ON104 / OncoOne - LARVOL DELTA

Venetoclax-Based Measurable Residual Disease Directed Therapy in Acute Myeloid Leukemia Is Associated with Emergent TP53 Microclones in Remission (ASH 2024) - "Venetoclax (VEN) combined with low-dose cytarabine (LDAC) is highly effective in acute myeloid leukemia (AML) with either measurable residual disease (MRD) or oligoblastic (5-15% blasts) relapse (VALDAC study) (Tiong et al, JCO 2024)...We next focused on 104 persisting or emerging TP53 variants in 17/22 pts post-VEN...These data give insights into resistance of the hematopoietic compartment to VEN-based therapy. The expansion of specific TP53 and/or BAX-mutated clones at relapse likely involves additional aberrations and requires further study."

Clinical • Residual disease • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • ASXL1 • BAX • DNMT3A • GATA2 • IDH1 • IDH2 • NPM1 • PHF6 • RAD21 • RUNX1 • TET2 • TP53

Intelligent DDoS Attack Detection in Software-Defined Networks Using Explainable Machine Learning. (PubMed, Sensors (Basel)) - "Gradient Boosting, Logistic Regression, AdaBoost, and Gaussian Naive Bayes were evaluated on 104,345 network-flow records using a 70:30 training-testing split...SHAP identified the most influential traffic features, while LIME linked individual predictions to feature-specific contributions. The proposed framework therefore combines reliable DDoS detection with transparent, analyst-oriented decision support for SDN security monitoring."

Journal

Optical coherence tomography angiography (OCTA) assessing microvascular and macrovascular health in healthy octogenarians. (PubMed, Geroscience) - "We conducted a cross-sectional analysis on 104 participants aged over 80 years to investigate the association between peripheral microvascular structures and subclinical cardiovascular changes...As a result, the cluster with denser, smaller, and less tortuous microvascular structure exhibits better cardiovascular conditions regarding resting heartbeats, systolic function, left ventricular sizes, and arterial stiffness. Our study highlights the potential of estimating cardiovascular health in the elderly from nailfold microvascular structure."

Journal • Cardiovascular

MRI-Based Deep Learning Image Classification for Screening Temporomandibular Joint Degenerative Joint Disease. (PubMed, J Clin Med) - " A retrospective analysis was conducted on 104 patients who had undergone both MRI and CBCT examinations of the temporomandibular joint... DenseNet201 showed preliminary potential for MRI-based TMJDJD classification, particularly on sagittal images. Based on image-level classification results, the model may provide preliminary support for identifying MRI findings associated with TMJDJD and assisting decisions regarding further CBCT evaluation."

Journal • Rheumatology

Comparative study of COVID-19 patients admitted during the first and second waves in a tertiary care hospital in Eastern India: a retrospective observational study. (PubMed, Sudan J Paediatr) - "This is a single-center retrospective study conducted in a Medical College's dedicated COVID-19 hospital in India during the first wave (March-November 2020) and second wave (March-May 2021) of the COVID-19 pandemic on 104 children below 18 years of age to compare the clinical characteristics and outcome of COVID-19 patients during the first and second waves...Use of steroids and low-molecular-weight heparin was similar in two waves, but intensive care unit (ICU) admission (p = 0.0031), oxygen via nasal prongs (p = 0.0003), use of CPAP/BIPAP (p = 0.031), blood and blood products (p = 0.044), comorbidity (p = 0.017), and mortality (p = 0.008) were significantly higher during second wave. ICU admission, use of blood and blood products, mechanical ventilation, comorbidity, and mortality were found to be higher during the second wave."

Journal • Observational data • Retrospective data • Cough • Critical care • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases • CRP

Impact of Metformin Use on Clinical and Pathological Outcomes in Breast Cancer Patients With Type 2 Diabetes. (PubMed, Cancer Rep (Hoboken)) - "Metformin use in breast cancer patients with T2DM is associated with lower disease stage, fewer involved lymph nodes, improved treatment response, and better prognosis. These findings suggest that metformin may play a beneficial role in breast cancer progression and treatment outcomes. Further prospective studies are warranted to confirm these results in a clinical setting and to elucidate the underlying mechanisms."

Journal • Retrospective data • Breast Cancer • Diabetes • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Metabolic Disorders • Oncology • Solid Tumor • Type 2 Diabetes Mellitus • ER • HER-2

An upper limit on anthropogenic 81Kr in the atmosphere. (PubMed, J Environ Radioact) - "The cosmogenic radionuclide 81Kr (half-life 229 ka) is widely used to date groundwater and ice on 104-106 year timescales...A pre-nuclear atmospheric krypton sample collected in the 1940s was measured alongside a present-day atmospheric sample, acquiring over one million 81Kr atom counts for each sample. Given the measured difference of δ = (0.09 ± 0.14)% and after correcting for the cross-sample contamination, we obtain an upper limit of 0.43% (90% confidence level) for the anthropogenic contribution, validating the stability of the atmospheric 81Kr baseline for high-precision dating applications."

Journal

The Effect of self-care Education with Smart Phone Applications on the Severity of Mucositis and Infection after Stem Cell Transplantation in Leukemia Patients. (PubMed, Indian J Hematol Blood Transfus) - "This clinical trial study was conducted on 104 SCT patients with leukemia who were assigned to two intervention and control groups with the blocked randomization method...Patients' infection levels in the two groups differed significantly at all three post-transplantation time points (2 weeks, 1 month, and 3 months) (p-value = 0.000). The post-SCT severity of mucositis and infection is influenced by self-care education using smart phone applications."

Journal • Hematological Malignancies • Infectious Disease • Leukemia • Mucositis • Oncology • Transplantation

Single-Cell Analysis Delineates Glutathione Metabolism-Related Gene Signatures in the Glioblastoma Microenvironment and Identifies GSTA4 as a Regulator of Malignant Behaviors. (PubMed, Int J Genomics) - "ScRNA-seq was performed on 104,789 GBM cells to systematically identify cell subpopulations and construct cell interaction networks...Furthermore, functional experiments demonstrate that GSTA4 acts as an oncogenic driver in GBM. Collectively, these findings advance the mechanistic understanding of GBM and identify GSTA4 as a promising therapeutic target for precision intervention."

Gene Signature • Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

Trastuzumab deruxtecan in advanced breast cancer: a real-world study of efficacy and safety in Chinese cohort with HER2-positive and HER2-low expression. (PubMed, Front Oncol) - "A retrospective analysis was conducted on 104 patients diagnosed with advanced breast cancer who received trastuzumab deruxtecan treatment at the Affiliated Hospital of Xuzhou Medical University, with the study period spanning from January 2023 to September 2025. Earlier initiation of trastuzumab deruxtecan may maximize survival benefits. These findings help bridge the gap between clinical trial evidence and routine clinical practice."

Journal • Real-world evidence • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • HER-2

Natural Compounds From Traditional Chinese Medicine Against Doxorubicin-Induced Cardiotoxicity: Biological Mechanisms and Therapeutic Potential. (PubMed, Basic Clin Pharmacol Toxicol) - "A systematic analysis was performed on 104 preclinical studies (encompassing in vivo and in vitro models) retrieved from PubMed, Web of Science and Embase, summarising the cardioprotective effects and mechanisms of 65 TCM-NCs. Target validation further identified Nrf2, Sirt1, mTOR and AMPK as potential central hub nodes underlying their protective actions. These findings offer a theoretical foundation and promising drug candidates for the prevention of chemotherapy-related cardiac injury, with future research directions focusing on clinical translation and druggability optimisation."

Journal • Review • Cardiovascular • Inflammation • AMPK • SIRT1

Treatment of Burkitt lymphoma in real-world setting: findings on 104 consecutive cases diagnosed and treated in Kazakhstan over the last decade. (PubMed, Ann Hematol) - No abstract available

Journal • Real-world evidence • Burkitt Lymphoma • Hematological Malignancies • Lymphoma • Oncology

Randomized controlled clinical trial of the impact of combined application of rhamnosus probiotics and oral nystatin on the colonization of intestinal Candida albicans in low birth weight neonates <2,500 grams. (PubMed, GMS Hyg Infect Control) - "This study was a randomized controlled clinical trial conducted on 104 infants born weighing <2,500 grams at Mohammad Kermanshahi Hospital in Kermanshah in 2021-22. The concurrent use of Rhamnosus probiotics and oral Nystatin can lead to a reduction of positive C. albicans stool culture results, average time for certain variables such as the onset of nutrition, time to reach 100 ml/kg of milk intake per day, NPO days, total NPO time during hospitalization, episodes of intolerance until discharge, and duration of hospitalization in infants weighing <2,500 grams. Hence, their simultaneous administration is recommended for these neonates."

Clinical • Journal

The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation. (PubMed, Am J Transplant) - "NMP was performed on 104 declined kidneys, and 94 (90%) were rescued for transplant...Kidneys undergoing NMP experienced significantly lower rates of DGF compared to non-NMP kidneys. Additional follow up is needed to determine the effects of NMP on long-term graft function."

Journal • Cardiovascular • Transplantation

Enhanced fNIRS-Based MCI Detection via Resting-State and Task-State Integration With Spatial-Temporal Feature Reduction. (PubMed, IEEE J Transl Eng Health Med) - "By resolving the integration gap between resting-state neurovascular patterns with task-evoked hemodynamic dynamics while reducing dimensionality, the framework achieves higher accuracy and interpretability, advancing fNIRS-based MCI detection."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia

Development and a TaqMan probe-based qPCR assay for Vibrio parahaemolyticus causing translucent post-larvae disease (TPD) detection in Litopenaeus vannamei. (PubMed, J Invertebr Pathol) - "It exhibited robust matrix interference resistance at high background DNA concentrations (≤ 2000 ng/μL), and clinical validation on 104 samples (100 infected shrimps and 4 healthy shrimps) demonstrated 100% diagnostic sensitivity and specificity, as reflected by the perfect concordance between test results and actual infection status...These experimental data revealed that the TaqMan probe-based qPCR assay, with its high precision, was ideal for confirmatory laboratory diagnostics, whereas the SYBR Green-based qPCR method offered a cost-effective alternative for large-scale field screening. This dual-method framework provides a comprehensive solution for TPD prevention and detection across diverse aquaculture environments."

Journal • Infectious Disease

Wideband Absorbance Among Aboriginal and/or Torres Strait Islander and Non-Aboriginal Children With Suspected Otitis Media Living in an Australian Urban Area. (PubMed, Ear Hear) - "For this sample of children living in an urban area, WBA is significantly reduced in the ears of children with suspected OM compared with those children with healthy middle ears. Aboriginal and/or Torres Strait Islander children without suspected OM show comparable WBA results to non-Aboriginal children with normal ears. However, Aboriginal and/or Torres Strait Islander children with suspected OM exhibit lower overall WBA than their non-Aboriginal peers with OM, with a significant difference observed at 800 Hz. These findings support previous research that suggests WBA may be a valuable tool in detecting OM, particularly in high-risk populations. Further research is needed to investigate the factors contributing to reduced WBA in Aboriginal and/or Torres Strait Islander children with OM and to validate WBA's potential in addressing the under-detection of OM in this population."

Journal • Otorhinolaryngology

Lateral Atlantoaxial (C1-C2) Joint Steroid Injections: A 22-Year Retrospective Characterization of Technique and Clinical Outcomes. (PubMed, Pain Med) - "This study comprises the largest cohort of patients with image-guided lateral atlantoaxial joint injections and provides descriptive data on technique, clinical outcomes, adverse events, and observed subsequent cervical fusion rates. Short-term reductions in pain were common 1-month from injections with no serious adverse events identified throughout follow-up and only one-quarter of patients undergoing eventual cervical fusion. This study adds valuable data to an uncommonly performed procedure."

Clinical data • Journal • Retrospective data • Pain

An Audit of Eye-Protection Practices in ENT-Related Facial Nerve Palsy: A Retrospective Review of Discharge Summaries. (PubMed, Cureus) - "Materials and methods A retrospective review was conducted on 104 discharge summaries from the Department of ENT - Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad, over a 32-month period (from January 2023 to August 2025)...Conclusion While basic eye-care instructions were frequently documented, critical elements such as corneal assessment and ophthalmology referral were often missing. Several discharge summaries were inadequate, emphasizing the need for standardized, comprehensive documentation to improve patient safety and reduce preventable ocular morbidity in ENT-related FNP."

Journal • Retrospective data • CNS Disorders • Head and Neck Cancer • Oncology • Ophthalmology • Otorhinolaryngology • Solid Tumor

Vitamin B12 and D status in long-term vegetarians: Impact of diet duration and subtypes in Beijing, China. (PubMed, Asia Pac J Clin Nutr) - "This study reveals a dual challenge among Beijing long-term vegetarians: vitamin B12 deficiency was strongly associated with the degree of exclusion of animal products from the diet (veganism), while vitamin D deficiency was highly prevalent and worsened with longer diet duration. The near-universal vitamin D deficiency observed in this study suggests that, in the Beijing context, the risk may extend beyond dietary choice, potentially reflecting regional environmental factors; however, this requires confirmation through comparative studies with omnivores controls."

Journal

Predictive value of CT target scan-based radiomics and clinical features for patients with chronic obstructive pulmonary disease combined with malignant pulmonary nodules. (PubMed, Biomed Eng Online) - "Radiomics features derived from CT target scanning, when combined with clinical features, demonstrate promising potential for differentiating between benign and malignant pulmonary nodules in patients with COPD. This approach may indirectly reflect patients' pulmonary function and serve as a reference for the early diagnosis of COPD combined with lung cancer."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Lung Cancer • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

There is No Difference in Outpatient Costs Within One Year Post-Total Hip Arthroplasty when Comparing Surgical Approach. (PubMed, J Arthroplasty) - "Cost analysis on the effect of surgical approach for THA in outpatient resources and expenses resulted in comparable overall costs between the anterior, posterior, and lateral approaches. Future directions include capturing long-term effectiveness measures to perform a cost-effectiveness analysis from a societal perspective."

Journal • Orthopedics

Multi-step retrieval and reasoning improves radiology question answering with large language models. (PubMed, NPJ Digit Med) - "We evaluated 25 LLMs spanning general-purpose, reasoning-optimized, and clinically fine-tuned models (0.5B → 670B parameters) on 104 expert-curated radiology questions and an independent set of 65 real radiology board-exam questions...These results show that multi-step retrieval enhances diagnostic reliability, especially in deployable mid-sized LLMs. Code, datasets, and RaR are publicly available."

Journal

A Study of the Etiology, Clinical Profile, and Outcome of Nontraumatic Cases of Impaired/Altered Sensorium in Patients Attending the Emergency Department in a South Indian Tertiary Care Hospital. (PubMed, J Assoc Physicians India) - "In this study, the duration of altered mental status, GCS score, level of altered consciousness, and etiology were found to be significant prognostic markers that correlated with outcome in nontraumatic cases with impaired/altered sensorium. Factors that offer early prognostic information can help with resource allocation decisions because the cost of intensive care has increased significantly. The prognosis can be predicted using a simple clinical evaluation of neurological function, paying particular attention to the degree of consciousness, focal neurological signs, and brainstem reflexes."

Journal • Observational data • Addiction (Opioid and Alcohol) • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Coronary Artery Disease • Critical care • Diabetes • Epilepsy • Hypertension • Infectious Disease • Ischemic stroke • Metabolic Disorders • Nephrology • Pain • Renal Disease

Impact of Dosimetric Parameters on Tumor Control in Stereotactic Radiotherapy for Pancreatic Cancer: A Prospective Study on 104 Patients Treated with Simultaneous Integrated Protection (SIP). (PubMed, Cancers (Basel)) - " In this prospective study, SIP planning strategy with six fractions is safe and effective in pancreatic targets with critical contact with critical OARs. Given its potential advantages, SIP planning is a potential innovative strategy that should be compared to standard SRT planning in an ad hoc trial design."

Journal • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor