epinephrine / Generic mfg. - LARVOL DELTA

Anaphylaxis and Fulminant Disseminated Intravascular Coagulation Due to Loxoprofen. (PubMed, Intern Med) - "He was admitted to the intensive care unit, where he was administered epinephrine, prednisolone, and d-chlorpheniramine maleate for hypotension, systemic pruritus, and flushing. After a transfusion of FFP and antithrombin concentrates, the coagulopathy rapidly improved. Subsequently, the patient was discharged without any bleeding or thrombotic episodes six days after admission."

Journal • Critical care • Dermatology • Hematological Disorders • Hypotension • Pain • Pruritus

It's a MIRACLE! Taking the Guesswork Out of Postcardiac Arrest Care. (PubMed, Circ Cardiovasc Interv) - No abstract available

Journal • Cardiovascular

Subject-specific modeling of response to physical stress via hypothalamic-pituitary-adrenal and sympathoadrenal axes. (PubMed, PLoS One) - "The HPA axis produces and secretes cortisol, while the SA axis produces and secretes the fast-acting catecholamines, epinephrine and norepinephrine, which in turn stimulate cortisol...We performed sensitivity analysis using Morris screening and estimated model parameters using constrained optimization with respect to time series data of cortisol and catecholamine dynamics under acute physical stress. After subject-specific parameter estimation, the proposed model that includes both the HPA and SA axes shows qualitative agreement with the collected data."

Journal

Hyperacute effects of non-code dose bolus epinephrine in paediatric cardiac intensive care patients: insights from high-fidelity physiologic data. (PubMed, Cardiol Young) - "Non-code dose bolus epinephrine is associated with a significant increase in heart rate, blood pressure, and systemic oxygen delivery. Cluster analysis using the peak change identified distinct clinical clusters."

Journal • Cardiovascular • Critical care • Pediatrics

Avoidance of Hyperoxemia Versus Routine Hyperoxia During Cardiopulmonary Bypass in Children With Cyanotic Congenital Heart Disease-A Systematic Review and Meta-Analysis. (PubMed, Paediatr Anaesth) - "No significant differences in postoperative outcomes were observed between oxygenation strategies aimed at avoiding hyperoxemia and routine hyperoxic management during CPB."

Journal • Retrospective data • Review • Cardiovascular • Critical care • Heart Failure

Intravenous adrenaline during general anaesthesia: incidence and adverse events over 11 years. (PubMed, BMC Anesthesiol) - No abstract available

Adverse events • Journal • Anesthesia

Periarticular Vasoconstrictor Infiltration in a Tourniquet-Free Total Knee Arthroplasty: A Case Report of Effective Blood Loss Control in High-Thrombotic-Risk Patient. (PubMed, Local Reg Anesth) - "The PVI solution included ropivacaine, dexmedetomidine, and epinephrine. This case demonstrates the feasibility and clinical benefit of integrating ultrasound-guided PVI into a multimodal, tourniquet-free anesthetic strategy for TKA in high-thrombotic-risk patients. The approach provided effective analgesia and hemostasis, aligned with ERAS principles, and may represent a valuable alternative for personalized perioperative care in orthopedic surgery."

Journal • Anesthesia • Cardiovascular • Hematological Disorders • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology • Thrombosis

Management Strategy for Anaphylaxis in a Patient With Suspected or Confirmed Mastocytosis: A Case Report. (PubMed, Am J Case Rep) - "As part of supportive treatment, antihistamines (rupatadine via a nasogastric tube) and intravenous glucocorticosteroids were given. In such patients, intravenous infusion of sodium bicarbonate can be necessary. Therefore, patients with mastocytosis who experience anaphylaxis may be less responsive to epinephrine and should be admitted to the intensive care unit early."

Journal • Critical care • Immunology • Metabolic Disorders • Respiratory Diseases

INCIDENCE and risk factors associated with fetal heart rate abnormalities within one hour of labor epidural analgesia initiation: a retrospective cohort study. (PubMed, J Gynecol Obstet Hum Reprod) - "Factors known beforehand (small for gestational age, abnormal fetal heart rate) or occurring afterwards (uterine hypertonia, severe hypotension) should be suspected or anticipated."

