Mifeprex (mifepristone) / Danco Laboratories, BioPro Medical - LARVOL DELTA

Neuroprotective and Antioxidant Properties of Different Novel Steroid-Derived Nitrones and Oximes on Cerebral Ischemia In Vitro. (PubMed, Int J Mol Sci) - "To advance neuroprotective strategies that could improve the safety and efficacy of existing treatments while preserving brain tissue, we synthesized and evaluated seven new nitrones (MC3, MC5, MC7) and oximes (MC1, MC2, MC4, MC6) derived from different neuroactive steroids-ethisterone (MC1-3), mifepristone (MC4-5) and stanolone (MC6-7)-in an in vitro model of cerebral ischemia. Overall, these derivatives exhibited neuroprotective and antioxidant effects superior to those of the reference compounds cholesteronitrone ChN2, α-tert-butyl nitrone (PBN) and N-acetylcysteine (NAC)...Among them, the stanolone-derived nitrone MC7, which lacks conjugated double bonds, displayed the most balanced and robust profile, consistently enhancing cell viability, reducing necrotic cell death, and suppressing superoxide anion production. Consequently, MC7 has been selected as a promising lead compound for further in vivo studies of cerebral ischemia."

Journal • Preclinical • Cardiovascular • Ischemic stroke

Tbcrc 058: a randomized phase 2 study of enzalutamide, enzalutamide with mifepristone, and treatment of physician's choice in patients with androgen receptor-positive metastatic triple-negative or estrogen receptor-low breast cancer (nct06099769) (SABCS 2025) - P2 | " This is a randomized phase II trial; 201 patients (pts) will be randomized in a 1:1:1 fashion to enza, enza plus mif, or TPC (carboplatin, paclitaxel, eribulin, or capecitabine). As of 7/9/2025, 19 of 201 pts have begun protocol-specified tx. This trial is supported by the Translational Breast Cancer Research Consortium, The Breast Cancer Research Foundation, The TaTa Sisterhood Foundation, Pfizer/Astellas, and Corcept Therapeutics."

Clinical • IO biomarker • Metastases • P2 data • Breast Cancer • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • AR • CTCs • ER • HER-2 • PGR

"You can do this at home and people won't find out": a qualitative exploration of women's experiences with the use of medication abortion drugs received directly from pharmacies in Nepal. (PubMed, BMC Public Health) - "Women seek pharmacy-based medication abortion services for various reasons, including barriers within the health system that limit access to public sector abortion sites. Strengthening the role of pharmacies as medication abortion providers is crucial as they are in a position to enhance women's agency by providing accurate information, medically sound services, and appropriate referrals. Establishing policies and guidelines to formally integrate pharmacies as safe medication abortion sites in Nepal appears warranted."

Journal • Pain

Comparison of the sequential use of mifepristone and dinoprostone vaginal insert with dinoprostone vaginal insert as the only method for induction of labor in very unripe cervix: a secondary analysis of a multicenter real-word evidence study. (PubMed, Int J Gynaecol Obstet) - "These findings suggest that the sequential use of mifepristone prior to dinoprostone administration enhances the likelihood of successful labor induction in women with a very low Bishop score. The study highlights the importance of optimizing cervical ripening methods to improve labor outcomes."

Journal • Obstetrics

iRGD-mediated MPN functionalization of MSNs for targeted delivery of MIF: a potential strategy for placenta accreta spectrum therapy. (PubMed, Front Bioeng Biotechnol) - "This study develops a targeted nanotherapeutic platform using iRGD peptide-functionalized mesoporous silica nanoparticles (MSNs) coated with metal-phenolic networks (MPNs) for mifepristone (MIF) delivery...Although this proof-of-concept study demonstrates a promising targeted therapeutic strategy using healthy animal models, we acknowledge the limitation of not using true PAS pathological models. Our findings establish a foundation for developing precision nanomedicines for placental disorders, with future studies required to validate efficacy in disease-specific models."

Journal • Hematological Disorders

Transforming Growth Factor-beta 1 Alleviates Uterine Bleeding after Medication Abortion in Early Pregnancy by Upregulating the p53/Plasminogen Activator Inhibitor-1 Pathway. (PubMed, J Interferon Cytokine Res) - "The MA rat model was established in vivo using mifepristone and misoprostol, and trophoblasts HTR8/SVneo were treated with lipopolysaccharide in vitro...Notably, these changes were partially reversed by overexpression of TGFB1. In conclusion, TGF-β1 protects trophoblasts and alleviates MA-induced uterine bleeding by upregulating the p53/PAI-1 pathway."

Journal • IL6 • TGFB1 • TNFA

A preclinical and pilot clinical study of mifepristone as an adjuvant treatment to chemo-radiation for high-grade gliomas: A fairytale comes true? (SNO 2025) - "The addition of mifepristone to chemoradiation is associated with multiple mechanisms of action against HGG and is clinically safe."

