medroxyprogesterone injection / Generic mfg. - LARVOL DELTA

Trends and patterns of concurrent contraceptive use with antihypertensive treatment in women using real-word data: Veteran Affairs Corporate Data Warehouse (AHA 2025) - "Types of contraceptive medication include combined oral contraceptive pills (yaz, ortho tri-cyclen), progestin-only pills (emicronor), vaginal rings (NuvaRing), transdermal patch (Ortho Evra), and injection (Depo-Provera). The most prescribed antihypertensive medication were beta blockers (43.78%), followed by diuretics (39.91%), alpha blockers (32.80%) and ACEI/ARBs (30.79%, n=40,518). Despite the current guideline, very low concomitant use of contraceptives (12%) with ACEI/ARB was observed in the study. While ACEI/ARB is the least prescribed medication to treat hypertension for reproductive age women, its use has been steadily increasing over the past decade, while rates of concurrent contraceptive use has decreased placing women at an increased risk of teratogenic exposure during pregnancy. Future studies are warranted to investigate the cause and barriers of suboptimal concomitant contraceptive utilization with ACEI/ARBs and pregnancy outcomes, including low birth..."

Clinical • Cardiovascular • Hypertension

Hormonal Contraceptive Formulations and Breast Cancer Risk in Adolescents and Premenopausal Women. (PubMed, JAMA Oncol) - "Higher risk was associated with oral desogestrel-only formulations (HR, 1.18; 95% CI, 1.13-1.23) and oral desogestrel-combined formulations (HR, 1.19; 95% CI, 1.08-1.31), as well as implants containing etonogestrel, desogestrel's active metabolite (HR, 1.22; 95% CI, 1.11-1.35), compared to levonorgestrel-containing combined pills (HR, 1.09; 95% CI, 1.03-1.15) and levonorgestrel, 52 mg, intrauterine system (HR, 1.13; 95% CI, 1.09-1.18). No statistically significant increased risk was observed for medroxyprogesterone acetate injection, etonogestrel vaginal ring, or combined oral drospirenone, despite having many users. Findings of this cohort study highlight that breast cancer risk varies substantially by progestin content in hormonal contraceptives, providing valuable insights to support more informed contraceptive prescription."

Journal • Breast Cancer • Cervical Cancer • Gynecology • Infertility • Oncology • Ovarian Cancer • Sexual Disorders • Solid Tumor • Uterine Cancer

#DepoProvera, An analysis of the most popular TikTok videos about Medroxyprogesterone Acetate. (PubMed, Contraception) - "#DepoProvera TikTok videos often depict negative personal experiences shared by laypeople, influencing patient perceptions of this contraceptive method."

Journal

Hormonal contraceptives and the risk of meningioma: a Swedish register-based case-control study. (PubMed, Neuro Oncol) - "This large register-based case-control study show a strong association between injectable hormonal contraceptives containing medroxyprogesterone and meningioma risk. The results add to the growing body of evidence of an association between meningiomas and progestins in general and the strong, consistent associations suggest a causal role of injectable medroxyprogesterone in meningioma growth. Our results correspond to two additional cases of meningioma per 10 000 women exposed to medroxyprogesterone per year."

Journal • Brain Cancer • Long-acting Reversible Contraceptives • Meningioma • Oncology • Solid Tumor

Uptake of intrauterine contraception after medical management of first trimester incomplete abortion: A cross-sectional study in central Uganda. (PubMed, PLoS One) - "The uptake of IUDs among post abortion women was nearly 60% emphasizing the potential impacts of integrated contraceptive services in Post abortion care. The impact of comprehensive and updated training on post abortion contraceptive counselling, is vital on the uptake of IUDs. Regardless of sociodemographic status, women seeking post abortion care in Uganda should be provided with high-quality integrated services by trained providers offering a range of contraceptive methods. Such efforts may not only prevent unintended pregnancies but also improve health equity across the country."

Journal • Observational data • Long-acting Reversible Contraceptives

PLEURAL ENDOMETRIOSIS AND CATAMENIAL PNEUMOTHORAX: A CASE REPORT FROM TREATMENT TO FAMILY PLANNING (FIGO 2025) - "She was referred to a tertiary gynecology service for follow-up after starting injectable medroxyprogesterone for hormonal blockage... The reported case emphasizes the importance of discussing the diagnosis and follow-up of a rare situation with variable clinical presentation, which is pleural endometriosis. The main pillar of treatment is the hormonal blockage of ectopic endometrial tissue, with special care in patients with gestational desire and the risk of disease recurrence after suspending or changing the hormonal method."

