chlorogenic acid / Jiuzhang Biotech - LARVOL DELTA

Carob Tree: A Review of Traditional Uses, Medicinal Properties, and Future Perspectives in Sustainable Forestry. (PubMed, Life (Basel)) - "Recent studies indicate that carob is a rich source of bioactive compounds, particularly phenolic acids and flavonoids such as gallic acid, chlorogenic acid, ellagic acid, catechins, quercetin, and luteolin...The review further addresses the ecological and socio-economic relevance of carob cultivation, particularly in countries such as Algeria, where reforestation and agro-industrial valorization remain underexploited despite their significant economic potential. Overall, this work highlights the need for a comprehensive and critical evaluation of carob-derived bioactive compounds and encourages further well-designed studies, especially clinical investigations, to better substantiate their health-related benefits while supporting sustainable use of this multipurpose species."

Journal • Review

Brewed Coffee and Its Components Act Through Orphan Nuclear Receptor 4A1 (NR4A1). (PubMed, Nutrients) - " Brewed coffee and several polyphenolics, including caffeic acid, ferulic acid, chlorogenic acid, p-coumaric acid, several cinnamic acid derivatives, kahweol, and cafestrol, bound NR4A1 in binding assays, and most Kd values were <10 µM... The results of this study demonstrate that brewed coffee and its major polyphenolics and polyhydroxy constituents are NR4A1 ligands and that NR4A1 may play an important role in the health-protective effects of coffee. These results, coupled with recent studies, indicate that NR4A1 and its ligands may play an important role in diet and health."

Journal • Oncology • NR4A1

Efficient recovery of chlorogenic acid and rutin from Ficus erecta leaves using liquid carbon dioxide-ethanol-water extraction with and without ultrasonic irradiation. (PubMed, Ultrason Sonochem) - "The results demonstrate compound-specific ultrasound effects: CGA extraction remains partially diffusion-limited, while rutin recovery is primarily dictated by equilibrium solubility in the CO2-ethanol-water system. These findings provide a thermodynamically supported framework for solvent-composition-driven optimization of green high-pressure extraction processes."

Journal

Anticariogenic Potential of Coffee in Adolescents: A Retrospective Exploratory Cohort Study. (PubMed, Children (Basel)) - "Coffee contains bioactive compounds, including chlorogenic acid and trigonelline, which have demonstrated antimicrobial and anticariogenic properties... Within the limitations of this retrospective exploratory design, habitual coffee consumption, particularly that of unsweetened coffee, was associated with lower caries increment. These findings are hypothesis-generating and require confirmation in prospective studies with standardized exposure assessment and biological outcome measures."

Journal • Retrospective data • Dental Disorders

Encapsulation of Bee Pollen Phenolics with β-Cyclodextrin: Effects on Antioxidant Activity, Antimicrobial Properties, and Digestive Stability. (PubMed, Foods) - "Phenolic profiling showed that chlorogenic acid and quercetin derivatives remained relatively stable throughout digestion. Overall, encapsulation with BCD effectively safeguarded pollen phenolics, improved their gastrointestinal stability, and increased bioaccessibility, highlighting the potential of encapsulated bee pollen as a functional food ingredient or nutraceutical."

Journal • Infectious Disease

Preliminary Anti-Melanoma Activity of a Chlorogenic Acid-Based PROTAC Targeting MDM4, a Candidate Protein Identified by Proteomics. (PubMed, Foods) - "These compounds incorporated the natural product CGA as the target-binding ligand, conjugated to pomalidomide (an E3 ligase-recruiting moiety) via various synthetic linkers. This study successfully applied an effective strategy for target identification and medication discovery of natural compounds. In addition, CGA-PROTAC A7 was synthesized in one step with an overall yield of 45.96%, providing a feasible route for synthesis and establishing a basis for the combination of natural product polyphenols with PROTAC technology."

Journal • Melanoma • Oncology • Solid Tumor • Targeted Protein Degradation • CDKN1A • MDM4

Cynara cardunculus subsp. cardunculus (Wild Artichoke) Extract: Antimicrobial Activity and Cytotoxicity, Apoptosis Induction, and Chemosensitization in Colon Cancer Cells. (PubMed, Biology (Basel)) - "Additionally, CCE demonstrated synergistic effects with 5-FU (combination index < 0.8). This evidence suggests that CCE exhibits selective antitumor activity and chemosensitizing properties, supporting its possible development as an adjunctive agent in CRC therapy."

Journal • Addiction (Opioid and Alcohol) • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CASP3

Stress-Associated Phenylpropanoid Metabolism and Nutritional Composition in Wild vs. MeJA-Elicited In Vitro Hypericum perforatum and Portulaca oleracea. (PubMed, Metabolites) - "Overall, the data indicate that wild-growing plants accumulate higher levels of key phenylpropanoids than MeJA-elicited in vitro cultures, underscoring the complexity of reproducing natural stress-associated metabolic patterns under controlled conditions."

Journal • Preclinical

Hydrogen Peroxide-Oxidative Signaling Enhances Biosynthesis of Specialized Metabolites in Baccharis conferta Kunth. (PubMed, Int J Mol Sci) - "Chemical analysis revealed that five compounds, including chlorogenic acid, differed significantly across treatments...Overall, these results suggest that moderate H2O2 levels function as a signaling molecule in B. conferta, simultaneously boosting phenolic and terpene pathways. This highlights controlled H2O2 elicitation as an effective biotechnological approach to increase the production of valuable metabolites in medicinal plant cultures."

Journal

Echinophora tenuifolia L. subsp. sibthorpiana Modulates Stress Response and Mitochondrial Quality Under Glucose Stress in Caenorhabditis elegans. (PubMed, Antioxidants (Basel)) - "The characterization of the extract by NMR spectroscopy and HPLC-PDA revealed the presence of secondary metabolites, with rutin being the most abundant phenolic compound identified in the extract, alongside the presence of chlorogenic acid, ferulic acid, rosmarinic acid, caffeic acid, p-coumaric acid, and salicylic acid...These findings indicate that E. tenuifolia extract possesses potential beneficial effects on metabolic and mitochondrial health under glucose-induced stress conditions. These observations are likely mediated by the synergistic phenolic composition of the extract, and reveal E. tenuifolia as a promising source of bioactive compounds relevant to aging and preventive strategies for cardiometabolic health."

Journal • Cardiovascular • Genetic Disorders • Obesity

Intestinal oxidative stress mitigation and transepithelial anti-inflammatory bioactivity mediated by EtOH-modified supercritical-CO2 coffee pulp extract. (PubMed, Food Funct) - "Bioinformatic analysis revealed that protocatechuic acid, chlorogenic acid, and caffeine metabolites potentially inhibit NF-κB-driven signaling. These results demonstrate that coffee pulp extracts obtained through EtOH-modified sc-CO2 extraction exhibit substantial bioavailability and bioactivity, reinforcing their potential application as functional food ingredients for the prevention of chronic diseases."

Journal • Inflammation • Inflammatory Bowel Disease • CCL2 • IL10 • IL1B • IL1R1 • IL6 • TNFA

The Potential of Chlorogenic Acid in Regulating Oxidative Damage, Lipid Metabolism, and Inflammation in Chickens: A Comprehensive Review. (PubMed, Vet Sci) - "This review summarizes current evidence on the effects of major stressors under intensive farming conditions on lipid metabolic homeostasis, redox balance, and immune regulatory networks, with particular emphasis on the supplementation strategies and physiological effects of chlorogenic acid (CGA) in chickens. Available studies indicate that CGA may regulate lipid metabolic homeostasis through adenosine monophosphate-activated protein kinase (AMPK)-related signaling pathways, enhance antioxidant defenses mediated by nuclear factor erythroid 2 related factor 2 (Nrf2), and suppress inflammatory responses associated with nuclear factor κB (NF-κB), thereby contributing to protective regulation at multiple levels."

Journal • Review • Inflammation • Metabolic Disorders

Alleviation of nonalcoholic steatohepatitis induced by tetracycline in rats by Coffee Arabica extract through autophagy signals (mTOR/LC3-B). (PubMed, Sci Rep) - "The autophagy mechanism is a key point for liver protection against nonalcoholic steatohepatitis (NASH). Docking study showed that chlorogenic acid has binding energy  - 7.554 favorable to mTOR than ATP-γS. We concluded that CAME stimulated a protective mechanism against NASH via LC3B and mTOR modulation which should attract further research to confirm our results and fully understand its mechanism of induction."

