sulfasalazine / Generic mfg. - LARVOL DELTA

Sulfasalazine combined with fruquintinib and sintilimab‌ for ‌third-line or later treatment of advanced pMMR/MSS colorectal cancer: an open-label, single-arm, exploratory study. (ChiCTR) - P2 | N=37 | Not yet recruiting | Sponsor: The First Afliated Hospital of Anhui Medical University; The First Afliated Hospital of Anhui Medical University

New P2 trial • Colorectal Cancer • Oncology • Solid Tumor • MSI

A single-center exploratory study on the efficacy and safety of tetrandrine tablets in the treatment of interstitial lung disease associated with rheumatoid arthritis (ChiCTR) - P=N/A | N=60 | Recruiting | Sponsor: The First Affiliated Hospital of Army Medical University (Southwest Hospital); The First Affiliated Hospital of Army Medical University (Southwest Hos | Not yet recruiting ➔ Recruiting | Initiation date: Aug 2025 ➔ Nov 2025

Enrollment open • Trial initiation date • Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology

Oral lichenoid lesions in association with immunotherapies: a report of two cases and a review of published work. (PubMed, BMC Oral Health) - "This article describes two rare and representative cases related to OLLs induced by immunotherapies to update our knowledge of the drugs used by patients and improve the management, recognition and reporting of oral adverse events."

Journal • Ankylosing Spondylitis • Follicular Lymphoma • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lymphoma • Oncology • Rheumatology • Seronegative Spondyloarthropathies

Letter to the Editor: Short-Term Effectiveness of Sulfasalazine and Tofacitinib in NSAID-Refractory Reactive Arthritis. (PubMed, Int J Rheum Dis) - No abstract available

Journal • Immunology • Rheumatology • Seronegative Spondyloarthropathies

Comparison of the effects of sulfasalazine and synbiotic treatments on the microbiota in a rat model of ulcerative colitis (ESCMID Global 2026) - No abstract available

Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Neuron-Glioma Synapses in Tumor Progression. (PubMed, Biomedicines) - "High functional connectivity within gliomas correlates with shorter patient survival. Therapies such as AMPA receptor antagonists (perampanel), glutamate release modulators (riluzole or sulfasalazine), and chloride cotransporter inhibitors (NKCC1 blockers) aim to improve outcomes for patients."

Journal • Review • Brain Cancer • Cognitive Disorders • Diffuse Midline Glioma • Epilepsy • Glioma • High Grade Glioma • Oncology • Solid Tumor

Progressive resolution of reactive arthritis treated with Upadacitinib. (PubMed, Inflamm Res) - "Conventional therapies, including antibiotics, nonsteroidal anti-inflammatory drugs, corticosteroids, and sulfasalazine, failed to control disease activity. Corticosteroids were tapered and discontinued without relapse, and reduced-dose upadacitinib maintained remission for more than three months. This case highlights the potential role of JAK1 inhibition in ReA pathogenesis and suggests upadacitinib as a promising therapeutic option for refractory disease."

Journal • Conjunctivitis • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Rheumatology • Seronegative Spondyloarthropathies

Hepatotoxicity Risk of Isoniazid in Patients with Autoimmune Rheumatic Diseases and Prior Liver Injury Due to Disease-Modifying Antirheumatic Drugs: A Single-Center Experience and Literature Review. (PubMed, J Clin Med) - "Literature review (19 studies) revealed INH-related hepatotoxicity rates of 1-41%, exacerbated by concurrent methotrexate, sulfasalazine, TNF inhibitors, and prior drug-induced liver injury. INH prophylaxis in R-IMID patients carries substantial hepatotoxic risk. Careful hepatic monitoring and individualized risk stratification are essential to prevent liver injury in immunosuppressed populations."

