RGH-706
/ Gedeon Richter
- LARVOL DELTA
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January 22, 2026
The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger.
(PubMed, J Med Chem)
- "The high MCHR1 potency and excellent receptor occupancy profile of 37 translated into statistically significant body weight loss after 14 days in a DIO mice study, supporting the potential use of this compound as a weight loss agent. Compound 37 (RGH-706) has successfully completed a phase I (SAD & MAD) clinical study in the indication of obesity, followed by an exploratory Phase II study in patients with Prader-Willi Syndrome (PWS)."
Journal • Genetic Disorders • Obesity • Prader–Willi syndrome
June 03, 2024
Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome
(clinicaltrials.gov)
- P2 | N=39 | Completed | Sponsor: Gedeon Richter Plc. | Active, not recruiting ➔ Completed | N=176 ➔ 39
Enrollment change • Trial completion • Prader–Willi syndrome
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