Nucynta (tapentadol) / Collegium Pharma, Grunenthal - LARVOL DELTA

The role of perioperative tapentadol in inguinal hernia repair: Implications for acute analgesia and chronic postoperative pain - a narrative review. (PubMed, Hernia) - No abstract available

Journal • Review • Gastroenterology • Neuralgia • Pain

Intranasal Tapentadol Dependence and Emerging Patterns of Harm: A Report of 2 Cases. (PubMed, Prim Care Companion CNS Disord) - No abstract available

Journal

Sorbent Strip Microextraction as a Practical Tool for Drug Screening: Application to Opioids and Local Anesthetics in Human Urine. (PubMed, Molecules) - "To demonstrate its applicability, three opioids (buprenorphine, tapentadol, and tramadol) and two local anesthetics (articaine and bupivacaine) were used as model compounds in urine matrices, followed by high-performance liquid chromatography with diode array detector (HPLC-DAD) analysis. The validated SSμE/HPLC-DAD methodology was successfully applied to real urine samples, confirming its high precision and accuracy. The proposed microextraction technique offers a practical, eco-friendly, and effective alternative for routine drug screening in complex biological matrices and presents significant advantages over traditional and other microextraction-based methods."

Journal • Aesthetic Medicine • Anesthesia

Optimizing Opioid Use in Pain Management: A Comprehensive Review of Clinical Benefits, Risks, and Dependence. (PubMed, Healthcare (Basel)) - "Recent advances, including partial agonists such as buprenorphine, dual-mechanism agents such as tapentadol, individualized titration, opioid rotation, and the integration of multimodal analgesia, support safer and more tailored prescribing...Clinicians must balance analgesic efficacy with adverse effects, such as tolerance, opioid-induced hyperalgesia, sedation, and respiratory depression, particularly in perioperative and critically ill populations. Opioids remain indispensable for selected indications but should be incorporated into a comprehensive, patient-centered, multimodal analgesic approach that prioritizes safety, ongoing reassessment, and individualized risk mitigation."

Journal • Review • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Critical care • Depression • Oncology • Pain • Psychiatry

Efficacy of oral tapentadol immediate-release for the management of moderate-to-severe cancer pain in patients presenting to the oncology ward of a tertiary care hospital. (PubMed, Pak J Med Sci) - "No relationship between the level of pain reduction and gender (p =0.28), cancer type (p =0.68), or previous analgesic use (p =0.096) were found. A starting dose of 75 mg BID of tapentadol IR led to a significant pain reduction in cancer patients with chronic pain in the Pakistani population, regardless of previous analgesic intake or cancer type."

Journal • Oncology • Pain

The Effects of Tegileridine and Sufentanil on Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy under Multimodal Antiemetic Strategy: A Prospective, Randomized Controlled Study (ChiCTR) - P=N/A | N=148 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New trial

Effects of Tapentadol on Gastrointestinal Function Recovery in Patients After Lumbar Spine Surgery (ChiCTR) - P4 | N=134 | Not yet recruiting | Sponsor: Shunde Hospital, Guangzhou University of Chinese Medicine; Shunde Hospital, Guangzhou University of Chinese Medicine

New P4 trial • Anesthesia • Orthopedics • GAST

A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers. (PubMed, Clin Neurophysiol) - "Our findings support the RIII threshold as an objective spinal biomarker to assess antihyperalgesic drug effect. This study informs future choices of biomarkers, optimal timing, and analysis strategies in analgesic research."

Biomarker • Clinical • Journal • Pain

Tapentadol induces progressive hepatic damage via disrupting Hippo-YAP and bile acid-FXR pathways: An integrated experimental and computational perspective. (PubMed, Tissue Cell) - "Our findings are further supported by in-silico analysis that showed strong binding affinity of TAP with key regulatory genes. Collectively, these findings suggest that TAP is a hepatotoxic agent and warrant further clinical trials to evaluate its effects in humans."

IO biomarker • Journal • B Cell Lymphoma • Inflammation • Lymphoma • Oncology • Pain • CASP3 • CASP9 • CAT • HMOX1 • IL1B • IL6 • LATS1 • TNFA • YAP1

Effect of Postoperative Analgesia with Tapentadol Fumarate on the Quality of Recovery in Patients Undergoing Laparoscopic Radical Resection for Colorectal Cancer (ChiCTR) - P=N/A | N=126 | Not yet recruiting | Sponsor: The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology

New trial • Colorectal Cancer • Oncology • Solid Tumor

Opioid detection and quantification in plasma and oral fluid by LC-MS/MS. (PubMed, Anal Bioanal Chem) - "This study aimed to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous detection and quantification of fentanyl, buprenorphine, oxycodone, morphine, tramadol, and tapentadol in plasma and oral fluid. Oral fluid concentrations were detectable across all target opioids, although plasma-oral fluid ratios showed some compound-dependent variability. These findings highlight the potential of oral fluid as a non-invasive complementary matrix to plasma for opioid monitoring, with relevant implications for forensic toxicology and clinical drug monitoring."

Journal • Addiction (Opioid and Alcohol)

Role of Preoperative Tapentadol in Reduction of Perioperative Analgesic Requirement After Breast Conservative Surgery in Cancer Patients. (clinicaltrials.gov) - P=N/A | N=70 | Completed | Sponsor: Shaukat Khanum Memorial Cancer Hospital & Research Centre

New trial • Breast Cancer • Oncology • Pain • Solid Tumor

Therapeutic challenges in a rare trigeminal autonomic cephalalgia (EHF-EHC 2025) - "A discrete improvement was noted with intravenous eptinezumab 300 mg every 12 weeks, in combination with duloxetine, gabapentin, topiramate and tapentadol. He makes excessive use of fast-acting tramadol and ibuprofen to alleviate acute pain... SUNCT remains a therapeutic challenge due to its rarity, limited evidence base, and frequent refractoriness. This reinforces the need for further research and therapeutic innovation."

Rheumatology

Hypoglycaemia after post-operative oral analgesics administration: A case series. (PubMed, J Pak Med Assoc) - "Analgesics prescribed on discharge were Acetaminophen, Tramadol-Acetaminophen, Pregabalin, Celecoxib, etoricoxib, Diclofenac-Misoprostol, Tapentadol, and Ketorolac Tromethamine. Patients were treated with dextrose, sugar, etc., and after adjustment of analgesics dose were directed to an endocrinologist. It seems that certain analgesics increase the risk of hypoglycaemia in elderly hypertensive and diabetic fracture patients which might be a combinatory effect of analgesics, anti-hypertensive, and/or anti-diabetic agents."

Journal • Diabetes • Hypoglycemia • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Effect of tapentadol combined with transverse abdominis plane block on postoperative pain in patients undergoing laparoscopic total hysterectomy (ChiCTR) - P=N/A | N=96 | Not yet recruiting | Sponsor: The First People’s Hospital of Jingzhou; The First People’s Hospital of Jingzhou

New trial • Cervical Cancer • Endometriosis • Gynecology • Oncology • Pain • Solid Tumor • Uterine Leiomyoma • Women's Health

Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial. (PubMed, World J Orthop) - "A preemptive single dose of 100 mg oral tapentadol is safe, effective, and significantly reduces postoperative pain and rescue analgesic requirements in TKA patients. This approach may reduce opioid dependence and support enhanced recovery protocols."

Clinical • Journal • Addiction (Opioid and Alcohol) • Musculoskeletal Diseases • Orthopedics • Pain

Effect of Preventive Analgesia with Tapentadol Fumarate on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Undergoing Thyroid and Breast Surgery: A Prospective, Double-Blind, Positive-Controlled Trial (ChiCTR) - P4 | N=152 | Not yet recruiting | Sponsor: Guangzhou Institute of Cancer Research,the Afliated Cancer Hospital, Guangzhou Medical University; Guangzhou Institute of Cancer Research,the Afliated

New P4 trial

OPIOID AVAILABILITY FOR PAIN IN PEDIATRIC ONCOLOGY POPULATIONS IN LOW- AND MIDDLE-INCOME COUNTRIES: A PAUCITY OF RESEARCH (SIOP 2025) - "The most frequently reported opioids were morphine and fentanyl, in 11 and 10 articles respectively, followed by tramadol (4), pethidine, methadone, and codeine (2 each), and tapentadol, remifentanil, alfentanil, and oxycodone (one each). Our finding of limited opioid research in pediatric oncology in LMICs highlights a significant research gap and possibly limited access to opioids for pain in LMICs in pediatric oncology. In the context in which opioid distribution is unequal and inequitable generally, this is especially concerning for the vulnerable pediatric oncology population."

Clinical • Pain • Palliative care • Pediatrics

Comparison of the 95% Effective Dose (ED95) and Efficacy between Tegileridine Fumarate and Fentanyl in Hysteroscopic Surgery: A Prospective, Multicenter, Randomized Controlled Trial (ChiCTR) - P=N/A | N=182 | Not yet recruiting | Sponsor: First Affiliated Hospital of Gannan Medical University; First Affiliated Hospital of Gannan Medical University

New trial

Preclinical assay of the effects of lacosamide, pregabalin, and tapentadol on the rat N1 spinal somatosensory evoked potential. (PubMed, Pain) - "Pregabalin (at any dose up to 30 mg/kg) did not modulate the N1 amplitude. These results show that the spinal N1 is differentially modulated in a way that reflects distinct mechanisms of analgesic action consistent with it being a translatable biomarker of target engagement."

Journal • Preclinical • Anesthesia • Pain

A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study Evaluating the Pharmacokinetics of Single-Dose Tapentadol Hydrochloride Intravenous Infusion and Tapentadol Hydrochloride Oral Tablets in Patients with Pain. (PubMed, Eur J Drug Metab Pharmacokinet) - "Tapentadol IV exhibits precise pharmacokinetics, promising pharmacodynamic properties, and a favorable safety profile compared with IR and ER routes for patients with moderate noncancer pain, supporting further clinical research and development of tapentadol injection."

Journal • PK/PD data • Oncology • Pain

EXPRESS: Efficacy of combined grapiprant and tapentadol for analgesia in cats undergoing elective ovariohysterectomy. (PubMed, J Feline Med Surg) - "At 3 hours postoperatively, FGS scores differed significantly between CON and GT groups (p = 0.0363). Rescue analgesia requirements also varied among groups (p = 0.0110): GT required rescue at 3 hours, compared with 1 hour in CON (p = 0.0007) and 2 hours in GRA (p = 0.0058).The results of this study showed that the analgesic effect of the grapiprant-tapentadol combination lasted up to 3 hours in the postoperative period, which was longer than the 2 hours of grapiprant and tapentadol alone, without compromising intraoperative physiological stability."

Journal • Anesthesia • Gynecology • Pain

Prevalence and Predictors of Opioid Use Before Spine Surgery: A Multicenter, Cross-Sectional Observational Study. (PubMed, Pharmacol Res Perspect) - "The most frequently used opioids were oxycodone (32%), codeine (20%), and tapentadol (9%)...Given the risks of opioids, efforts to better understand and manage opioid use before spine surgery are warranted. Addressing this issue could lead to more effective pain management strategies and improved patient outcomes."

Journal • Observational data • Orthopedics • Pain

Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation. (PubMed, J Am Chem Soc) - "The synthetic utility of this methodology is demonstrated through the preparation of key intermediates for a number of natural products. Particularly, stereodivergent synthesis of an analgesic drug derivative Me-tapentadol has been achieved, exhibiting significantly enhanced μ-opioid receptor agonistic activity compared to its parent compound."

Journal • Pain

Long-Term Neuropathic Pain Management Following Thoracolumbar Neurinoma Surgery: A Case Report withMultimodal and Neuromodulation Strategies (NeuPSIG 2025) - "Psychological screening questionnaires revealed positive scores for anxiety and depression at baseline, highlighting the need for an integrated biopsychosocial approach.Strategies included medication adjustments (carbamazepine, duloxetine, trazodone, methadone, and eventually tapentadol), cannabis-based therapy, epidural and transforaminal blocks, pulsedradiofrequency (PRF) of dorsal root ganglia (DRGs), sympathetic blocks via venous access (BSV), and spinal cord stimulation (SCS)...Within one week, the patient experienced a 70% reduction in pain, with a mean pain score of 2/10 and low interference in daily function: 30% for general activity and interpersonal relations, and no interference with work or enjoyment of life.This improvement was achieved while maintaining a stable regimen of duloxetine, trazodone, methadone, and pregabalin... This case demonstrates the value of individualized, stepwise multimodal management for complex neuropathic pain, especially when..."

Case report • Clinical • Surgery • CNS Disorders • Depression • Neuralgia • Pain • Psychiatry