Journal • Ankylosing Spondylitis • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Psoriatic Arthritis • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Scleroderma • Seronegative Spondyloarthropathies • Spondylarthritis • Systemic Sclerosis • Tuberculosis

Anti-CD19 Chimeric Antigen Receptor T-cell Therapy for Patients with Non-Hodgkin's Lymphoma and Concurrent Autoimmune Disease (TCT-ASTCT-CIBMTR 2026) - "9 pts (37.5%) remained on AID tx at apheresis, including hydroxychloroquine (HCQ) (n=4), sulfasalazine/mesalamine (n=2), and 1 each of prednisone, colestipol, sulfasalazine, and apremilast. In this study of CART for NHL we found no difference in clinical outcomes for pts with AID; we therefore propose that AID should not preclude the use of CART. The majority of pts were able to taper off AID tx prior to CART and HCQ was able to be safely continued throughout CART collection with no effect on efficacy. Our study also highlights the potential effect of CD19 directed CART on pt's AID given the majority of patients remained off AID tx for an extended time post-CART."

CAR T-Cell Therapy • Clinical • Ankylosing Spondylitis • B Cell Non-Hodgkin Lymphoma • CNS Disorders • Dermatology • Dermatomyositis • Gastroenterology • Hematological Disorders • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lymphoma • Myasthenia Gravis • Myositis • Non-Hodgkin’s Lymphoma • Psoriasis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies

CaCO3-assisted engineering of NIR-II phototheranostics enables photothermally enhanced ferroptosis in cancer through synergistically depleting intracellular glutathione. (PubMed, Nanoscale Horiz) - "Herein, we developed a pH-responsive phototheranostic agent (designated as FSB4Ca NPs) by encapsulating conjugated boron dipyrromethene tetramers (B4) within ferric ion-sulfasalazine metallo-network polymer-coated calcium carbonate hollow nanoparticles...Combined with localized 915-nm laser irradiation, intravenously administered FSB4Ca NPs achieved substantial tumor suppression in mouse models, with a complete remission rate of 80%. This study establishes a facile strategy for developing long-circulating NIR-II phototheranostic agents with self-amplified lipid peroxidation induction capacity, enabling photothermally augmented ferroptosis for cancer therapy."

Journal • Oncology

Effect of curcumin on the expression of IL‑36α and IL‑36γ in TNBS‑induced colitis in rats (ECCO-IBD 2026) - "In comparison with the model group, the curcumin and sulfasalazine groups showed decreased IL‑36α and IL‑36γ protein expression in the colonic mucosa, with the curcumin group again exhibiting lower expression than the sulfasalazine group; these differences were statistically significant (F = 3.461, 3.524; P < 0.001). Conclusion Curcumin markedly suppresses the expression of IL‑36α and IL‑36γ in both serum and colonic mucosa of rats with experimentally induced colitis."

Preclinical • Immunology • Inflammatory Bowel Disease

Management of IBD through improving intestinal barrier function by a novel Lactiplantibacillus plantarum C4 strain. (PubMed, Arch Microbiol) - "It also strengthens the intestinal barrier by increasing the expression of tight junction proteins in colon tissue and CaCo2 cell line. The effect of the novel Lactiplantibacillus strain was comparable to sulfasalazine and over performed commercial probiotic preparation."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CAT • CLDN1 • IL6 • OCLN • TJP1 • TNFA

Evaluation of drug-induced lymphocyte stimulation test in mesalazine-associated allergic drug reaction. (PubMed, J Allergy Clin Immunol Glob) - "We aimed to examine the utility of the drug-induced lymphocyte stimulation test (DLST) in predicting successful rotation from mesalazine to sulfasalazine (SASP) in patients with UC...DLST serves as a useful diagnostic tool for guiding treatment in patients with UC and suspected 5-ASA-associated hypersensitivity reactions. Prospective multicenter studies are needed to validate its clinical utility."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Solute Carrier Family 19 Member 1 Mediates Acquired Bortezomib Resistance in Multiple Myeloma Through Chronic Stimulator of Interferon Genes Activation and Mitochondrial DNA Release. (PubMed, Cell Biol Int) - "Acquired drug resistance is a major cause of poor prognosis in multiple myeloma (MM). Treatment with the SLC19A1 inhibitor sulfasalazine or the STING inhibitor H-151 reduced mtDNA release and restored BTZ sensitivity. These findings highlight SLC19A1 and STING signaling as potential therapeutic targets for overcoming acquired drug resistance in MM."

Journal • Hematological Malignancies • Immune Modulation • Immunology • Multiple Myeloma • Oncology • SLC19A1 • STING

Topical 10% sulfasalazine ointment attenuates imiquimod-induced psoriasiform inflammation in mice compared with clobetasol. (PubMed, Inflammopharmacology) - "Topical sulfasalazine was found to possess significant anti-inflammatory activity, both clinical and histological, against IMQ-induced inflammation resembling psoriasis."

