epinephrine / Generic mfg. - LARVOL DELTA

Epinephrine and Emergency Medical Services Activation Recommendations During Acute Allergic Reactions in Community Settings: International Consensus Report. (PubMed, J Allergy Clin Immunol) - "We developed consensus recommendations for administering epinephrine (adrenaline) and activating emergency services during acute allergic reactions in the community. The care recommendations account for the range of severity and the dynamic nature of reactions. They can be integrated into patient-facing technologies to enhance reaction management and improve outcomes."

Journal • Allergy • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Safety and Efficacy of Very Low-Dose Multi-Nut Oral Immunotherapy in Children. (PubMed, Clin Transl Allergy) - P2 | "VLOIT led to a significant increase in the tolerated dose to multiple nuts."

Journal • Allergy • Food Hypersensitivity • Immunology • Pediatrics

Navigating triple therapy in a high-risk cardiac patient with a covered stent and embolic stroke: A case report (ASH 2025) - "He was diagnosed with NSTEMI, and was initiated on aspirin, clopidogrel, enoxaparin, and nitroglycerin...Persistent cardiogenic shock necessitated Impella CP support, vasopressors (epinephrine, norepinephrine), and inotropes (dobutamine)...Following readmission, neurological evaluation revealed small subacute infarcts, following which anticoagulation with enoxaparin (later apixaban) was initiated alongside DAPT (aspirin, clopidogrel)...Repeat coronary angiography plays a major role here, allowing physicians to assess stent integrity and to make informed decision about de-escalation or continuation of therapy. Unfortunately, there are no current guidelines specifically addressing management strategies for patients with coronary artery aneurysms and recent embolic stroke, underscoring an urgent need for further research in this area."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Hematological Disorders • Ischemic stroke • Nephrology • Peripheral Arterial Disease • Pulmonary Disease • Renal Disease • Respiratory Diseases • Thrombosis

Is dual targeting of FXII and Gas6 a good strategy to prevent thrombosis with no risks of bleeding? (ASH 2025) - "Thrombosis wasevaluated using a platelet-dependent venous thromboembolism (VTE) model (collagen/epinephrine),ultrahigh-frequency ultrasound (UHFUS) monitoring of ferric chloride-induced vena cava thrombosis, andintravital confocal microscopy (IVM) of thrombus formation in mesenteric arterioles... Dual targeting of FXII and Gas6 effectively reduced bleeding but unexpectedly increasedthrombus instability and embolism risk, likely due to reduced NET formation and enhanced fibrinolysis.These findings highlight challenges of combined inhibition and the need to clarify underlyingmechanisms. Gas6 inhibition alone appears safer for thrombosis prevention and warrants furtherstudies as a bleeding-free antithrombotic strategy."

Cardiovascular • Hematological Disorders • Thrombosis • Venous Thromboembolism • AXL • GAS6 • MERTK

EpiDOSE: Epinephrine Dose: Optimal Versus Standard Evaluation Trial (clinicaltrials.gov) - P4 | N=3790 | Recruiting | Sponsor: Unity Health Toronto | Trial completion date: Jun 2028 ➔ Dec 2028

Trial completion date • Cardiovascular • Ventricular Tachycardia

Late-Onset Digital Ischaemia after WALANT: Successful Reversal with Off-Label Urapidil. (PubMed, Handchir Mikrochir Plast Chir) - "The patient recovered fully without sequelae.This case highlights a rare but critical complication of WALANT. Urapidil may represent a safe and effective alternative to phentolamine in the management of epinephrine-induced vasospasm."

Journal • Anesthesia

The role of catecholamines in aneurysmal subarachnoid hemorrhage: a narrative review. (PubMed, Acute Crit Care) - "Catecholamines, including epinephrine, norepinephrine, and dopamine, are the body's stress responses, which can lead to secondary injuries following aSAH...The review highlights the implications of catecholamine levels; where higher concentrations correlate with poorer outcomes and higher mortality rates. Understanding the mechanisms responsible for secondary injury due to catecholamines surge following aSAH shall facilitate the development of therapeutic approaches to prevent secondary brain injury and improve outcomes."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Impact of cardiovascular autonomic neuropathy on cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes. (PubMed, Diabetologia) - "In adults with type 1 diabetes, CAN was associated with exercise intolerance characterised by impairments in various cardiopulmonary, sympathoadrenal system and metabolic responses to GXT. These data support uncovering the presence of CAN when prescribing a personalised physical training plan."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • Pain • Type 1 Diabetes Mellitus

Atrial Fibrillation in a Young Healthy Adult: A Case Report From Anaphylaxis to Arrhythmia. (PubMed, Cureus) - "The arrhythmia occurred within five minutes of intramuscular epinephrine administration and resolved following rate control with intravenous diltiazem. He remained in sinus rhythm during telemetry monitoring and was discharged with outpatient follow-up. This case highlights the potential for transient AF in the setting of allergic reactions and raises diagnostic and therapeutic questions regarding the role of venom-induced autonomic effects versus sympathomimetic drug administration."

Journal • Allergy • Atrial Fibrillation • Cardiovascular

Flexible hydrogel sensor based on MoS2 for highly selective dopamine detection against catecholamine cross-interference. (PubMed, Analyst) - "However, achieving high selectivity in such platforms remains a major challenge, especially in the presence of structurally similar catecholamines such as epinephrine (EP), which often coexist with DA in physiological environments...The sensor achieves a low detection limit of 6.1 nM and maintains reliable DA response even in the presence of high concentrations of EP. This work presents a promising strategy toward soft, selective, and interference-resilient biosensors for dynamic neurochemical sensing."

Journal • CNS Disorders

Comparing Etizolam and Music Distraction on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial. (PubMed, Anesth Prog) - "All patients received a standard IANB with 2% lidocaine with 1:200,000 epinephrine...No significant difference was found in IANB success between the placebo and etizolam groups. IANB success was significantly higher in patients who listened to music during endodontic therapy than in patients who received etizolam or placebo."

Clinical • Journal • Anesthesia • Dental Disorders • Mood Disorders • Pain • Psychiatry

Machine learning prediction of stress-induced D-dimer reactivity in male physicians with and without burnout. (PubMed, Semin Thromb Hemost) - "LASSO regression identified five key predictors of D-dimer stress reactivity: pre-stress D-dimer, habitual alcohol consumption, pre-stress cortisol, stress-induced epinephrine surge, and adverse childhood experiences (ACEs)...Our findings highlight the role of early adversity, alcohol consumption, and sympathoadrenal activation in stress-induced coagulation activation, as reflected by D-dimer reactivity. If validated, these predictors may help identify individuals at elevated risk for stress-triggered ACS and inform targeted prevention strategies."

Journal • Acute Coronary Syndrome • Addiction (Opioid and Alcohol) • Cardiovascular

Assessing the Influence of a Statewide Dosing Reference Aid on Prehospital Pediatric Medication Dosing Errors: A Mixed-Methods Simulation-Based Investigation. (PubMed, Prehosp Emerg Care) - "Each crew completed three high-fidelity simulations (infant seizure, infant cardiac arrest and child burn) requiring two doses of midazolam, epinephrine, or fentanyl. Immediate causes of error involve incorrect weight, administering air, and improper dilution, which tools like the MI-MEDIC dosing reference aid do not address. Further research is needed to develop comprehensive strategies addressing the active errors identified in our study."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Infectious Disease • Pediatrics

The effects of allostatic load, bullying, and social mobility belief on depression among socioeconomically disadvantaged Chinese adolescents. (PubMed, J Res Adolesc) - "AL was measured using eight biomarkers: heart rate, systolic and diastolic blood pressure, body mass index (BMI), cortisol, epinephrine, norepinephrine, and dehydroepiandrosterone...A higher social mobility belief may exacerbate depression in adolescents with high AL who face significant bullying. These findings highlight that the role of social mobility belief is context-dependent, rather than a universally protective factor and suggest that interventions should address both physiological stress and perceived opportunity."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion. (PubMed, Mol Metab) - "Electrogenic Na+/K+ ATPases (NKAs) control β-cell Ca2+ influx and insulin secretion by integrating the signal strength of stimulatory G protein (Gs)-coupled ligands (e.g., GLP-1, glucagon) and inhibitory G protein (Gi)-coupled ligands (e.g., somatostatin, epinephrine)...NKAβ1βKD in human pseudoislets led to tonically elevated intracellular Ca2+ and increased insulin secretion. These findings establish NKAβ1-containing NKA complexes as critical regulators of β-cell electrical activity, Ca2+ oscillations, and secretory patterns, with direct consequences for systemic glucose homeostasis."

Journal

Pharmacological Hypotensive Treatment in Very Preterm Newborns: Systematic Review and Meta-Analysis of Randomised Controlled Trials. (PubMed, Acta Paediatr) - "Pharmacological treatment of neonatal hypotension may improve blood pressure without positive effects on mortality and neurodevelopment in very preterm newborns. However, associated adverse effects such as intraventricular haemorrhage and hyperglycemia appear relevant."

Journal • Retrospective data • Review • Diabetes • Hypotension

Stability of emergency medications during extreme cold: a controlled environmental study. (PubMed, Scand J Trauma Resusc Emerg Med) - "Emergency medications can remain chemically stable under extreme cold conditions when stored in sealed, insulated packaging. While our study simulated prehospital conditions without direct environmental exposure, these findings support the feasibility of extended storage and transport of emergency medications in challenging field settings. Further research should assess the impact of direct environmental exposure and evaluate additional stability parameters to optimize storage protocols in real-world scenarios."

Journal

Metabolomic changes associated with treatment response of neoadjuvant chemotherapy with TEC regimen in HER2-negative breast cancer. (PubMed, Front Pharmacol) - "This study aimed to characterize time-dependent metabolic alterations and identify metabolites associated with treatment response in HER2-negative breast cancer patients undergoing neoadjuvant chemotherapy (NAC) with the TEC regimen (docetaxel, epirubicin, and cyclophosphamide)...Following six cycles, elevated epinephrine levels were positively associated with therapeutic efficacy, while increased cysteine levels were linked to unfavorable outcomes...Combined analysis of ursodeoxycholic acid and cysteine improved the predictive performance for treatment response. These findings reveal dynamic metabolic reprogramming during NAC and suggest that ursodeoxycholic acid and cysteine may serve as potential predictive biomarkers of therapeutic efficacy in HER2-negative breast cancer patients treated with the TEC regimen."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Oncology • Solid Tumor • HER-2

Influence of a rapid volume infusion during advanced cardiopulmonary resuscitation of severely asphyxic near-term lambs. (PubMed, Arch Dis Child Fetal Neonatal Ed) - "Volume infusion with saline improved blood pressure stability during and after cardiopulmonary resuscitation but was inferior to intravenous epinephrine in achieving ROSC and reducing cerebral micro-haemorrhages. The use of volume infusion during resuscitation in moderately asphyxiated euvolaemic newborns is unlikely to have clinical benefit."

Journal

Anaphylaxis to aminocaproic acid in the setting of liver transplantation. (PubMed, BMJ Case Rep) - "Epinephrine was administered with improvement in haemodynamics and ventilation...Aminocaproic acid during liver transplantation may cause anaphylactic shock. Haemodynamic and ventilatory changes after administration warrant consideration for empiric treatment and measurement of tryptase levels while other potential aetiologies are also being assessed."

Journal • Anesthesia • Fibrosis • Hematological Disorders • Hepatitis C • Hypotension • Immunology • Infectious Disease • Inflammation • Transplantation

Unlocking survival in traumatic cardiac arrest: global insights, innovations, and unmet needs. (PubMed, Crit Care) - "Conversely, routine use of epinephrine shows at best inconsistent benefits and may be detrimental in blunt trauma...Notwithstanding notable progress, major knowledge gaps persist in defining optimal intervention timing, reporting standards, and long-term neurologic recovery. The findings underscore the critical need for multicenter, prospective research, harmonized trauma registries, and global consensus to inform future guidelines and optimize outcomes for TCA patients."

Journal • Review • Cardiovascular • CNS Disorders • Hematological Disorders • Pediatrics • Vascular Neurology

Nebulised Magnesium Sulphate Plus Epinephrine versus Epinephrine Alone in Infants with Acute Bronchiolitis: Authors' Reply. (PubMed, Indian J Pediatr) - No abstract available

Journal • Pulmonary Disease • Respiratory Diseases

Bradycardia with haemodynamic compromise in children: A scoping review. (PubMed, Resusc Plus) - "Three studies reported conflicting associations between clinical outcomes (progression to pulselessness, return of circulation, survival) with epinephrine use during CPR...Current guidelines are based on limited evidence and expert opinion. Comparative trials evaluating possible treatments for children with bradycardia with haemodynamic compromise are needed."

Journal • Review • Cardiovascular • Hypotension • Pediatrics

Caffeine enhances lipolysis in primary rat adipocytes via adenosine A1 receptor pathway. (PubMed, J Physiol Pharmacol) - "It was shown that caffeine significantly increased lipolysis induced by epinephrine (an adrenergic receptor agonist), forskolin (a direct activator of adenylate cyclase (AC)), and dibutyryl-cAMP (a direct stimulator of protein kinase A (PKA))...The pharmacological suppression of PKA abolishes the stimulatory effect. Increased lipolysis in the presence of caffeine contributes to reduced lipid accumulation in adipocytes."

Journal • Preclinical

Food allergy and anaphylaxis in a university campus dining program. (PubMed, J Allergy Clin Immunol Glob) - "While dining halls have enhanced FA support measures, tree nut and peanut continue to be high-risk foods. Stock epinephrine proved to be a crucial, potentially life-saving intervention."

Journal • Allergy • Dermatology • Food Hypersensitivity • Immunology • Urticaria