ON104 / OncoOne - LARVOL DELTA

Impact of Dosimetric Parameters on Tumor Control in Stereotactic Radiotherapy for Pancreatic Cancer: A Prospective Study on 104 Patients Treated with Simultaneous Integrated Protection (SIP). (PubMed, Cancers (Basel)) - " In this prospective study, SIP planning strategy with six fractions is safe and effective in pancreatic targets with critical contact with critical OARs. Given its potential advantages, SIP planning is a potential innovative strategy that should be compared to standard SRT planning in an ad hoc trial design."

Journal • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor

Effectiveness of N-acetylcysteine (NAC) as Adjunct Therapy in Community-acquired Pneumonia Patients Receiving Levofloxacin at National Respiratory Center, Rumah Sakit Persahabatan (APSR 2025) - "Methods : A retrospective cohort study was conducted on 104 hospitalized CAP patients at Persahabatan Hospital National Respiratory Center. Further clinical trials are needed to validate these findings. NAC is cost-effective and has potential as an adjunct therapy for CAP, which may improve clinical outcomes without significant additional burden."

Clinical • Cough • Infectious Disease • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases

Development and validation of a clinical prediction model for coronary microcirculatory impairment post-PCI in STEMI patients based on lactate, creatinine, and hs-CRP. (PubMed, Medicine (Baltimore)) - "A retrospective analysis was conducted on 104 STEMI patients treated with emergency PCI...A multivariable prediction model incorporating biochemical and clinical indicators offers reliable early identification of CMD risk in STEMI patients after PCI. This tool may guide tailored post-revascularization management strategies aimed at improving myocardial perfusion and patient outcomes."

Biomarker • Journal • Observational data • Retrospective data • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Myocardial Infarction • CRP

The Learning Curve of Reverse-Sequence Endoscopic Nipple-Sparing Mastectomy with Immediate Prepectoral Implant Reconstruction: CUSUM Analysis. (PubMed, Breast Cancer (Dove Med Press)) - "Between January 2023 and February 2024, we collected data on 104 consecutive patients who underwent RSEM-IPI at our hospital (53 for group 1 and 51 for group 2)...The estimated learning curve for RSEM-IPI was achieved after 18 cases in the well-trained surgeon group. The endoscopic training and assistance were critical to master the breast endoscopic surgeries for breast surgeons."

Journal • Breast Cancer • Cardiovascular • Infectious Disease • Oncology • Solid Tumor

Venetoclax-Based Measurable Residual Disease Directed Therapy in Acute Myeloid Leukemia Is Associated with Emergent TP53 Microclones in Remission (ASH 2024) - "Venetoclax (VEN) combined with low-dose cytarabine (LDAC) is highly effective in acute myeloid leukemia (AML) with either measurable residual disease (MRD) or oligoblastic (5-15% blasts) relapse (VALDAC study) (Tiong et al, JCO 2024)...We next focused on 104 persisting or emerging TP53 variants in 17/22 pts post-VEN...These data give insights into resistance of the hematopoietic compartment to VEN-based therapy. The expansion of specific TP53 and/or BAX-mutated clones at relapse likely involves additional aberrations and requires further study."

Clinical • Residual disease • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • ASXL1 • BAX • DNMT3A • GATA2 • IDH1 • IDH2 • NPM1 • PHF6 • RAD21 • RUNX1 • TET2 • TP53

Myelodysplasia-Related Gene Mutations for NGS-Based MRD Assessment in Acute Myeloid Leukemia (ASH 2023) - " MRD was assessed on 104 adult newly-diagnosed AML patients (median age 58.6) with a total of 166 MRGM, resulting in a median of one MRGM per patient (range 1-4)... 65.4% of AML-MRGM patients in CR/CRi remained MRD positive when MRGMs were used for MRD assessment by NGS. MRD positivity was associated with age above 60 years and male sex. Using all MRG mutations for MRD assessment at a threshold of 0.01% or by various degrees of log-reduction was not predictive of outcome after intensive induction chemotherapy."

