RT-100 / Renova Therap - LARVOL DELTA

Five Weeks of Whole-body Vibration in Prehabilitation for Knee Function Following Anterior Cruciate Ligament Reconstruction: A Single-blinded Randomized Controlled Trial. (PubMed, Sports Med Open) - P=N/A | "Five weeks of WBV in prehabilitation enhanced quadriceps strength pre-ACLR and had potential to enhance knee function post-ACLR. WBV can be considered as an adjunct to prehabilitation protocols."

Clinical • Journal

Hamstrings corticomotor and neuromechanical function in individuals with anterior cruciate ligament reconstruction. (PubMed, J Electromyogr Kinesiol) - "Neuromechanical function was quantified via maximal voluntary isometric contraction (MVIC) torque, early and late-phase rate of torque development (RTD100, RTD200), and semitendinosus electromyographic amplitude.Paired-samples t-tests or Wilcoxon signed-rank tests compared outcomes between limbs...Lower AMT (r = 0.462, p = 0.026) and ICF (r = 0.510, p = 0.013) associated with lower RTD200, and lower MEP associated with lower MVIC torque (r = 0.448, p = 0.032). Hamstrings neural adaptation following ACLR, characterized by lower corticospinal inhibition (semitendinosus) and torque deficits, highlights the need for rehabilitation approaches targeting both neural and peripheral impairments."

Journal

Both Isometric and Dynamic Testing Are Essential for a Comprehensive Assessment of the Knee Extensors. (PubMed, J Strength Cond Res) - "Principal component analysis identified 4 components: (a) "Maximal force" (composed by MVT, T0, RTD100, RTD150, Topt, Pmax), (b) "Explosiveness" (composed by RTD50, RTDpeak, RTD50N, RTD100N, RTD150N, RTDpeakN, time to peak torque, time to RTDpeak), (c) "Force at high velocity" (composed by V0 and Vopt), and (d) "Curvature" (C). When data were normalized by sex differences, "Explosiveness" resulted as the first component and Pmax was included in the "Force at high velocity" component. The present findings remark the importance of testing the explosiveness (i.e., early RTD and normalized RTD metrics) together with torque-velocity profiling, to have a more comprehensive assessment of neuromuscular qualities."

Journal

Astaxanthin mitigates radiation-induced erectile dysfunction: protective effects on corpus cavernosum in a rat model. (PubMed, Int J Impot Res) - "Alpha smooth muscle actin (SH:165 (136.25-188.75) vs RT:100 (87.5-112.5), AST:137.5 (107.5-155), p < 0.001), endothelial nitric-oxide synthase (NOS) (SH:127.5 (115-167.5) vs RT:92.5 (81.25-98.75), AST:115 (86.25-128.75), p = 0.002) and neuronal NOS (SH:152.5 (133.75-163.75) vs RT:95 (81.25-103.75), AST:135 (125-140), p < 0.001) were diminished in the RT-group and preserved in the AST-group according to immunohistochemical scoring. Biochemical measurements of the corpus cavernosum revealed that the level of cGMP was significantly higher (93.15 (71.22-103.38) vs 70.8 (65-72.35) pmol/ml) in the AST-group, while lipid peroxidation was significantly higher (32.38 (29.07-36.98) vs 20.14 (17.85-21.04) nmol.mda/g) in the RT-group (p = 0.004, p < 0.001). This trial showed that AST preserved ICP/MAP values and histopathological-biochemical parameters after exposure to iR."

Journal • Preclinical • Erectile Dysfunction • NOS1

Validity and Agreement of a Portable Dynamometer in Evaluating Hip Strength and Rate of Torque Development: Influence of Fixation Methods. (PubMed, Int J Sports Phys Ther) - "Hip abduction and extension strength (peak torque) and RTD (early phase: RTD0-100 ms and late phase: RTD100-200 ms) were assessed using PDpush, PDpull, and an IKD...The PD is valid tool for evaluating hip strength and RTD, with PDpull offering strong validity for certain measures; however, PD measurements did not agree with the absolute values obtained from IKD. Level 3."

Journal

Early Measures of Torque Development are Related to Peak Torque at Six Months Following ACL Reconstruction. (PubMed, Int J Sports Phys Ther) - "Isometric testing was utilized to measure torque from 0-100ms (RTD100) and from 100-200ms (RTD200), and isometric peak torque...Incorporation of interventions focusing on development of force quickly is encouraged during rehabilitation. 3b."

Journal

Data-Driven Recommendations for Assessing the Early-Phase Rate of Torque Development: An Intersession Reliability Study in Physically Active Men and Women. (PubMed, Scand J Med Sci Sports) - "Selection criteria based on peak RTD100 ensured optimal reliability and absolute RTD measurements for both peak50, RTD50 and RTD100. The assessment of knee flexion requires more repetitions than knee extension to ensure reproducible early-phase RTD outcomes."

Journal

Determining the safety, feasibility, and effects of anodal transcranial direct current stimulation on corticospinal excitability and quadriceps performance after anterior cruciate ligament reconstruction: a randomized crossover design. (PubMed, Ann Jt) - P1 | "Surgical limb quadriceps performance [peak torque normalized to body mass, rate of torque development from onset to 100 ms (RTD100), and RTD from 100 to 200 ms (RTD200)] and CSE [active motor threshold (AMT) and slope of a stimulus-response curve (SLOPE)] were measured using an isokinetic dynamometer and transcranial magnetic stimulation (TMS), respectively...Multiple sessions of tDCS and/or tDCS during other tasks (e.g., during isolated quadriceps exercises) may lead to improved CSE and quadriceps performance. ClinicalTrials.gov ID: NCT04504344."

Journal

Nucleophilic Aromatic Substitution of Heteroaryl Halides with Thiols. (PubMed, J Org Chem) - "The nucleophilic aromatic substitution (SNAr) between heteroaryl halides (Cl, Br) and thiols proceeds smoothly in DMAc under the action of K2CO3 at rt-100 °C...The reactivity trend of heteroaryl halides is highly dependent on the electronic nature of the heteroarenes and orientation of halogens. Besides thiols, a couple of functionalized thioureas and thioamides are compatible with these conditions, providing the corresponding heteroaryl thioethers in good yields."

Journal

Investigation on the dynamic characteristic of occupant during the frontal collision between high-speed train and obstacle. (PubMed, Accid Anal Prev) - "The risk boundary for AIS 3 + injury risk ≤ 5 % was higher than that for GM/RT2100. The findings in this study are helpful to understand the occupant injury mechanism during the frontal collision between high-speed train and obstacle."

Journal

Sex differences in corticospinal excitability and quadriceps performance after ACL reconstruction. (PubMed, J Orthop Res) - "Quadriceps performance (peak torque, PT; rate of torque development from onset to 100ms, RTD100; and RTD from 100-200ms, RTD200) and CSE (active motor threshold, AMT; slope of the stimulus response curve, SR curve slope) were measured using an isokinetic dynamometer (HUMAC NORM) and transcranial magnetic stimulation respectively...Females after ACLR had worse surgical limb quadriceps PT than control males and slower RTD100 and RTD200 than control males and control females. Higher CSE in males after ACLR may point to a potentially adaptive neurological change in males post-ACLR and indicate greater need for novel interventions to address cortical drive in females after ACLR."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Fully Automated Pseudophakic Manifest Refraction: A Missing Piece in IOL Surgery (ASCRS-ASOA 2023) - "Purpose To determine the efficacy of automated manifest refraction in pseudophakic patients.MethodsThis is a prospective and longitudinal study that included 100 eyes of 100 patients who underwent uncomplicated cataract surgery.The visual acuity and manifest refraction of each patient was evaluated using two different evaluation methods by two examiners, the automated platform Nidek RT-6100 in comparison with the standard Topcon VT-10 phoropter with a minimum of 6-weeks postoperatively.Two groups of patients were evaluated.The first group included 50 eyes of 50 patients with uncorrected visual acuity of 20/30 or better, residual cylinders less than 1.00 D.The second group included 50 eyes of 50 patients with residual cylinders less than 2D with visual acuity less at 20/40.ResultsFor SEQ a mean of -0.1372 +- 0.42 and -0.1372 +- 0.38 for RT-6100 and Manual Refraction was obtain respectably.For cylinder a mean of -0.66 +-0.52 for the RT6100 group and -0.62 +- 0.57 for the..."

Surgery • Cataract • Ophthalmology

Rate of torque development as a discriminator of playing level in collegiate female soccer players. (PubMed, J Musculoskelet Neuronal Interact) - "Our findings indicate that RTD may be a better parameter than peak torque at differentiating between playing level in collegiate female soccer players. The discriminant analysis thresholds for the RTD variables demonstrated good sensitivity and specificity, and therefore, may be used as indices to identify players with a high degree of soccer playing ability."

Journal • Developmental Disorders

HyperArc Dosimetric Validation for Multiple Targets Using Ionization Chamber and RT-100 Polymer Gel. (PubMed, Gels) - "For each target volume, the obtained results in terms of gamma index passing rate show an agreement >95% with 5% 2 mm and 3% 2 mm criteria for both 2D and 3D distributions. The obtained results confirmed that the use of a single isocenter for multiple lesions reduces the treatment time without compromising accuracy, even in the case of target volumes that are quite distant from the isocenter."

Journal • Oncology • Solid Tumor

Energy And Carbohydrate Intake Are Associated With Quadriceps Rate Of Torque Development Following ACL Injury (ACSM 2022) - "Food records were analyzed, and participants completed isokinetic dynamometer assessment including knee extension maximal voluntary isometric contraction (MVIC, Nm/kg) and rate of torque development (Nm*kg-1*s-1) evaluated from contraction initiation to 100 ms (RTD100) and 100 ms to 200 ms (RTD200)... Our results show total energy and carbohydrate intake positively associate with strength indices following ACL injury. These findings underscore the importance of nutritional status to support functional recovery following ACL injury and highlight the need to study the role of carbohydrate intake needs during recovery from ACL injury."

Musculoskeletal Diseases

Knee Extensor Rate Of Torque Development Assessment Post-acl Reconstruction: Does Sampling Rate Matter? (ACSM 2022) - "RTD was characterized with multiple variables: from contraction onset to 50, 100, and 200 ms (RTD0-50, RTD0-100, and RTD0-200, respectively), in sequence from 50 to 100 ms and 100 to 200 ms (RTD50-100 and RTD100-200), as the slope of 20-80% of peak torque (RTD20-80), and as the maximal instantaneous slope (RTDPeak)... Involved limb RTD and RTD LSI for RTD0-200, RTD20-80, and RTDPeak can be accurately assessed with reduced sampling rates, thereby facilitating use of clinically available equipment for assessing knee extensor RTD post-ACLR."

Utility of peak torque and rate of torque development characteristics to identify walking performance ability in older women. (PubMed, J Musculoskelet Neuronal Interact) - "These findings suggest that knee extensor muscle strength, and in particular RTD, may be an effective discriminator and predictor of walking performance ability in older women."

Clinical • Journal

Influence of light intensity distribution characteristics of light source on measurement results of canopy reflectance spectrometers. (PubMed, Plant Methods) - "According to the research results of this paper, sunlight is the most ideal detection light source. If the passive light source spectrometer can improve the measurement method to adapt to the change of sunlight intensity, its measurement performance will be better than any active-light spectrometer."

Journal

The Acute Effects of Fast-Paced Walking on Isometric Peak Torque and Rate of Torque Development in Regularly Exercising and Inactive Older Women. (PubMed, J Aging Phys Act) - "A significant decrease in RTD100 was observed after walking for the inactive group (p = .005) but not for the regular exercisers (p = .909). These findings highlight the importance of physical activity and suggest that a task as simple as walking may impair the rapid strength capacities of inactive older women."

Clinical • Journal • Fatigue

[VIRTUAL] Utility Of Strength-based Torque Characteristics To Distinguish Between Older Women Of Different Walking Performance Abilities (ACSM 2021) - "For each MVC, participants sat in an upright position and were instructed to extend the leg as hard and fast as possible for 3-4 s. Isometric PT and early (RTD100), late (RTD200), and maximum (Peak RTD) RTD measurements were calculated and displayed by a novel strength testing device at the conclusion of each MVC and were normalized to body mass... These findings suggest that knee extensor muscle strength, and in particular RTD, may be an effective measure at distinguishing between older women of different six-minute walking performance abilities. Physical therapists and other practitioners may use these findings to help with the identification and early detection of older adults who are at a high risk for functional performance deficits."

Clinical

"Means NNT 20 even if nodal RT 100% effective which is unlikely. Next step for me is adding IO to chemoRT as per our #RADIO trial with durvalumab and 992 with pembrolizumab. Adding drugs usually beats adding photons!" (@Prof_Nick_James)

Real-time measurement of isometric peak torque and rate of torque development using a novel strength testing device: a validity and reliability study. (PubMed, Physiol Meas) - "These findings suggest that the Dynamo Torque Analyzer may be a valid and reliable device for measuring isometric PT and RTD of the lower-body musculature."

Journal

Early and late rapid torque characteristics and select physiological correlates in middle-aged and older males. (PubMed, PLoS One) - "Late rapid torque parameters of the PFs were preferentially impaired in OM compared to MM, and PT as well as CSA appeared to mediate this result."

Journal

Association of plant growth-promoting Serratia spp. with the root nodules of chickpea. (PubMed) - Res Microbiol - "Results of plant inoculations indicated that Serratia sp. 5D and RTL100 can serve as effective microbial inoculants, particularly in nutrient-deficient soils in rainfed areas, where chickpea is the only major crop grown during the entire year."

Journal • Biosimilar

Lonza and Renova Therapeutics announce manufacturing agreement for clinical supply of RT-100 gene therapy (PRNewswire) - "Lonza...and Renova™ Therapeutics...have entered into a Manufacturing Services Agreement to develop a scalable manufacturing process and produce cGMP-grade RT-100...Drug Product for use in Renova's future clinical trials."

Licensing / partnership • Gene Therapies