Nucynta (tapentadol) / Collegium Pharma, Grunenthal - LARVOL DELTA

Evaluating discharge opioid prescribing practices in elective surgical patients: a retrospective audit from a tertiary surgical and rehabilitation centre. (PubMed, Aust Health Rev) - "Discharge opioid prescribing was reasonably individualised by patient and procedure, but quantity was frequently standardised rather than tailored, and a minority of patients received an opioid despite no recent inpatient need. Strengthening quantity individualisation, discharge simple analgesia, and patient education around cessation would further align prescribing with opioid stewardship principles."

Journal • Retrospective data • Musculoskeletal Diseases • Ophthalmology • Orthopedics • Pain

Ten-year outcomes of medical cannabis for chronic low back pain: opioid reduction, pain relief, and functional improvement in 1,000 patients. (PubMed, Eur Spine J) - "In this uncontrolled observational study, medical cannabis therapy was associated with reductions in opioid use, pain intensity, and functional disability over 10 years, accompanied by polypharmacy reduction and acceptable tolerability. Effect sizes substantially exceeded RCT benchmarks (e.g., - 0.6 NRS difference vs. placebo in a recent phase 3 trial), suggesting observational biases contribute to these findings. These hypothesis-generating data warrant validation in randomized controlled trials."

Journal • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain • Psychiatry

Long-Term Tapentadol Use for Neuropathic Pain in a Hemodialysis Patient with End-stage Renal Disease: A Case Report. (PubMed, Pain Med Case Rep) - "This case suggests long-term tapentadol may be a safe and effective pain management option in selected patients with end-stage renal disease on hemodialysis, though further study is needed."

Journal • Chronic Kidney Disease • Nephrology • Neuralgia • Pain • Renal Disease

Clinician Perspectives on Prescribing Restrictions and Opioid Pain Management in Australian Podiatric Practice: A Qualitative Study. (PubMed, J Foot Ankle Res) - "Australia's NPSML is perceived by clinicians to be structurally misaligned with current pharmacological evidence, professional competencies and equitable care principles. These findings support the transition to a dynamic, scope-of-practice-based prescribing model that can respond to emerging evidence and meet the analgesic needs of diverse patient populations."

Journal • Pain

Buprenorphine vs tapentadol for pain management post haemorrhoidectomy: an open-label randomised clinical trial (BOLT) (ANZCTR) - P=N/A | N=74 | Not yet recruiting | Sponsor: Prince of Wales Hospital | N=52 ➔ 74

Enrollment change • Pain

Digital Gangrene Following Intravascular Injection of Crushed Tapentadol Tablets: A Case of Excipient-Induced Microvascular Embolization. (PubMed, Indian Dermatol Online J) - No abstract available

Journal

Cannabis use increases the likelihood that head and neck surgery patients receive postoperative opiate pain medications. (AHNS 2026) - "The incidence of postoperative high-potency opioid prescriptions (oxycodone, morphine, oxymorphone, hydromorphone, tapentadol, fentanyl) was compared between the cohorts during two time points: postoperative day (POD) 0 and the first week following surgery POD 1–7. These findings may help guide more individualized postoperative pain management, particularly for patients who use cannabis. Future studies are needed to understand how to optimize perioperative pain strategies in cannabis users, including tailoring multimodal pain management to this specific patient population, evaluating whether specific analgesic regimens can reduce their need for high-potency opioids after surgery, and improving counseling around preoperative cannabis use in the outpatient setting."

Clinical • Surgery • Otorhinolaryngology • Pain

CYP450-based reclassification of urinary metabolic ratio cutoffs for pain management and substance abuse treatment drugs. (PubMed, J Opioid Manag) - "These pairs include dextrorphan/dextromethorphan, oxymorphone/oxycodone, hydromorphone/hydrocodone, O-desmethyltramadol/tramadol, hydromorphone/-morphine, norbuprenorphine/buprenorphine, norfentanyl/-fentanyl, -noroxycodone/-oxycodone, norhydrocodone/hydrocodone, -7-aminoclonazepam/clonazepam, α-hydroxyalprazolam/alprazolam, norquetiapine/quetiapine, meprobamate/carisoprodol, N-desmethyltapentadol/tapentadol, norketamine/ketamine, -2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine/methadone, -desipramine/imipramine, and nortriptyline/amitriptyline. MR-derived phenotype classifications aligned with the phenotype frequencies reported in Zhu et al., indicating that population-level MR distributions reflect known CYP450 genetic variability. Incorporating CYP-specific cutoffs alongside traditional 95 percent RIs may improve identification of expected genetic metabolism, reduce misclassification, and enhance the interpretive accuracy of MR analysis in clinical UDT."

