ON104 / OncoOne - LARVOL DELTA

Venetoclax-Based Measurable Residual Disease Directed Therapy in Acute Myeloid Leukemia Is Associated with Emergent TP53 Microclones in Remission (ASH 2024) - "Venetoclax (VEN) combined with low-dose cytarabine (LDAC) is highly effective in acute myeloid leukemia (AML) with either measurable residual disease (MRD) or oligoblastic (5-15% blasts) relapse (VALDAC study) (Tiong et al, JCO 2024)...We next focused on 104 persisting or emerging TP53 variants in 17/22 pts post-VEN...These data give insights into resistance of the hematopoietic compartment to VEN-based therapy. The expansion of specific TP53 and/or BAX-mutated clones at relapse likely involves additional aberrations and requires further study."

Clinical • Residual disease • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • ASXL1 • BAX • DNMT3A • GATA2 • IDH1 • IDH2 • NPM1 • PHF6 • RAD21 • RUNX1 • TET2 • TP53

Wideband Absorbance Among Aboriginal and/or Torres Strait Islander and Non-Aboriginal Children With Suspected Otitis Media Living in an Australian Urban Area. (PubMed, Ear Hear) - "For this sample of children living in an urban area, WBA is significantly reduced in the ears of children with suspected OM compared with those children with healthy middle ears. Aboriginal and/or Torres Strait Islander children without suspected OM show comparable WBA results to non-Aboriginal children with normal ears. However, Aboriginal and/or Torres Strait Islander children with suspected OM exhibit lower overall WBA than their non-Aboriginal peers with OM, with a significant difference observed at 800 Hz. These findings support previous research that suggests WBA may be a valuable tool in detecting OM, particularly in high-risk populations. Further research is needed to investigate the factors contributing to reduced WBA in Aboriginal and/or Torres Strait Islander children with OM and to validate WBA's potential in addressing the under-detection of OM in this population."

Journal • Otorhinolaryngology

Lateral Atlantoaxial (C1-C2) Joint Steroid Injections: A 22-Year Retrospective Characterization of Technique and Clinical Outcomes. (PubMed, Pain Med) - "This study comprises the largest cohort of patients with image-guided lateral atlantoaxial joint injections and provides descriptive data on technique, clinical outcomes, adverse events, and observed subsequent cervical fusion rates. Short-term reductions in pain were common 1-month from injections with no serious adverse events identified throughout follow-up and only one-quarter of patients undergoing eventual cervical fusion. This study adds valuable data to an uncommonly performed procedure."

Clinical data • Journal • Retrospective data • Pain

An Audit of Eye-Protection Practices in ENT-Related Facial Nerve Palsy: A Retrospective Review of Discharge Summaries. (PubMed, Cureus) - "Materials and methods A retrospective review was conducted on 104 discharge summaries from the Department of ENT - Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad, over a 32-month period (from January 2023 to August 2025)...Conclusion While basic eye-care instructions were frequently documented, critical elements such as corneal assessment and ophthalmology referral were often missing. Several discharge summaries were inadequate, emphasizing the need for standardized, comprehensive documentation to improve patient safety and reduce preventable ocular morbidity in ENT-related FNP."

Journal • Retrospective data • CNS Disorders • Head and Neck Cancer • Oncology • Ophthalmology • Otorhinolaryngology • Solid Tumor

Vitamin B12 and D status in long-term vegetarians: Impact of diet duration and subtypes in Beijing, China. (PubMed, Asia Pac J Clin Nutr) - "This study reveals a dual challenge among Beijing long-term vegetarians: vitamin B12 deficiency was strongly associated with the degree of exclusion of animal products from the diet (veganism), while vitamin D deficiency was highly prevalent and worsened with longer diet duration. The near-universal vitamin D deficiency observed in this study suggests that, in the Beijing context, the risk may extend beyond dietary choice, potentially reflecting regional environmental factors; however, this requires confirmation through comparative studies with omnivores controls."

