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Challenges in causality assessment of renal dysfunction during sequential treatment for presumed rifampicin-resistant tuberculosis in an elderly patient. (PubMed, IDCases) - "Eighteen days after initiation of a long oral regimen (D2: levofloxacin, clofazimine, linezolid, pyrazinamide, and cycloserine), acute kidney injury developed, with serum creatinine increasing to 140 µmol/L and eGFR declining to 42.34 mL/min/1.73 m²...Advanced age, low BMI, frailty, and fluctuating hydration status should be considered when interpreting changes in renal function. Careful interpretation requires integration of the clinical course and available diagnostic information rather than reliance on temporal associations alone."

Journal • Acute Kidney Injury • Infectious Disease • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Tuberculosis

Treatment outcomes for people with multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) : global findings (ERS 2026) - " detection and treatment coverage of MDR/RR-TB remain low, but treatment success has improved since 2012, concurrent with increased global use of all-oral regimens with effective drugs like bedaquiline and linezolid. Access continues to improve, and 6-month MDR/RR-TB regimens are now used in ~100 countries, with >34,000 people started on them in 2024, a 20-fold increase compared with 2022. With further scale-up of these regimens, cure rates can approach those for rifampicin-susceptible TB."

Clinical • Infectious Disease • Respiratory Diseases • Tuberculosis

Anaemia, hypoalbuminemia, and risk of cycloserine-associated neuropsychiatric toxicity in a shortened oral regimen for multidrug/rifampicin-resistant TB. (PubMed, IJTLD Open) - "Baseline anaemia and hypoalbuminemia were associated with increased neuropsychiatric toxicity risk during treatment with a cycloserine-containing regimen. Whether these associations are specific to cycloserine merits further study."

Journal • Anemia • CNS Disorders • Epilepsy • Hematological Disorders • Infectious Disease • Pain • Psychiatry • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A Randomized, Open-label, Two-arm, Non-inferiority Clinical Study to Evaluate the Safety and Efficacy of Linezolid Tablets in the Treatment of Neurosyphilis (ChiCTR) - P2 | N=120 | Not yet recruiting | Sponsor: Hospital for Skin Diseases, Chinese Academy of Medical Sciences; Fight Infections Foundation (Lluita), Spain

Head-to-Head • New P2 trial • Infectious Disease • CD4 • MBP

Spectrum, Clinical Characteristics, and Outcomes of Infections in Renal Allograft Recipients: A Three-Year Prospective Study (TTS 2026) - "UTIs were treated requently with broad-spectrum antibiotic,meropenem and ceftriaxone, followed by piperacillin–tazobactam, colistin, fosfomycin, and oral cephalosporins...Gram-positive infections were managed with linezolid, teicoplanin, or vancomycin.Skin and soft-tissue infections clinically significant, including herpes zoster (3.0%), cutaneous aspergillosis, viral warts (HPV), non-tuberculous mycobacterial wound infection,and multiple staphylococcal abscesses... Infections are a major contributor to morbidity in renal allograft recipients. Strengthening infection surveillance, preventive measures, and prompt treatment may help improve patient survival and long-term outcomes."

Clinical • Chronic Kidney Disease • Glomerulonephritis • Herpes Zoster • Infectious Disease • Lupus Nephritis • Nephrology • Nontuberculous Mycobacterial Disease • Pneumonia • Respiratory Diseases • Tuberculosis • Varicella Zoster

Comparative pharmacovigilance analysis of intravenous versus oral linezolid: Insights from the FDA Adverse Event Reporting System. (PubMed, Medicine (Baltimore)) - "The safety profiles of linezolid differ significantly between intravenous and oral routes, largely driven by treatment duration, patient population, and clinical setting. These findings support route-specific monitoring strategies: acute toxicity surveillance for intravenous therapy and long-term neurotoxicity and hematologic monitoring for oral therapy."

Adverse events • Clinical • Journal • Acute Kidney Injury • Agranulocytosis • Granulocytopenia • Hematological Disorders • Leukopenia • Metabolic Disorders • Nephrology • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Renal Disease

Giant Abdominal Haematoma and Rapid Multidrug-Resistant Infection After Low-Molecular-Weight Heparin in a Patient With COVID-19 and Rheumatoid Arthritis. (PubMed, Infect Drug Resist) - "After admission, the patient was given subcutaneous injection of LMWH (2500 IU, qd) for anticoagulation, combined with Simnotrelvir/Ritonavir for antiviral treatment...During this period, the patient received multiple rounds of anti-infective treatment with meropenem, linezolid, minocycline, etc. and underwent 5 debridements, Vacuum Sealing Drainage (VSD), and skin grafting...Under the superposition of multiple immunosuppressive factors such as COVID-19, long-term prednisone use and additional in-hospital glucocorticoid therapy, conventional-dose LMWH can induce an unusually large hematoma (15cm×15cm), with rapid disease progression (secondary infection within 1 day), which is prone to refractory MDROs infection. For such high-risk patients, clinical practice should formulate highly individualized anticoagulant treatment plans and further strengthen the monitoring of adverse reactions."

