Humulin N (isophane insulin) / Eli Lilly - LARVOL DELTA

Impact of insulin storage and syringe reuse on insulin sterility in diabetes mellitus patients in Mwanza Tanzania. (PubMed, Sci Rep) - "Contaminated products included Humulin R, Humulin N, and Biosulin 30/70. Improper storage practices, such as immersing vials in water or a mixture of water and sand within clay pots expose insulin to microbial contamination, which increases the risk of infections. To ensure safety and effectiveness patients should be educated to follow the manufacturer's storage guidelines."

Journal • Diabetes • Infectious Disease • Metabolic Disorders

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin (clinicaltrials.gov) - P4 | N=22 | Completed | Sponsor: Université NAZI BONI | Recruiting ➔ Completed

Trial completion • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model. (PubMed, ACS Pharmacol Transl Sci) - "We then examined the influence of a commercial insulin analogue (Humulin-N) using an in vitro macrophage-material model, which uses adsorbed fibroblast lysate (containing damage-associated molecular patterns) to activate macrophages and recapitulates macrophage responses on implanted biomaterials...Additionally, high insulin concentrations arising from therapeutic doses induced macrophage apoptosis with and without adsorbed lysate. This study contributes to emerging evidence that infused insulin affects the tissue response to IIS."

Journal • Preclinical • Diabetes • Inflammation • Metabolic Disorders • Type 1 Diabetes Mellitus

SUPRAPHYSIOLOGICAL INSULIN CONCENTRATIONS AT INFUSION SITES ENHANCE PRO‐INFLAMMATORY RESPONSE IN MOUSE MACROPHAGES IN AN IN VITRO CELL‐BIOMATERIAL INTERACTION MODEL (ATTD 2024) - "Supraphysiological insulin concentrations amplified the mouse macrophage response to pro-inflammatory stimuli in an in vitro cell-material interaction model."

Preclinical • Inflammation

P-13 Topical insulin eye drops in infective keratitis. (PubMed, BMJ Open Ophthalmol) - "Insulin eye drops may be helpful in cases of post-infective keratitis ED and non-concomitant use of any other drops, which may interfere or cause epithelial toxicity."

Journal • Herpes Simplex • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin (clinicaltrials.gov) - P4 | N=20 | Recruiting | Sponsor: Université NAZI BONI | Not yet recruiting ➔ Recruiting | N=30 ➔ 20

Enrollment change • Enrollment open • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Functional Hypogonadotropic Hypogonadism and Failure to Thrive in a Poorly Controlled Type 1 Diabetes Patient (ENDO 2023) - "He had reportedly been using a family member's Tresiba and over the counter Humulin in the interim...A growth hormone stimulation test (with clonidine and arginine) was performed outpatient... We report this case to highlight that although uncommon in the developed world, delayed puberty and growth failure are known but rare complications of poorly controlled type 1 diabetes.*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. Abstracts presented at a news conference are embargoed until the date and time of the news conference."

Clinical • Celiac Disease • Diabetes • Endocrine Disorders • Growth Hormone Deficiency • Growth Hormone Deficiency (Adult) • Hepatology • Immunology • Metabolic Disorders • Nephrology • Obesity • Renal Disease • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • IGF1 • IGFBP3

P-13 Topical insulin eye drops in infective keratitis. (PubMed, BMJ Open Ophthalmol) - "Insulin eye drops may be helpful in cases of post-infective keratitis ED and non-concomitant use of any other drops, which may interfere or cause epithelial toxicity."

Journal • Herpes Simplex • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: Université NAZI BONI | Trial completion date: Dec 2023 ➔ May 2024 | Initiation date: Mar 2023 ➔ Jun 2023

Trial completion date • Trial initiation date • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: Université NAZI BONI

New P4 trial • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus

Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin N with US-licensed Humulin® N formulation in healthy subjects: Results from the RHINE-2 (Recombinant Human INsulin Equivalence-2) study. (PubMed, Diabetes Obes Metab) - "PK and PD equivalence was demonstrated between Biocon's Insulin-N and Humulin-N in healthy subjects and both treatments were well tolerated and considered safe."

Journal • PK/PD data • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

"Eli Lilly's Humulin N is literally $25 bucks in my country. What's wrong with the US???" (@DerSchneewolf9)

TREAT-TO-TARGET TRIAL OF CONTINUOUS SUBCUTANEOUS INSULIN-PUMP THERAPY IN NEW-ONSET DIABETES AFTER TRANSPLANTATION (SAPT-NODAT) (ESOT 2021) - P3 | "Materials and KTRs without previous diabetes were randomized 1:1:1 into CSII (insulin lispro [Humalog], applied with a MiniMed Paradigm Veo pump) versus BI (intermediate-acting insulin isophane [Humulin N]) versus CTR. Early postoperative glycemic control using CSII therapy was safe but did not prevent an increase in HbA1c. Development of PTDM at month 12 was similar in all 3 groups, but results from a larger clinical trial (ITP-NODAT, NCT03507829) have previously indicated that BI can prevent PTDM incidence in patients who adhere to the protocol."

Diabetes • Hypoglycemia • Metabolic Disorders • Transplantation

Afrezza® INHALE-1 Study in Pediatrics (clinicaltrials.gov) - P3; N=264; Not yet recruiting; Sponsor: Mannkind Corporation

New P3 trial • Diabetes • Metabolic Disorders • Pediatrics • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

"@lillypad cuando van a abastecer de Humulin N ???" (@daedmonte59)

Comparison Study of Insulin Glargine and NPH Insulin (clinicaltrials.gov) - P4; N=0; Withdrawn; Sponsor: Providence Health & Services; N=500 ➔ 0

Clinical • Enrollment change

"Do you offer a savings card for humulin-n for pets? Even with goodrx at Walmart its still $96.75" (@DogDutchy)

Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia (clinicaltrials.gov) - P4; N=3; Terminated; Sponsor: Northwestern University; N=50 ➔ 3; Trial completion date: Dec 2020 ➔ Aug 2019; Recruiting ➔ Terminated; Trial primary completion date: Mar 2020 ➔ Aug 2019; Unable to recruit sufficient number of patients

Enrollment change • Trial completion date • Trial primary completion date • Trial termination