VG201 / ViroGin Biotech - LARVOL DELTA

VG201-C101: A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Patients with Solid Tumors (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Shanghai Virogin Biotech Co., Ltd. | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Dec 2023 ➔ Oct 2025

Trial completion date • Trial primary completion date • Oncology • Solid Tumor

Study of VG2025 Delivered Intraperitoneally in Patients with Advanced Solid Tumors with Carcinomatosis (clinicaltrials.gov) - P1 | N=0 | Withdrawn | Sponsor: M.D. Anderson Cancer Center | N=21 ➔ 0 | Trial completion date: Mar 2030 ➔ Oct 2024 | Not yet recruiting ➔ Withdrawn | Trial primary completion date: Mar 2028 ➔ Oct 2024

Enrollment change • Metastases • Trial completion date • Trial primary completion date • Trial withdrawal • Oncology • Solid Tumor

The updated report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/Rα payloads, in patients with advanced solid tumors (CSCO 2024) - No abstract available

Clinical • Metastases • Oncolytic virus • P1 data • Oncology • Solid Tumor • IL12A • IL15

The updated report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/Rα payloads, in patients with advanced solid tumors (ESMO 2024) - P1 | "Intratumoral injection of VG2025 monotherapy has demonstrated anti-cancer activity with a well-tolerant safety profile in pts progressed after standard of care therapies, which support further investigation of the efficacy of VG2025 in potential indications such as TNBC, ICC, and duodenal adenocarcinoma."

Clinical • IO biomarker • Metastases • Oncolytic virus • P1 data • Breast Cancer • Gastrointestinal Cancer • Liver Cancer • Oncology • Small Intestinal Carcinoma • Solid Tumor • Triple Negative Breast Cancer • CD8 • CEACAM5 • HLA-DQA1 • HLA-DRB1 • IL12A • IL15 • PD-L1

The updated report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/RA payloads, in patients with advanced solid tumors (ESMO Asia 2023) - P1 | "Nanostring analysis of paired biopsies from the PR pts demonstrated upregulation of integrin signaling pathway, antigen-presenting MHC (HLA-DQA1 and HLA-DRB1) and chemokine receptor (CMKLR1) genes, and activation of CD8+ T cells. Conclusions Monotherapy with VG2025 demonstrated activity with a well-tolerant safety profile in pts with advanced solid tumors that progressed after standard of care therapy."

Clinical • IO biomarker • Metastases • Oncolytic virus • P1 data • Endocrine Cancer • Gastrointestinal Cancer • Lung Cancer • Neuroendocrine Tumor • Non Small Cell Lung Cancer • Oncology • Pancreatic Cancer • Small Intestinal Carcinoma • Solid Tumor • CD8 • CEACAM5 • HLA-DQA1 • HLA-DRB1 • IL12A • IL15 • PD-L1

Phase I Study VG2025 as a Single Agent and in Combination Therapy With Nivolumab in Subjects With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: Virogin Biotech Canada Ltd | Trial primary completion date: Dec 2023 ➔ Dec 2024

Combination therapy • Metastases • Trial primary completion date • Oncology • Solid Tumor

The initial report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/RA payloads, in patients with advanced solid tumors. (ASCO 2023) - P1 | "Monotherapy activity was observed with an acceptable safety profile in heavily pretreated pts with advanced solid tumors. Clinical trial information: NCT05266612."

Clinical • Metastases • Oncolytic virus • P1 data • Biliary Cancer • Cholangiocarcinoma • Gastrointestinal Cancer • Infectious Disease • Leiomyosarcoma • Novel Coronavirus Disease • Oncology • Sarcoma • Solid Tumor • CD8 • CEACAM5 • CXCR4 • HLA-DQA1 • HLA-DRB1 • IL12A • IL15 • PD-L1

Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1. (PubMed, Mol Ther Oncolytics) - "VG2025 is a recombinant oncolytic herpes simplex virus type 1 (HSV-1) that uses transcriptional and translational dual regulation (TTDR) of critical viral genes to enhance virus safety and promote tumor-specific virus replication without reducing virulence...Absence of neurotoxicity was verified in mice and in rhesus monkeys. Taken together, the enhanced tumor clearance, excellent safety profile, and positive correlation between CEA levels and viral replication efficiency may provide an opportunity for using biomarker-based precision medicine in oncolytic virotherapy."

Journal • Embryonal Tumor • Herpes Simplex • Oncology • CEACAM5 • IL12A • IL15

A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Subjects With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: Virogin Biotech Canada Ltd | Not yet recruiting ➔ Recruiting

Enrollment open • Oncology • Solid Tumor

A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Patients With Solid Tumors (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: Shanghai Virogin Biotech Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Oncology • Solid Tumor

A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Subjects With Advanced Malignant Solid Tumors (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: Virogin Biotech Canada Ltd | Initiation date: Jun 2022 ➔ Nov 2022

Trial initiation date • Oncology • Solid Tumor

A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Patients With Solid Tumors (clinicaltrials.gov) - P1 | N=30 | Not yet recruiting | Sponsor: Shanghai Virogin Biotech Co., Ltd.

New P1 trial • Oncology • Solid Tumor

Nanostructured materials for harnessing the power of horseradish peroxidase for tailored environmental applications. (PubMed, Sci Total Environ) - "High catalytic efficiency, stereoselectivity, and sustainability outcomes of enzymes entice chemists for considering biocatalytic transformations to supplant conventional synthetic routes...Furthermore, the general physicochemical aspects, improved catalytic attributes, and the robust practical implementations of engineered HRP-based catalytic cues are also discussed with suitable examples. To end, concluding remarks, challenges, and worthy suggestions/perspectives for future enzyme immobilization are also given."

Journal • Review

Genetic variability and genome-wide association analysis of flavor and texture in cooked beans (Phaseolus vulgaris L.). (PubMed, Theor Appl Genet) - "SNPs associated with total flavor intensity (six SNPs across three chromosomes), beany (five SNPs across four chromosomes), earthy (three SNPs across two chromosomes), starchy (one SNP), bitter (one SNP), seed-coat perception (three SNPs across two chromosomes), and cotyledon texture (two SNPs across two chromosomes) were detected. These findings lay a foundation for incorporating flavor and texture in breeding programs for the development of new varieties that entice growers, consumers, and product developers alike."

Journal

An assessment of hospital maternal health services in northern Ghana: a cross-sectional survey. (PubMed, BMC Health Serv Res) - "The management of emergency obstetric care and referrals are likely to be affected by the limited human resources and equipment in hospitals in Northern Ghana. Financial and non-financial incentives to entice midwives, obstetricians and medical officers to the Northern region should be implemented. Resources should be mobilised to improve the availability of essential equipment such as vacuum extractors and reliable ambulances to enhance referral services. Considerable health system strengthening efforts are required to achieve the required standards."

Clinical • Journal • Obstetrics

Perfusion Recruitment Strategies Using Choice-Based Conjoint Analysis. (PubMed, J Extra Corpor Technol) - "Offering large sign-on bonuses and relocation packages to entice new employees is not indicated as a viable way to satisfy perfusionists. Appropriate management of hours worked, days on call, and how ECMO impacts the perfusionists will be most impactful in recruitment of new employees."

Journal

The Robot Made Me Do It: Human-Robot Interaction and Risk-Taking Behavior. (PubMed, Cyberpsychol Behav Soc Netw) - "Our results reveal that participants who were encouraged by the robot did take more risks, while the mere presence of the robot in the robot control condition did not entice participants to show more risk-taking behavior. Our results point to both possible benefits and perils that robots might pose to human decision-making. Although increasing risk-taking behavior in some cases has obvious advantages, it could also have detrimental consequences that are only now starting to emerge."

Journal

[VIRTUAL] MT.08 - Meet the Trialists #8 (AHA 2020) - "This meet the trialist session will entice cross specialty discussion based on cardiovascular outcomes using finerenone in patients with chronic kidney disease and type II diabetes. Also, included in this session is the study of ticagrelor added to aspirin in acute ischemic stroke/TIA. Made possible in part from support of Amgen and Cytokinetics."

Cardiovascular • Chronic Kidney Disease • Diabetes • Ischemic stroke • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Localized Interleukin-12 for Cancer Immunotherapy. (PubMed, Front Immunol) - "Nevertheless, IL-12's pleiotropic activity, i.e., its ability to engage multiple effector mechanisms and reverse tumor-induced immunosuppression, continues to entice cancer researchers...Advantages and limitations of different delivery technologies are highlighted. Finally, perspectives on how IL-12-based immunotherapies may be utilized for widespread clinical application in the very near future are offered."

Journal • Review • Oncology

TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution. (PubMed, Glycoconj J) - "Surprisingly, neither glycan scaffold or multivalent presentation of TF antigen on the scaffold was able to entice Gal-1 recognition to the level of affinity expected for functional significance. Future evaluations of the Gal-1/TF binding interaction in order to draw connections between immunohistochemical data and analytical measurements are warranted."

Journal • Oncology • MUC1

Factors That Influence Nurse Manager Job Satisfaction: An Integrated Literature Review. (PubMed, J Nurs Manag) - "Findings from this study reveal areas for improvement that healthcare institutions and senior nursing leadership can use to transform practice environments, increase nurse managers' job satisfaction, and entice them to stay."

Journal • Review

A psycho-linguistic profile of online grooming conversations: A comparative study of prison and police staff considerations. (PubMed, Child Abuse Negl) - "Findings challenge the common perception that the relationship is centred on deception and identify the intention of some adults as the development of a perceived genuine interpersonal relationship."

Journal

Inter-sexual mate competition in three cultures. (PubMed, PLoS One) - "During these interactions, women and feminine males both attempted to manipulate the man who was the object of sexual competition; feminine males attempted to entice the target man, whereas women engaged in guarding and emotionally punitive behaviours. We do not anticipate that inter-sexual mate competition will be common in most species or across all cultures. However, when males and females prefer the same sexual partners, who themselves behave in a bisexual manner, then inter-sexual mate competition can ensue."

Journal • Preclinical

Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations. (PubMed, Chem Soc Rev) - "In addition, we will discuss the biological applications of Aza-BODIPY dyes in probing various biological activities, as well as in fluorescence bioimaging/detection, newly-emerging photoacoustic bioimaging/detection, and phototherapy together with future challenges and implications in this field. We aim at providing an insightful design guideline and a clear overview of Aza-BODIPY dyes, which might entice new ideas and directions."

Journal • Preclinical • Review

[VIRTUAL] Healthcare Workers Emotions, Perceived Stressors and Coping Strategies during SARS-Cov-2 pandemic. (EUSEM 2020) - "They appreciated recognition of their efforts by hospital management and expected similar acknowledgment, infection control guidance, and equipment would entice them to work during future epidemics. The Covid-19 pandemic is a distressing time for our staff. Hospitals can enhance HCWs experiences during any future outbreak by focusing on the above mentioned aspects."

CNS Disorders • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Psychiatry