NBI-'675
/ Neurocrine Biosciences
- LARVOL DELTA
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December 17, 2025
Details of Neurocrine's transformed R&D engine, designed to deliver at least four new Phase 1 and two Phase 2 programs per year by focusing on genetically or clinically validated mechanisms of action were shared during today's event. Highlighted programs include:
(PRNewswire)
- "NBI-'569, a dual M1 / M4 agonist for Alzheimer's psychosis, and NBI-'567, an M1 preferring agonist for Alzheimer's cognition and Lewy body dementia; Next-generation VMAT2 inhibitors; NBI-'890 and NBI-'675, engineered for increased half-life and potency and decreased solubility, and which provide the potential for long-acting injectable administration across multiple central nervous system indications; A suite of differentiated assets for better quality weight loss, including NBIP-'2118, a CRF2 agonist expected to enter Phase 1 development in the first half of 2026....Neurocrine plans to provide update on its emerging early-stage Neurology and Immunology pipeline in 2026."
New P1 trial • Pipeline update • Alzheimer's Disease • Dementia • Lewy Body Disease • Obesity
March 05, 2025
Neurocrine Biosciences Announces Initiation of Phase 1 Clinical Study Evaluating NBI-1140675, a Second-Generation VMAT2 Inhibitor, in Healthy Adults
(PRNewswire)
- "Neurocrine Biosciences, Inc...today announced the initiation of a Phase 1 clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of investigational compound NBI-1140675 in healthy adult participants. NBI-1140675 is an investigational, oral, selective second-generation small molecule inhibitor of the vesicular monoamine transporter 2 (VMAT2) in development for the potential treatment of certain neurological and neuropsychiatric conditions."
New P1 trial • CNS Disorders • Psychiatry
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