Journal • Preclinical • Dermatology • Immunology • Inflammation • Psoriasis • IL6 • TNFA

Drug delivery system based on the novel acidic self-assembling peptide hydrogels: Insights into N-terminal modulation, assembly mechanism, and applications. (PubMed, Colloids Surf B Biointerfaces) - "Among all variants, G(RADA)4 was identified as the optimal candidate, exhibiting high-yield production (25.9 mg/L, 70.6 % recovery rate) and exceptional acid and pepsin-resistance at pH 1.2 over 14 days, rendering them suitable as oral carriers for sulfasalazine and insulin in simulated gastrointestinal environments...Transmission electron microscopy and cryo-scanning electron microscopy analysis revealed that pH-mediated disassembly of nanofibers and loss of porous architecture, transitioning from entangled fibers at pH 2.0 to aggregated short fibers at pH 7.2, accounted for the pH-responsive release behavior of the encapsulated drugs. In conclusion, the acid-stable G(RADA)4 hydrogel system minimized gastric drug loss and enabled targeted intestinal delivery, highlighting its significant potential in gastrointestinal drug delivery."

Journal • Gastrointestinal Disorder

Beyond the Skin: Nail Clues to a Bone Disease. (PubMed, Cureus) - "Most patients respond to nonsteroidal anti-inflammatory drugs, but refractory cases may need corticosteroids, bisphosphonate therapy, or disease-modifying antirheumatic drugs (DMARDs) like methotrexate, sulfasalazine, tumor necrosis factor-alpha (TNF-α) inhibitors, or even anti-interleukin-1 (anti-IL-1) blockers...Treatment with naproxen, topical calcitriol, and methotrexate resulted in complete clinical remission and resolution of nail dystrophy within eighteen months...As reported in the literature, CRMO is often associated with other inflammatory disorders, such as psoriasis, with an estimated prevalence of around 4%. Moreover, a thorough physical examination was essential in this case, allowing the identification of trachyonychia or twenty-nail dystrophy, a potential manifestation of conditions such as alopecia areata, lichen planus, or psoriasis, which may precede cutaneous lesions and, in 1-5% of patients, may be the only manifestation of the disease, making its..."

Journal • Alopecia • Dermatology • Dermatopathology • Immunology • Inflammation • Lichen Planus • Musculoskeletal Pain • Oncology • Orthopedics • Pain • Pediatrics • Psoriasis • Rheumatology

Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyses. (PubMed, Asian J Androl) - "Poor lifestyle habits (obesity, sleep disorders, and smoking), exposure to pollutants and various compounds (carbon disulfide, organophosphates, and lead), the use of medications (sulfasalazine, mesalazine, and selective serotonin reuptake inhibitors), and even some viral infections (severe acute respiratory syndrome coronavirus 2, human papillomavirus, and hepatitis viruses) were associated with decreased semen quality...An increasing number of factors are associated with infertility; however, some of the aforementioned studies lack verification of causal relationships. Future studies need to be well designed to further confirm these relationships."

Journal • CNS Disorders • Diabetes • Endocrine Disorders • Genetic Disorders • Immunology • Infectious Disease • Infertility • Inflammation • Inflammatory Arthritis • Lupus • Metabolic Disorders • Novel Coronavirus Disease • Obesity • Oncology • Respiratory Diseases • Sexual Disorders • Sleep Disorder • Systemic Lupus Erythematosus • Type 1 Diabetes Mellitus

Probiotic-drug co-delivery system enhances sulfasalazine activation for inflammatory bowel disease therapy. (PubMed, Mater Today Bio) - "On the other hand, CB modulates the disordered gut microbiota. This provides a new strategy for integrating probiotic therapy with pharmacological treatment in the management of IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Mucositis

A Biomimetic Manganese Complex Synergistically Disables Antioxidant Defenses and Amplifies Oxidative Stress to Potentiate Ferroptosis in Hepatocellular Carcinoma. (PubMed, Adv Healthc Mater) - "The complex undergoes glutathione (GSH)-triggered disassembly within tumor cells, releasing Mn2+ ions and sulfasalazine (SAS)...Furthermore, the GSH-responsive release of Mn2+ enables activatable T1-weighted magnetic resonance imaging, allowing real-time monitoring of treatment response. Our work presents an integrated theranostic strategy that combines precise ferroptosis induction with non-invasive imaging, offering a promising approach for the management of advanced HCC."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • GPX4

Tofacitinib Use in a Patient With Rheumatoid Arthritis and Polycythemia Vera: A Case Report. (PubMed, Clin Case Rep) - "Treatment for polycythemia vera included hydroxyurea. Methotrexate and sulfasalazine were prescribed for rheumatoid arthritis but were withdrawn due to intolerance, and therapy was switched to tofacitinib 5 mg twice daily...After 12 months of therapy, RA remission persisted without adverse events or cytopenias. Tofacitinib demonstrated rheumatologic efficacy but minimal effect on PV-related hematologic activity."

Journal • Cardiovascular • Hematological Disorders • Immunology • Inflammatory Arthritis • Myeloproliferative Neoplasm • Oncology • Polycythemia Vera • Rheumatoid Arthritis • Rheumatology • JAK1 • JAK2

Protective Effects of Herbacetin in Experimental Colitis: Targeting NF-κB and NLRP3 Pathways. (PubMed, Drug Dev Res) - "Mice were administered with herbacetin (25, 50, 100 mg/kg) or sulfasalazine (100 mg/kg) orally for 7 days...Herbacetin decreased the mRNA expression levels of NF-κB, iNOS, COX-2, NLRP3, IL-1β, and IL-18 in a dose-dependent (p < 0.05-0.001). Herbacetin exerts a protective effect in colitis by suppressing neutrophil infiltration, oxidative stress, and NF-κB-NLRP3-mediated inflammation, highlighting the potential of herbacetin-based treatment for UC and related inflammatory bowel diseases."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • IL18 • IL1B • NFKB1 • NLRP3

Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report. (PubMed, In Vivo) - "This case suggests molecular hydrogen therapy as a potential adjuvant for refractory Rhupus with multiple drug intolerances, showing immune modulation, reduced inflammation, steroid withdrawal, and sustained control with low-dose rituximab. Further studies are needed to confirm its efficacy and standardize its use."

Journal • Glomerulonephritis • Immune Modulation • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Orthopedics • Rheumatoid Arthritis • Rheumatology • Systemic Lupus Erythematosus

Navigating the Misdiagnosis of Pityriasis Rubra Pilaris and Successful Treatment With Guselkumab: A Case Report of Dual Biologic Therapy. (PubMed, Cureus) - "The patient had failed topical steroids, topical calcineurin inhibitors, sulfasalazine, and methotrexate. He had a past medical history of asthma treated with dupilumab...It underscores the importance of accurate diagnosis through biopsy and demonstrates the feasibility of concurrent biologic therapies for managing comorbid inflammatory conditions. Further research is needed to optimize biologic treatment strategies and enhance understanding of dual biologic use in complex dermatologic cases."

Journal • Asthma • Dermatology • Immunology • Psoriasis • Pulmonary Disease • Respiratory Diseases

Carbutamide, an Obsolete Anti-Diabetic Drug, Has Potential as a Potent Anticolitic Agent via Azo-Conjugation with Mesalazine. (PubMed, Pharmaceutics) - "Additionally, oral administration of CAA and Sulfasalazine (SSZ), a colon-specific prodrug of 5-ASA currently used for IBD treatment, resulted in similar levels of 5-ASA accumulation in the rat cecal region...The two drugs also jointly suppressed valacyclovir uptake via peptide transporter 1 (PepT1) in the distal colon, supporting PepT1 as a target contributing to their combined anticolitic effect. Unlike CBT, which significantly reduced blood glucose following oral administration, equimolar administration of CAA did not alter glycemic levels, consistent with reduced systemic exposure to CBT. In conclusion, CAA functions as a colon-specific mutual prodrug that surpasses SSZ in anticolitic performance while minimizing hypoglycemia risk, thus facilitating the repurposing of CBT as a treatment for IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Hypoglycemia • Immunology • Inflammation • Inflammatory Bowel Disease