Journal • Preclinical • Hepatology • Metabolic Dysfunction-Associated Steatohepatitis

Formulation and analysis of probiotic Bacillus licheniformis MCC 2514 infused osmo dried carrot. (PubMed, J Food Sci Technol) - "Chlorogenic acid and the other five major polyphenols were detected in both dried samples...The data obtained from this study suggest that B. licheniformis has excellent viable stability when supplemented with an osmo-dried carrot. The online version contains supplementary material available at 10.1007/s13197-025-06245-8."

Journal

Pharmacokinetic-pharmacodynamic modeling of Laportea bulbifera extract in adjuvant-induced arthritis rats via joint cavity microdialysis. (PubMed, J Pharm Biomed Anal) - "Based on half maximal inhibitory concentration, the inhibitory potency of the five components against the four biomarkers was ranked as follows: kaempferol-3-O-rutinoside > neochlorogenic acid > rutin > chlorogenic acid > cryptochlorogenic acid. The effect compartment model revealed a linear relationship between RF and multiple components, underscoring RF's potential role as a key therapeutic target in the joint cavity. This study represents the first systematic elucidation of the local PK-PD characteristics of LBE, providing a scientific basis for developing this Miao medicinal herb and its clinical application in rheumatoid arthritis."

Journal • PK/PD data • Preclinical • Immunology • Inflammatory Arthritis • Oncology • Rheumatoid Arthritis • Rheumatology • IL1B • IL6 • TNFA

Digestive performance differences between lotus seed starch-chlorogenic acid inclusion and non-inclusion complexes: Comparative analysis of static and dynamic high-pressure preparation systems. (PubMed, Int J Biol Macromol) - "This study revealed the mechanisms by which static and dynamic pressures influence digestive pathways through the regulation of complex types. This provides a theoretical basis for the precise design of functional foods with low glycemic index properties."

Journal

Evaluation of allelopathic potentialities of an invasive taxon, Mesosphaerum suaveolens (L.) Kuntze, and bio-assay-guided identification of the involved allelochemicals. (PubMed, Sci Rep) - "Chlorogenic acid (- 6.24 and - 6.32 kcal/mol) interacted prominently with tryptophan synthase β-subunit (PDB: 5DW3) and auxin-binding protein 1 (PDB: 1LRH), while caryophyllene oxide (-6.91 kcal/mol) modulated the activity of 4-hydroxyphenylpyruvate dioxygenase (PDB: 6J63). The present findings firmly establish the allelopathic potential of the invasive herb M. suaveolens as a robust, eco-friendly bioherbicide and provide clear direction for the sustainable management of the alien species."

Journal • CAT

Integrated LC-ESI-MS/MS and Chemometric Profiling of Carduus pycnocephalus subsp. albidus: Linking Phenolic Diversity to Antioxidant and Enzyme Inhibitory Potentials. (PubMed, Chem Biodivers) - "Twenty-three phenolic compounds were quantified, with chlorogenic acid (9452-9840 µg/g), hesperidin (3678-4069 µg/g), and hyperoside (1028-1145 µg/g) as major constituents...These results identify C. pycnocephalus subsp. albidus as a phenolic-rich thistle exhibiting extraction-dependent chemical and biofunctional diversity."

Journal • Tyrosinase

Glucose/ROS-responsive and redox-gated adaptive hydrogel dressing for accelerating diabetic wound repair via synergistic cGAS/STING pathway inhibition and oxidative stress alleviation. (PubMed, Bioact Mater) - "In this study, we developed a glucose/ROS-responsive hydrogel dressing (SG) employing dynamic crosslinking via boronate ester between chlorogenic acid (CGA)-conjugated gelatin and sodium alginate functionalized with 3-aminophenylboronic acid...The HPSL@SG hydrogel collectively enhances angiogenesis, evidenced by a 6.6-fold increase in CD31 levels and a 7.3-fold increase in VEGF levels, while also facilitating collagen deposition, with collagen content escalating from 32.6% to 69.3%. This procedure culminates in an 89.7% recovery within 10 days and nearly complete wound healing within 14 days, indicating its potential for clinical application in diabetic wound healing."

