Mifeprex (mifepristone) / Danco Laboratories, BioPro Medical - LARVOL DELTA

Integrative in silico and in vitro approach for clarifying mode of action to activate estrogen receptor alpha and lipid accumulation by methiocarb. (PubMed, Ecotoxicol Environ Saf) - "Co-treatment with MPP attenuated this effect, whereas antagonists for the glucocorticoid receptor (RU-486) and ERβ (PHTPP) had no effect...Methiocarb binding to ERα promotes lipid accumulation and upregulates adipogenic/lipogenic transcriptional networks. This approach highlights the utility of ERα-mediated screening to identify potential metabolic disruptors among structurally related pesticides."

Journal • Preclinical • Metabolic Disorders • ER • FABP4 • PPARG • SREBF1

Electroacupuncture at ST36/SP6 Restores Surgical Stress-Induced Impairment of Dendritic Cell Maturation via GR/GILZ Signaling in Mice. (PubMed, Immun Inflamm Dis) - "Application of electroacupuncture (EA) at the ST36 and SP6 acupoints can mitigate the suppressive effects of surgical stress on DC maturation through the GR/GILZ signaling pathway throughout the surgical process."

IO biomarker • Journal • Preclinical • CD40 • CD86 • IL1B • IL6 • ITGAX

Novel SUN5 Mutation Associated with Acephalic Spermatozoa Syndrome: A Cross-sectional Study. (PubMed, J Hum Reprod Sci) - "SUN5 protein expression was completely undetectable in the patient with c.1073G>A. Based on current results, it could be concluded that c.1073G>A detected mutations in the SUN5 gene could alter the SUN5 protein expression and lead to male infertility due to ASS."

Journal • Observational data • Infertility • Sexual Disorders • SUN5

Ectopic Intramural Isthmic Pregnancy: Case Report. (PubMed, J Clin Med) - "We first administered mifepristone 600 mg, followed by intracavitary methotrexate under ultrasound guidance. Progressive reabsorption of pregnancy was observed over the course of 8 months. Non-surgical management can be considered for IMP, thus allowing fertility preservation."

Journal • Gynecology • Hematological Disorders

Deoxypodophyllotoxin induces apoptosis in non-small cell lung cancer cells by targeting the glucocorticoid receptor. (PubMed, Arch Biochem Biophys) - "These findings suggest that DPT exerts its anticancer effects by disrupting the GR/TSC22D3 axis in NSCLC cells, highlighting its potential as a therapeutic agent for GR-associated cancers."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • ANXA5 • CASP3 • NR3C1 • TSC22D3

Acceptability of misoprostol-only medication abortion dispensed by mail-order or retail pharmacy: a qualitative study based on in-depth interviews in the United States. (PubMed, Sex Reprod Health Matters) - "The WHO recommends two medication abortion regimens, either misoprostol used with mifepristone or misoprostol-only...In reflections on the overall model, satisfaction was high across participants, but those who were adolescents at the time of their abortion had a distinct unmet need for emotional support compared to older participants. These results contribute to a growing evidence base on the acceptability of misoprostol-only regimens and mail-order and retail pharmacy service delivery models."

Interview • Journal

Paradoxical Steroid Use in Ectopic ACTH Syndrome: Navigating Complications of Small Cell Lung Cancer and Chemotherapy-Related Immune Hepatitis (ENDO 2025) - "Initial HbA1c was 11.6% (n <5.7%), reflecting chronic poor glycemic control despite metformin and insulin...Labs demonstrated elevated ACTH (210 pg/mL, n 10-50 pg/mL) and serum cortisol (44 μg/dL, n 6-23 μg/dL), consistent with ectopic ACTH production.Management Treatment began with ketoconazole, later switched to metyrapone and mifepristone due to poor tolerance and drug interactions. His SCLC was treated with cisplatin/etoposide followed by maintenance atezolizumab...Liver biopsy was deferred due to the patient's clinical stability and the high likelihood of drug-induced liver injury (DILI).In a paradoxical therapeutic maneuver, exogenous corticosteroids (prednisone 40 mg daily) were initiated to mitigate the immune-mediated hepatotoxicity...The paradoxical use of exogenous steroids to address chemotherapy-induced liver injury underscores the need for innovative and individualized therapeutic approaches. Further investigation is warranted to establish guidelines..."