Case report • Clinical • Endometriosis • Gynecology • Long-acting Reversible Contraceptives • Respiratory Diseases • Women's Health

PULMONARY THROMBOEMBOLISM AFTER CONCURRENT SELF-MEDICATED HORMONE THERAPY IN A HIV TRANSGENDER WOMAN (FIGO 2025) - "At the beginning of 2023, the patient also started taking, every ten days, a non-prescribed monthly injectable contraceptive containing estradiol valerate 5 mg and norethisterone enanthate 50 mg. In April 2023, the patient took a dose of injectable medroxyprogesterone... Self-medication is a sociocultural phenomenon that persists even when medical care is available. Expanding provision of medical follow-up, providing safer options for those at increased risk for thromboembolic events, addressing expectatives and satisfaction of the patients with their hormone therapy, health education and mental health care are measures that can reduce the exposure of this population to such risks."

Clinical • Cardiovascular • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Long-acting Reversible Contraceptives • Pulmonary Disease • Pulmonary Embolism

THE LIVED EXPERIENCE OF SELF-INJECTABLE CONTRACEPTIVE USE: PERSPECTIVES FROM WOMEN IN RURAL MALAWI (FIGO 2025) - "The illustrative stories include "Nabanda," a 28-year-old who, after experiencing side effects from Depo-Provera, embraced SI for its logistical ease and the opportunity to involve her partner in the self-care experience. The lived experiences of women using SI in Malawi provide insights into the impact it can have in rural communities and the importance of investing in HSAs, addressing stockouts, and harnessing social support to optimize implementation of this novel self-care technology."

Clinical • Long-acting Reversible Contraceptives

Reproductive health knowledge and contraceptive use in never pregnant systemic lupus erythematosus patients: A cross-sectional survey. (PubMed, Lupus) - "Compared to the past, the current use of male condoms and withdrawal has significantly decreased (76.92% to 62.64%, p = .007, and 47.25% to 37.36%, p = .020, respectively), and effective contraceptive methods (oral contraceptive pills and medroxyprogesterone acetate injections) also have significantly declined (19.78% to 2.20%, p < .001, and 8.79% to 4.40%, p = .046, respectively)...There was no difference in contraceptive methods used, frequency of sexual activity, and SLE disease activity between patients who did and did not live with their partners.ConclusionsKnowledge of reproductive health, particularly contraceptive use in SLE patients, remains suboptimum. Formal reproductive health counseling should be carried out in all SLE patients for better contraception planning."

Journal • Immunology • Inflammatory Arthritis • Long-acting Reversible Contraceptives • Lupus • Nephrology • Systemic Lupus Erythematosus

Cervical Secretions from Women After Depot Medroxyprogesterone Acetate (Depo-Provera) Administration Promote HIV Infectivity Ex Vivo. (PubMed, Viruses) - "Additionally, changes in IL-1α at visit 3 were positively associated with changes in HIV infectivity compared with visit 1. These findings suggest that Depo-Provera may increase the HIV risk by shifting the mucosal milieu that promotes HIV infectivity."

Journal • Preclinical • Human Immunodeficiency Virus • Infectious Disease • CD4 • IL17A • IL4

Contraceptive method continuation among a prospective cohort study of Malawian women on antiretroviral treatment initiating the Levonorgestrel Implant or the Depot Medroxyprogesterone Acetate Injectable for pregnancy prevention (the FP-ART study). (PubMed, AIDS Care) - "1,179 participants (86.8%) usedefavirenz-based therapy at enrollment, with 874 (74.1%) switching to dolutegravir-based therapy by their last study visit. The time by which 25% of women had discontinued their initial contraceptive also differed markedly: 76.0 weeks for the DMPA group and 142.7 weeks for the implant group. Future studies can evaluate the factors that lead to contraceptive continuation versus discontinuation among WLWH."

Journal • Human Immunodeficiency Virus • Infectious Disease • CD4

Bilateral spheno-orbital meningioma: What's there to see? (ESHNR 2025) - "All patients had a history of contraceptive use and at least seven patients had a history of injectable medroxyprogesterone usage.At presentation 3 patients had normal vision, 6 had unilateral and 1 bilateral visual impairment or exophthalmos...Diagnostic workup including imaging is key in diagnosing bilateral SOM. The decision to perform a surgical procedure is mainly based on ophthalmologic considerations in which the presence of compressive optic neuropathy plays a pivotal role."

Brain Cancer • CNS Disorders • Depression • Genetic Disorders • Major Depressive Disorder • Meningioma • Neurofibromatosis • Ocular Inflammation • Ophthalmology • Optic Neuritis • Psychiatry • Solid Tumor • NF2

Measuring Lactation Initiation After Early Postpartum Injectable Progestin (DMPA) Use Among Women in Dhanusha District of Nepal: A Pilot Study (clinicaltrials.gov) - P4 | N=40 | Completed | Sponsor: University of California, San Diego | Not yet recruiting ➔ Completed | Trial completion date: Mar 2026 ➔ Jul 2025 | Trial primary completion date: Mar 2026 ➔ Jul 2025

Trial completion • Trial completion date • Trial primary completion date

Maternal physical and social characteristics that influence the occurrence of preeclampsia/eclampsia and hemorrhage in Eastern Region of Ghana. A prospective cohort study. (PubMed, SAGE Open Med) - "Those who opted for Jadelle contraceptives had 3.4 times the odds (aOR: 3.419, p = 0.028, 95% CI: 1.143-10.227) of developing preeclampsia/eclampsia compared to those who used Depo-Provera contraceptives...Women need to seek medical advice on contraceptives before and during pregnancy before choosing contraceptives methods. Also, effective community-based health planning and services concept should be implemented to improve access to family planning services in the rural communities."

Journal • Gynecology • Hematological Disorders

Serum norethisterone (NET) levels in NET-enanthate (NET-EN) injectable contraception users substantially interfere with testosterone immunoassay measurements and confound interpretation of biological outcomes. (PubMed, Contracept Reprod Med) - "We show for the first time that physiological concentrations of NET in premenopausal NET-EN users interfere with testosterone quantification using a CMIA method. The degree of interference is much higher and occurs at lower concentrations of NET than has previously been reported for oral NET and confounds the biological outcome of NET-EN use on testosterone concentrations, individually and relative to DMPA-IM."

Journal • Long-acting Reversible Contraceptives

Comparative pharmacokinetics and safety of subcutaneous and intramuscular depot medroxyprogesterone acetate when used among women living with HIV on doravirine-containing antiretroviral therapy (IAS-HIV 2025) - "A formulation of subcutaneous depot medroxyprogesterone acetate (SC MPA, 104mg, i.e., Sayana Press), dosed lower than intramuscular (IM) DMPA (150mg), is available commercially. The data provides valuable insights into the pharmacokinetics and safety of SC MPA and IM DMPA in WLWH using and doravirine-containing ART. While MPA concentrations were lower in the SC MPA vs. IM DMPA groups, as expected, there was no significant impact on ART concentrations providing a signal of limited drug-drug interactions."

Clinical • PK/PD data • Human Immunodeficiency Virus • Infectious Disease • Long-acting Reversible Contraceptives

Severe Hypoglycemia Following Accidental Intramuscular Injection of Regular Insulin (ENDO 2025) - "She had a medical history of hypertension and gastroesophageal reflux disease, managed with Cozaar and Prilosec, respectively. Her symptoms began hours after she mistakenly injected 10 cc (1,000 units) of regular insulin intramuscularly instead of her usual Depo-Provera birth control injection...Prompt recognition and appropriate management with intravenous dextrose infusion are essential for recovery. To prevent such incidents, healthcare providers must emphasize patient education on safe medication practices and handling."

Cardiovascular • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Hypertension • Hypoglycemia • Long-acting Reversible Contraceptives • Metabolic Disorders • Movement Disorders • Psychiatry • Severe Hypoglycemia

Bone mineral density changes during use of progestin-only contraceptives: a rapid review of recent evidence. (PubMed, AJOG Glob Rep) - "While there is a clear association between bone mineral density loss and depot medroxyprogesterone acetate injectable use, treatment during contraceptive use and bone health restoration following discontinuation are not adequately researched. In this review, we provide evidence that bone health can be partially or completely restored after depot medroxyprogesterone acetate discontinuation, identify opportunities to learn more about depot medroxyprogesterone acetate injectables and bone health during and after use, and find gaps in knowledge on potential associations between bone health and other progestin-only contraceptives."

Journal • Review • Long-acting Reversible Contraceptives • Osteoporosis

Comparing Dydrogesterone Versus Medroxyprogesterone in Progestin-Primed Ovarian Stimulation (PPOS) for Patients Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review. (PubMed, Cureus) - "These findings indicate that both DYG and MPA are effective and safe for LH surge suppression in PPOS protocols, with DYG potentially offering a more physiologic hormonal profile and reduced gonadotropin use. Further randomized controlled trials are recommended to validate these results."

Journal • Preclinical • Review • Gynecology

Maternal hormonal contraceptive use and childhood central nervous system tumor risk in a large Scandinavian cohort. (PubMed, Int J Cancer) - "In conclusion, no association was found between maternal use of common types of hormonal contraception and CNS tumors in children. The rarely used progestin-only injections (medroxyprogesterone acetate) were associated with malignant CNS tumor risk in children, though based on few children."

Journal • Brain Cancer • CNS Tumor • Oncology

Menstrual Dysphoria and Preferences for Menstrual Suppression in Transgender and Gender-Diverse Youth. (PubMed, J Pediatr Adolesc Gynecol) - "The study underscores the considerable distress that menstruation can cause in TGD youth. Moreover, the importance of personalized, patient-centered counseling is emphasized, with the objective of empowering individuals to make decisions based on their specific needs."

Journal • CNS Disorders • Long-acting Reversible Contraceptives

Lack of association between contraception initiation at delivery discharge and 6-week postpartum psychopathology symptoms (ACOG 2025) - "Depression symptomatology was compared across patients who chose local contraception (ie, intrauterine device) versus systemic hormonal contraception (ie, medroxyprogesterone acetate injection, etonogestrel implant, etonogestrel-ethinyl estradiol ring, norelgestromin/ethinyl estradiol transdermal patch, norethindrone pills), and no contraception using chi-squared and multivariable logistic regression. Among 3,644 patients, 57% received contraception at discharge. We did not identify an association between local, systemic, or no contraception and PHQ-9 scores at the 6-week postpartum visit in univariate or multivariable logistic regression analyses. However, odds of moderate/severe depression symptomatology scores were elevated with previous psychiatric diagnosis (odds ratio [OR] 3.58; 95% CI, 2.15–5.97), Black race (OR 2.02; 95% CI, 0.91–4.48), and being separated/divorced/widowed as compared to married/life partnership (OR 5.08; 95% CI, 1.35–19.14)."

CNS Disorders • Depression • Long-acting Reversible Contraceptives • Mental Retardation • Psychiatry

Switching to a patient-administered injectable contraceptive: a Quality Improvement Project. (PubMed, Br J Gen Pract) - "Since June, there has been a 150% (n = 6) increase in patients prescribed Sayana Press, with these being trained in self-injection. Having received positive verbal feedback from staff, confidence in discussing and prescribing Sayana Press has increased. This progression could save nursing and patient time and offer patients more contraceptive options. With distribution of patient leaflets, patients are now aware of Sayana Press, allowing them the opportunity to consider changing contraceptive in the future. A second PDSA cycle can be completed to look for sustainable change."

Journal • Long-acting Reversible Contraceptives

Addressing the Social Determinants of Health in the Amazon River Communities of Loreto, Peru, to Improve Maternal Health Access. (PubMed, Cureus) - "Geographic isolation has a significant impact on healthcare access, with education and transportation emerging as critical factors in maternal health outcomes. The findings highlight the need for culturally sensitive interventions that address these root causes. Proposed sustainable solutions include basic medical training for community members, emergency plans, and improved transportation to reduce maternal health disparities in these communities."

Journal

Depot medroxyprogesterone acetate (DMPA)-associated early-onset osteoporotic fracture. (PubMed, Endocrinol Diabetes Metab Case Rep) - "Evidence shows that intramuscular depot medroxyprogesterone acetate (DMPA) negatively affects BMD by inhibiting the hypothalamic-pituitary-ovarian axis...Herein, we present a case of a premenopausal woman with an unusual hip fracture and a history of prolonged use of intramuscular DMPA contraception. Our case also highlights that the patient's clinical presentation is essential for interpreting genetic sequencing results."

Journal • Long-acting Reversible Contraceptives • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Rheumatology • ALPL