Journal • Diabetes • CD31 • IL10 • IL6 • PECAM1 • TNFA

Comparative metabolome and metallomic analyses of three organs from Cistus creticus. (PubMed, Planta) - "Other secondary metabolites, such as cistusin, chlorogenic acid, nicotinic acid, and punicalin, were most abundant in the flowers. We have identified metabolites with different beneficial activities in C. creticus and demonstrated that their levels greatly vary depending on the type of organ they are present in. These findings indicate that organ-specific enrichment of bioactive metabolites could inform targeted therapeutic development for diabetes, infections, and inflammatory disorders."

Clinical • Journal • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Pain

THE EFFECTIVENESS OF MORINGA OLEIFERA LEAF ON KIDNEY DAMAGE REPAIR ALBUMINURIA IN DIABETIC KIDNEY DISEASE (ISN-WCN 2026) - "It contains crypto-chlorogenic acid, quercetin 3-O-glucoside and kaempferol 3-O-glucoside that have antioxidant and antiinflammation effect to repair endothelial damage in glomerulus, decrease albuminuria levels...After that, albuminuria levels was checked again.Results Groups 2 and 3 decreased albuminuria levels compared to group 1, and the one that lowered albuminuria the most was group 3. The combination group of calcitriol and Moringa oleifera leaf extract best lowered levels of albuminuria (-4.18; p ≤ 0.001).Download: Download high-res image (186KB)Download: Download full-size imageDownload: Download high-res image (128KB)Download: Download full-size imageConclusion Moringa oleifera leaf extract lower albuminuria levels in male Sprague dawley mice in a DKD model"

Cardiovascular • Chronic Kidney Disease • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease

Therapeutic potential of Qihuang Biwen Formula and its bioactive compounds for the treatment of ulcerative colitis in Drosophila and mice. (PubMed, Phytomedicine) - "QHBWF exerted anti-colitis effects by regulating immunity and metabolism, targeting the TLR4/NF-κB signaling pathway and mitochondrial oxidative phosphorylation. Kaempferol, emodin, quercetin, isochlorogenic acid, and chlorogenic acid were the bioactive compounds of QHBWF against UC. This study provides the potential of QHBWF as a multi-target treatment for UC."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis • IL1B • IL6 • MYD88 • SDHB • TLR4

Investigation of in vitro antibacterial, antiglycation, and antioxidant activities of selamectin/chlorogenic acid system and their interaction with immunoglobulin G. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "In addition, the antiviral potential of CGA and SEI was preliminary predicted by molecular docking, and their strong binding to SARS-CoV-2 main protease (Mpro) may indicate the good antiviral activity of the drug combination. It is expected to provide theoretical support for developing more efficient antibacterial and antiviral drugs by the results of this research, and for rational drug co-administration in treating specific diseases."

Journal • Preclinical • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Kinetics of dissolution and computational modeling of calcium oxalate monohydrate crystals in the presence of aqueous coffee bioactive extract compounds. (PubMed, Sci Rep) - "LC-LTQ-MS/MS and NMR profiling identified chlorogenic acids, quinic acid derivatives, and caffeine as the principal constituents...FTIR, SEM, EDX, and XRD analyses confirmed physical adsorption without altering crystal structure. These findings suggest that coffee metabolites act as natural modulators of COM behavior, offering promising insights into urolithiasis prevention."

Journal • Renal Calculi • Urolithiasis

Healing mechanism of PSO on deep second-degree burn wounds in a porcine model. (PubMed, J Ethnopharmacol) - "UHPLC-MS analysis identified potential active constituents in PSO. PSO improved burn wound healing, as shown by wound closure rates, histological staining, immunohistochemistry, ELISA, and WST-8 assays. It reduced inflammation and oxidative stress. It also supported skin tissue regeneration. The study identifies both the active components of PSO and its pharmacological actions in burn wound healing."

Journal • Preclinical • Inflammation • Pain • Thermal Injury • IL1B • IL6 • TGFB1 • TNFA