Preclinical • Brain Cancer • Glioblastoma • Glioma • High Grade Glioma • Solid Tumor • MGMT

Good Quality 66.7% 5-year Overall Survival in Terminal Lung Cancer Patients Treated With Mifepristone. (PubMed, Anticancer Res) - "The likelihood of this type of response occurring by chance is extremely low. It is hoped that this report will encourage oncologists, scientists, and clinicians to further investigate the use of SPRMs in a larger cohort of patients with stage IV lung cancer, and potentially in those with less advanced disease."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Small Cell Lung Cancer • Solid Tumor • PGR

Glucocorticoids Modulate Expression of Perineuronal Net Component Genes and Parvalbumin During Development of Mouse Cortical Neurons. (PubMed, Mol Neurobiol) - "In cultured mouse cortical neurons, we detected effects of hydrocortisone on many PNN component genes, via diverse mechanisms...Overall, the data demonstrate a complex and profound, but developmental stage-dependent, regulation of PNN component gene expression by glucocorticoids. This may contribute to the action of severe prenatal or perinatal stress to increase schizophrenia risk."

Journal • Preclinical • CNS Disorders • Psychiatry • Schizophrenia • ACAN • HAS 3 • HAS1 • PNN • VCAN

Trajectories of contraception before pregnancy and after medication abortion among women accessing clinic vs pharmacy services in Ghana. (PubMed, Sex Reprod Healthc) - "A relatively greater share of women who accessed MA in pharmacies did not use any contraceptive method following the abortion. Additionally, receiving contraception information enhanced modern contraception adoption after MA. Findings highlight the need to develop programmes and strategies to expand the provision of contraception information to women seeking MA, including those using the pharmacy route."

Journal

Women's real-time pain and stress during medical abortion: An ecological momentary assessment study. (PubMed, Acta Obstet Gynecol Scand) - "Our results highlight large interindividual variations in women's pain and stress experiences during first trimester medical abortion and thus emphasize the need for individualized counseling and pain treatment. Screening for ACEs, along with using event-based EMA protocols for future pain-management research, may promote tailored care."

Journal • Pain

Management of Bleeding Irregularities during Contraceptive Implant Use: A Systematic Review. (PubMed, Contraception) - "Implications: Patients experiencing bothersome bleeding irregularities during contraceptive implant use may be offered different options to manage bleeding and improve their satisfaction. More data are needed on the effectiveness of specific interventions (drugs, regimens, and repeat dosing) and patient satisfaction outcomes."

Clinical • Journal • Review • Long-acting Reversible Contraceptives

Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice. (PubMed, Sci Rep) - "Furthermore, we show that combining mifepristone with an approved SMN-directed gene therapy (scAAV9-SMN1) results in improved tissue- and sex-specific responses to treatment. Our study demonstrates that a multi-tissue targeting SMN-independent drug, alone and in combination with an approved SMN-dependent therapy, has the potential to improve SMA disease pathology."

Journal • Preclinical • CNS Disorders • Gene Therapies • Genetic Disorders • Movement Disorders • Muscular Atrophy • Rare Diseases • KLF5 • SMA4 • SMN1

A preclinical and pilot clinical study of mifepristone as an adjuvant treatment to chemo-radiation for high-grade gliomas: A fairytale comes true? (WFNOS 2025) - "The addition of mifepristone to chemoradiation is associated with multiple mechanisms of action against HGG and is clinically safe."

Preclinical • Brain Cancer • Glioblastoma • Solid Tumor • MGMT

A Novel Method of "Pre-fabricated Knot" Hysteroscopic Levonorgestrel-releasing Intrauterine System Suture Fixation. (PubMed, Fertil Steril) - "The technique offers equal efficacy, reduced operative time, and enhanced safety due to its simplified procedural steps. However, its indication should currently be limited to adenomyosis patients with anemia, dysmenorrhea and menorrhagia, particularly those with a history of intrauterine device expulsion. Future studies with extended follow-up periods and larger patient cohorts are warranted to further evaluate the long-term outcomes of this technique."

Journal • Endometriosis • Gynecology • Hematological Disorders • Long-acting Reversible Contraceptives • Women's Health

The Sociodemographic Benefits of Extending MS-2Step to 70 Days in Australia. (PubMed, Aust N Z J Obstet Gynaecol) - "In many areas of the world, outpatient early medical abortion (EMA) is provided through mifepristone and misoprostol up to 10 weeks or 70 days gestation; however in Australia access is restricted to 63 days...Currently, socioeconomic disadvantage is associated with a higher rate of presenting for abortion after 9 weeks. Extending EMA access would be of particular benefit for groups with socioeconomic disadvantage."

Journal

Insular cortex mediates chronic restraint stress-induced irritable bowel syndrome-like behaviors via glucocorticoid signaling. (PubMed, Neurobiol Dis) - "Furthermore, elevated plasma corticosterone was identified as a key mediator of CRS-induced effects, and glucocorticoid receptor blockade with mifepristone mitigated the symptoms. Finally, administration of lamotrigine, an inhibitor of neuronal hyperexcitability, was found to attenuate CRS-induced IBS-like symptoms, anxiety-like behaviors, hyperalgesia, and IC activation. These results highlight the IC as a critical cortical node in IBS pathophysiology and suggest lamotrigine as a potential therapeutic agent."

Journal • CNS Disorders • Gastrointestinal Disorder • Mood Disorders • Pain • Psychiatry • FOS

Standardized rice bran supplement ameliorates depressive behaviors via FKBP5 mediated glucocorticoid receptor signaling. (PubMed, NPJ Sci Food) - "RBS (250, 500, and 1000 mg/kg/day) or fluoxetine (FLU, 20 mg/kg/day) was orally administered...These effects were similar to those observed with RU486 (GR antagonist) and GR siRNA knockdown. Additionally, RBS restored ERK-CREB-BDNF signaling pathway in HT-22 cells and in the hippocampus of the CORT-injected mice. RBS exerts antidepressant-like effects by modulating HPA axis activity and inhibiting GR signaling and its downstream pathway, thereby highlighting its potential as a natural therapeutic agent for stress-related depression."

Journal • CNS Disorders • Depression • Psychiatry • FKBP5 • NR3C1

An Insight into Experimental Animal Models for Polycystic Ovarian Syndrome and Associated Disorders. (PubMed, Reprod Sci) - "Multiple models, including those influenced by androgens (testosterone and DHEA), estrogen, aromatase inhibitors (such as letrozole), and progesterone receptor antagonists (like RU486), are examined for their capacity to recreate the clinical characteristics of PCOS. Furthermore, it emphasizes the significance of these models in understanding the pathophysiology of PCOS and in developing beneficial therapeutic approaches. Future research must concentrate on improving current models and investigating novel approaches for a more accurate depiction of this complex disease to optimize translational results in clinical conditions."

Journal • Preclinical • Review • Endocrine Disorders • Polycystic Ovary Syndrome

Laparoscopic resection of an intramural pregnancy under transvaginal ultrasound guidance: A case report. (PubMed, Medicine (Baltimore)) - "In cases where the lesion's location remains unclear during laparoscopy, TVUS can assist in accurate localization and enable complete resection of the lesion."

Journal • Gynecology • Musculoskeletal Pain • Pain • Women's Health

"Cementing Our Place on the Right Side of History": Primary Care Perspectives on Mifepristone Provision Post-Dobbs. (PubMed, Womens Health Issues) - "Participants in our sample expressed that the Dobbs decision increased their clinics' motivation to overcome barriers and expand access to abortion and early pregnancy loss care. Other primary care providers may consider leveraging concern about mounting abortion restrictions to advance access to this care in their own settings."

Journal • Women's Health

Demographic Factors Influencing Eligibility for EMA in South Australia. (PubMed, Aust N Z J Obstet Gynaecol) - "Eligibility for EMA was affected by age, rurality and socio-economic disadvantage. Interventions to improve access should investigate and address the specific barriers facing these groups of women."

Journal

What motivates primary care providers to prescribe mifepristone medication abortion? Results of a qualitative investigation in Canada. (PubMed, BMC Prim Care) - "Our results highlight that, after five years, barriers still exist to providing mifepristone medication abortion in Canadian primary care. We illustrate the importance of addressing ongoing perceptions of logistical barriers to care, concerns about advertising abortion services to the community, and the need for robust mentorship and consultation pathways."

Journal

Minimizing Hemorrhage Risk Strategies in Cervical Pregnancy-Stepwise Pharmacologic Priming and Delayed Surgical Evacuation: A Narrative Review. (PubMed, J Clin Med) - " A narrative literature review (PubMed, Scopus, Web of Science; inception-July 2025) was conducted using the following key terms: "CP," "HCP," "methotrexate," "mifepristone," "misoprostol," "uterine artery embolization," "hysteroscopy," and "Doppler ultrasound." We integrated a personal institutional case that applied stepwise pharmacologic priming, Doppler-guided surveillance, and delayed evacuation. Conservative, imaging-guided management is promising for reducing hemorrhagic complications and preserving fertility in CP/HCP. Future multicenter registries and standardized Doppler-based protocols are urgently needed to refine decision-making and optimize outcomes."

Journal • Review • Gynecology • Hematological Disorders

Early Pregnancy Termination with Mifepristone and Misoprostol: Concurrent vs. 48-Hour Interval Administration in a Randomized Controlled Trial. (PubMed, J Clin Med) - P=N/A | " Concurrent administration of mifepristone and misoprostol is less effective and less satisfactory than the standard 48-h regimen, although safety and pain profiles are comparable. It should not replace the interval protocol, and patients choosing concurrent treatment should be counseled about its lower efficacy and higher likelihood of requiring additional intervention."

Journal • Pain