mafenide / Generic mfg. - LARVOL DELTA

Progress in small-molecule inhibitors of gasdermin D. (PubMed, Eur J Med Chem) - "Examples include small-molecule drugs targeting Cys191/192 such as DMF, DSF, NSA, and NU6300, as well as molecules targeting other residues like mafenide, GI-Y1, and GI-Y2. Optimizing specificity and exploring disease-specific applications remain pivotal to advancing these inhibitors as therapeutic agents. Current research focuses on developing clinically translatable, highly effective, and safe GSDMD-targeted therapies through structure-guided optimization, drug repurposing, innovations in precision delivery systems, and synergistic mechanism approaches."

Journal • Review • Immunology • Infectious Disease • Inflammation • Oncology • Septic Shock

Control of invasive Pseudomonas burn wound infection with mafenide acetate electrospun wound dressing. (PubMed, Burns) - "The extent and rate of mafenide acetate release from the dressing were determined in vitro using drug release and skin permeation tests and in vivo using a rat burn model. Finally, the mafenide acetate electrospun wound dressing's antimicrobial activity in vitro and its capability to control invasive Pseudomonas infection in vivo was determined using a modified AATCC 100 test and the modified Walker-Mason scalded rat burn model, respectively."

Journal • Infectious Disease

Supramolecular Gelators Derived from Fmoc-Amino Acid Conjugates of Mafenide for Treating Melanoma: Toward Developing Vehicle-Free Drug Delivery. (PubMed, ACS Appl Bio Mater) - "Rheological studies confirmed rheoreversibility and moldability, which are ideal for topical application. Although the results indicated a plausible VFDD application using the topical gel of FmocL-M, which eliminates the need for a gel matrix, bypassing challenges like cytotoxicity and drug release, it remains to be evaluated the effect of gel itself in treating melanoma."

Journal • Melanoma • Oncology • Solid Tumor

Designing anti-bacterial supramolecular gels from primary ammonium dicarboxylate (PAD) salts for self-delivery applications. (PubMed, Faraday Discuss) - "Synthesis, structure and supramolecular gelation behaviour of 20 PAD salts derived from 5 dicarboxylic acids - (CH2)n-(COOH)2 (n = 4, 7, 10, 12 and 14) - and 4 therapeutic amines - amantadine (AMN), tyramine (TRM), tryptamine (TRP) and mafenide (MAF) - are reported. Detailed biological studies suggested that the C14·2MAF anti-bacterial property is caused by bacterial cell membrane disruption and ROS generation. Gradual release of C14·2MAF from a MS-gel bed and sheer thinning of the gel phase, clearly indicated that the C14·2MAF MS gel has potential use as a supramolecular topical gel for anti-bacterial treatment."

Journal

Cost Analysis of Pure Hypochlorous Acid Preserved Wound Cleanser versus Mafenide for the Irrigation of Burn Wounds. (PubMed, Clinicoecon Outcomes Res) - "Based upon 100,000 simulated patients, pHA was expected to save $133 ($123 to $144, 10th to 90th percentile) for the hospital compared to using a mafenide solution over 14 days. Adoption of pHA should be considered a cost-saving strategy when treating patients with burns."

Cost-analysis • HEOR • Journal • Thermal Injury

Evaluation of pain associated with the application of burn dressings. (PubMed, Int J Burns Trauma) - "Further studies are needed with additional validated pain assessment tools and clinically relevant endpoints to fully elucidate the impact of burn dressings and other topical wound care options on pain."

Journal • Infectious Disease • Pain

Fighting A New Front On An Old Battlefield: Examining the Development of Topical Antimicrobial Care to Control Burn Wound Sepsis. (PubMed, J Burn Care Res) - "Topical antimicrobial burn care has evolved from the use of anecdotal remedies to scientific breakthroughs such as Moyer's successful dilution of silver nitrate solution, Fox's described benefit of silver sulfadiazine use in animal models, and Pruitt's dramatic improvement in post-burn mortality using topical mafenide acetate in burn wounds. Newer advances in topical antimicrobial care such as nanosilvers and dressing technologies that improve the morbidity and mortality associated with burn wound sepsis and novel approaches to management will also be discussed. To improve burn care, it is prudent to look to the past and learn from the experiences of those who contributed to the control of burn wound sepsis."

Journal • Infectious Disease • Septic Shock

PCL/PGLA Coaxial Electrospun Mat Infused with Mafenide Acetate for Treatment of Invasive Wound Infection after Burn Injuries (ASM Microbe 2024) - "Based on the zone of inhibition against P. aeruginosa and S. aureus, MA loaded in the electrospun fabrics demonstrated antimicrobial activity. This study shows that electrospinning MA in fabric form is feasible."

Infectious Disease • Thermal Injury

The Antimicrobial Efficacy of Topically Applied Mafenide Acetate, Citric Acid and Wound Irrigation Solutions Lavanox and Prontosan against Pseudomonas aeruginosa. (PubMed, Antibiotics (Basel)) - "The results demonstrated the antimicrobial efficacy of all solutions against PA. Further investigation is needed to explore the potential clinical applications of a combination or alternating use of these solutions for infection prophylaxis and treatment of wound infections caused by PA."

Journal • Infectious Disease • Septic Shock • Thermal Injury

Safety and Efficacy of Mafenide and Amphotericin Solution in Burn Patients (ASHP 2023) - No abstract available

Clinical • Critical care

The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds. (PubMed, Burns) - "In rats treated with Mafenide acetate, graft survival was higher on day 7 and gradually decreased towards day 14. Application of a 2.5% solution of Mafenide acetate longer than 7 days on inoculated skin grafts in a rat model causes significant cytotoxicity and graft loss."

Journal • Infectious Disease

Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens. (PubMed, Future Med Chem) - "Importantly, they retained activity against a panel of superbugs (methicillin- and vancomycin-resistant staphylococci, enterococci, multidrug-resistant Mycobacterium tuberculosis) without any cross-resistance. Toxicity to HepG2 cells was also investigated. Schiff bases were significantly more active than the parent drug, with iodinated salicylidene and 5-nitrofuran/thiophene-methylidene scaffolds being preferred in identifying the most promising drug candidates."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Phenylalanine conjugated supramolecular hydrogels developed from the mafenide and flurbiprofen multidrug for biological applications. (PubMed, Org Biomol Chem) - "These covalent amidic bioconjugates were further reacted individually with mafenide (a drug for treating burn wounds) and amantadine (an antiviral drug) to develop primary ammonium monocarboxylate (PAM) salts. The temperature-dependent H-NMR spectroscopy of the selected HG further provided insights into the gelation mechanism and the only isolated single-crystal of the weakly diffracted gelator FLR·AMN also revealed the presence of 1D hydrogen-bonded networks. The pure hydrogelator FLR·PHE·MAF salt (which is also an ambidextrous gelator) was found to be promising in both mechanical (rheoreversible) and biological applications and was found to be effective in cytotoxicity, biocompatibility, anti-cancer activity (MTT and cell migration assay), antibacterial response (zone inhibition, turbidity, INT, and resazurin assay) and haemolysis studies."

Journal • Hematological Disorders • Oncology

Letter to the Editor: A New Twist on an Old Trick: Use of Mafenide Acetate/Amphotericin B Soaks via Irrigating Wound Vacuum System to Treat Angioinvasive Fusarium Infection. (PubMed, Surg Infect (Larchmt)) - No abstract available

Journal • Infectious Disease

Strategies to prevent suppurative chondritis following auricular burns: a systematic review. (PubMed, J Wound Care) - "The most common interventions were pressure avoidance (70%), daily cleansing (60%), topical mafenide acetate (60%) and targeted debridement (30%). Packages of measures which included pressure avoidance were the most effective, all of which achieved a chondritis incidence of <6%. Low-level but strong published evidence suggests that important treatment principles include prevention by pressure relief, targeted debridement, prophylactic local antibiotics, local antisepsis and the avoidance of desiccation."

Journal • Retrospective data • Review • Immunology • Infectious Disease • Inflammation • Thermal Injury

Supramolecular Hydrogels Developed from Mafenide and Indomethacin as a Plausible Multidrug Self-Delivery System as Antibacterial and Anti-inflammatory Topical Gels. (PubMed, ACS Appl Bio Mater) - "Following a structural rationale, a series of simple organic salts derived from mafenide (a drug for treating burn wounds) and n-alkyl carboxylic acids (Me-(CH)-COOH; n = 1-3, 10-15) and various nonsteroidal anti-inflammatory drugs (NSAIDs), namely, indomethacin (IND), diclofenac (DIC), meclofenamic acid (MEC), tolfenamic acid (TOL), and flufenamic acid (FLU) (designated as salts 1-14, respectively) were synthesized as potential hydrogelators. Single-crystal structures of the nongelator salts 1-3 and the gelator salt 10 were determined by X-ray diffraction. The results obtained from various studies, which included the solubility, biostability, biocompatibility (MTT assay), and anti-inflammatory (PGE assay) response of salt 10, the antibacterial response (zone inhibition assay) of salt 10, its components, and 10(HG), and the release of salt 10 in vitro from the corresponding hydrogel bed to the bulk solvent at 37 °C in 24 h, suggested their plausible use in..."

Journal

Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis. (PubMed, J Cell Mol Med) - "Immunoprecipitation and Biotin-labelled assay confirmed the targeted binding relationship of Sulfa-4 and Sulfa-22 with GSDMD protein in the iBMDM model in vitro. In this study, we investigated a new type inhibitor of GSDMD cleavage, which exerted a good inhibitory effect on pyroptosis and provided new references for the development of inflammatory drugs in the future."

Journal • Alzheimer's Disease • CNS Disorders • Immunology • Inflammation

Alpha Carbonic Anhydrase 5 Mediates Stimulation of ATP Synthesis by Bicarbonate in Isolated Arabidopsis Thylakoids. (PubMed, Front Plant Sci) - "This stimulation was not observed in thylakoids of wild-type in the presence of mafenide, a soluble carbonic anhydrase inhibitor, and was absent in thylakoids of two mutant lines lacking the gene encoding alpha carbonic anhydrase 5 (αCA5). Using mass spectrometry, we revealed the presence of αCA5 in stromal thylakoid membranes of wild-type plants. A possible mechanism of the photophosphorylation stimulation by bicarbonate that involves αCA5 is proposed."

Journal

PRESTO:Osteo: Patients Response to Early Switch To Oral:Osteomyelitis Study (clinicaltrials.gov) - P1; N=11; Terminated; Sponsor: Julio Ramirez; N=456 ➔ 11

Enrollment change

Nanohybrid magnetic composite optosensing probes for the enrichment and ultra-trace detection of mafenide and sulfisoxazole. (PubMed, Talanta) - "Recoveries of mafenide and sulfisoxazole in spiked bovine milk ranged from 80.4 to 97.9% with RSDs <5% and the analysis results agreed well with HPLC analysis. The proposed probes provided excellent sensitivity, selectivity, ease and convenience of use."

Journal

"Same. Usually mafenide+ampho or mafenide+nystatin. Occasionally Dakins." (@KSRomanowski)

Topical Antimicrobial Agents for Burn Wound Care: History and Current Status. (PubMed, Surg Infect (Larchmt)) - "Patients with impaired wound healing and those with advanced age or medical comorbidities may not benefit from early excision, and the benefits of early excision may not be available in austere or remote locations. For these reasons, research on optimal topical treatment continues."

Journal • Anesthesia • Complement-mediated Rare Disorders • Critical care • Infectious Disease • Thermal Injury

Comparative Antimicrobial Activity of Commercial Wound Care Solutions on Bacterial and Fungal Biofilms. (PubMed, Ann Plast Surg) - "Biofilms represent a major clinical challenge, with no clear consensus for treatment of chronic wounds or prosthetic devices. Our results suggest that hypochlorous acid-based wound solutions such as Vashe and PhaseOne are more efficacious than mafenide in eliminating bacterial and fungal biofilms. Further studies are necessary to investigate and compare the in vivo efficacy of these products in clinical care."

Journal

Topical treatment for facial burns. (PubMed, Cochrane Database Syst Rev) - "There is mainly low to very low-certainty evidence on the effects of any topical intervention on wound healing in people with facial burns. The number of RCTs in burn care is growing, but the body of evidence is still hampered due to an insufficient number of studies that follow appropriate evidence-based standards of conducting and reporting RCTs."

Journal • Review • Complement-mediated Rare Disorders • Pain • Thermal Injury

Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors. (PubMed, Eur J Pharm Sci) - "The mechanism underlying the regulation of MAF on inflammatory response was correlated with the inhibition of pyroptosis. MAF could inhibit GSDMD cleavage by directly binding to GSDMD."

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