nitroglycerin / Generic mfg. - LARVOL DELTA

Photobiomodulation and Migraine: Mechanisms and Therapeutic Potential. (PubMed, Photobiomodul Photomed Laser Surg) - "Preclinical models relevant to migraine, including trigeminovascular activation, nitroglycerin-induced hypersensitivity, and cortical spreading depression, support its translational plausibility by demonstrating reductions in hyperalgesia, oxidative stress, and neural inflammation. Although migraine-specific evidence remains limited, photobiomodulation represents a safe and potentially disease-modifying therapeutic approach. Future controlled clinical trials are needed to determine optimal stimulation parameters and clinical efficacy in migraine management."

Clinical • Journal • Review • CNS Disorders • Depression • Immunology • Inflammation • Metabolic Disorders • Migraine • Pain • Psychiatry

Effect of Intravenous Nimodipine-Induced Controlled Hypotension on Postoperative Delirium in Patients Undergoing Rotator Cuff Surgery: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University

New trial • CNS Disorders • Hypotension

Exploration of the Synergistic Effect and Mechanism of Kuanxiong Aerosol Combined with Moxibustion Therapy on Cardiac Function in Patients with Coronary Heart Disease Complicated with Chronic Heart Failure Based on the Theory of "Qi-Blood Correlation" (ChiCTR) - P=N/A | N=126 | Not yet recruiting | Sponsor: The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine; The Third Affiliated People's Hospital of Fujian Universi

New trial • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure

INTRAVENOUS LABETALOL VS GLYCERYL TRINITRATE IN HYPERTENSIVE CRISIS: A RANDOMISED CONTROLLED TRIAL (CHEST 2026) - No abstract available

Clinical • Critical care

Nitroglycerin and Chest Pain for the Anesthesia Team: Optimizing Pulse Field Ablations. (PubMed, J Cardiothorac Vasc Anesth) - No abstract available

Journal • Anesthesia • Pain

Peculiar stimulatory action of high-energy chemicals: Fifty years of explosive-induced hormesis evidence. (PubMed, Environ Pollut) - "Key explosive classes inducing hormesis include nitroaromatics (TNT, 1,3,5-trinitrobenzene, TNB, picric acid), nitramines (RDX, HMX), and nitrate esters (nitroglycerin). These findings challenge traditional linear or threshold dose-response models used in ecological risk assessment, and highlight the need to revise standard testing protocols to include low-concentration treatments and hormetic modeling."

Journal • Review

Profile and Outcomes of Patients Presenting With Sympathetic Crashing Acute Pulmonary Edema (SCAPE) to a Tertiary Care Emergency Department in North India: A Prospective Observational Study. (PubMed, J Acute Med) - "This prospective observational study described the clinical profile of patients with SCAPE who were managed with high-dose nitroglycerin (NTG)...Male sex, chronic kidney disease, longer symptom duration, plethoric inferior vena cava on POCUS, higher initial lactate, and the need for hemodialysis were identified as predictors of poor outcomes in the univariate analysis. This study highlights that a protocol-based approach using high-dose NTG and NIV in managing SCAPE patients shows a favorable outcome, resulting in low rates of mechanical ventilation and mortality despite high comorbidity burden and ICU admission rates."

Journal • Observational data • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease • Respiratory Diseases

Structure-Function Analysis of the Benzyloxy Moiety of the Delta-Opioid Receptor Positive Modulator BMS-986187: Identification of a Derivative with High Selectivity for the Delta-Opioid Receptor over the Mu-Opioid Receptor In Vitro and In Vivo. (PubMed, J Med Chem) - "One pyridyl derivative (compound 35) retained high DOR-PAM potency and efficacy (EC50 = 0.1 μM, Emax = 91%) with no detectable MOR activity. In mice, compound 35 enhanced DOR-mediated reversal of nitroglycerin-induced hyperalgesia, an effect absent in DOR-knockout mice, without enhancing MOR-mediated antinociception, demonstrating in vivo selectivity."

Journal • Preclinical • CNS Disorders • Depression • Psychiatry • ARRB1

Acute Inferior Myocardial Infarction with Anomalous Origin of the Right Coronary Artery, Myocardial Bridging and Fibro-Lipid Plaque. (PubMed, Catheter Cardiovasc Interv) - "An abnormal origin of the right coronary artery (RCA) from the left coronary sinus was discovered by emergency coronary angiography, along with mild stenosis in the mid-RCA segment that persisted even after intracoronary nitroglycerin was administered...The patient experienced total symptom alleviation and an uneventful recovery after receiving dual antiplatelet therapy, intense lipid-lowering treatment, diltiazem for myocardial bridging, and stringent risk factor control. For long-term risk reduction, a multidisciplinary evaluation is planned for surgical of the coronary abnormality. In addition to highlighting the significance of tailored management approaches for congenital coronary anomalies combined with acquired vulnerable plaques, this case underscores the crucial role of multimodality imaging, particularly IVUS, in accurate etiological diagnosis and treatment decision-making for young patients with acute myocardial infarction (AMI) caused by complex coronary..."

Journal • Cardiovascular • Myocardial Infarction • Pain

Repurposing a Dual-Head Programmable Power Injector for Controlled Intra-Arterial Vasodilator Delivery During Cerebral Vasospasm Treatment. (PubMed, World Neurosurg) - "One chamber delivers contrast for angiographic runs, while the other contains a triple vasodilator cocktail of verapamil, nicardipine, and nitroglycerin, delivered via the injector's programmable Infusion Mode at operator-defined flow rates and volumes. No procedural complications related to the delivery method occurred. These preliminary findings suggest the dual-head programmable injector provides a feasible, ergonomic, and reproducible closed-system workflow for intra-arterial vasodilator delivery during cerebral vasospasm treatment, with broader applicability to other intra-arterial drug delivery settings."

Journal • Cardiovascular • Hematological Disorders • Subarachnoid Hemorrhage

A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease (clinicaltrials.gov) - P1 | N=36 | Not yet recruiting | Sponsor: Bayer | Initiation date: Oct 2026 ➔ Jan 2027

Trial initiation date • Cardiovascular • Coronary Artery Disease

Tear Fluid Calcitonin Gene-Related Peptide Levels Are Elevated in Glycerol Trinitrate-Induced Cluster Headache Attacks: Results From an Exploratory Study. (PubMed, Eur J Neurol) - "Our study results support the role of CGRP in the pathophysiology of CH. Further studies with a larger study sample and investigation of other neuropeptides are needed to better understand the underlying mechanisms."

Journal • Chronic Cluster Headache • CNS Disorders • Migraine • Pain

Adrenalectomy versus esaxerenone: comparison of vascular benefits in patients with aldosterone-producing adenoma. (PubMed, J Hypertens) - "Compared with esaxerenone treatment, adrenalectomy provided more favorable improvements in vascular function and arterial stiffness in patients with APA. Nevertheless, esaxerenone also improved blood pressure, serum potassium levels, vascular function, and arterial stiffness, suggesting that it may be a beneficial treatment option for patients with APA who are inoperable or refuse surgery."

Journal • Cardiovascular • Endocrine Disorders

Nitroglycerin plus whole intracranial radiotherapy for brain metastases in non-small cell lung cancer patients: A randomized, open-label, phase II clinical trial. (PubMed, Int J Radiat Oncol Biol Phys) - "The concurrent administration of NTG and radiotherapy improves iORR and ICPFS among NSCLC patients with BM. The benefit is particularly significant in the EGFRm patient subgroup."

Journal • P2 data • Immunology • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR • HIF1A

Impact of spasmolytic cocktail and Glidesheath Slender on radial artery spasm in transradial cerebral angiography: A randomized factorial trial. (PubMed, J Vasc Interv Radiol) - "In this exploratory randomized trial, prophylactic intra-arterial NV did not significantly reduce clinical RAS during diagnostic TRCA. GSS use was associated with higher rates of clinical RAS and RAO under the evaluated procedural conditions. These findings should be interpreted cautiously and require validation in future studies."

Journal

Total intravenous anesthesia for open fetal myelomeningocele repair: a case series from a single-center in Peru (2017-2025). (PubMed, Int J Obstet Anesth) - "Total intravenous anesthesia combined with intravenous uterine relaxants was feasible for open fetal myelomeningocele repair in this case series."

Journal • Anesthesia • Cardiovascular • Respiratory Diseases

Visual, vestibular, and ocular motor changes during nitroglycerin-triggered vestibular migraine. (PubMed, Headache) - "Quantitative slow phase velocity measures of nystagmus did not show a uniform group-level change during NTG provocation in VM, despite frequent subjective vestibular symptoms. VM episodes may reflect altered central sensory processing and vestibular hypersensitivity rather than changes in vestibulo-oculomotor output."

Journal • CNS Disorders • Immunology • Migraine • Ophthalmology • Pain • Retinal Disorders

A Retrospective Analysis of the Novel Use of Sublingual Nitroglycerin for Vasodilator Challenge During Right Heart Catheterization (AHA 2026) - "Abstract is embargoed at this time."

Retrospective data • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study. (PubMed, Hypertens Res) - "The most used drugs were intravenous furosemide, nitroglycerin, clonidine and labetalol for HE. Finally, regarding the exploratory analysis, BP at ED admission and its management didn't present significant association with in-hospital mortality. In conclusions, our study demonstrated that adherence to guidelines in the management of HE/UH could be further improved."

Journal • Retrospective data • Acute Coronary Syndrome • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Mechanism of Tianshu Capsules in treating migraine rats based on gut microbiota (PubMed, Zhongguo Zhong Yao Za Zhi) - "A migraine rat model was established via subcutaneous injection of nitroglycerin. The Sprague-Dawley rats were randomly divided into a control group, a model group, a low-dose TS group, a medium-dose TS group, a high-dose TS group, and an ibuprofen group...Spearman correlation analysis reveals that partial gut microbiota are significantly associated with migraine-related behavioral and biochemical indices(c-fos, ET-1, CGRP, and 5-HT). In conclusion, TS can regulate the disrupted gut microbiota structure and microbial functions related to neurotransmitter metabolism, intestinal barrier function, and inflammatory regulation in migraine model rats, which may be one of the potential key ways through which TS exert its anti-migraine effect."

Journal • Preclinical • CNS Disorders • Infectious Disease • Migraine • Pain • EDN1 • FOS

A case report of acute heart failure, pulmonary edema, and pleural effusion in an elderly patient with organic mental disorder: An integrative holistic nursing approach. (PubMed, Medicine (Baltimore)) - "Holistic nursing effectively manages cardiopulmonary-psychiatric comorbidities through multidimensional assessment and multidisciplinary collaboration. Strengthening discharge planning and hospital-community continuity is essential."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Congestive Heart Failure • Heart Failure • Hepatology • Hypertension • Infectious Disease • Insomnia • Mental Retardation • Psychiatry • Pulmonary Disease • Respiratory Diseases • Sleep Disorder

The impact of soluble guanylate cyclase stimulator on cardiac and venous return characteristics: a framework analysis using generalized circulatory equilibrium (ESC 2026) - "The same protocol was performed using nitroglycerin (NTG, 5 µg/kg/min) in baroreflex-intact condition. Baroreflex impairment amplified vericiguat-induced reductions in SVR and AP. These findings suggest an increased risk of hypotension and underscore the importance of individualized therapy in heart failure patients with impaired baroreflex function."

Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension

Age related differences in clinical phenotype, care and outcomes in ambulance attended acute heart failure: a population-based cohort study (ESC 2026) - "EMS were more likely to accurately recognise HF in older age groups, who presented more often with respiratory distress and tachypnoea, and were more frequently treated with supplemental oxygen and glyceryl trinitrate (all p<0.002). Younger patients more commonly had chest pain, hypotension and tachycardia, prompting more non-HF directed therapy such as aspirin, fluids and adrenaline (all p<0.001)... Patients with acute decompensated HF are a heterogenous group with distinct age-related phenotypes that influence diagnosis, treatment and outcomes. Recognising these patterns may enable more precise pre-hospital risk stratification and management."

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Hypertension • Hypotension

A dense fibrin network favours layered plaque formation in the infarct-related artery in patients with ST-segment elevation myocardial infarction (ESC 2026) - "Endothelial and vascular function were assessed within 3 days using brachial artery flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD), respectively. The layered plaques in IRA were identified in 67 (71.3%) patients... The layered plaques in IRA, identified in two-thirds of STEMI patients, were more common in women and were present irrespective of endothelial and vascular function. Layered culprit plaques in IRA were independently associated with a more compact fibrin network."

Clinical • Cardiovascular • Myocardial Infarction

A faster, optimized pulsed field timing sequence demonstrates safety under aggressive lesion stacking without evidence of electrode heating (ESC 2026) - "All coronary spasms resolved following administration of a nitroglycerin dose and no hemodynamic compromise was observed...PFA applications near coronary arteries, under these excessive use conditions, resulted in self-limiting spasm. These findings suggest that the accelerated pulse protocol preserves PFA’s non-thermal safety characteristics and remains well-tolerated even during excessive use conditions."

Clinical • Atrial Fibrillation • Cardiovascular