Cinnal F (follitropin alfa biosimilar) / CinnaGen - LARVOL DELTA

Comparing Stair-Step Letrozole with Letrozole/Gonadotropin Combined Regimens for Ovulation Induction in Letrozole-Resistant Infertile PCOS Candidates of Intrauterine Insemination. (PubMed, Iran Biomed J) - "The present study was conducted to compare ovulation induction in infertile polycystic ovarian syndrome (PCOS) women candidates of intrauterine insemination (IUI) who were resistant to letrozole by two regimens: single-drug stair step letrozole vs. combined letrozole plus human menopausal gonadotropin...Control cases received letrozole (5 mg) from day 3 of the cycle for five days plus Cinnal-f® (75 international units subcutaneously daily) on days 8 and 9...Our study found similar frequencies of dominant follicles between the stair-step letrozole and letrozole/ gonadotropin groups and a significantly higher frequency of chemical pregnancy (positive beta-hCG) and clinical and ongoing pregnancy in the stair-step letrozole group. As an easy and acceptable method for patients, this protocol can be a suitable alternative for ovulation induction."

Clinical • Journal • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Superovulation of high-producing Holstein lactating dairy cows with human recombinant FSH and hMG. (PubMed, Theriogenology) - "However, pregnancy rates on Day 60 and the number of calves born healthy was less in heifers that received embryos from Cinnal-f treated donors (P < 0.05). In conclusion, Cinnal-f and Menotropins could provide similar superovulatory response to Folltropin-V for superovulation of high-producing Holstein lactating dairy cows."

Journal

Comparing a biosimilar follitropin alfa (Cinnal-fⓇ) with Gonal-fⓇ in women undergoing ovarian stimulation: An RCT. (PubMed, Int J Reprod Biomed) - "Participants began a pituitary downregulation protocol with buserelin. Cinnal-fⓇ proved non-inferior to Gonal-fⓇ, based on the percentage of MII oocytes in women aged 35 yr undergoing ICSI. Our findings confirm that the efficacy and safety profiles of Cinnal-fⓇ and Gonal-fⓇ are similar."

Clinical • Journal