Journal • Retrospective data • Hypotension • Small for Gestational Age • Women's Health

The Effect of Cocktail Formula Solution for Erector Spinae Plane Block on Postoperative Pain After Laparoscopic Major Upper Abdominal Surgery: A Single-Center Randomized Controlled Study. (PubMed, J Pain Res) - "The experimental group received ultrasound-guided bilateral ESPB with 40 mL of a cocktail solution (0.375% ropivacaine + 2μg/mL epinephrine + 0.1mg/mL dexamethasone + 2.5mg/mL magnesium sulfate + 15mg/mL sodium bicarbonate)...The primary outcome was total intravenous morphine equivalent analgesic consumption (including PCIA and rescue analgesia) at 0-48h and 24-48h postoperatively...There were no significant differences in sedation scores, complication rates, or recovery indices between the groups. A single ESPB with the cocktail formula solution significantly prolongs analgesia for up to 48 hours and provides superior analgesic efficacy compared to plain ropivacaine in patients undergoing laparoscopic major upper abdominal surgery, without increasing complications."

Clinical • Journal • Anesthesia • Pain

Back to the flow: a comprehensive systematic review and meta-analysis of epinephrine in the treatment of no-reflow. (PubMed, Coron Artery Dis) - "Therefore, intracoronary epinephrine was associated with encouraging but exploratory findings, and the higher success rate in primary no-reflow may reflect earlier intervention and less severe microvascular damage. Its modest advantage over adenosine suggests potential therapeutic value, though evidence remains limited and heterogeneous."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section (clinicaltrials.gov) - P3 | N=100 | Recruiting | Sponsor: Cairo University | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

Real-World Challenges in Pediatric Anaphylaxis: The Role of Epinephrine (EAACI 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Immunology

Novel Treatment with Epinephrine in Emergencies: World Expert Consensus and Best Practices (EAACI 2026) - No abstract available

Allergy • Food Hypersensitivity • Immunology

Nitrogen-Doped Dehydrobenzoannulene as an Electron Acceptor Enabling Trace Epinephrine Analysis. (PubMed, Org Lett) - "Furthermore, their intramolecular charge transfer properties were disclosed by solvent-dependent fluorescence and density functional theory calculations. Finally, an azadehydrobenzoannulene-based sensor for the epinephrine assay was constructed, which provided a sensitive analytical system for early diagnosis of neurodegenerative diseases."

Journal • CNS Disorders

Variation in observation time after nebulized racemic epinephrine among children with croup (PAS 2026) - No abstract available

Clinical

Intramuscular versus intravenous epinephrine administration during cardiopulmonary resuscitation in a neonatal piglet model of asystole (PAS 2026) - No abstract available

Evaluating Femoral Occlusion as an Alternative to Epinephrine During Neonatal Cardiopulmonary Resuscitation in an Asphyxiated Term Ovine Model. (PAS 2026) - No abstract available

Epinephrine Through Advanced Airway During Neonatal Resuscitation - A Simulation and Translational Model Study (PAS 2026) - No abstract available

Metastases

Epinephrine Savvy: Recognize, React, Rescue! (PAS 2026) - "Practical tips for integration of these tools into private practice, inpatient, or ED workflow will be given throughout. Learning Objectives: Recognize the signs and symptoms of anaphylaxis, including the variations in presentation between different age groups Demonstrate competency with the most common home epinephrine administration devices including intramuscular and intranasal epinephrine Construct an allergy action plan for food allergy patients and choose candidates for home management of allergic reactions"

Food Hypersensitivity • Immunology

Femoral Occlusion as an Alternative to Epinephrine: Is It feasible? (PAS 2026) - No abstract available

Epinephrine: all you need to know (PAS 2026) - No abstract available

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Damascus University | Recruiting ➔ Completed

Trial completion • Immunology • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology

Accidental Environmental Hypothermia in a Nonagenarian Resulting in Cardiac Arrest. (PubMed, Prague Med Rep) - "She was successfully resuscitated with chest compressions, epinephrine, atropine, and two defibrillations...She died approximately two years later at the age of 93. Thus, full neurologic recovery remains possible after CA induced by severe hypothermia from environmental exposure, despite extreme age and frailty."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Geriatric Disorders • Infectious Disease • Pneumonia • Respiratory Diseases

Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section (clinicaltrials.gov) - P3 | N=100 | Not yet recruiting | Sponsor: Cairo University

New P3 trial • Anesthesia