nitroglycerin / Generic mfg. - LARVOL DELTA

Vasospastic Angina Following Capecitabine Initiation: A Rare But Serious Cardiotoxic Effect. (PubMed, J Emerg Med) - "The cardiotoxic effect most commonly associated with 5-fluorouracil (5-FU) is coronary vasospasm, which typically occurs within the first hours or days following administration and can present with a spectrum of manifestations ranging from stable angina to acute coronary syndrome with hemodynamic instability...Nitroglycerin relieved symptoms and normalized ECG changes...WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Emergency physicians should suspect fluoropyrimidine-induced cardiotoxicity in patients with chest pain after starting capecitabine, even without cardiac risk factors. Early recognition, drug discontinuation, and vasodilator therapy are critical to prevent serious complications and ensure timely cardiology-oncology coordination."

Journal • Acute Coronary Syndrome • Cardiovascular • Cognitive Disorders • Colorectal Adenocarcinoma • Colorectal Cancer • Oncology • Pain • Rectal Adenocarcinoma • Solid Tumor

Pulsed-Field vs Thermal Ablation of Atrial Fibrillation in Patients From the Marshall Islands: A Study of Generalized Coronary Spasm. (PubMed, JACC Clin Electrophysiol) - "In this Marshallese cohort, Gen-CS occurred universally after PFA but not after thermal ablation and was frequently clinically severe. These findings suggest population-specific susceptibility and raise the hypothesis that PFA may confer higher Gen-CS risk than thermal energies."

Journal • Atrial Fibrillation • Cardiovascular

TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice. (PubMed, Br J Pharmacol) - "These data show that TREM2 plays a protective role in CM by modulating microglial activation and autophagy in the TNC via the mTOR/p70s6k pathway."

Journal • Preclinical • CNS Disorders • Immunology • Inflammation • Migraine • Pain • FOS • TREM2

Acute Myocardial Infarction Caused by Oral-Contraceptive - Related Spontaneous Coronary Artery Dissection: a Case Report. (PubMed, Kardiologiia) - "Coronary angiography revealed diffuse LAD narrowing that improved after intracoronary nitroglycerin...At one-year follow-up, the patient had recovered with normalized left ventricular function.Conclusion    Clinicians should be highly suspicious of SCAD in young women with ACS or AMI, particularly those using oral contraceptives. Early identification with appropriate imaging can lead to favorable outcomes."

Journal • Cardiovascular • Coronary Artery Disease • Myocardial Infarction • Pain

Unanticipated intraoperative haemodynamic challenges during adrenalectomy for a phaeochromocytoma misdiagnosed as an adrenocortical tumour. (PubMed, BMJ Case Rep) - "Intraoperatively, tumour manipulation precipitated abrupt hypertensive surges with bradycardia, necessitating nitroglycerine and sodium nitroprusside infusion. Intraoperative haemodynamic instability during adrenal manipulation should raise suspicion of catecholamine secretion, even in the absence of classical symptoms. The report emphasises the importance of invasive monitoring and anaesthetic preparedness to manage unexpected catecholamine release."

Journal • Adrenal Cortex Carcinoma • Anesthesia • Cardiovascular • Endocrine Disorders • Genito-urinary Cancer • Hypertension • Hypotension • Nephrology • Oncology • Pain • Solid Tumor • SYP

Transradial Access Without Radial Cocktail for Mechanical Thrombectomy is Safe and Feasible (ISC 2026) - "Three groups are divided: full dose cocktail (Heparin 2000 units, Verapamil 2.5mg, and Nitroglycerin 200mg), half dose cocktail (Heparin 1000 units or none, Verapamil 2.5mg, and Nitroglycerin 200mg) and none cocktail. In the modern era of mechanical thrombectomy the fast procedural time may make the need of intra-arterial radial cocktail unnecessary during transradial access. These findings should be corroborated with a larger prospective multicenter data."

Hematological Disorders

Rapid Assessment of Stroke Severity: Development of a Visual Infarct and Comprehensive Scoring System in Ischemic Rats with MCAO (ISC 2026) - "Treatments, including therapeutic hypothermia, nitroglycerin, remote ischemic conditioning followed by exercise, significantly reduced infarct volume, Infarct Score_48h and neurological deficits, at 24- and 48-hours post-stroke while attenuating weight loss...The Infarct Score provides a simple, rapid, and cost-effective method for infarct and brain damage assessment. The Comprehensive Score further enhances predictive precision, supporting its use as a multidimensional tool for assessing stroke severity and treatment efficacy in preclinical studies."

