miR-16 / Synlogic - LARVOL DELTA

MicroRNA Profile in Immune Response of Alveolar and Cystic Echinococcosis Patients. (PubMed, Parasite Immunol) - "Twenty-five microRNAs, including let-7a-5p, let-7c, let-7e-5p, miR-15b-5p, miR16, miR-17-5p, miR-23a-5p, miR-24-3p, miR-25-3p, miR-26a-3p, miR-26b-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e-5p, miR-98-5p, miR-101-3p, miR-106b-5p, miR-125b-5p, miR-142-5p, miR-222-3p and miR-223-3p were found as down-regulated in Alveolar and Cystic Echinococcosis patients than control groups...It has been shown that T and B cell activities are related in the progressive of both Alveolar and Cystic Echinococcosis in this study. The miRNA panel activated by T and B cells may be important for exploring the mechanisms underlying early development in Alveolar and Cystic Echinococcosis providing novel information that may be used to discover new therapeutics for these diseases."

Clinical • Journal • Infectious Disease • Let-7c • miR-125b • MIR142 • MIR146A • MIR21 • MIR223 • MIR23A • MIR27A • MIR30B • MIR30D • MIR30E • PCR

mir15a/mir16-1 cluster and its novel targeting molecules negatively regulate cardiac hypertrophy. (PubMed, Clin Transl Med) - "Importantly, decreased serum mir15a/mir16-1 levels predicted the occurrence of left ventricular hypertrophy in a cohort of patients with hypertension. Therefore, mir15a/mir16-1 cluster is a promising therapeutic target and biomarker for cardiac hypertrophy."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • IR • SGK1