NRG5051
/ NRG Therap
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September 08, 2025
British biotechnology company NRG Therapeutics on Monday said it raised £50 million, or about $67 million, to advance its lead experimental medicine for neurodegenerative disorders into clinical testing.
(BioPharma Dive)
- "Preclinical testing gave the company hope its most advanced drug, a small molecule dubbed NRG-5051, might be able to reduce brain inflammation and treat Parkinson’s and ALS. With the new funding, the company aims to bring that therapy into clinical trials by early 2026."
Financing • New trial • Amyotrophic Lateral Sclerosis • Parkinson's Disease
October 31, 2024
NRG Therapeutics Selects First Development Candidate, NRG5051, and Secures Grant from The Michael J. Fox Foundation for Development of mPTP Inhibitors to Treat Neurodegenerative Diseases
(GlobeNewswire)
- "NRG Therapeutics, Ltd...is pleased to announce that it has achieved a key milestone with the nomination of its first development candidate, NRG5051 and has been awarded a $5M grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to support the development of NRG5051 as a novel disease-modifying treatment for Parkinson’s disease. NRG5051 also has potential in other neurological diseases such as ALS (also known as MND)...In pre-clinical models of Parkinson’s and ALS, NRG5051 is neuroprotective and significantly reduces the neuroinflammation observed in these diseases. NRG’s grant from MJFF’s Therapeutics Pipeline Program will fund the completion of key IND-enabling studies with the aim of advancing NRG5051 into first-in-human clinical studies in 2025."
Financing • New trial • Pipeline update • Amyotrophic Lateral Sclerosis • CNS Disorders • Parkinson's Disease
September 05, 2024
NRG Therapeutics Awarded Grant Funding from Target ALS to Support the Development of mPTP Inhibitors as Novel Treatments for ALS/MND
(GlobeNewswire)
- "NRG Therapeutics, Ltd...is pleased to announce that it has been awarded a non-dilutive grant from Target ALS Foundation...The funding will be used to support its discovery programme for a treatment for Amyotrophic Lateral Sclerosis...It has discovered a new class of small molecule mitochondrial permeability transition pore (mPTP) inhibitors that can block mitochondrial dysfunction...The In Vivo Target Validation Program aims to generate high-quality data on candidate therapeutics in animal models of ALS, provide access to in-kind funding for a resource-intensive step of drug discovery, and accelerate the progress of candidate therapeutics from preclinical testing towards clinical trials."
Financing • Amyotrophic Lateral Sclerosis • CNS Disorders
May 30, 2022
NRG Therapeutics Announces £2.68M Innovate UK Award to Develop New Medicines to Treat Parkinson’s and Motor Neuron Disease
(PRNewswire)
- "NRG Therapeutics Ltd...is pleased to announce that it has received a highly competitive Biomedical Catalyst (BMC) award to fund pre-clinical development of its novel small molecule disease-modifying medicines for the treatment of Parkinson's disease, motor neuron disease (MND) and other debilitating chronic neurodegenerative disorders....The £2.68 million early-stage BMC award part-funded by the government-backed agency Innovate UK will support a 24-month project, commencing this month."
Financing • CNS Disorders • Parkinson's Disease
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