Cardiovascular • Cough • Cushing’s Disease • Diabetes • Endocrine Disorders • Hepatology • Hypertension • Inflammation • Liver Failure • Lung Cancer • Metabolic Disorders • Oncology • Respiratory Diseases • Small Cell Lung Cancer • Solid Tumor • Type 2 Diabetes Mellitus

Protective effect of glucocorticoid receptor against lung inflammation induced by nicotine-derived nitrosamine ketone is mediated by suppression of the ROS-mediated cyclooxygenase-2/prostaglandin E2 pathway in human distal lung epithelial A549 cells. (PubMed, Toxicol Lett) - "The NNK-induced increase in COX-2 expression and PGE2 production was inhibited by glucocorticoids, and this effect was antagonized by the GR antagonist, RU38486...The ROS scavenger N-acetylcysteine inhibited the NNK-induced increase in COX-2 mRNA levels and promoter activity. Furthermore, dexamethasone significantly inhibited NNK-induced cell invasion. Conclusively, the data collectively indicate that NNK-induced ROS activates the COX-2/PGE2 pathway and cell invasion in lung cancer cells. These findings elucidate the pathophysiological connection between NNK, GR, inflammatory responses, and cell metastasis."

Journal • Inflammation • Lung Cancer • Oncology • Pneumonia • Solid Tumor • PTGS2

Investigation of Stress-Induced Cortisol Effects on Decision Making After Pharmacological Mineralocorticoid or Glucocorticoid Receptor Blockade. (PubMed, Pharmacopsychiatry) - "While previous studies suggest specific effects for MR and GR, the role of both receptor types in decision-making is insufficiently investigated.In this study, stress-induced effects of cortisol on decision-making processes were investigated after pharmacological receptor blockade of the MR (spironolactone, 300 mg) or the GR (mifepristone, 600 mg) in 318 healthy men (M=25.42, SD=5.01). Thus, cortisol did not mediate this effect.The stress effect on decision-making was attenuated when MR was blocked. This corresponds to previous findings of increased risk-taking after MR activation and highlights a functional differentiation of both receptors for this domain."

Journal

Decoding pharmaceutical removability in full-scale wastewater treatment plants via machine learning model integrating modified electrophilicity index. (PubMed, Water Res) - "Specifically, pharmaceuticals such as carbamazepine, diazepam, and citalopram exhibited higher predicted amenability to chemical treatment, whereas mifepristone, erythromycin, and sulfacetamide were more likely to be effectively removed under biological processes. Extended sludge and hydraulic retention time, along with optimized influent loading, were expected to further enhance the removal of persistent pharmaceuticals. This study offers predictive insights into pharmaceutical removal potential through the developed ML model and provides scientific support for pharmaceutical management in WWTPs."

Journal

Assessing Change in Medical Management of Early Pregnancy Loss before and after Implementation of a Learning Collaborative for Initiation of Mifepristone Use. (PubMed, Matern Child Health J) - "After participation in ExPAND Mifepristone, there was an increase in medical management for EPL by PCPs and referrals to OB/GYN declined. ExPAND Mifepristone can help facilitate PCP use of mifepristone plus misoprostol for medical management of EPL."

Journal • Gynecology • Obstetrics • Women's Health

MIST: Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial (clinicaltrials.gov) - P4 | N=30 | Completed | Sponsor: Washington University School of Medicine | Recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ Jul 2025 | Trial primary completion date: Dec 2024 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date

Molecular Mechanisms of Progesterone Receptor in Inguinal Hernia Formation via Skeletal Muscle Fibrosis and Atrophy (ENDO 2025) - "We also found that co-administration of RU486 (P4/PGR antagonist) in these E2/P4-treated mice prevented hernia development... Our results suggest that P4/PGR signaling in highly P4-sensitive LAM tissues is critical for LAM fibrosis and hernia development partially via TGFB2 signaling. Our findings are one of the first to show the importance of PGR signaling in men and provide evidence that PGR antagonists may be useful as a therapeutic alternative to hernia repair surgery."

Fibrosis • Gastroenterology • Immunology • ER • FBXO32 • PGR • PLOD2 • TGFB2 • TGFBR2

Effects Of Relacorilant On Pituitary Tumor Volume In Patients With Cushing Disease: Results From The Phase 3 Grace Study (ENDO 2025) - P3 | "Previous case reports suggested that the pituitary tumor effects of relacorilant in patients with Cushing Disease (CD) are distinct from those of the FDA-approved GR antagonist mifepristone (Pivonello Front Endocrinol 2022)...In summary, pituitary tumor volume decreased or remained unchanged following treatment with relacorilant for the majority of patients with CD in the GRACE study. Relacorilant was also well-tolerated and led to significant improvements in HC-related signs and symptoms."

Clinical • Late-breaking abstract • P3 data • Cardiovascular • Cushing’s Disease • Diabetes • Endocrine Cancer • Hypertension • Oncology • Pituitary Gland Carcinoma • SSTR • SSTR2

In-vitro Inhibition Of Human Gastric Cancer Cell (nugc3) Line Growth By A Cocktail That Had Already Inhibited Human Melanoma And Liver Cancer Cell Lines Growth In-vitro (ENDO 2025) - "Our previous work using human melanoma cell lines (BLM, 1205Lu, WM238) identified two effective combinations: (1) progesterone + RU-486 + curcumin, and (2) vitamin A + RU-486. The vitamin A + RU-486 cocktail significantly inhibited cell growth in human melanoma, liver, and now gastric cancer cell lines. These results support further investigation of this combination as a potential broad-spectrum anticancer therapy. Future studies will involve testing the combination on normal gastric cells for control comparisons and utilizing ELISA arrays to identify cytokines involved in growth regulation."

