improved fibrinogen / CSL Behring - LARVOL DELTA

Cryo on call: Pathogen-reduced cryoprecipitated fibrinogen complex is associated with improved fibrinogen supplementation in hemorrhaging trauma patients. (PubMed, J Trauma Acute Care Surg) - "INTERCEPT fibrinogen complex implementation at our level 1 trauma center was independently associated with FS, but not mortality or TR. Hemorrhaging patients with hypofibrinogenemia, a time-sensitive predictor of mortality in trauma, may benefit from IFC."

Journal • Hematological Disorders

Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials. (PubMed, Phytomedicine) - "This is the first relatively comprehensive systematic review of the clinical efficacy and safety of PNS preparations for treating COPD with HCS. The study revealed that PNS preparations considerably improve lung function, hypoxia, and blood hypercoagulability in patients with COPD and HCS without increasing the risk of hemorrhage and has a good safety profile; therefore, it can be used as a new modulating agent and anticoagulant."

Journal • Retrospective data • Chronic Obstructive Pulmonary Disease • Hematological Disorders • Immunology • Pulmonary Disease • Respiratory Diseases

Effectiveness of Administration of Fibrinogen Concentrate as Prevention of Hypofibrinogenemia in Patients with Traumatic Brain Injury with a Higher Risk for Severe Hyperfibrinolysis: Single Center Before-and-After Study. (PubMed, Neurocrit Care) - "Coagulation abnormalities on arrival, severe skull fracture, and multiple trauma are severe HF risk factors. FC administration may contribute to rapid correction of developing hypofibrinogenemia."

Journal • CNS Disorders • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Vascular Neurology

Effectiveness of clotting factor replacement therapy after antivenom treatment on coagulopathic envenomation following green pit viper bites: a retrospective observational study. (PubMed, BMC Emerg Med) - "There is no improvement in coagulopathy profile in patients with T. albolabris and T. stejnegeri bites who received clotting factor replacement after antivenom administration. But the results from GPVs may not be generalized to other species of venomous snakes."

Journal • Observational data • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders