JZP541 / Jazz - LARVOL DELTA

BEHAVIORAL AND TRANSCRIPTOMIC EFFECTS OF A NOVEL CANNABINOID ON A RAT VALPROIC ACID MODEL OF AUTISM. (PubMed, Neuropharmacology) - "This approach indicated a strong and dose-dependent reduction of the autism-associated gene expression signature in brain samples from animals dosed with JZP541. Our findings demonstrate JZP541 was able to ameliorate ASD associated behavioral deficits, and this was supported by improvements in putative transcriptional biomarkers of ASD."

Journal • Preclinical • Autism Spectrum Disorder • Genetic Disorders

A Study of JZP541 in Adults With Irritability Associated With Autism Spectrum Disorder (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: Jazz Pharmaceuticals | Terminated ➔ Withdrawn

Trial withdrawal • Autism Spectrum Disorder • Genetic Disorders

A Study of JZP541 in Adults With Irritability Associated With Autism Spectrum Disorder (clinicaltrials.gov) - P2 | N=1 | Terminated | Sponsor: Jazz Pharmaceuticals | N=90 ➔ 1 | Trial completion date: Mar 2025 ➔ Nov 2023 | Recruiting ➔ Terminated | Trial primary completion date: Feb 2025 ➔ Nov 2023; A decision has been made to prioritize other pipeline programs and terminate this study.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Autism Spectrum Disorder • Genetic Disorders

CALM-IT: Cannabinoid Liquid Medication Intervention Trial (clinicaltrials.gov) - P2 | N=60 | Recruiting | Sponsor: Sunnybrook Health Sciences Centre | Not yet recruiting ➔ Recruiting

Enrollment open • Alzheimer's Disease • CNS Disorders

CALM-IT: Cannabinoid Liquid Medication Intervention Trial (clinicaltrials.gov) - P2 | N=60 | Not yet recruiting | Sponsor: Sunnybrook Health Sciences Centre

New P2 trial • Alzheimer's Disease • CNS Disorders

A Study of JZP541 in Adults With Irritability Associated With Autism Spectrum Disorder (clinicaltrials.gov) - P2 | N=90 | Recruiting | Sponsor: Jazz Pharmaceuticals | Not yet recruiting ➔ Recruiting

Enrollment open • Autism Spectrum Disorder • Genetic Disorders