completed; Sponsor: Gloucestershire Hospitals NHS Foundation Trust and

Clinical • Combination therapy • New P4 trial