uprevstobart (INCA00186)
/ Incyte
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September 03, 2025
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=57 | Terminated | Sponsor: Incyte Corporation | Completed ➔ Terminated; This was a strategic business decision. There were no safety concerns contributing to this decision.
Monotherapy • Trial termination • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Pancreatic Ductal Adenocarcinoma • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8
June 03, 2025
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=57 | Completed | Sponsor: Incyte Corporation | Active, not recruiting ➔ Completed | Trial completion date: Jun 2025 ➔ Sep 2024 | Trial primary completion date: Jun 2025 ➔ Sep 2024
Monotherapy • Trial completion • Trial completion date • Trial primary completion date • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Pancreatic Ductal Adenocarcinoma • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8
December 27, 2023
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=57 | Active, not recruiting | Sponsor: Incyte Corporation | Trial completion date: Jan 2024 ➔ Jun 2025 | Trial primary completion date: Jan 2024 ➔ Jun 2025
Combination therapy • Metastases • Monotherapy • Trial completion date • Trial primary completion date • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Pancreatic Ductal Adenocarcinoma • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8
July 12, 2023
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=57 | Active, not recruiting | Sponsor: Incyte Corporation | Recruiting ➔ Active, not recruiting | N=210 ➔ 57 | Trial completion date: Feb 2025 ➔ Jan 2024 | Trial primary completion date: Feb 2025 ➔ Jan 2024
Combination therapy • Enrollment change • Enrollment closed • Metastases • Monotherapy • Trial completion date • Trial primary completion date • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Pancreatic Ductal Adenocarcinoma • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8
September 14, 2022
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1 | N=210 | Recruiting | Sponsor: Incyte Corporation | Trial completion date: Aug 2024 ➔ Jan 2025 | Trial primary completion date: Aug 2024 ➔ Jan 2025
Combination therapy • Monotherapy • Trial completion date • Trial primary completion date • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD8
October 05, 2021
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1; N=230; Recruiting; Sponsor: Incyte Corporation; Not yet recruiting ➔ Recruiting
Clinical • Combination therapy • Enrollment open • Monotherapy • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD73 • CD8
August 04, 2021
Study of INCA 0186 in Subjects With Advanced Solid Tumors
(clinicaltrials.gov)
- P1; N=230; Not yet recruiting; Sponsor: Incyte Corporation
New P1 trial • Esophageal Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Head and Neck Cancer • Hepatocellular Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CD73 • CD8
March 11, 2021
[VIRTUAL] Discovery and preclinical characterization of INCA00186, a humanized monoclonal antibody antagonist of CD73, as a cancer immunotherapy
(AACR 2021)
- "In summary, the data presented in this study demonstrates that INCA00186 is a potent CD73 antagonist and effectively attenuates adenosine induced immunosuppression in the tumor microenvironment. INCA00186 demonstrated anti-tumor immunity alone and, to a greater extent, in combination with the A2A/A2B adenosine receptor antagonist INCB106385."
Late-breaking abstract • Preclinical • Breast Cancer • Melanoma • Oncology • Solid Tumor • CD34 • CD73 • ENTPD1 • IFNG
March 11, 2021
Incyte Announces Data from Multiple Programs Within its Oncology Portfolio Accepted for Presentation at the AACR Annual Meeting 2021
(Businesswire)
- "Incyte...announced that multiple abstracts from across its oncology portfolio will be presented during Week 1 of the upcoming American Association for Cancer Research (AACR) Annual Meeting 2021, held virtually from April 10-15, 2021....'At AACR 2021, we look forward to sharing clinical and pre-clinical data from INCB106385, our novel A2A/A2B adenosine receptor antagonist, and INCA00186, our novel CD73 monoclonal antibody—both of which highlight our ongoing efforts targeting the adenosine pathway. Presentations at the congress will also feature updated data from our LIMBER development program, including results from our Phase 2 combination study of ruxolitinib, a janus kinase (JAK1/JAK2) inhibitor, and parsaclisib, a potent, highly selective oral inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ)'"
Clinical data • Preclinical • Acute Myelogenous Leukemia • Hematological Malignancies • Lung Cancer • Myelofibrosis • Non Small Cell Lung Cancer • Oncology
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