21BW / Pfizer - LARVOL DELTA

Synovial Fluid Concentrations of Matrix Metalloproteinase-3 and Interluekin-6 Following Anterior Cruciate Ligament Injury Associate with Gait Biomechanics 6 months Following Reconstruction. (PubMed, Osteoarthritis Cartilage) - "High SF concentrations of a proinflammatory cytokine and a degradative enzyme early post-ACL injury are associated with aberrant gait biomechanics in the injured limb at 6 months post-ACLR (i.e. lesser vGRF, KFA and KEM) linked to posttraumatic osteoarthritis development."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL6 • MMP3

Research Note: Evaluation of boric acid as a chemoprophylaxis candidate to prevent histomoniasis. (PubMed, Poult Sci) - "Moreover, liver and cecal lesions were not statistically different between the BA and PC groups. Taken together, these data suggest that BA was not efficacious in the prevention or reduction of histomoniasis disease severity when provided at 0.2% dietary concentration under these experimental conditions."

Journal

Peripherally Physiological Responses to External Emotions and Their Transitions in Bipolar I Disorder With and Without Hypersexuality. (PubMed, Arch Sex Behav) - "The heart rate difference when responses to the primer happiness were subtracted from responses to the noncongruent neutral was negatively correlated with mania in BO. BW and BO patients behaved differently to external emotions and their transitions, particularly regarding erotica and sadness, which might characterize unique pathophysiological processes of the two bipolar I disorder subtypes."

Journal • Bipolar Disorder • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry

Effects of increasing Fe dosage in newborn pigs on suckling and subsequent nursery performance and hematological and immunological criteria. (PubMed, J Anim Sci) - "Providing an additional 100 mg of Fe on d 11 of age increased Hb, and Hct values at weaning and 14 d into the nursery but did not provide a growth performance benefit in lactation or nursery. These results indicate that providing 200 mg of injectable Fe provided from GleptoForte is sufficient to optimize lactation and subsequent nursery growth performance and blood Fe status."

Journal • Hematological Disorders • Immunology

[VIRTUAL] Identifying genomic alterations in small cell lung cancer using the liquid biopsy of bronchial washing fluid. (ASCO 2020) - "For SCLC patients, the liquid biopsy of BWF showed high potential to identify DNA alterations and calculate TMB grades, which suggested that genomic analysis of BWF liquid biopsy may have clinical value in predicting the effectiveness of targeted therapy and immunotherapy. It can be widely used in routine clinical practice. Research Funding: None"

IO Biomarker • Liquid Biopsy • Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • Thoracic Cancer • TMB

Force production during maximal effort bend sprinting: Theory vs reality. (PubMed) - "Also, the force requirements of bend sprinting are considerably different to straight-line sprinting and are asymmetrical in nature. Overall, bend-specific strength and technique training may improve performance during this portion of 200- and 400-m races."

Journal • Biosimilar

Biomechanics of the shoulder girdle: a case study on the effects of union rugby tackles. (PubMed, Acta Bioeng Biomech) - "During a tackle, the clavicle, scapula, trapezius and acromioclavicular joint are the anatomical structures with higher risk of injury. Also, the strike force on the feet decreases for stability purposes. After performing multiple impacts the muscular activity of the trapezius and rotator cuff muscles decreases, which may lead, in the long-term, to instability of the shoulder and inefficiency of the scapulohumeral rhythm."

Clinical • Journal • Biosimilar

An Exploration of Machine-Learning Estimation of Ground Reaction Force from Wearable Sensor Data. (PubMed, Sensors (Basel)) - "The model based on sacrum data was the most accurate single sensor model (unilateral landings: RMSE = 0.24 BW, r = 0.95; bilateral landings: RMSE = 0.21 BW, r = 0.98) with the refined model still showing good accuracy (unilateral: RMSE = 0.42 BW, r = 0.80; bilateral: RMSE = 0.39 BW, r = 0.92). Machine-learning models applied to wearable sensor data can provide a field-based system for GRF estimation during ballet jumps."

Journal

EMG-driven Forward Dynamics Simulation to Estimate in Vivo Joint Contact Forces During Normal, Smooth, and Bouncy Gait. (PubMed, J Biomech Eng) - "The predicted medial, lateral, and total tibiofemoral forces represented the overall measured magnitude and temporal patterns with good root mean squared errors (RMSEs) and Pearson's correlation (?2). The model accuracy was high: medial, lateral, and total tibiofemoral contact force RMSEs = 0.15, 0.14, 0.21 body weight (BW), and (0.92< ?2<0.96) for normal gait; RMSEs = 0.18 BW, 0.21 BW, 0.29 BW, and (0.81< ?2<0.93) for smooth gait; and RMSEs = 0.21 BW, 0.22 BW, 0.33 BW, and (0.86< ?2<0.95) for bouncy gait, respectively."

Journal

"How Nationalism Can Destroy a Nation https://t.co/21BWfq7ybF" (@gary_lyman)