Journal

Predictive value of CT target scan-based radiomics and clinical features for patients with chronic obstructive pulmonary disease combined with malignant pulmonary nodules. (PubMed, Biomed Eng Online) - "Radiomics features derived from CT target scanning, when combined with clinical features, demonstrate promising potential for differentiating between benign and malignant pulmonary nodules in patients with COPD. This approach may indirectly reflect patients' pulmonary function and serve as a reference for the early diagnosis of COPD combined with lung cancer."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Lung Cancer • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

There is No Difference in Outpatient Costs Within One Year Post-Total Hip Arthroplasty when Comparing Surgical Approach. (PubMed, J Arthroplasty) - "Cost analysis on the effect of surgical approach for THA in outpatient resources and expenses resulted in comparable overall costs between the anterior, posterior, and lateral approaches. Future directions include capturing long-term effectiveness measures to perform a cost-effectiveness analysis from a societal perspective."

Journal • Orthopedics

Multi-step retrieval and reasoning improves radiology question answering with large language models. (PubMed, NPJ Digit Med) - "We evaluated 25 LLMs spanning general-purpose, reasoning-optimized, and clinically fine-tuned models (0.5B → 670B parameters) on 104 expert-curated radiology questions and an independent set of 65 real radiology board-exam questions...These results show that multi-step retrieval enhances diagnostic reliability, especially in deployable mid-sized LLMs. Code, datasets, and RaR are publicly available."

Journal

A Study of the Etiology, Clinical Profile, and Outcome of Nontraumatic Cases of Impaired/Altered Sensorium in Patients Attending the Emergency Department in a South Indian Tertiary Care Hospital. (PubMed, J Assoc Physicians India) - "In this study, the duration of altered mental status, GCS score, level of altered consciousness, and etiology were found to be significant prognostic markers that correlated with outcome in nontraumatic cases with impaired/altered sensorium. Factors that offer early prognostic information can help with resource allocation decisions because the cost of intensive care has increased significantly. The prognosis can be predicted using a simple clinical evaluation of neurological function, paying particular attention to the degree of consciousness, focal neurological signs, and brainstem reflexes."

Journal • Observational data • Addiction (Opioid and Alcohol) • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Coronary Artery Disease • Critical care • Diabetes • Epilepsy • Hypertension • Infectious Disease • Ischemic stroke • Metabolic Disorders • Nephrology • Pain • Renal Disease

Impact of Dosimetric Parameters on Tumor Control in Stereotactic Radiotherapy for Pancreatic Cancer: A Prospective Study on 104 Patients Treated with Simultaneous Integrated Protection (SIP). (PubMed, Cancers (Basel)) - " In this prospective study, SIP planning strategy with six fractions is safe and effective in pancreatic targets with critical contact with critical OARs. Given its potential advantages, SIP planning is a potential innovative strategy that should be compared to standard SRT planning in an ad hoc trial design."

Journal • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor

Effectiveness of N-acetylcysteine (NAC) as Adjunct Therapy in Community-acquired Pneumonia Patients Receiving Levofloxacin at National Respiratory Center, Rumah Sakit Persahabatan (APSR 2025) - "Methods : A retrospective cohort study was conducted on 104 hospitalized CAP patients at Persahabatan Hospital National Respiratory Center. Further clinical trials are needed to validate these findings. NAC is cost-effective and has potential as an adjunct therapy for CAP, which may improve clinical outcomes without significant additional burden."

Clinical • Cough • Infectious Disease • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases

Development and validation of a clinical prediction model for coronary microcirculatory impairment post-PCI in STEMI patients based on lactate, creatinine, and hs-CRP. (PubMed, Medicine (Baltimore)) - "A retrospective analysis was conducted on 104 STEMI patients treated with emergency PCI...A multivariable prediction model incorporating biochemical and clinical indicators offers reliable early identification of CMD risk in STEMI patients after PCI. This tool may guide tailored post-revascularization management strategies aimed at improving myocardial perfusion and patient outcomes."

Biomarker • Journal • Observational data • Retrospective data • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Myocardial Infarction • CRP

The Learning Curve of Reverse-Sequence Endoscopic Nipple-Sparing Mastectomy with Immediate Prepectoral Implant Reconstruction: CUSUM Analysis. (PubMed, Breast Cancer (Dove Med Press)) - "Between January 2023 and February 2024, we collected data on 104 consecutive patients who underwent RSEM-IPI at our hospital (53 for group 1 and 51 for group 2)...The estimated learning curve for RSEM-IPI was achieved after 18 cases in the well-trained surgeon group. The endoscopic training and assistance were critical to master the breast endoscopic surgeries for breast surgeons."

Journal • Breast Cancer • Cardiovascular • Infectious Disease • Oncology • Solid Tumor

Myelodysplasia-Related Gene Mutations for NGS-Based MRD Assessment in Acute Myeloid Leukemia (ASH 2023) - " MRD was assessed on 104 adult newly-diagnosed AML patients (median age 58.6) with a total of 166 MRGM, resulting in a median of one MRGM per patient (range 1-4)... 65.4% of AML-MRGM patients in CR/CRi remained MRD positive when MRGMs were used for MRD assessment by NGS. MRD positivity was associated with age above 60 years and male sex. Using all MRG mutations for MRD assessment at a threshold of 0.01% or by various degrees of log-reduction was not predictive of outcome after intensive induction chemotherapy."

Next-generation sequencing • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • ASXL1 • BCOR • RUNX1 • SF3B1 • SRSF2 • STAG2 • U2AF1 • ZRSR2

Application of Next-Generation Cytogenetics in a Clinical Laboratory for Diagnostic Work-up of Myelodysplastic Syndromes/Neoplasms (MDS) (ASH 2024) - "Based on CBA, 26 (24%), 51 (48%) and 28 (26.7%) patients had normal, non-complex and complex karyotypes respectively.OGM was performed on 104 patients (in one patient, there were not enough cells)...In contrary, even though limit of detection of OGM is similar to CBA (10-20%), OGM missed clonal (seen in at least 2 metaphases) abnormalities in 5 cases due to absence of proliferative bias, underscoring the necessity of performing CBA work-up in parallel.Conclusions. OGM is a powerful tool for identification of genome-wide chromosomal abnormalities and can be used to accurately apply WHO5 and ICC classification criteria."

Clinical • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • KMT2A • MECOM • NPM1 • TP53

Overall Survival and Duration of Treatment in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib Versus Midostaurin or Best Available Therapy in a Real-World Setting (ASH 2024) - P=N/A, P2 | "Mean age at treatment initiation was 66.6 and 65.5 years and mean duration of follow-up was 22.1 and 25.2 months, respectively, in the avapritinib (n=67) and BAT (n=73) cohorts; 73 BAT pts contributed data on 104 lines of therapy (LOTs). Agent-level information was available for 89 LOTs in the BAT cohort, and common 2L+ agents received were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%)...The results from this study also affirm that AdvSM pts with prior treatment experienced significantly improved OS and DOT on avapritinib compared to pts treated with BAT in the real world. These data offer important insights on the superior efficacy of avapritinib as compared to available therapies for pts with AdvSM and may help inform treatment decisions."

Clinical • Metastases • Real-world • Real-world evidence • Hematological Malignancies • Oncology • ASXL1 • RUNX1 • SRSF2

Overall Survival and Duration of Treatment in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib Versus Midostaurin or Best Available Therapy in a Real-World Setting (DGHO 2025) - P=N/A, P2 | "In 1L IPTW-weighted Cox analyses, OS (hazard ratio [HR] [95% CI]: 0.19 [0.06, 0.57]; P=0.003) and DOT (HR [95% CI]: 0.37 [0.19, 0.70]; P=0.002) were significantly longer in avapritinib- vs midostaurin-treated patients.2L+ BAT patients contributed data on 104 lines of therapy. Common 2L+ agents were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%). This study supports the use of avapritinib for AdvSM for patients with prior treatment, demonstrating significant OS and DOT benefits vs 1L midostaurin and 2L+ BAT, respectively."

Clinical • Metastases • Real-world • Real-world evidence • Myeloproliferative Neoplasm

Antimicrobial resistance in bacterial pathogens from postoperative surgical site infections in a tertiary care centre in India. (PubMed, BMC Microbiol) - "Linezolid and ofloxacin emerged as the most effective agents against S. aureus and P. aeruginosa respectively. These findings highlight the importance of continuous antimicrobial resistance surveillance to guide appropriate empirical therapy for SSIs."

Journal • Gastroenterology • Infectious Disease • Oncology

The evolution of the aquaporin gene family and drought tolerance mechanisms in green plants. (PubMed, Hortic Res) - "A comprehensive genome-wide analysis was therefore performed on 104 representative species spanning the green plant lineage, from algae to angiosperms...By systematically analyzing the evolutionary history of the members of PIPs and TIPs subfamilies and subclusters, and combining their gene expression patterns, it was confirmed that PIP2, TIP1, and TIP4 subcluster members exhibit more significant expression response characteristics under drought stress. This study is the first to analyze the evolutionary patterns and drought-tolerance mechanisms of the AQP gene family at a multidimensional scale, providing important molecular targets for crop drought resistance breeding."

Journal

Enhanced Two Dimensional Warping For Fast, Accurate, and Robust Segmentation of Continuous Ambulatory ECG Recordings (AHA 2025) - "The enhanced 2DW framework was evaluated on 104 manually annotated, 15-minute, two-channel ECG recordings... By combining dynamic template adaptation and optimized warping, our enhanced 2DW framework delivers improved accuracy, speed, and resilience to noise and arrhythmias in long-term ECG recordings. These advancements address critical challenges in real-time applications such as ambulatory cardiac monitoring, offering a scalable solution for remote patient care in resource-constrained environments."

Cardiovascular

OVERALL SURVIVAL AND DURATION OF TREATMENT IN PATIENTS WITH ADVANCED SYSTEMIC MASTOCYTOSIS RECEIVING AVAPRITINIB VERSUS MIDOSTAURIN OR BEST AVAILABLE THERAPY IN A REAL-WORLD SETTING (SIE 2025) - P=N/A, P2 | "2L+ BAT patients contributed data on 104 lines of therapy. Common 2L+ agents were midostaurin (46.1%), cladribine (32.6%), and hydroxyurea (7.9%)...Table 1. Baseline characteristics."

Clinical • Metastases • Real-world • Real-world evidence • Myelodysplastic Syndrome • Myeloproliferative Neoplasm

DIGITAL DROPLET PCR FOR MINIMAL RESIDUAL DISEASE MONITORING IN PHILADELPHIA NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA: A REPORT FROM THE PROSPECTIVE NORTHERN ITALY LEUKEMIA GROUP (NILG) ALL 10/07 STUDY (SIE 2025) - "Forty-three pts were included in the study, and ddPCR was performed on 104 samples: 42 samples from TP2, 31 from TP3, and 31 from TP4...In our study, ddPCR had a higher specificity than RQPCR in MRD monitoring in Ph- B-ALL, identifying a subset of pts with increased relapse rate and reduced survival that may have benefited from early HSCT intensification. In the era of novel immunotherapy, improving MRD monitoring techniques in ALL is crucial to optimize patient management and minimize relapse risk."

Clinical • IO biomarker • Minimal residual disease • Residual disease • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia

ASSOCIATION OF PRE-ECMO ARTERIAL OXYGEN AND CARBON DIOXIDE LEVELS WITH MORTALITY AND NEUROLOGICAL OUTCOMES: A FIVE-YEAR RETROSPECTIVE ANALYSIS (CHEST 2025) - " A retrospective chart review was conducted on 104 ARDS patients managed on VV ECMO from January 2019 to December 2024... Pre-ECMO severe hypoxia (Pao260 mm Hg). Future management should consider not only the P/F ratio but also the degree of hypoxemia based on PaO2 levels to achieve optimal outcomes. CLINICAL IMPLICATIONS: Although ECMO has become a cornerstone treatment for severe ARDS, it remains associated with high mortality and neurological complications."

Retrospective data • Acute Respiratory Distress Syndrome • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Hematological Disorders • Ischemic stroke • Vascular Neurology

The impact of preoperative choroidal detachment on short-term surgical outcomes in highly myopic macular hole retinal detachment. (PubMed, Front Med (Lausanne)) - "A retrospective analysis was carried out on 104 highly myopic MHRD eyes that underwent vitrectomy and intraocular tamponade...Choroidal detachment exerts an adverse impact on postoperative visual acuity and is associated with a significantly higher rate of rescue surgical intervention. Younger age and higher preoperative intraocular pressure (IOP) may impede MH closure."

Journal • Retinal Disorders

Impact of Cage Angle on Spinal Alignment in Posterior Lumbar Interbody Fusion: A Comparison of 12°, 16°, and 22° Cages. (PubMed, Spine Surg Relat Res) - "A retrospective analysis was performed on 104 patients who underwent PLIF at the L4/5 level between January 2021 and August 2023...LL in the lower lumbar spine can be achieved relatively easily using a cage with a larger angle in PLIF. However, although a cage with a larger angle may be advantageous for lordosis formation, postoperative clinical outcomes do not differ; therefore, cage selection should consider the surgeon's skill and patient factors, such as the degree of preoperative lumbar disc degeneration, instability, and alignment."

Journal • Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain