Mifeprex (mifepristone) / Danco Laboratories, BioPro Medical - LARVOL DELTA

Effectiveness, safety and acceptability of mifepristone compared with other interventions in reproductive-age women using emergency contraception for the prevention of pregnancy: a systematic review and meta-analysis. (PubMed, BMJ Sex Reprod Health) - "Mifepristone is an effective emergency contraceptive, potentially more effective than commonly used oral EC methods, with a favourable side effect profile aside from delayed menstruation."

Clinical • Journal • Retrospective data • Review • Long-acting Reversible Contraceptives

Tbcrc 058: a randomized phase 2 study of enzalutamide, enzalutamide with mifepristone, and treatment of physician's choice in patients with androgen receptor-positive metastatic triple-negative or estrogen receptor-low breast cancer (nct06099769) (SABCS 2025) - P2 | " This is a randomized phase II trial; 201 patients (pts) will be randomized in a 1:1:1 fashion to enza, enza plus mif, or TPC (carboplatin, paclitaxel, eribulin, or capecitabine). Pts must have normal organ function and no history of brain mets. As of 7/9/2025, 19 of 201 pts have begun protocol-specified tx."

Clinical • IO biomarker • Metastases • P2 data • Breast Cancer • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • AR • CTCs • ER • HER-2 • PGR

Progesterone receptor modulators for endometriosis. (PubMed, Cochrane Database Syst Rev) - "Mifepristone may improve dysmenorrhoea in women with endometriosis, but it might increase the prevalence of adverse events, such as hot flushes. The evidence is very uncertain regarding its effect on dyspareunia. Gestrinone may be less effective than leuprorelin in treating dysmenorrhoea, but it may improve dyspareunia. It may be associated with lower rates of hot flushes and similar rates of nausea. We are uncertain about the effect of gestrinone compared to danazol. We found insufficient evidence to permit firm conclusions about the safety and effectiveness of other progesterone receptor modulators."

Clinical • Journal • Review • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning. (PubMed, Psychiatry Investig) - "This study reveals the critical roles of CXCL1 and IGFBP5 in AD-CD comorbidity, providing a theoretical basis for exploring gut-brain axis mechanisms and potential targeted interventions."

Gene Signature • Journal • Alzheimer's Disease • CNS Disorders • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CXCL1 • IGFBP5

Abortion: South Korea to approve mifepristone. (PubMed, BMJ) - No abstract available

Journal

Mifepristone versus other interventions for the prevention of pregnancy in reproductive-age women using emergency contraception. (PubMed, Cochrane Database Syst Rev) - "Both mid-dose and low-dose mifepristone are probably more effective than levonorgestrel. Mifepristone is likely more effective than the Yuzpe regimen in preventing pregnancy following unprotected intercourse. Nausea and vomiting are less common with all mifepristone doses than with Yuzpe. A delay in menses is probably the main adverse effect of mifepristone; higher doses of mifepristone seem to lead to increased frequency of delayed menses than lower doses."

Clinical • Journal • Review • Long-acting Reversible Contraceptives

Glucocorticoid induces a therapy-tolerant dormant state in glioblastoma via orchestrating lipid metabolism plasticity (EANO 2026) - "Mechanistic studies were performed in human BTSC lines using genetic perturbation (GR or GPD1 knockout) and pharmacologic modulation with dexamethasone (DEXA) or mifepristone (MIFE), followed by RNA-seq, metabolic profiling, Seahorse analysis, and ferroptosis assays...In vivo, Dexamethasone (GR agonists) reinforced a GPD1-positive slow-cycling state and attenuated temozolomide (TMZ) response, whereas MIFE treatment or adrenalectomy reduced GPD1-positive tumor cells and improved survival...Glucocorticoids actively promote a therapy-tolerant metabolic state in GBM through the GR-GPD1 axis. Disrupting this pathway induces ferroptosis, reduces BTSC fitness, and enhances therapeutic response in preclinical models. These findings provide a mechanistic explanation for the adverse association between steroid exposure and treatment outcome in GBM and support GR inhibition as a promising strategy to improve current therapies."

Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Corticosteroid Receptor Modulation in the Dorsal Striatum Prevents Morphine-Induced Place Preference and Reduction in Dopamine Transporter (DAT) Immunoreactivity in Rats. (PubMed, Addict Biol) - "Before conditioning sessions, animals received bilateral intra-dorsal striatal infusions of corticosterone, the glucocorticoid receptor (GR) antagonist RU-38486 or the mineralocorticoid receptor (MR) antagonist spironolactone. Importantly, the present findings do not establish whether corticosterone's effect is mediated by classical GR signalling, rapid corticosteroid actions or GR-independent mechanisms. Given the role of the dorsal striatum in addiction-related learning and the transition towards habitual and compulsive drug seeking, these findings identify corticosteroid-dopamine interactions within this region as an important mechanism for further investigation in opioid use disorders."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry • Substance Abuse

Placenta accreta and uterine arteriovenous malformation following medically treated missed abortion in patient with undiagnosed cesarean scar pregnancy. (PubMed, J Surg Case Rep) - "Ultrasound initially showed an intrauterine pregnancy, but follow-up confirmed a missed abortion, and mifepristone/misoprostol regimen was initiated...Histopathological examination showed placenta accreta. Early diagnosis and management of CSP are essential to reduce serious complications."

Journal • Cardiovascular • CNS Disorders • Gynecology • Hematological Disorders • Oncology

Chronic stress exacerbates myasthenia gravis via HPA axis-mediated immune dysregulation: Mechanisms and drug interventions. (PubMed, Psychoneuroendocrinology) - "RU486, a glucocorticoid receptor antagonist, can alleviate the aggravation of CSR-induced MG symptoms by inhibiting the HPA axis activity, suggesting that the HPA axis is an important target for the treatment of CSR-related MG. This study provides a new explanation of the mechanism by which CSR aggravates MG symptoms."

Journal • CNS Disorders • Depression • Fatigue • Immunology • Mood Disorders • Myasthenia Gravis • Psychiatry

Immunomodulatory Effects of Tokishakuyakusan on Progesterone Withdrawal-Induced Uterine Inflammation in Pregnant Mice. (PubMed, Am J Reprod Immunol) - "These findings suggest that TSS mitigates inflammation associated with progesterone withdrawal by suppressing uterine IL-6 and increasing the expression of progesterone-responsive anti-inflammatory molecules such as SLPI and PGRN. These findings suggest that TSS may modulate progesterone-responsive anti-inflammatory pathways through increased expression of SLPI and PGRN while suppressing uterine IL-6."

Journal • Preclinical • Inflammation • IL6 • SLPI

KV7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth. (PubMed, Commun Med (Lond)) - "These findings support KV7 activation as a promising approach to suppress uterine contractility and hence delay preterm birth, highlighting a potential new direction for either drug repurposing or therapeutic development."

Journal • Preclinical

Computational Identification of Progesterone Receptor Modulators for Breast Cancer through 3D Pharmacophore Screening and MD Simulation of the ChEMBL Database. (PubMed, Curr Cancer Drug Targets) - "Several potential progesterone receptor modulators with favourable binding and ADME-Tox characteristics were identified. These findings demonstrate the value of computational methods in accelerating early-stage breast cancer drug discovery."

Journal • Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • PGR

Telehealth Access to Mifepristone - Evaluating Reproductive-Coercion Arguments. (PubMed, N Engl J Med) - No abstract available

Journal

Glucocorticoid-induced RPE injury in ARPE-19 cells: association with excessive autophagy and AMPK/mTOR signaling. (PubMed, Int J Ophthalmol) - "This study shows that GR-dependent GC exposure induces autophagic flux with ultrastructural evidence suggestive of mitochondria-targeted autophagy and alters AMPK/mTOR signaling, correlating with RPE barrier collapse and phagocytic failure, a possible link to steroid-associated central serous chorioretinopathy (CSC)."

Journal • Retinal Disorders • MAP1A • TJP1

Effectiveness and Safety of Medication Abortion with Mifepristone and Misoprostol in Minors. (PubMed, Am J Obstet Gynecol) - No abstract available

Journal

MOLI: Mifepristone Outpatient Labour Induction (clinicaltrials.gov) - P2 | N=400 | Recruiting | Sponsor: Chelsea and Westminster NHS Foundation Trust | Trial completion date: Dec 2026 ➔ May 2027 | Trial primary completion date: Dec 2026 ➔ Mar 2027

Trial completion date • Trial primary completion date

Chronic corticosterone exposure disrupts bile acids homeostasis associated with circadian dysfunction in the liver of chickens. (PubMed, Poult Sci) - "Separately, AML12 hepatocytes were cultured with vehicle, dexamethasone (DEX), or DEX plus RU486, and bile acid transport activity was assessed using a Transwell system. Results indicated that chronic corticosterone exposure disrupted the hepatic circadian clock in chickens, reducing BMAL1 and REV-ERBβ mesors to 0.75- and 0.65-fold of control levels, respectively (P < 0.05), suppressing REV-ERBβ amplitude to 0.27-fold (P < 0.0001), and inducing significant phase delays in multiple core clock genes...In vitro, dexamethasone upregulated MRP2 expression (1.39-fold, P < 0.05) and promoted its membrane translocation via the glucocorticoid receptor, enhancing apical bile acid efflux. These findings indicate that chronic stress disrupts bile acid homeostasis via hepatic clock dysregulation, while glucocorticoids enhance MRP2-mediated efflux, linking stress to enterohepatic bile acid remodeling."

Journal • CNS Disorders • Hepatology • Liver Failure • Metabolic Disorders • ARNTL • BMAL1 • CYP8B1

Implementing a Medication Abortion Curriculum in an Internal Medicine Residency: An Educational Innovation. (PubMed, J Grad Med Educ) - "Medication abortion using mifepristone and misoprostol is safe and effective, yet few internal medicine (IM) physicians provide this care due to barriers such as stigma, institutional restrictions, and limited training...Post-survey results showed significant improvements in comfort with counseling on early abortion options (95% CI, 0.54-1.84; P<.001), determining eligibility (95% CI, 0.61-1.86; P<.001), counseling on medication abortion regimens (95% CI, 0.62-1.89; P<.001), and managing failed abortions (95% CI, 0.50-1.79; P=.001). This curriculum significantly increased IM residents' comfort in providing medication abortion services over 6 months."

Journal

Is induction of fetal asystole associated with adverse health outcomes during second-trimester termination induction of labor? (PubMed, Pregnancy (Hoboken)) - "A priori, the receipt of mifepristone was chosen as a confounding covariate...IFA is not associated with increased duration of labor when compared to FCA during 2T termination IOL. It is also not associated with adverse outcomes including uterine rupture, need for blood transfusion, clinical chorioamnionitis, ICU admission, or need for hospital admission."

Adverse events • HEOR • Journal • Critical care

Outcomes of early first-trimester medical abortion following bariatric surgery: A retrospective cohort study. (PubMed, Int J Gynaecol Obstet) - "Prior BS was not significantly associated with medical TOP failure overall, although a trend toward increased risk was observed. In subgroup analysis, RBS was associated with higher adjusted odds of failure than MBS. These results highlight the need for further prospective research to evaluate whether procedure-specific protocols or enhanced monitoring are warranted in this unique population."

Journal • Retrospective data

Glucocorticoid receptor antagonism in major depressive disorder with childhood trauma: a randomized controlled trial. (PubMed, Psychiatry Res) - "Adverse events were more frequent with mifepristone; mild and severe events occurred significantly more often, while the proportion reporting at least one adverse event was numerically higher but not statistically significant (93.6%vs. 82.5%, χ²(1)=3.60, p=0.058). Mifepristone produced the expected endocrine response but did not lead to clinical improvements in individuals with MDD and CT compared to placebo."

Clinical • Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Protective effects of Jiao-Ai Decoction against progesterone withdrawal-induced pregnancy loss: Insights from rat model assays, bioactive component analysis, molecular simulation, and zebrafish angiogenesis evaluation. (PubMed, J Ethnopharmacol) - "The anti-abortive effects of JAD are associated with the restoration of uterine vascular homeostasis, endometrial receptivity and hemodynamics. Similar expression trends of VEGF-related angiogenic markers were observed in both rat and zebrafish models after JAD treatment. This work provides experimental evidence linking the traditional use of JAD for pregnancy maintenance to the restoration of uterine vascular homeostasis, thereby bridging classical TCM theory with modern pharmacological insights for mechanistic interpretation."

Journal • Preclinical • Gynecology • Hematological Disorders • CD31 • FLT1 • HIF1A • HOXA11 • KDR • PECAM1

Successful live birth in a woman with partial 17α-hydroxylase/17,20 lyase deficiency: a case report. (PubMed, Front Med (Lausanne)) - "Thr390Arg) and c.1073G>A (p. For women with infertility accompanied by abnormal progesterone and 17-hydroxyprogesterone levels, the possibility of 17-OHD should be ruled out. Standardized treatment with glucocorticoids and assisted reproductive technology could be considered when needed."

Journal • Cardiovascular • Congenital Adrenal Hyperplasia • Endocrine Disorders • Gynecology • Hypertension • Infertility • Sexual Disorders • CYP17A1

Patient Perspectives on Accessing Medication Abortion at a Family Medicine-Led Community Health Center: An Opportunity for Person-Centered Care. (PubMed, Womens Health Rep (New Rochelle)) - "We elicited patient perspectives on hypothetical access to medication abortion from their primary care provider via semistructured phone interviews with patients treated for EPL at one FQHC in Illinois that was using mifepristone for EPL but not abortion...They expressed a range of feelings about abortion and, regardless of personal abortion attitude, believed that medication abortion should be offered in the primary care setting. Patients receiving care for EPL at a family medicine-led FQHC expressed a range of personal views about abortion but commonly supported offering medication abortion at their clinic."

Journal • Obstetrics