Journal • Cardiovascular • Diabetes • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Metabolic Disorders • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Type 2 Diabetes Mellitus

Guidelines for off-label use of anti-tuberculosis drugs (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "NAT2 genotype-inferred acetylator phenotype may support individualized dose adjustment together with TDM, efficacy, and safety assessments (2, B).Recommendation 7: Off-label rifampicin use includes a 3-month regimen of isoniazid and rifampicin (3HR) (1, B) or a 4-month regimen of rifampicin (4R) (2, B) for tuberculosis preventive treatment; individualized high-dose use in TBM or investigational use in drug-susceptible pulmonary tuberculosis (2, C); local administration as adjunct therapy only (2, D); and use during pregnancy, including early pregnancy, after individualized benefit-risk assessment (2, C).Recommendation 8: Based on pharmacokinetic and safety data from Chinese populations, the 3H₂P₂ regimen-isoniazid 500-600 mg, plus rifapentine, 450-600 mg, twice weekly for 3 months-is recommended for tuberculosis preventive treatment (1, B).Recommendation 9: Levofloxacin is a key drug for fluoroquinolone-susceptible MDR/RR-TB (1, B); it may also be used for..."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure • Hepatology • Infectious Disease • Liver Failure • Metabolic Disorders • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • Tuberculosis • NAT2

Treatment of multidrug-resistant tuberculosis with bedaquiline, pretomanid, linezolid, and moxifloxacin following near-total gastrectomy. (PubMed, ASM Case Rep) - "Phenotypic drug susceptibility testing could not be performed due to poor growth; however, a line probe assay performed on the isolate identified resistance to rifampin and isoniazid...This case demonstrates successful use of the all-oral BPaLM regimen in a patient with prior gastrectomy when supported by therapeutic drug monitoring. Evaluating drug exposure may help optimize treatment outcomes in patients at risk for drug malabsorption."

Journal • Gastric Adenocarcinoma • Gastric Cancer • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Tuberculosis

Bacteriological Spectrum and Antibiotic Utilization in Community-Acquired Pneumonia: An Observational Study at a Tertiary Care Center in Western Uttar Pradesh, India. (PubMed, Cureus) - "A significant proportion of isolates demonstrated resistance to commonly used antibiotics such as beta-lactams. Streptococcus pneumoniae remains the dominant pathogen, but the substantial burden of Gram-negative organisms with high resistance to first-line agents underscores the need for culture-guided therapy."

Journal • Observational data • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Hidden in Plain Sight: Nocardia farcinica Posterior Shoulder Abscess Temporally Associated With Sports Massage in an Immunocompetent Host. (PubMed, Cureus) - "Microbiological culture identified heavy growth of N. farcinica, necessitating cessation of empirical intravenous flucloxacillin and initiation of linezolid, followed by a planned six-month course of oral co-trimoxazole...The patient achieved satisfactory clinical improvement with preserved neurovascular function at follow-up. This case represents a potentially novel mechanism of nocardial inoculation via vigorous deep soft-tissue massage and underscores the importance of considering atypical pathogens in deep soft-tissue infections that follow an unexpected or treatment-refractory clinical course."

Journal • Esophageal Cancer • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Oncology • Pain

Avoiding the Scalpel: Pyoderma gangrenosum Mimicking Necrotizing Infection in Ulcerative Colitis (ACG 2026) - "She received piperacillinâtazobactam and linezolid, and surgical debridement was scheduled...High-dose IV methylprednisolone was initiated with plans for infliximab induction; wound care included silver alginate dressings, compression, and elevation without sharp debridement...Satellite erosions and smaller ulcerations are visible at the periphery, suggesting centrifugal expansion. The surrounding skin shows post-inflammatory hyperpigmentation and induration, trending favorably with initiation of biologics and steroids."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

From Bacteremia to Dual-Organ Transplant: Streptococcus Intermedius Liver Abscesses Complicated by Portal Vein Thrombosis, Non-Cirrhotic Portal Hypertension, and Hepatorenal Syndrome (ACG 2026) - "He received ertapenem followed by prolonged oral amoxicillin-clavulanate and linezolid, and started on apixaban on discharge for PVT...A) Coronal T2-weighted fat-suppressed MRI sequence with a few dilated venous collaterals along the main portal vein (red circle) and two liver parenchyma T2 hyperintensities, consistent with pyogenic liver abscesses (light blue circles). B) 12-week coronal T2-weighted fat-suppressed MRI sequence, with interval resolution of the liver abscesses, but increased size and number of venous collaterals, consistent with cavernous transformation of portal vein (circle in red), and worsening ascites."

Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Fibrosis • Heart Failure • Hepatology • Hypertension • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Nephrology • Portal Hypertension • Renal Disease • Septic Shock • Solid Organ Transplantation • Thrombosis • Transplantation • Type 2 Diabetes Mellitus

Black hairy tongue: an early adverse effect of linezolid in treatment of multidrug resistant tuberculosis. (PubMed, BMJ Case Rep) - "A man in his 20s with microbiologically confirmed multidrug-resistant pulmonary tuberculosis was initiated on a regimen comprising bedaquiline, pretomanid, linezolid and moxifloxacin...The patient was advised on oral hygiene measures with which complete resolution occurred within 8-10 days, with no recurrence on follow-up and he was transitioned to an individualised longer regimen.This case highlights that black hairy tongue is a rare, early and reversible adverse effect of linezolid. Prompt recognition and appropriate management can prevent unnecessary discontinuation of effective multidrug-resistant tuberculosis therapy and improve treatment adherence."

Adverse events • Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Evaluation of a short, all oral treatment regimen including bedaquiline, delamanid, linezolid, clofazimine, and pyrazinamide named "Regimen C" for pre-XDR tuberculosis in Niger. (PubMed, Front Tuberc) - "Undernourished patients tended to have an increased risk of unfavorable treatment outcomes, although this association was not statistically significant (p = 0.18). These findings suggest that the regimen evaluated in this study appears to be effective for the management of pre-XDR tuberculosis in Niger, with a promising treatment success rate."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

The "yeast-drop" treatment protocol in the Drosophila model for rapid and cost-effective TB drug testing. (PubMed, Front Tuberc) - "HDTs such as aspirin, metformin, and simvastatin also enhanced survival rates and reduced CFUs following treatment, demonstrating conserved immune and metabolic mechanisms between flies and mammals...Overall, the Drosophila-M. marinum model, combined with the yeast-drop methodology, offers a reliable, low-cost, and biologically relevant platform for early-stage screening of antimycobacterial, host-directed, and anti-virulence compounds, effectively bridging the gap between in vitro systems and mammalian models."

HEOR • Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Clinical improvement of methicillin-resistant Staphylococcus epidermidis prosthetic knee joint infection after changing therapy from tedizolid to linezolid: A case report. (PubMed, J Infect Chemother) - "The patient achieved sustained clinical improvement without severe thrombocytopenia. This case suggests that switching from TZD to LZD may be an effective therapeutic strategy when TZD fails to control MRSE PKJI and that therapeutic drug monitoring-guided dose adjustment may facilitate prolonged LZD therapy while minimizing hematological toxicity."

Journal • Hematological Disorders • Infectious Disease • Orthopedics • Thrombocytopenia

A rare invader on a cardiac stent: Mycobacterium abscessus mediastinitis managed with tedizolid after linezolid intolerance. (PubMed, IDCases) - "The patient received a multidrug regimen anchored by amikacin and an oxazolidinone...Because of early hematologic intolerance to linezolid, therapy was transitioned to tedizolid 200 mg once daily, with clofazimine later used as the companion oral agent after intolerance to minocycline...Serial imaging showed substantial regression of the mediastinal lesion without clinically significant FDG uptake at end of therapy. This case highlights three clinically relevant lessons: first, post-PCI M. abscesses stent-associated mediastinitis demands aggressive source control; second, tedizolid can serve as a viable salvage therapy after linezolid intolerance; third, serial cardiac PET-CT can assist treatment monitoring when repeat deep tissue sampling is impractical; and fourth, advanced multimodal imaging plays a critical role in diagnosis, surgical planning, and monitoring of complex post-cardiac surgical infections."

Journal • Cardiovascular • Coronary Artery Disease • Diabetes • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nontuberculous Mycobacterial Disease • Pain • Respiratory Diseases

ESKAPE pathogens: Emerging isolates in odontogenic orofacial infections. (PubMed, J Oral Biol Craniofac Res) - "High resistance rates were seen to amoxicillin-clavulanic acid (62.07%), cefuroxime (62.5%) and trimethoprim-sulfamethoxazole (68.42%). Linezolid, ertapenem, and clindamycin demonstrated the highest susceptibility (100%), followed by imipenem (86.96%, p ≤ 0.05)...These findings reinforce the necessity of culture-based therapy and highlight imipenem as a potential option for resistant cases. Strengthened antibiotic stewardship and continued surveillance are essential to manage the growing threat of multidrug-resistant organisms in maxillofacial infections."