Late-breaking abstract • Preclinical • Gastric Cancer • Liver Cancer • Melanoma • Oncology • Solid Tumor

Molecular Profiling of the Selective Glucocorticoid Receptor Modulators CORT118335 (Miricorilant) and CORT125385 With Lipid-Lowering Properties in the Liver (ENDO 2025) - "Mice were subsequently treated with vehicle, the GR agonist corticosterone (3 mg/kg/day), the GR antagonist mifepristone, CORT118335 or CORT125385 (all 60 mg/kg/day) for three days...GO-term analysis on gene subsets after applying molecular filters suggested that the lipid-lowering effects of SGRMs likely involve corticosterone-like upregulation and SGRM-specific downregulation of genes. We tentatively conclude that CORT118335- and CORT125385-induced GR modulation results in a unique transcriptional profile, thereby lowering hepatic lipid levels."

Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease

Molecular Mechanisms of Progesterone Receptor in Inguinal Hernia Formation via Skeletal Muscle Fibrosis and Atrophy (ENDO 2025) - "We also found that co-administration of RU486 (P4/PGR antagonist) in these E2/P4-treated mice prevented hernia development... Our results suggest that P4/PGR signaling in highly P4-sensitive LAM tissues is critical for LAM fibrosis and hernia development partially via TGFB2 signaling. Our findings are one of the first to show the importance of PGR signaling in men and provide evidence that PGR antagonists may be useful as a therapeutic alternative to hernia repair surgery."

Fibrosis • Gastroenterology • Immunology • ER • FBXO32 • PGR • PLOD2 • TGFB2 • TGFBR2

E-cigarette Vaping Exposure Elevates Hepatic Glucocorticoid Action and Impairs Glucose Homeostasis in Mice (ENDO 2025) - "Additionally, RU486 treatment mitigated the increases in hepatic 11β-HSD1 and GR expression induced by nicotine vapor, improving fasting hyperglycemia and insulin sensitivity, although it did not affect the elevated plasma corticosterone levels in nicotine-exposed mice. These data indicate that e-cig vapor exposure adversely impacts glucose homeostasis, with these effects potentially arising, in part, from aerosol nicotine-induced hepatic GC action."

Preclinical • Metabolic Disorders • Type 2 Diabetes Mellitus • NR3C1 • PCK2

Mifepristone as a Potential Risk Factor for Hypothyroidism: A Case Report of a Puerto Rican Woman with Cushing Disease (ENDO 2025) - "Initial treatment with transsphenoidal surgery was unsuccessful, with postoperative 1-mg overnight dexamethasone suppression test levels remaining elevated. Although our patient remained clinically euthyroid, these findings suggest mifepristone can propel a subclinical patient into a more symptomatic state. In addition, this case presents the importance of baseline TFTs and repeat monitoring of patients with autoimmune predisposition to hypothyroidism. Furthermore, this raises important considerations regarding patients with pre-existing hypothyroidism, who may exhibit increased levothyroxine requirements while receiving mifepristone."

Case report • Clinical • Cardiovascular • Cushing’s Disease • Diabetes • Dyslipidemia • Endocrine Disorders • Genetic Disorders • Hypertension • Immunology • Metabolic Disorders • Obesity • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • Type 2 Diabetes Mellitus

Neural Activity Patterns Underlying the Glucocorticoid Withdrawal Syndrome (ENDO 2025) - "To investigate this, we developed a mouse model of precipitated glucocorticoid withdrawal where male and female mice received 2x daily intraperitoneal injections of 5mg/kg dexamethasone (or vehicle) for 10 days followed by a single injection of 20mg/kg mifepristone (or vehicle)...Future work will focus on the role of these brain regions in the behavioral phenotype. Understanding the mechanisms leading to the GWS will eventually allow us to better treat patients and relieve the burden of excess glucocorticoid treatment and its associated morbidity and mortality."

