TT-30 / AstraZeneca - LARVOL DELTA

Exogenous Ketosis Impairs 30-min Time-Trial Performance Independent of Bicarbonate Supplementation. (PubMed, Med Sci Sports Exerc) - "Neutralization of acid-base disturbance by BIC co-ingestion is insufficient to counteract the slightly negative effect of KE intake during high-intensity exercise."

Journal • Metabolic Disorders

Vaccination with nanoparticles combined with micro-adjuvants protects against cancer. (PubMed, J Immunother Cancer) - "The combination of nano- and micro-particles may optimally harness the physiological properties of the lymphatic system. Since the nanoparticles are well defined virus-like particles and the micron-sized adjuvant MCT has been used for decades in allergen-specific desensitization, this approach may readily be translated to the clinic."

Clinical • Journal • Infectious Disease • Melanoma • Oncology • Solid Tumor • Tetanus

The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity. (PubMed) - Cancer Immunol Immunother - "Finally, the MAG-Tn3 vaccine was able to induce anti-Tn antibody responses in cynomolgus monkeys, which targeted Tn-expressing tumor cells and mediated tumor cell death both in vitro and in vivo. Thus, MAG-Tn3 is a highly promising anticancer vaccine that is currently under evaluation in a phase I clinical trial."

Journal • Biosimilar • Breast Cancer • Oncology • Triple Negative Breast Cancer

Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects. (PubMed, J Allergy Clin Immunol) - "Vaccination of cats with Fel-CuMV induces neutralizing antibodies and might result in reduced symptoms of allergic cat owners. Both human subjects and animals could profit from this treatment because allergic cat owners would reduce their risk of developing chronic diseases, such as asthma, and become more tolerant of their cats, which therefore could stay in the households and not need to be relinquished to animal shelters."

Clinical • Journal • Allergy • Asthma • Immunology • Infectious Disease • Respiratory Diseases • Tetanus

Thermotolerance evaluation of Taiwan Japonica type rice cultivars at the seedling stage. (PubMed, Bot Stud) - "The temperature induction screening tool established by this study could determine the potential of each variety to adapt to high temperature stress. Additionally, thermotolerance during different growth stages (i.e., the germination, seedling, and grain maturation stages) exhibited low correlations. In this study, the varieties obtained through preliminary screening (i.e., TK14, HC56, TT30, TNG70, and TK8) exhibited outstanding thermotolerance. The screen tools and thermotolerance varieties could be valuable resources for the countries that grow Japonica type rice to apply when breeding thermotolerant varieties in the future."

Journal

Treating insect-bite hypersensitivity in horses with active vaccination against IL-5. (PubMed, J Allergy Clin Immunol) - "Our therapeutic vaccine inducing autoantibodies against self IL-5 brings biologics to horses, is the first successful immunotherapeutic approach targeting a chronic disease in horses, and might facilitate development of a similar vaccine against IL-5 in human subjects."

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