Journal • Infectious Disease

Pediatric pyopneumothorax caused by Prevotella oris successfully diagnosed via mNGS: a case report and literature review. (PubMed, Front Med (Lausanne)) - "A high index of suspicion should be maintained for anaerobic infections in children presenting with a history of dental procedures, abnormal immune parameters or possible immunological vulnerability, or poor response to empirical antibiotics. Traditional cultures are often inadequate; therefore, mNGS serves as a crucial tool for the early detection and precise treatment of difficult-to-culture anaerobes."

Journal • Infectious Disease • Pain • Pediatrics • Pneumonia • Respiratory Diseases

Persistent CD4+ lymphopenia is associated with recurrent Nocardia farcinica infection and acquired resistance in an AIDS patient: a case report with immunological warning. (PubMed, Front Immunol) - "A 32-year-old man with AIDS and persistent CD4+ count below 100 cells/μL for over three years (nadir 2 cells/μL) developed right lower lobe pneumonia caused by Nocardia farcinica four years before the current admission, which was cured with a TMP-SMX-containing regimen...One year before the current admission, he received sulfadiazine plus pyrimethamine for clinically diagnosed cerebral toxoplasmosis, but his adherence was poor and irregular...He improved after switching to imipenem plus amikacin...The distinction between true reinfection and late relapse could not be definitively established in the absence of strain-level homology data. Irregular, sub-therapeutic sulfonamide exposure, combined with a non-functional immune system, can select for resistant strains."

Journal • Preclinical • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock • CD4

Corynebacterium in Granulomatous Mastitis: Clinical Features and Treatment Outcomes. (PubMed, Infect Dis Clin Microbiol) - "The impact of lipophilic antibiotics (tetracyclines, linezolid, rifampin) combined with steroids was assessed...Further studies are needed to define optimal treatment duration and the role of surgery in refractory GM. Graphical Abstract."

Journal • Infectious Disease • Inflammation

Diagnosis, Management, and Outcome of Antituberculous Drug-Induced Liver Injury in a Low-Resource Setting: A Case Report. (PubMed, Case Rep Infect Dis) - "The patient failed rechallenge and was transitioned to an all-oral second-line antituberculous regimen consisting of bedaquiline, pretomanid, linezolid, and moxifloxacin, alongside direct-acting antiviral therapy for chronic hepatitis C. This resulted in the resolution of liver injury and the successful completion of tuberculosis treatment without complications. This case highlights the diagnostic and management challenges of AT-DILI in low-resource settings, particularly where baseline liver function testing, serial monitoring, and access to single-drug formulations for rechallenge are limited."

Journal • Anorexia • Fibrosis • Gastroenterology • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Liver Failure • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A Perfect Storm in Advanced AIDS: Severe Acute Respiratory Distress Syndrome From Pneumocystis Jirovecii and Mycobacterium Avium Complex Coinfection. (PubMed, J Investig Med High Impact Case Rep) - "He was initially treated empirically with broad-spectrum antibiotics (piperacillin-tazobactam and linezolid) and subsequently started on trimethoprim-sulfamethoxazole and corticosteroids for PJP...Sputum cultures grew MAC, prompting initiation of azithromycin, rifampin, and ethambutol...This case highlights the rapid progression and complexity of opportunistic infections in advanced AIDS. Extensive diagnostic evaluation, early recognition of co-infections, and aggressive multidisciplinary management are essential, though outcomes may remain poor in patients with profound immunosuppression and multi-organ failure."

Journal • Acute Respiratory Distress Syndrome • Critical care • Fatigue • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • CD4

Isolated Forearm Abscess with Bilateral Psoas Abscesses: An Unusual Presentation of Extrapulmonary Preextensively Drug-resistant Tuberculosis without Pulmonary Involvement. (PubMed, Ann Afr Med) - "GeneXpert MTB/RIF performed on pus aspirated from both sites confirmed M. tuberculosis complex with rifampicin resistance; a line-probe assay subsequently documented additional resistance to isoniazid and fluoroquinolones - fulfilling the definition of preextensively drug-resistant (XDR) TB. An all-oral modified longer regimen comprising cycloserine, linezolid, clofazimine, bedaquiline, and delamanid was initiated, with steady clinical recovery. Pre-XDR TB may manifest as disseminated soft-tissue disease at unconventional sites - forearm and paravertebral musculature - even when the lungs are radiologically clear. Early molecular resistance testing on pus aspirates shortened the interval to appropriate second-line therapy and likely shaped the favourable trajectory observed here."

Journal • Anorexia • Cough • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis