PF-07293893 / Pfizer - LARVOL DELTA

Discovery of clinical candidate PF-07293893: A novel and selective AMPK gamma 3 activator for the treatment of heart failure (ACS-Fall 2025) - "From these new leads, the team utilized structure based drug design and medicinal chemistry strategies such as conformational constraint to improve potency, while also working to remove undesirable off-target activity. This work, in combination with improvements in ADME properties ultimately led to the identification of PF-07293893 as a clinical candidate for the treatment of heart failure."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • AMPK

A Study to Understand the Effect of Multiple Ascending Doses of PF-07293893 in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=88 | Completed | Sponsor: Pfizer | Recruiting ➔ Completed

Trial completion

A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS (clinicaltrials.gov) - P1 | N=31 | Completed | Sponsor: Pfizer | Recruiting ➔ Completed | N=60 ➔ 31 | Trial completion date: Mar 2025 ➔ Aug 2024 | Trial primary completion date: Mar 2025 ➔ Aug 2024

Biomarker • Enrollment change • Trial completion • Trial completion date • Trial primary completion date

A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Pfizer | Trial completion date: Oct 2024 ➔ Mar 2025 | Trial primary completion date: Oct 2024 ➔ Mar 2025

Biomarker • Trial completion date • Trial primary completion date

A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Pfizer | Not yet recruiting ➔ Recruiting

Biomarker • Enrollment open

A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS (clinicaltrials.gov) - P1 | N=60 | Not yet recruiting | Sponsor: Pfizer

Biomarker • New P1 trial

A Study to Learn About the Study Medicine (PF-07293893) at Different Dose Levels in Healthy Adults (clinicaltrials.gov) - P1 | N=30 | Completed | Sponsor: Pfizer | Recruiting ➔ Completed

Trial completion

A Study to Understand the Effect of Multiple Ascending Doses of PF-07293893 in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=108 | Recruiting | Sponsor: Pfizer | Not yet recruiting ➔ Recruiting

Enrollment open

A Study to Understand the Effect of Multiple Ascending Doses of PF-07293893 in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=108 | Not yet recruiting | Sponsor: Pfizer

New P1 trial