SHC0646151
/ Nanjing Sanhome Pharma
- LARVOL DELTA
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October 13, 2025
Novel covalent WRN inhibitors SHC0646151 and SHC0646198 for the treatment of microsatellite instability-high (MSI-H) cancers
(AACR-NCI-EORTC 2025)
- "SHC0646151 and SHC0646198 are highly selective covalent WRN inhibitors demonstrating strong preclinical efficacy in MSI-H cancers. The recently generated in vivo PDX data, together with favorable safety profiles and synergistic activity with irinotecan, underscore their promise as novel therapeutic options."
Late-breaking abstract • MSI-H • Colorectal Cancer • Endometrial Cancer • Microsatellite Instability • Oncology • MSI • WRN
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