Noxafil (posaconazole) / Merck (MSD), Ligand - LARVOL DELTA

Successful Outcome of Rhino-Orbital-Cerebral Mucormycosis With Extensive Intracranial Disease in a Patient With Poorly Controlled Diabetes. (PubMed, Perm J) - "This included high-dose liposomal amphotericin B, targeted serial endoscopic debridements of extracranial disease, and adjunctive therapies comprising iron chelation (deferasirox), hyperbaric oxygen, and combination antifungal therapy with caspofungin and posaconazole. Despite the inability to achieve complete surgical clearance, this regimen halted disease progression and resulted in clinical and radiological regression. This case illustrated that a coordinated, multimodal approach utilizing aggressive medical management can achieve favorable outcomes in select patients with otherwise inoperable, extensive intracranial mucormycosis."

Journal • Cardiovascular • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Thrombosis

Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients. (PubMed, Drug Des Devel Ther) - "The trough concentrations of venetoclax were 9326.88 ± 12,169.05 ng/mL in patients treated with venetoclax alone, and 31,623.55 ± 28,453.67 ng/mL in patients treated with venetoclax in combination with posaconazole. A rapid and simple method was established and successfully applied to the simultaneous determination of the concentrations of venetoclax and posaconazole in AML patients, providing a basis for TDM and clinical pharmacokinetic analysis of these drugs in AML patients."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • CYP3A4

Two decades of mucormycosis: molecular epidemiology and antifungal susceptibility trends in Türkiye. (PubMed, Front Cell Infect Microbiol) - "Posaconazole exhibited greater in vitro activity than amphotericin B (p < 0.001), while Cunninghamella species showed elevated amphotericin B minimum inhibitory concentrations. This single-center study provides the most comprehensive data on mucormycosis in Türkiye and highlights the importance of molecular surveillance to guide antifungal therapy and monitor regional variations."

Journal • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases

Cutaneous Paraconiothyrium cyclothyrioides Infection in Lung Transplant Recipient, Georgia, USA. (PubMed, Emerg Infect Dis) - "The infection resolved with posaconazole after substantial diagnostic delays and related side effects. This case underscores the need for improved clinical awareness, diagnostic testing, treatments, and surveillance for such infections."

Journal • Dermatology • Infectious Disease • Respiratory Diseases • Transplantation

Restoring the pink of health: primary Rhodotorula mucilaginosa pneumonia in an immunocompetent host successfully treated with posaconazole (ESCMID Global 2026) - No abstract available

Infectious Disease • Pneumonia • Respiratory Diseases

Assessing voriconazole Etest as a surrogate marker for isavuconazole and posaconazole susceptibility in Aspergillus species (ESCMID Global 2026) - No abstract available

Optimising posaconazole dosing in children through population PK modelling and simulation (ESCMID Global 2026) - No abstract available

Clinical

Incidence and risk factors of breakthrough invasive fungal infection among patients with myeloid leukemia during posaconazole prophylaxis in King Chulalongkorn Memorial Hospital, Thailand (ESCMID Global 2026) - No abstract available

Clinical • Hematological Malignancies • Infectious Disease • Leukemia

Invasive Conidiobolus infection in an immunocompromised pediatric patient in Southern California. (PubMed, ASM Case Rep) - "Ultimately, the patient was discharged on posaconazole and trimethoprim-sulfamethoxazole. Conidiobolus can be an agent of invasive fungal infection and may be considered a potential infectious agent in the immunocompromised patient. Treatment and outcomes of invasive Conidiobolus remain elusive."

Journal • Bone Marrow Transplantation • Critical care • Dermatology • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Pediatrics • Transplantation

ReSPECT: Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation (clinicaltrials.gov) - P3 | N=602 | Completed | Sponsor: Mundipharma Research Limited | Active, not recruiting ➔ Completed

Trial completion • Acute Lymphocytic Leukemia • Hematological Malignancies • Hodgkin Lymphoma • Infectious Disease • Multiple Myeloma • Myelodysplastic Syndrome • Transplantation

Drug-Resistant Candida auris and Mucor in Liver Transplant: Fosmanogepix as Salvage Therapy (SCCM 2026) - "His postoperative course was further complicated by a persistent abdominal wall infection involving drug-resistant C. auris and M. circinelloides, unresponsive to amphotericin B, micafungin, and posaconazole. The observed decline in beta-D-glucan and transition to oral therapy contributed to infection control and stabilization. Fosmanogepix may provide a much-needed alternative for transplant recipients with multidrug resistant fungal infections unresponsive to existing therapies."

Fibrosis • Hepatology • Immunology • Infectious Disease • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Respiratory Diseases • Transplantation

Incidence of Therapeutic Azole Dosing in ECMO Patients (SCCM 2026) - "Azole antifungals during ECMO are therapeutic only 41.6% of the time, with voriconazole having a higher proportion of subtherapeutic concentrations (39% vs 50%). Voriconazole had a large variation in dosing required to be therapeutic and subsequent studies should investigate which patients may be more likely to need higher doses."