Next-generation sequencing • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • ASXL1 • BCOR • RUNX1 • SF3B1 • SRSF2 • STAG2 • U2AF1 • ZRSR2

Application of Next-Generation Cytogenetics in a Clinical Laboratory for Diagnostic Work-up of Myelodysplastic Syndromes/Neoplasms (MDS) (ASH 2024) - "Based on CBA, 26 (24%), 51 (48%) and 28 (26.7%) patients had normal, non-complex and complex karyotypes respectively.OGM was performed on 104 patients (in one patient, there were not enough cells)...In contrary, even though limit of detection of OGM is similar to CBA (10-20%), OGM missed clonal (seen in at least 2 metaphases) abnormalities in 5 cases due to absence of proliferative bias, underscoring the necessity of performing CBA work-up in parallel.Conclusions. OGM is a powerful tool for identification of genome-wide chromosomal abnormalities and can be used to accurately apply WHO5 and ICC classification criteria."

Clinical • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • KMT2A • MECOM • NPM1 • TP53

Overall Survival and Duration of Treatment in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib Versus Midostaurin or Best Available Therapy in a Real-World Setting (ASH 2024) - P=N/A, P2 | "Mean age at treatment initiation was 66.6 and 65.5 years and mean duration of follow-up was 22.1 and 25.2 months, respectively, in the avapritinib (n=67) and BAT (n=73) cohorts; 73 BAT pts contributed data on 104 lines of therapy (LOTs). Agent-level information was available for 89 LOTs in the BAT cohort, and common 2L+ agents received were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%)...The results from this study also affirm that AdvSM pts with prior treatment experienced significantly improved OS and DOT on avapritinib compared to pts treated with BAT in the real world. These data offer important insights on the superior efficacy of avapritinib as compared to available therapies for pts with AdvSM and may help inform treatment decisions."

Clinical • Metastases • Real-world • Real-world evidence • Hematological Malignancies • Oncology • ASXL1 • RUNX1 • SRSF2

Overall Survival and Duration of Treatment in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib Versus Midostaurin or Best Available Therapy in a Real-World Setting (DGHO 2025) - P=N/A, P2 | "In 1L IPTW-weighted Cox analyses, OS (hazard ratio [HR] [95% CI]: 0.19 [0.06, 0.57]; P=0.003) and DOT (HR [95% CI]: 0.37 [0.19, 0.70]; P=0.002) were significantly longer in avapritinib- vs midostaurin-treated patients.2L+ BAT patients contributed data on 104 lines of therapy. Common 2L+ agents were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%). This study supports the use of avapritinib for AdvSM for patients with prior treatment, demonstrating significant OS and DOT benefits vs 1L midostaurin and 2L+ BAT, respectively."

Clinical • Metastases • Real-world • Real-world evidence • Myeloproliferative Neoplasm

Antimicrobial resistance in bacterial pathogens from postoperative surgical site infections in a tertiary care centre in India. (PubMed, BMC Microbiol) - "Linezolid and ofloxacin emerged as the most effective agents against S. aureus and P. aeruginosa respectively. These findings highlight the importance of continuous antimicrobial resistance surveillance to guide appropriate empirical therapy for SSIs."

Journal • Gastroenterology • Infectious Disease • Oncology

The evolution of the aquaporin gene family and drought tolerance mechanisms in green plants. (PubMed, Hortic Res) - "A comprehensive genome-wide analysis was therefore performed on 104 representative species spanning the green plant lineage, from algae to angiosperms...By systematically analyzing the evolutionary history of the members of PIPs and TIPs subfamilies and subclusters, and combining their gene expression patterns, it was confirmed that PIP2, TIP1, and TIP4 subcluster members exhibit more significant expression response characteristics under drought stress. This study is the first to analyze the evolutionary patterns and drought-tolerance mechanisms of the AQP gene family at a multidimensional scale, providing important molecular targets for crop drought resistance breeding."

Journal

Enhanced Two Dimensional Warping For Fast, Accurate, and Robust Segmentation of Continuous Ambulatory ECG Recordings (AHA 2025) - "The enhanced 2DW framework was evaluated on 104 manually annotated, 15-minute, two-channel ECG recordings... By combining dynamic template adaptation and optimized warping, our enhanced 2DW framework delivers improved accuracy, speed, and resilience to noise and arrhythmias in long-term ECG recordings. These advancements address critical challenges in real-time applications such as ambulatory cardiac monitoring, offering a scalable solution for remote patient care in resource-constrained environments."

Cardiovascular

OVERALL SURVIVAL AND DURATION OF TREATMENT IN PATIENTS WITH ADVANCED SYSTEMIC MASTOCYTOSIS RECEIVING AVAPRITINIB VERSUS MIDOSTAURIN OR BEST AVAILABLE THERAPY IN A REAL-WORLD SETTING (SIE 2025) - P=N/A, P2 | "2L+ BAT patients contributed data on 104 lines of therapy. Common 2L+ agents were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%)...Table 1. Baseline characteristics."

Clinical • Metastases • Real-world • Real-world evidence • Myelodysplastic Syndrome • Myeloproliferative Neoplasm

DIGITAL DROPLET PCR FOR MINIMAL RESIDUAL DISEASE MONITORING IN PHILADELPHIA NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA: A REPORT FROM THE PROSPECTIVE NORTHERN ITALY LEUKEMIA GROUP (NILG) ALL 10/07 STUDY (SIE 2025) - "Forty-three pts were included in the study, and ddPCR was performed on 104 samples: 42 samples from TP2, 31 from TP3, and 31 from TP4...In our study, ddPCR had a higher specificity than RQPCR in MRD monitoring in Ph- B-ALL, identifying a subset of pts with increased relapse rate and reduced survival that may have benefited from early HSCT intensification. In the era of novel immunotherapy, improving MRD monitoring techniques in ALL is crucial to optimize patient management and minimize relapse risk."

Clinical • IO biomarker • Minimal residual disease • Residual disease • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia

ASSOCIATION OF PRE-ECMO ARTERIAL OXYGEN AND CARBON DIOXIDE LEVELS WITH MORTALITY AND NEUROLOGICAL OUTCOMES: A FIVE-YEAR RETROSPECTIVE ANALYSIS (CHEST 2025) - " A retrospective chart review was conducted on 104 ARDS patients managed on VV ECMO from January 2019 to December 2024... Pre-ECMO severe hypoxia (Pao260 mm Hg). Future management should consider not only the P/F ratio but also the degree of hypoxemia based on PaO2 levels to achieve optimal outcomes. CLINICAL IMPLICATIONS: Although ECMO has become a cornerstone treatment for severe ARDS, it remains associated with high mortality and neurological complications."

Retrospective data • Acute Respiratory Distress Syndrome • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Hematological Disorders • Ischemic stroke • Vascular Neurology

The impact of preoperative choroidal detachment on short-term surgical outcomes in highly myopic macular hole retinal detachment. (PubMed, Front Med (Lausanne)) - "A retrospective analysis was carried out on 104 highly myopic MHRD eyes that underwent vitrectomy and intraocular tamponade...Choroidal detachment exerts an adverse impact on postoperative visual acuity and is associated with a significantly higher rate of rescue surgical intervention. Younger age and higher preoperative intraocular pressure (IOP) may impede MH closure."

Journal • Retinal Disorders

Impact of Cage Angle on Spinal Alignment in Posterior Lumbar Interbody Fusion: A Comparison of 12°, 16°, and 22° Cages. (PubMed, Spine Surg Relat Res) - "A retrospective analysis was performed on 104 patients who underwent PLIF at the L4/5 level between January 2021 and August 2023...LL in the lower lumbar spine can be achieved relatively easily using a cage with a larger angle in PLIF. However, although a cage with a larger angle may be advantageous for lordosis formation, postoperative clinical outcomes do not differ; therefore, cage selection should consider the surgeon's skill and patient factors, such as the degree of preoperative lumbar disc degeneration, instability, and alignment."

Journal • Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A bony landmark in craniotomy for hemifacial spasm: The inferior retrosigmoid eminence. (PubMed, Neurosurg Rev) - "Accurate identification of the sigmoid sinus location is crucial for precise craniotomy during microvascular decompression (MVD) for hemifacial spasm (HFS).We investigated individual variations in the bony eminence between the occipitomastoid suture and the digastric groove (the inferior retrosigmoid eminence, IRE) and its relationship to the sigmoid sinus.A retrospective review was conducted on 104 patients who underwent MVD for HFS...Postoperative resolution of HFS was immediately observed in 87 patients (83.7%) and 103 patients (99%) at the one-year follow-up.Recognizing anatomical variations of the IRE is valuable for estimating the location of the inferior sigmoid sinus. The IRE aligns with the medial margin of the lower sigmoid sinus, which could serve as a reliable bony landmark."

Journal • Retrospective data

The capsular vein as a novel surgical landmark for safe access to the temporomandibular joint: a retrospective cohort study. (PubMed, Maxillofac Plast Reconstr Surg) - "The capsular vein serves as a reliable anatomic landmark for TMJ surgery, enabling a safe and efficient approach without the need for facial nerve dissection. Its use minimizes intraoperative bleeding and nerve injury, particularly in patients with ankylosis or severe inflammation, and may improve surgical outcomes across a variety of TMJ procedures."

Journal • Retrospective data • Inflammation • Pain

Dose reduction in 4D CT imaging: Breathing signal-guided deep learning-driven data acquisition. (PubMed, Int J Radiat Oncol Biol Phys) - "The proposed DL-driven data acquisition approach has the ability to reduce radiation exposure during 4D CT imaging while preserving diagnostic quality, offering a clinically viable, ALARA-adhering solution for 4D CT imaging."

Journal • Oncology • Thoracic Cancer

Out-of-the-box bioinformatics capabilities of large language models (LLMs). (PubMed, bioRxiv) - "Utilizing questions from Rosalind, a bioinformatics educational platform, we compare the performance of the LLMs vs. humans on 104 questions undertaken by 110 to 68,760 individuals globally...To the best of our knowledge, this presents the first assessment of general purpose LLMs on basic bioinformatics tasks in distinct areas relative to the performance of hundreds to thousands of humans. LLMs provide correct answers to several questions that require use of biological knowledge, reasoning, statistical analysis and computer code."

Journal

Development and application of a dual RT-qRPA assay for rapid differentiating of goose astrovirus genotypes 1 and 2. (PubMed, Poult Sci) - "The developed dual RT-qRPA assay was further evaluated on 104 liver and cloacal swab samples from goslings, The GAstV-1 and GAstV-2 were detected in 19 (18.27 %, 19/104) and 69 (66.35 %, 69/104) samples, respectively, in which 16 samples (15.38 %, 16/104) carried both GAstV-1 and GAstV-2 nucleic acids...Further analysis indicated a good linear relationship between the TT values from RT-qRPA and the CT values from RT-qPCR, with R2 values of 0.965 and 0.948 for GAstV-1 and GAstV-2, respectively. The developed dual RT-qRPA assay in this study performed well on the clinical samples, thereby providing robust technical support for the rapid field differential detection of GAstV infections in goose flocks."

Journal • Gout • Infectious Disease • Inflammatory Arthritis • Rheumatology

A Novel Method for Analysing the Curvature of the Anterior Lens: Multi-Radial Scheimpflug Imaging and Custom Conic Fitting Algorithm. (PubMed, J Imaging) - "A cross-sectional study was conducted on 104 right eyes from healthy participants aged 21-62 years...By enabling detailed, meridionally stratified in vivo assessment of anterior lens curvature, this novel method provides a valuable non-invasive approach for characterizing age-related biomechanical changes during accommodation. The resulting insights enhance our understanding of presbyopia progression, particularly regarding the spatial remodelling of the anterior lens surface."

Journal • Ophthalmology

Immunological and clinical overlap between autoimmune gastritis and autoimmune liver diseases: a prospective cohort study. (PubMed, Front Immunol) - "We conducted a prospective study on 104 patients with a confirmed diagnosis of AILD...This study found that a significant number of patients with autoimmune liver diseases, especially those with primary biliary cholangitis, also show signs of autoimmune gastritis. These results support the consideration of targeted screening for gastric involvement in selected patients to improve early detection and clinical management of associated complications."

Journal • Autoimmune Hepatitis • Endocrine Disorders • Gastrointestinal Disorder • Hepatology • Immunology • Mucositis • Oncology • Primary Biliary Cholangitis

Associations between serum biomarkers and gut microbial imbalance in predicting chemotherapy response in colorectal cancer: A retrospective analysis. (PubMed, World J Gastrointest Oncol) - "Serum S100A12 and sCD14 levels are closely associated with gut microbiota imbalance and chemotherapy response in CRC patients. These markers may serve as promising predictive indicators for treatment efficacy and offer potential value in individualized treatment strategies."

Biomarker • Journal • Retrospective data • Colorectal Cancer • Oncology • Solid Tumor • CD14 • S100A12