biapenem / Generic mfg. - LARVOL DELTA

Tricyclic boronic acids as broad-spectrum serine and metallo-β-lactamase inhibitors with in vitro activity against acinetobacter baumannii: a patent evaluation (us 2025/0223303). (PubMed, Expert Opin Ther Pat) - "This article concisely reviews structurally novel xeruborbactam-inspired tricyclic boronates (reported in US 2025/0223303) with promising inhibitory activities in vitro. By introducing novel thioether-based C5 sidechains onto the previously optimized bicyclic boronate core, the inventors explored novel chemical space yielding SBL/MBL inhibitors with seemingly improved activities against carbapenem-resistant (CR) Escherichia coli, Klebsiella pneumoniae, and, importantly, Acinetobacter baumannii, when used in combination with meropenem and/or biapenem (at least with respect to taniborbactam, i.e. boronate inhibitor in late-stage clinical development). Due to the major societal importance of β-lactams for modern medicine, and the clearly demonstrated clinical potential of functionalized cyclic boronates as potent dual-acting SBL/MBL inhibitors when used in combination therapies, there is ample opportunity and scope for continued investigation of this pharmacophore,..."

Journal • Preclinical • Review • Infectious Disease • Pneumonia

Dietary Sucrose Exacerbates Antibiotic-Induced Microbiome Injury in Allo-HCT (ASH 2024) - "To validate this finding, we developed a simple mouse model of antibiotic-induced expansion of Enterococci endogenous to the mouse gut microbiome by administering a single subcutaneous dose of the carbapenem antibiotic biapenem to C57BL/6 mice induced a moderate bloom of Enterococci, as assessed by dilution plating on selective agar...Avoiding sugar-enriched foods while taking antibiotics may also have relevance outside the setting of cancer treatment. The general recommendation to limit consumption of sweets for cardiovascular health might, with further study, be tailored to abbreviated periods of avoidance to mitigate microbiome disruption during antimicrobial therapy."

Hematological Malignancies • Oncology

From reaction energetics to automated analysis tool auxiliary identification: A self-validating multidimensional liquid chromatography- mass spectrometry framework for characterizing polymerized impurities in carbapenem antibiotics. (PubMed, J Chromatogr A) - "HPSEC and RP-HPLC methods with novel separation principles and two-dimensional chromatographic methods (UHPLC-Q-TOF MS and 2D HPSEC × LC-Q-Exactive MS) were established to resolve polymerized species in biapenem and meropenem. The dimer configurations identified from the LC-MS/MS results were consistent with the dominant dimer configurations revealed by theoretical calculations. This work establishes a self-validating methodology that integrates "multidimensional separation-high-resolution MSn characterization -mechanistic validation- automated analysis tool auxiliary identification analysis," for the precise characterization of polymerized impurities."

Journal • Allergy

Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones. (PubMed, J Antimicrob Chemother) - "Nocardia spp. exhibited varying patterns of susceptibility to carbapenems and fluoroquinolones respectively. Importantly, different Nocardia spp. exhibited different patterns of susceptibility to carbapenems and fluoroquinolones, respectively."

Journal

Efficacy and safety of Chaihu Anxin Capsule in the treatment of mild to moderate depression: a multicenter, randomized, double-blind, placebo parallel-controlled clinical trial and mechanism of action (ChiCTR) - P=N/A | N=142 | Not yet recruiting | Sponsor: The First Hospital of Hebei Medical University; The First Hospital of Hebei Medical University

New trial • CNS Disorders • Depression • Mood Disorders • Psychiatry

In Vitro Activity of Minocycline in Combination with Biapenem Against Cefiderocol-Resistant NDM-Producing Enterobacterales (ASM Microbe 2025) - "In addition, the cMIC90 and susceptible rate of aztreonam/avibactam, used as a comparator, were 4 μg/mL and 90.6%, respectively. MINO has been suggested to exhibit an ability to cell wall damage in addition to inhibiting protein synthesis, and its bactericidal effect has been confirmed when used in high concentrations. Therefore, it was considered that the cell wall damage caused by BIPM increased the intracellular internalization of MINO, resulting in a more effective bactericidal effect even at low concentrations of MINO against NDME."

Combination therapy • Preclinical • Infectious Disease • Pneumonia

FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry. (PubMed, Front Pharmacol) - "Pyridoxal 5'-phosphate, Dovitinib, Adefovir dipivoxil, and Biapenem potently inhibit ACE2-dependent viral entry with inhibitory concentration 50% (IC50) values of 57nM, 74 nM, 130 nM, and 183 nM, respectively. We identified four novel FDA-approved candidate drugs for anti-SARS-CoV-2 combination therapy. Our findings contribute to the growing body of evidence supporting drug repurposing as a viable strategy for rapidly developing COVID-19 treatments."

FDA event • Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance. (PubMed, Microbiol Spectr) - "We showed that OprD and OpdP porins contribute both to internalize meropenem and biapenem. In this study, we measure the low permeability coefficient of the P. aeruginosa outer membrane to β-lactams. The methodology we develop to determine the permeability can be applied to other antibiotic families and/or pathogens."