Preclinical • Cardiovascular • CNS Disorders • Ischemic stroke • Vascular Neurology

Nitroglycerin (GTN) Alleviates Ischemic Stroke Injury via GPR35-Dependent Regulation of Mitochondrial Dysfunction and Neuronal PANoptosis (ISC 2026) - "GTN confers neuroprotection in AIS with reperfusion by preserving mitochondrial dynamics, improving bioenergetics, and inhibiting PANoptosis through the NO-GPR35 axis. Pharmacological blockade experiments confirm GPR35 as an essential target in mediating these effects, highlighting GTN as a potential therapeutic adjunct in stroke."

Cardiovascular • Gastrointestinal Disorder • Inflammation • Ischemic stroke • Metabolic Disorders • Reperfusion Injury • BAX • CASP3 • NLRP3 • RIPK1

Pulsed Field Ablation vs Standard Radiofrequency Ablation for Typical Atrial Flutter: ADVANTAGE AF Trial Substudy. (PubMed, J Am Coll Cardiol) - P=N/A | "This subanalysis of ADVANTAGE AF extends the primary results by allowing comparison of bipolar linear PFA and RF ablation for CTI, integrating preclinical lesion modeling with clinical dosing, and establishing a standardized reliable coronary safety protocol. Although not randomized comparisons, these findings suggest that CTI ablation with a linear PFA catheter is associated with safety and efficacy similar to RF ablation and greater efficiency. (A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation [ADVANTAGE AF; NCT05443594])."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders

A Descriptive Analysis of Coronary Computed Tomography Angiography Results among Patients Presenting with Chest Pain in a Deployed Combat Environment. (PubMed, Mil Med) - "The initial data of this study is proof of concept that CCTA is feasible for assessing intermediate risk patients presenting with acute chest pain in the deployed setting, to rule our coronary pathology. The researchers' initial evaluation shows promise and suggests that this is a useful modality to continue to utilize and study in this environment."

Journal • Acute Coronary Syndrome • Cardiovascular • Pain

Effects of aerobic exercise on integrated cardiovascular health and energy metabolism in patients with type 2 diabetes mellitus: study protocol for a randomized controlled trial. (PubMed, Front Endocrinol (Lausanne)) - "Therefore, we designed a randomized controlled trial to investigate its impact on integrated cardiovascular health - specifically assessed by nitroglycerin-mediated dilation (NMD) and myocardial global work efficiency (GWE) - and systemic energy metabolism in patients with T2DM...This study provides an integrated physiological perspective on how 12-week moderate-intensity aerobic exercise influences cardiovascular function and systemic metabolism in patients with T2DM. We hypothesize that 12 weeks of aerobic exercise will significantly improve NMD and GWE, concurrent with enhanced metabolic flexibility and reduced fatigue compared to the non-exercise control group."

Clinical protocol • Journal • Cardiovascular • Diabetes • Fatigue • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus

Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation (clinicaltrials.gov) - P4 | N=68 | Not yet recruiting | Sponsor: Ying Zhu

New P4 trial • Gastroenterology • Gastrointestinal Disorder • Pain

Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling. (PubMed, J Headache Pain) - "We demonstrated OHCs as the key targets in CM-induced, CGRP-mediated peripheral hearing impairment. CGRP exerts its pathogenic role by triggering a cascade of intracellular stress and inflammatory pathways, ultimately leading to cell death. These findings provide a phenotypic basis for a subtype of migraine-induced hearing loss, paving the way for auditory protection strategies."

Journal • CNS Disorders • Migraine • Otorhinolaryngology • Pain • IGF2BP1 • ZBP1

Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel (clinicaltrials.gov) - P2 | N=190 | Not yet recruiting | Sponsor: University of Basrah | Trial primary completion date: Jan 2026 ➔ Apr 2026

Trial primary completion date • Breast Cancer • Colon Cancer • Colorectal Cancer • Oncology

Topical Nitropaste Reduces Partial Free Nipple Graft Loss in Gender Affirming Mastectomy: A Randomized Controlled Trial. (PubMed, Plast Reconstr Surg) - P4 | "Topical nitroglycerin application in DIFNG significantly reduces partial nipple graft loss without affecting wound complications.ClinicalTrials.gov Registry: NCT06428669."

Journal

Comparative Efficacy and Safety of Vasodilators Used to Prevent Internal Thoracic Artery Spasm in Coronary Artery Bypass Grafting: A Systematic Review. (PubMed, Cureus) - "This review systematically evaluates the comparative efficacy and safety of vasodilators used to prevent ITA spasm, including papaverine, glyceryl trinitrate-verapamil (GV) solution, systemic diltiazem, and efonidipine. Delivery method influenced efficacy, with topical or intraluminal administration providing rapid, direct vasodilation. Overall, combination therapy (GV solution) offers a practical and safe approach for intraoperative ITA spasm prevention."

Journal • Review

Kuanxiong Aerosol vs Nitroglycerin for Acute Chest Symptoms: A Multicenter Randomized Trial on Efficacy and Safety (ChiCTR) - P=N/A | N=1000 | Not yet recruiting | Sponsor: Peking University First Hospital; Peking University First Hospital

New trial • Pain

Spatial metabolomics combined with MALDI-MSI unveils gut-brain axis mechanisms of angelica dahurica radix in migraine rats. (PubMed, Phytomedicine) - "Baizhi alleviates migraine through multi-target regulation of the gut-brain axis, including intestinal barrier repair, gut microbiota remodeling, and cerebral metabolic restoration. Notably, this study on Baizhi represents the first integration of spatial metabolomics (MALDI-MSI) with gut microbiome and systemic metabolomics to elucidate migraine mechanisms, providing a novel multi-omics strategy for understanding the holistic therapeutic effects of traditional Chinese medicine. These findings provide a mechanistic basis for its clinical application in migraine treatment."

Journal • Preclinical • CNS Disorders • Metabolic Disorders • Migraine • Pain • Solid Tumor • OCLN • TJP1 • TNFA

Ventilatory limitation to exercise in patients with HFpEF and obesity: No room to breathe. (PubMed, Respir Physiol Neurobiol) - P=N/A | "We conclude that mechanical ventilatory constraints coupled with increased ventilatory inefficiency impose a ventilatory limitation to exercise in patients with HFpEF and obesity."

Journal • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Obesity

Peripheral autonomic dysregulation in response to standing: a new form associated with cardiovascular disease, mobility reduction, and cognitive alterations. (PubMed, Eur Heart J) - "These findings reveal a novel variant of the autonomic cardiovascular response to standing, with important clinical implications for functional decline in older adults."

Journal • Cardiovascular • Diabetes • Geriatric Disorders • Metabolic Disorders

Prehospital blood pressure lowering in acute hemorrhagic stroke: a systematic review and meta-analysis of randomized controlled clinical trials. (PubMed, Eur Stroke J) - "Our meta-analysis indicates that prehospital BP-lowering in acute hemorrhagic stroke does not improve functional outcome and survival. Future RCTs conducted in mobile stroke units, and exclusively focusing on patients with acute hemorrhagic stroke, are required."

Clinical • Journal • Retrospective data • Review • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders

Ventilatory Limitation to Exercise in Patients with HFpEF and Obesity: No room to breatheVentilatory Limited Exercise in HFpEF. (PubMed, Respir Physiol Neurobiol) - P=N/A | "We conclude that mechanical ventilatory constraints coupled with increased ventilatory inefficiency impose a ventilatory limitation to exercise in patients with HFpEF and obesity."

Journal • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Obesity

INVASIVE CORONARY FUNCTION TESTING: FROM TOTAL OCCLUSION TO TIMI-3 FLOW, INTRACORONARY NITROGLYCERIN REVEALS SEVERE VASOSPASTIC ANGINA IN A WOMAN WITH RECURRENT CHEST PAIN (ACC 2026) - "Abstract is embargoed at this time."

Clinical • Cardiovascular • Pain

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Headache Symptoms in Migraine Model Mice by the Locus Coeruleus/Noradrenergic System: An Experimental Study in a Mouse Model of Migraine. (PubMed, Biomedicines) - "A migraine model was established by administration of nitroglycerin...TaVNS increased the number of NE neurons in the LC (p < 0.05), promoted the release of NE in Sp5C (p < 0.05), and upregulated the expression of α-2A adrenergic receptors in Sp5C (p < 0.05). The analgesic effects of taVNS are related to the activation of the LC-NE system and the inhibition of the decrease in Sp5C in migraine mice."

Journal • Preclinical • CNS Disorders • Migraine • Pain

Refractory Prinzmetal Angina With Severe Right Coronary Artery Vasospasm and Bradycardia in a 46-Year-Old Female: A Complex Case Associated With Hypophosphatemia. (PubMed, Cureus) - "Two hours after discontinuation of intravenous nitroglycerin due to hypotension, the patient developed recurrent chest pain with 3-mm ST-segment elevation in the inferior leads and sinus bradycardia...This case highlights the importance of clarifying the temporal relationship between electrolyte abnormalities and vasospastic events and recognizing hypophosphatemia as a possible reversible contributor to refractory vasospastic angina. Severe right coronary artery spasm can closely mimic acute coronary syndrome and result in hemodynamic instability; prompt angiographic diagnosis, intracoronary vasodilator therapy, and correction of underlying metabolic disturbances are essential for effective management."

Journal • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease • Hypotension • Metabolic Disorders • Pain • Renal Disease