Clinical • Infectious Disease • Respiratory Diseases

BREAKING THE MOLD: A UNIQUE CASE OF LOEFFLER ENDOCARDITIS COMPLICATED BY CARDIOGENIC SHOCK AND ANGIOINASIVE FUSARIUM FUJIKUROI INFECTION (ACC 2026) - "She was initiated on apixaban, prednisone, rituximab and prophylactic trimethoprim-sulfamethoxazole (TMP-SMX). One month later, the patient noted necrotic ulcerations on all four extremities since starting rituximab; lesion biopsies revealed angioinvasive Fusarium fujikuroi, so she was admitted and posaconazole and amphotericin were started...Diuresis with oral torsemide failed due to oliguria, after which she developed cardiogenic shock with a cardiac index of 1.7 L/min/m2 requiring dobutamine and continuous renal replacement therapy (CRRT). With the afterload reduction CRRT provided, she was weaned off dobutamine and CRRT and transitioned to oral furosemide before discharge... Management of LE in patients undergoing immunosuppressive therapy may be complicated by opportunistic infections and medication toxicity. Cardiogenic shock can be caused by the restrictive ventricular physiology of LE."

Clinical • Acute Kidney Injury • Cardiomyopathy • Cardiovascular • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Fibrosis • Heart Failure • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Langerhans Cell Histiocytosis • Myocardial Infarction • Rare Diseases • Renal Disease • Vasculitis

VENETOCLAX-INDUCED NEW-ONSET SYSTOLIC HEART FAILURE IN A PATIENT WITH HIGH-GRADE MYELODYSPLASTIC SYNDROME (ACC 2026) - "Background: Venetoclax, in combination with azacitidine, is increasingly used in the treatment of high-grade myelodysplastic syndromes (MDS). Venetoclax-associated cardiomyopathy is rare but potentially reversible. Cardiac monitoring, especially when used with CYP3A4 inhibitors such as posaconazole is warranted to mitigating cardiac complications."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Hematological Malignancies • Myelodysplastic Syndrome • Pulmonary Disease • Respiratory Diseases

Evaluation of the Synergistic Activity of Anidulafungin with Isavuconazole, Voriconazole, Posaconazole, and Amphotericin B in Candida auris (Candidozyma auris) Isolates. (PubMed, Infect Drug Resist) - "High resistance rates were observed for fluconazole (72%) and amphotericin B (48%), whereas no isolates were resistant to echinocandins. The predominance of indifferent interactions, with some partial synergy, suggests that combination therapy may not consistently offer a strong synergistic benefit for these isolates. This exploratory study characterizes the in vitro interaction landscape in our isolate collection, providing foundational data to guide future research and inform clinical decisions where treatment options are scarce."

Journal • Infectious Disease

Fusarium on the Surface: Cutaneous Clues to a Deadly Disseminated Infection (AAD 2026) - "Patient History: Here we present a 68-year-old man with past medical history of acute myeloid leukemia (AML) treated with an allogeneic stem cell transplant, chronic hepatic graft-versus-host disease (GVHD), and cutaneous and pulmonary mucormycosis, which had been successfully managed for two years with posaconazole, who was admitted for chemotherapy with cladribine, cytarabine, and venetoclax...Treatment: Management included surgical nasal sinus debridement and near-total ethmoidectomy, in addition to aggressive systemic antifungal therapy with voriconazole, liposomal amphotericin B, micafungin, and oral terbinafine. Supportive treatment included meropenem and filgrastim to address concurrent neutropenia... In immunocompromised patients with hematologic malignancies, dermatologists should have a low threshold to perform biopsies and tissue cultures on even non-specific skin findings. Prompt dermatologic evaluation, biopsy, and tissue culture are essential for early..."

Acute Myelogenous Leukemia • Graft versus Host Disease • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Leukemia • Liver Failure • Neutropenia • Otorhinolaryngology

Antifungal susceptibility and in vitro virulence characteristics of clinical Magnusiomyces/Saprochaete isolates: a multicenter study from Türkiye. (PubMed, Sci Rep) - "MICs of amphotericin B, fluconazole, voriconazole, itraconazole, posaconazole, and flucytosine were determined using the EUCAST broth microdilution method. This study provides the most extensive multicenter dataset on Magnusiomyces/Saprochaete in Türkiye and underscores their considerable pathogenic potential through strong biofilm formation and tissue-degrading enzyme activities. Accurate species-level identification using MALDI-TOF MS supported by molecular methods is essential, and limited fluconazole activity suggests that voriconazole and amphotericin B should be prioritized in species-guided treatment strategies."

Clinical • Journal • Preclinical • Infectious Disease

PERSISTING FEVER AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A CASE REPORT OF A RARE INFECTION WITH LOMENTOSPORA PROLIFICANS (EBMT 2026) - "Cytoreductive therapy with hydroxyurea was initiated immediately after diagnosis, with no other prior antineoplastic treatment administered. Conditioning with fludarabine, thiotepa, and melphalan was started 7 months after the initial diagnosis...The patient received an HLA-identical unrelated male donor peripheral blood stem cell graft, with graft-versus-host disease prophylaxis comprising cyclosporine, mycophenolate mofetil, and anti-thymocyte globulin (ATG)...On day −3, the patient developed febrile neutropenia and broad-spectrum antibiotic treatment (piperacillin/tazobactam) was initiated. Recurrent fever on day +1 led to escalation to meropenem and a switch from fluconazole to posaconazole; blood cultures remained negative.Under these measures, the fever persisted...On day +11, increasing somnolence, pathological breathing pattern, and new oxygen requirement prompted sampling of peripheral and central blood cultures and empiric addition of linezolid and..."

Case report • Clinical • Bone Marrow Transplantation • Chronic Myelomonocytic Leukemia • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Neutropenia • Respiratory Diseases • Septic Shock • Transplantation • ASXL1 • NRAS • RUNX1 • SETBP1 • SRSF2

POSACONAZOLE IN PAEDIATRICS: ARE WE HITTING THE MARK OR MISSING THE TARGET? (EBMT 2026) - "Posaconazole is effective in preventing and treating IFIs in children but requires higher than recommended doses to achieve therapeutic targets for treatment."

Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Pediatrics

ANTIFUNGAL PROPHYLAXIS PATTERNS AND INVASIVE FUNGAL INFECTIONS OUTCOMES IN PAEDIATRIC ALLOGENIC HCT: A MULTICENTRE COHORT STUDY (EBMT 2026) - "Choice of antifungal prophylaxis was classified as non–mould-active (fluconazole), mould-active (including micafungin, liposomal amphotericin B, voriconazole and posaconazole), or mixed (both non-mould active and mould active agents). Antifungal prophylaxis in paediatric allogenic HCT was strongly risk-adapted, with increased mould-active use in patients with prior history of IFI. IFIs occurred across all prophylaxis strategies, with all proven IFIs occurring in patients on fluconazole monotherapy. Most IFIs arose post-engraftment, highlighting the need for consistent, risk-based escalation to mould-active prophylaxis in immunosuppressed children."

Clinical • Infectious Disease • Pediatrics

OPEN WIDE: EXPLORING SALIVA AS A NON-INVASIVE TOOL FOR POSACONAZOLE LEVELS IN CHILDREN (EBMT 2026) - "This is the first prospective study assessing salivary detection of posaconazole in children. Our findings indicate that saliva sampling is unsuitable for posaconazole TDM in immunocompromised children. The minimal detection is possibly related to its high protein binding (>98%) similar to itraconazole and in contrast to voriconazole (~58%) and fluconazole (~10%), which have demonstrated reliable salivary penetration."

Clinical • Non-invasive • Infectious Disease • Mucositis • Stomatitis

Osteoarticular Coccidioidomycosis in California: A Single-Center Experience. (PubMed, Open Forum Infect Dis) - "Itraconazole was the most common antifungal used (n = 16, 50%), followed by posaconazole (n = 8, 25%), and surgery was performed in 24 (75%) patients. Knee and multisite infections were associated with poorer outcomes. Larger studies are needed to validate these findings and optimize treatment strategies."

Journal • Infectious Disease • Musculoskeletal Diseases • Respiratory Diseases

Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome in Lung Transplant Patient (ISHLT 2026) - "His infection prophylaxis included trimethoprim-sulfamethoxazole, valganciclovir, and posaconazole...The patient was empirically started on cefepime and minocycline...Antibiotics were escalated to meropenem, vancomycin and levofloxacin...Parvovirus B19 may contribute to pancytopenia but should not cause systemic inflammation. Otherwise, no alternative explanation was identified."

Clinical • Acute Kidney Injury • Chronic Obstructive Pulmonary Disease • Epstein-Barr Virus Infections • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Kaposi Sarcoma • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Sarcoma • Solid Organ Transplantation • Solid Tumor • Systemic Inflammatory Response Syndrome • Transplantation • CSF2 • IL10 • IL6 • TNFA

Synergistic activity of caspofungin and posaconazole against Candida (Candidozyma) auris biofilms based on phenotypic, transcriptomic, and in vivo insights. (PubMed, Microbiol Spectr) - "Additional responses included activation of RCT1 (fluconazole-inducible protein) and MDR1 (drug efflux pump), collectively promoting survival under combined antifungal pressure. Our study demonstrates that the combination of caspofungin and posaconazole exerts a strong synergistic effect against C. auris biofilms, both in vitro and in vivo. By elucidating the molecular mechanisms behind this synergy-including stress-response activation, cell wall and membrane remodeling, calcium signaling, and regulation of drug efflux pumps-this work provides important insights into antifungal therapeutic responses in C. auris and underscores combination therapy as a promising strategy to overcome biofilm-associated antifungal resistance in this high-risk pathogen."

Journal • Preclinical • Infectious Disease • ABCB1

Simultaneous determination of selinexor， posaconazole， venetoclax， and voriconazole in human plasma using ultra-high performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "Notably， significant inter-individual variability in the peak plasma concentration （Cmax） of SEL was observed within the same treatment cycle for approximately 30% of the patient cohort. This study offers evidence-based support for personalized precision therapy in this patient population， which exhibits substantial inter-individual variability and complex drug-drug interactions in clinical practice."

Journal • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology