allogeneic CAR-T therapy / EdiGene, Beijing Imunopharm - LARVOL DELTA

Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients (ASH 2024) - "Following lymphodepletion of fludarabine (30-50 mg/m2/d) and cyclophosphamide (500-1000 mg/m2/d) for a duration of 3 days, patients receive a single-dose infusion of ET-901 at escalating doses of 1*10e6/kg, 3*10e6/kg, and 10*10e6/kg. All patients demonstrated objective responses, with significant CAR-T cell expansion, confirming the engineered cells' long-term immune privilege and activity. This represents a significant step in making allogeneic CAR T-cell therapy more viable and effective."

Clinical • Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Oncology • Thrombocytopenia • B2M

Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients (ASGCT 2024) - P1/2 | "An ongoing clinical trial (NCT06014073) with these allogeneic CAR T-cell demonstrated high anti-tumor activity and persistence for more than 3 months in first 5 evaluable R/R NHL patients (Data cut-off date is January 20, 2024), with 100% ORR and 60% CR and manageable safety profile. Our research highlights the complex immune interactions and positions GeneX engineering as a promising strategy for creating universal therapeutic cells."

Clinical • Graft versus Host Disease • Hematological Malignancies • Immunology • Oncology • Transplant Rejection • B2M