Journal • Pain • Substance Abuse • CYP2C19 • CYP2C9 • CYP3A4

Role of Preoperative Tapentadol in Reduction of Peri-operative Analgesics Requirements After Breast Conservative Surgery in Cancer Patients: A Randomized Controlled Trial. (PubMed, J Cancer Allied Spec) - "Pre-emptive tapentadol administration significantly reduced perioperative morphine use and improved postoperative pain scores at certain time points. However, the increase in time to first rescue analgesia was not statistically significant."

Journal • Anesthesia • Oncology • Pain

Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses. (PubMed, J Vet Pharmacol Ther) - "The maximum concentrations of tapentadol-O-glucuronide following single 1, 3, and 5 mg/kg oral doses and a single 0.32 mg/kg IV dose of tapentadol were 532.6 ± 171.4, 1169.4 ± 345.4, 1559.5 ± 574.6, and 226.4 ± 51.5 ng/mL at times 6.0, 6.0, 7.0, and 0.5 h. Tapentadol was well-tolerated at all doses."

Journal • PK/PD data • Pain

Efficacy and safety of oral tapentadol for cancer-related pain: an updated systematic review and meta-analysis. (PubMed, Minerva Med) - "Tapentadol demonstrated similar efficacy and safety compared to other opioids for cancer-related pain, with no evidence of superiority. Given the limited number and methodological quality of studies, further high-quality trials are needed to establish more robust conclusions."

Clinical • Journal • Retrospective data • Review • Oncology • Pain

Effects of Biochar-Nitrogen Interaction on Soil Nitrogen Transformation and Cucumber Growth in Facility Cultivation. (PubMed, Plants (Basel)) - "Eight pot treatments: no nitrogen (N0), 100 kg·hm-2 of nitrogen (N100), 150 kg·hm-2 of nitrogen (N150), 200 kg·hm-2 of nitrogen (N200), and which with the addition of 5% biochar named BN0, BN100, BN150, BN200...These changes collectively improved soil nitrogen transformation and ultimately promoted cucumber plant growth. This study reveals the potential role of biochar in regulating soil nitrogen transformation and facilitating plant growth."

Journal

A landscape analysis of clinical trials in cancer pain management: current trends and emerging therapeutic targets. (PubMed, Front Oncol) - "The most advanced innovations are currently limited to dual-mechanism agents (e.g., tapentadol combining MOR agonism and norepinephrine reuptake inhibition) and novel delivery systems (e.g., iontophoretic transdermal patches or intrathecal pumps)...To surmount this therapeutic stagnation, future priorities must include expanding early-phase trials on novel pathways (e.g., tumor-microenvironment interactions), adopting composite endpoints integrating pain with function and QoL, and leveraging real-world evidence and AI-driven phenotyping to advance precision analgesia. This paradigm shift is critical to addressing the multidimensional burden of cancer pain."

Journal • Review • Addiction (Opioid and Alcohol) • Musculoskeletal Pain • Oncology • Pain • NAV1

Tapentadol and Zolpidem addiction management with Ayurvedic intervention: A case report. (PubMed, J Ayurveda Integr Med) - "Observations suggested that with the Ayurvedic management, withdrawals and insomnia were completely resolved within three weeks of treatment. The baseline investigations were normal, and the patient continued to practice yoga and counselling during and after therapy, abstaining for 60 days post treatment."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Insomnia • Pain • Psychiatry • Sleep Disorder

Urine tapentadol quantification in people injecting supratherapeutic doses: Clinical utility and liquid chromatography-tandem mass spectrometry method validation. (PubMed, Indian J Psychiatry) - "Tapentadol concentration decreased exponentially over time (first-order elimination kinetics), but remained detectable beyond 48 hours, possibly due to saturation kinetics with supratherapeutic-dose IV use or the impact of excipients. These concentration thresholds can support objective monitoring of abstinence/relapse in clinical care."

Journal

Buprenorphine vs tapentadol for pain management post haemorrhoidectomy: an open-label randomised clinical trial (BOLT) (ANZCTR) - P=N/A | N=52 | Not yet recruiting | Sponsor: Prince of Wales Hospital

New trial • Pain

Identifying Sex Differences in Adverse Events Reported on Opioid Drugs in the FDA's Adverse Event Reporting System (FAERS). (PubMed, Pharmaceuticals (Basel)) - "The largest sex disparities were observed for codeine, fentanyl, tapentadol, hydrocodone, and sufentanil, with significantly higher disproportionate reporting rates among women. These results suggest the need for increased awareness of sex-specific safety differences and support sex-informed prescribing and monitoring strategies to improve opioid safety in women. Since pharmacists are medication experts and play a key role in promoting rational and safe use, our findings may further support pharmacists counseling patients and monitoring for opioid-related adverse events."

Adverse events • Journal • Pain

Preoperative Tapentadol Enhances the Depth of Anesthesia-Induced Sleep, Recovery Profile, and Serotonergic Modulation in Dogs Undergoing Ovariectomy with Propofol-Sevoflurane Anesthesia. (PubMed, Vet Sci) - "Preoperative tapentadol enhances anesthetic stability, supports smoother early recovery, and modulates serotonin levels in dogs, suggesting benefits for perioperative pain management and overall surgical welfare."

Journal • Anesthesia • Pain

Tapentadol-induced urticarial rash in a patient with acute pancreatitis. (PubMed, Indian J Pharmacol) - "The rash resolved after discontinuation of tapentadol and administration of a short course of corticosteroids and antihistamines. Cutaneous reactions to tapentadol are extremely rare but should be recognized promptly to ensure timely management and prevent unnecessary investigations."

Journal • Allergy • Dermatology • Immunology • Pain • Pancreatitis • Urticaria

Acute extensive leukoencephalopathy secondary to transdermal fentanyl and oral tapentadol intoxication: a case report. (PubMed, Neurologia (Engl Ed)) - No abstract available

Journal • CNS Disorders

The role of perioperative tapentadol in inguinal hernia repair: Implications for acute analgesia and chronic postoperative pain - a narrative review. (PubMed, Hernia) - No abstract available

Journal • Review • Gastroenterology • Neuralgia • Pain

Intranasal Tapentadol Dependence and Emerging Patterns of Harm: A Report of 2 Cases. (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

Sorbent Strip Microextraction as a Practical Tool for Drug Screening: Application to Opioids and Local Anesthetics in Human Urine. (PubMed, Molecules) - "To demonstrate its applicability, three opioids (buprenorphine, tapentadol, and tramadol) and two local anesthetics (articaine and bupivacaine) were used as model compounds in urine matrices, followed by high-performance liquid chromatography with diode array detector (HPLC-DAD) analysis. The validated SSμE/HPLC-DAD methodology was successfully applied to real urine samples, confirming its high precision and accuracy. The proposed microextraction technique offers a practical, eco-friendly, and effective alternative for routine drug screening in complex biological matrices and presents significant advantages over traditional and other microextraction-based methods."

Journal • Aesthetic Medicine • Anesthesia

Optimizing Opioid Use in Pain Management: A Comprehensive Review of Clinical Benefits, Risks, and Dependence. (PubMed, Healthcare (Basel)) - "Recent advances, including partial agonists such as buprenorphine, dual-mechanism agents such as tapentadol, individualized titration, opioid rotation, and the integration of multimodal analgesia, support safer and more tailored prescribing...Clinicians must balance analgesic efficacy with adverse effects, such as tolerance, opioid-induced hyperalgesia, sedation, and respiratory depression, particularly in perioperative and critically ill populations. Opioids remain indispensable for selected indications but should be incorporated into a comprehensive, patient-centered, multimodal analgesic approach that prioritizes safety, ongoing reassessment, and individualized risk mitigation."

Journal • Review • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Critical care • Depression • Oncology • Pain • Psychiatry

Efficacy of oral tapentadol immediate-release for the management of moderate-to-severe cancer pain in patients presenting to the oncology ward of a tertiary care hospital. (PubMed, Pak J Med Sci) - "No relationship between the level of pain reduction and gender (p =0.28), cancer type (p =0.68), or previous analgesic use (p =0.096) were found. A starting dose of 75 mg BID of tapentadol IR led to a significant pain reduction in cancer patients with chronic pain in the Pakistani population, regardless of previous analgesic intake or cancer type."

Journal • Oncology • Pain