CollatampG (gentamicin surgical implant) / Innocoll - LARVOL DELTA

ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions (clinicaltrials.gov) - P3 | N=6610 | Recruiting | Sponsor: University of Birmingham | Trial completion date: Feb 2022 ➔ Aug 2023 | Trial primary completion date: Nov 2021 ➔ May 2023

Trial completion date • Trial primary completion date • Infectious Disease

Use of gentamicin-collagen sponge (Collatamp® G) in minimally invasive colorectal cancer surgery: A propensity score-matched study. (PubMed, PLoS One) - "Applying a gentamicin-collagen sponge to the mini-laparotomy wound did not reduce the frequency of SSIs. Further studies should be conducted on whether the selective use of gentamicin-collagen sponges may help reduce SSIs in high-risk patients."

Journal • Colorectal Cancer • Gastrointestinal Cancer • Hepatology • Infectious Disease • Oncology • Solid Tumor

Gentamicin-Containing Collagen Implant May Reduce Surgical Site Infections After Open Infrainguinal Arterial Revascularisation. (PubMed, Ann Vasc Surg) - "This is the first study that examined the effect of gentamicin-containing collagen implants on the severity of surgical site infections in vascular surgery. Gentamicin-containing collagen implants may reduce the odds of overall surgical site infections. It did not reduce the odds of deep-space surgical site infections or the severity and reintervention rate of surgical site infections following infrainguinal arterial revascularisation. Larger studies are required to achieve adequate power to assess for these outcomes."

Journal • Chronic Kidney Disease • Dyslipidemia • Genetic Disorders • Infectious Disease • Obesity • Renal Disease

Technology for Repairing Osteomyelitic Bone Defects Using Autologous Mesenchymal Stromal Cells on a Collagen Matrix in Experiment. (PubMed, Sovrem Tekhnologii Med) - "In the study group, autologous MSCs in Collatamp EG collagen carrier were placed into the bone defect...Our results indicate that the use of a collagen matrix with autologous MSCs is a promising plastic material for repairing osteomyelitic defects following necrectomy.The MSCs were able to increase the density of the filling material in the bone cavity, significantly accelerate the formation of bone beams around the matrix, and increase the tissue volume around the implant. The presence of MSCs significantly decreased the interference of a connective tissue component with osteogenesis and chondrogenesis."

Journal • Fibrosis • Immunology • Inflammation • Myelofibrosis