Mental Retardation • Pain • FOS

Management Challenges in Bilateral Adrenal Adenomas with Aldosterone-Cortisol Co-secretion. (ENDO 2025) - "Laboratory workup showed a GFR of 19 mL/min/1.73m2, K of 5.0 mmol/L (reference 3.5-5.3 mmol/L) , AM serum cortisol of 13 mcg/dL (reference: 6.2-19.4 mcg/dL) and ACTH13 pg/mL (6 - 50 pg/mL) , an elevated aldosterone 34 ng/dL (Reference 0.0 - 30.0 ng/dL) and a renin of 0.14 ng/mL/h (Reference 0.25 - 5.82 ng/mL/h) Cortisol after a 1 mg dexamethasone suppression test was 7.7 mcg/dL, and a salivary cortisol at 11 pm was 0.06, along with a 24-hour urine cortisol of 30 mcg/24 h (Reference 4.0 - 50.0 mcg/24 h). These results indicated the presence of hyperaldosteronism and a secondary diagnosis of MACS.Arterial venous sampling (AVS) revealed no lateralization of aldosterone secretion, Eplerenone was added to the patient's antihypertensive medications (Amlodipine, lisinopril, chlorthalidone and Carvedilol) with significant improvements in blood pressure control. Subsequently, due to difficulties associated with managing his diabetes mellitus, Mifepristone was added to his..."

Cardiovascular • Chronic Kidney Disease • Congenital Adrenal Hyperplasia • Cushing’s Disease • Diabetes • Diabetic Nephropathy • Dyslipidemia • Endocrine Disorders • Hypertension • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Type 2 Diabetes Mellitus

Mifepristone-induced gynecomastia, hyperestrogenemia, and secondary hypogonadism in a male with primary bilateral macronodular adrenal hyperplasia (ENDO 2025) - "Work-up revealed baseline AM cortisol 17.3 mcg/dL [reference range (RR) 4.8-20], ACTH 10 pg/mL (RR 7.2-63) and DHEA-S 55 mcg/dL (RR 12-227); two abnormal AM cortisols after 1 mg overnight dexamethasone (5.4 and 6.9 mcg/dL; cut-off <1.8), and a normal 24-hour urine free cortisol (23 mcg/24h, RR 3.5-45)...Despite discontinuation of eplerenone for 1 month, estradiol again increased (91 pg/mL), TT remained low (77 ng/dL), and mastalgia persisted. This is a previously unreported incident of symptomatic estradiol-induced secondary hypogonadism on mifepristone therapy. Hyperestrogenism with gynecomastia and secondary hypogonadism with mifepristone suggests that some individuals may convert cortisol precursors to estradiol."

Cardiovascular • Endocrine Disorders • Fatigue • Hypertension • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus • Women's Health

Rectal ectopic pregnancy diagnosed through laparoscopy and pathological analysis: An extremely rare case report. (PubMed, Medicine (Baltimore)) - "This case emphasizes the necessity of thorough laparoscopic examination of the pelvic and abdominal cavities in suspected EP to avoid missed diagnoses in concealed implantation sites, such as the rectal wall."

Journal • Hematological Disorders • Pain • Thrombosis • Women's Health

Exploring the inhibitory effects of Brassica juncea extract and sinigrin on lipid accumulation in BPA-Induced 3T3-L1 cells via the glucocorticoid receptor and peroxisome proliferator-activated receptor-γ pathways. (PubMed, Food Sci Biotechnol) - "This study explored the role of the GR in BPA-induced lipid accumulation using the GR antagonist mifepristone (10 μM) and the PPAR-γ antagonist GW9662 (15 μM) in 3T3-L1 preadipocytes...Mechanistic investigations revealed that BJE and sinigrin suppressed phospho-GR and PPAR-γ protein expression. Overall, the findings indicate that BPA promotes adipocyte differentiation via both GR and PPAR-γ pathways and that BJE and sinigrin may serve as natural anti-obesogenic agents targeting these mechanisms."

Journal • Genetic Disorders • Obesity • ER • PPARA

The stem bark decoction of Myrianthus arboreus P. Beauv. (Cecropiaceae) shows anti-uterine leiomyoma effects in Wistar rat. (PubMed, Reprod Fertil) - "Normal control and model groups received distilled water, positive groups received mifepristone (5.2 mg/kg) and the remaining 3 groups were treated with 50, 100, and 200 mg/kg of M. arboreus extract, respectively. Compared to the model group, the extract at 50 and 100 mg/kg reduced the E2B- and progesterone-induced uterine horn asymmetry and thickening, as well as relative uterine weight and diameter, myometrial thickness; and collagen density (at 100 and 200 mg/kg)...Consuming boiled M. arboreus stem bark in water reduced uterine wall thickness, inflammation, collagen deposition, and increased the ability of the uterus to fight cell damage. Thus, this extract may prevent or shrink uterine fibroids by reducing uterine swelling, fibrosis and excessive cell growth."

Journal • Preclinical • Back Pain • Fibrosis • Gynecology • Immunology • Infertility • Musculoskeletal Pain • Obstetrics • Oncology • Pain • Sexual Disorders • Solid Tumor • Uterine Leiomyoma • Women's Health • CAT • TGFB1 • TNFA