Journal • Infectious Disease

Bloodstream Infection Combined with Thoracic Infection Caused by Mycoplasma hominis: A Case Report and Review of the Literature. (PubMed, Infect Drug Resist) - "Then, replacing the broad-spectrum antimicrobial drugs such as biapenem, imipenem, linezolid still had no obvious curative effect...The results of antibiotic susceptibility testing (AST) showed that M. hominis was susceptible to doxycycline, minocycline, josamycin, sparfloxacin, and spectinomycin but resistant to azithromycin, clarithromycin, norfloxacin, roxithromycin, and ofloxacin. According to the AST results and clinical symptoms, moxifloxacin was selected as targeted therapy for M. hominis infection, and cefoperazone/sulbactam was combined to prevent the infection of other gram-negative bacteria...When routine empirical anti-infection treatment is ineffective, the pathogen should be identified as early as possible. If necessary, gene sequencing technology should be used for diagnosis and sensitive anti-infection drug treatment should be promptly administered to reduce the risk of bloodstream infections."

Journal • CNS Disorders • Immunology • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Rheumatology • Urology

Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature. (PubMed, J Med Case Rep) - "Tropheryma whipplei pneumonia is a rare condition with nonspecific symptoms. The application of metagenomic next-generation sequencing technology in pulmonary infections helps to rapidly identify rare pathogens, providing a solid foundation for precise and effective antibacterial treatment for patients."

Journal • Review • Cough • Fatigue • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Respiratory Diseases

Clostridium difficile Bacteremia in an Elderly Patient with Multiple Comorbidities: A Case Report. (PubMed, Surg Infect (Larchmt)) - "After receiving a combination treatment of vancomycin and biapenem, the patient successfully recovered and was subsequently discharged. This case report elucidates the clinical presentation and treatment strategies for C. difficile ST81 bacteremia, underscoring the critical need for heightened monitoring of extraintestinal infections in high-risk patients."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases

Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital. (PubMed, Acta Med Okayama) - "Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control."

Journal • Infectious Disease • Novel Coronavirus Disease

Current trend of biapenem susceptibility and disc diffusion breakpoints in Enterobacterales and Pseudomonas aeruginosa. (PubMed, Indian J Med Microbiol) - "It is more accurate to test biapenem at a 10μg disc concentration and apply more stringent disc diffusion breakpoints for interpretation."

Journal • Infectious Disease • Nephrology • Pneumonia

Cross-talk of MLST and transcriptome unveiling antibiotic resistance mechanism of carbapenem resistance Acinetobacter baumannii clinical strains isolated in Guiyang, China. (PubMed, Front Microbiol) - "Furthermore, these A. baumannii strains showed high resistance to ertapenem, biapenem, meropenem, and imipenem, among which the resistance to ertapenem was the strongest. All these resistant strains were distributed in various departments, but most of them were distributed in intensive care units (ICU). The bla OXA-23 was the main antibiotic resistance genotype; In summary, the epidemic trend of clinical A. baumannii in Guiyang, China was analyzed from the molecular level, and the resistance mechanism of A. baumannii to carbapenem antibiotics was analyzed with transcriptome, which provided a theoretical basis for better control of A. baumannii."

Journal • Critical care • Infectious Disease

Determination of the minimum inhibitory concentration of biapenem against strains of Pseudomonas aeruginosa isolated from the respiratory tract of patients with cystic fibrosis (ECFS 2024) - "The difference in MIC values for strains isolated from one patient may be due to the heterogeneity of the P. aeruginosa population in the respiratory tract of patients. An increase in the MIC of biapenem may be due to the implementation of genetic determinants of resistance in P. aeruginosa strains, as well as possible microevolutionary changes - mutations and antibiotic resistance gene horizontal transfer."

Clinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Population pharmacokinetics, dosing optimization and clinical outcomes of biapenem in patients with sepsis. (PubMed, Front Pharmacol) - "The current daily dosage regimen of 1.2 g may insufficient to achieve 70% fT >MIC in septic patients. The dosage regimen of 600 mg every 6 h appears to be the optimal choice."

Clinical data • Journal • PK/PD data • Infectious Disease • Septic Shock

In Vitro Activity, Pharmacodynamic Profile and Dose Optimization of Biapenem against NDM and OXA-48-like Carbapenemase Producing Klebsiella pneumoniae: a Multicenter Study in Thailand. (PubMed, J Glob Antimicrob Resist) - "BIPM exhibited a partially susceptible rate among the CRKP isolates in Thailand. The current suggested dose of BIPM with prolonged infusion appears appropriate regimen against CRKP MICs of ≤2 mg/L. However, the empirical use of BIPM for severe CRE infection is not recommended unless the susceptibility has been confirmed."

Clinical • Journal • PK/PD data • Preclinical • Infectious Disease • Pneumonia

Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration. (PubMed, J Pharmacol Toxicol Methods) - "Firstly, in vitro electrophysiological measurement by a multielectrode array system in rat hippocampal brain slices was employed to confirm an increase in electrically evoked population spike (PS) area, the occurrence of multiple population spikes (MPSs), and thereby the seizure liability of five positive control chemicals: picrotoxin, 4-aminopyridine, pentylenetetrazole, penicillin G, and chlorpromazine. Aspirin, a negative control, did not affect PS area or generate MPSs. Furthermore, baclofen, an anticonvulsant drug, decreased PS area and inhibited the increase in PS area or occurrence of MPSs induced by picrotoxin. A comparative study of seizure liability among carbapenem antibiotics revealed that tienam > carbenin > omegacin and finibax. Despite leading to a strong decrease in PS area, physostigmine, cisplatin, and paroxetine still produced MPSs...In contrast, the in vitro electrophysiological measurement could not detect the seizure liability of..."

Journal • Preclinical • CNS Disorders • Epilepsy

Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation. (PubMed, Antimicrob Agents Chemother) - "Supplement dosing algorithms were developed to achieve broth concentrations close to their target over 24 h. During incubation in broth (pH 7.25)/agar, degradation half-lives were 16.9/21.8 h for imipenem, 20.7/31.6 h for biapenem, 29.0 h for clavulanic acid (studied in broth only), 23.1/71.6 h for cefsulodin, 40.6/57.9 h for doripenem, 46.5/64.6 h for meropenem, 50.8/97.7 h for cefepime, 61.5/99.5 h for piperacillin, and >120 h for all other compounds...This study provides comprehensive stability data on β-lactams and BLIs in relevant in vitro media using LC-MS/MS. Future studies are warranted applying these data to antimicrobial susceptibility testing and assessing the impact of β-lactamase-related degradation."

Journal • Preclinical • Infectious Disease

Preferential meropenem absorption activated by 1α,25-dihydroxyvitamin D3 and shared with foscarnet, a phosphate transporter substrate, in the rat ileum. (PubMed, Drug Metab Pharmacokinet) - "The extensive MEPM disappearance in the ileum was significantly reduced in the presence of foscarnet, a Na+-dependent phosphate transporter (NaPi-T) substrate, whereas glycylsarcosine, thiamine, taurocholic acid, and biapenem had no effects. The present results suggest that MEPM is preferentially absorbed in the rat ileum, sharing with foscarnet, and that 1,25(OH)2D3 potentially activates the absorption of MEPM there. A likely candidate for involvement in MEPM absorption was NaPi-T or a related transporter."

Journal • Preclinical • Infectious Disease

Simultaneous determination of five carbapenems, highly polar antibiotics, in milk by LC-MS/MS. (PubMed, Food Addit Contam Part A Chem Anal Control Expo Ri) - "The simultaneous determination of five carbapenems (biapenem, doripenem, ertapenem, imipenem, and meropenem) in raw and pasteurised bovine milk samples using LC-MS/MS was achieved and validated. None of the 60 milk samples commercially available in Tokyo contained any analytes. This novel method exhibited high-quality performance and can easily be implemented for the routine monitoring of carbapenems, which are highly polar antibiotics in milk."

Journal

A network pharmacology and molecular docking approach to reveal the mechanism of Chaihu Anxin Capsule in depression. (PubMed, Front Endocrinol (Lausanne)) - "According to the bioinformatics data, the antidepressant effects of Chaihu Anxin Capsule may be primarily linked to cholesterol and atherosclerosis as well as the AGE-RAGE signaling pathway in diabetic complications. These results emphasize that the expected therapeutic targets may be possible indicators for antidepressant activity."

Journal • Atherosclerosis • Cardiovascular • CNS Disorders • Depression • Diabetes • Dyslipidemia • Mental Retardation • Mood Disorders • Psychiatry • AKT1 • IL6 • STAT3 • TP53

Concordance of bone culture and deep tissue culture during the operation of diabetic foot osteomyelitis and clinical characteristics of patients. (PubMed, Eur J Trauma Emerg Surg) - "The culture results of deep soft tissues near the bone cannot accurately represent the true pathogen of DFO. For DFO patients, bone culture should be taken as much as possible, and appropriate antibiotics should be selected according to the drug susceptibility results."

Discordant • Journal • Infectious Disease • Inflammation

In vitro activity of β-lactamase inhibitors avibanvctam and relebactam in combination with β-lactams against multidrug-resistant Mycobacterium tuberculosis and mutations of resistance genes (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "Drug activity of six β-lactams (biapenem, meropenem, imipenem, doripenem, ertapenem and tebipenem) alone or in combination with β-lactamase inhibitors (clavulanic acid, avibactam and relebactam) was examined by minimum inhibitory concentration method (MICs) against 105 clinical isolates. The combination of tebipenem and relebactam showed the most potent activity against MDR-TB isolates. In addition, the Ser111Arg and Asn213Thr substitution of BlaC may be associated with an increased susceptibility of MDR-TB isolates to meropenem in the presence of clavulanate."

Combination therapy • Journal • Preclinical • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis. (PubMed, Microbiol Spectr) - "The generation of long-lived central memory T lymphocyte subset significantly improved the disease outcome and provided sterilizing immunity in the murine model of TB. The present investigation's encouraging results have helped us depict BPM as a potent adjunct immunomodulator for treating TB."

Journal • Immune Modulation • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CD4 • CD8