human hepatitis B immunoglobulin / China Biologic Products - LARVOL DELTA

Cesarean section to prevent mother-to-child transmission of hepatitis B virus in China: A meta-analysis. (PubMed, BMC Pregnancy Childbirth) - "Cesarean section could reduce the risk of MTCT of HBV in comparison to vaginal delivery in China. However, owing to several limitations of our meta-analysis, future well-designed randomized controlled trials with adequate statistical power, might be a more appropriate next step."

Journal • Biosimilar • Immunology

ROLE OF INFERTILE FEMALE CHRONIC HEPATITIS B VIRUS INFECTION IN ASSISTED REPRODUCTION AND INFANTILE OUTCOMES:A SYSTEMATIC REVIEW AND META-ANALYSIS (AASLD 2019) - "This first systematic assessment demonstrated that female hepatitis B virus infection appeared to no significant influence on assisted reproduction outcomes of infertile females. Assisted reproduction of CHB females are generally safe. Nevertheless, it remains explored in females with high or extremely high HBV DNA level."

Retrospective data • Review

Caesarean section versus vaginal delivery to prevent mother-to-child transmission of hepatitis B virus: A meta-analysis (EASL-ILC 2019) - "Cesarean section could reduce the risk of MTCT of HBV in comparison to vaginal delivery. Performing cesarean in highly viremic mothers with pre-delivery HBV-DNA levels log10 copies/ml and/or HBeAg positive may be considered with caution. Moreover, future well-designed randomized control trials are needed to confirm our findings."

Retrospective data

Association of cytotoxic T-lymphocyte antigen-4 + 49A/G gene polymorphism with hepatocellular carcinoma risk in Chinese. (PubMed, J Cancer Res Ther) - "...Hepatitis B virus infection, also called chronic hepatitis B (CHB), is the leading cause of HCC...Furthermore, G allele and GG genotype were associated with the CHB patients developing into HCC (G allele: OR = 0.81, 95% CI: 0.66-0.98, P = 0.03; GG genotype: OR = 0.75, 95% CI: 0.57-0.99, P = 0.04). CTLA4 A/G gene polymorphism was associated with HCC risk and CTLA4 G allele/GG genotype is associated with CHB patients developing into HCC in Chinese."

IO Biomarker • Journal