chlorogenic acid / Jiuzhang Biotech - LARVOL DELTA

Bio-Based Potential of Phenolic-Rich Fabaceae Seeds (Gonocytisus angulatus, Podocytisus caramanicus): Chemical Standardization, Functional Screening, and Molecular Insights. (PubMed, Chem Biodivers) - "Phytochemical analysis revealed that flavonoids and phenolic acids were the dominant constituents, with chlorogenic acid, rutin, quercetin, kaempferol, and gallic acid as the major compounds, particularly enriched in methanolic extracts...In contrast, antioxidant activity was more pronounced, with ABTS radical scavenging reaching 97.40%, comparable to the reference standard. Molecular docking supported these findings by indicating favorable binding interactions of major phenolic compounds with target enzymes."

Journal • Pain

Liposomes, Niosomes, Ethosomes, and Transethosomes for Curcumin and Chlorogenic Acid Delivery: Formulation Design and Dermal Performance. (PubMed, Antioxidants (Basel)) - "Future progress requires quality-by-design strategies, standardized characterization, predictive skin models, long-term stability and safety studies, and scalable manufacturing. Overall, antioxidant-loaded vesicles represent multifunctional platforms for developing stable and effective pharmaceutical and cosmetic products."

Journal • Review • Oncology

Bioactive Phenolics from Medemia argun: Biological Activities, Molecular Docking, Encapsulation in Alginate-Whey Protein Hydrogel Beads, and Functional Yoghurt Fortification. (PubMed, Antioxidants (Basel)) - "Molecular docking revealed favorable interactions of rutin, chlorogenic acid, and rosmarinic acid with the HAV 3C protease. SAlg/WP beads achieved 78.92% encapsulation efficiency, while FTIR and SEM confirmed successful phenolic entrapment. Encapsulation effectively preserved MAPE functionality and significantly enhanced yoghurt antioxidant activity during storage, demonstrating its potential for functional dairy applications."

Journal • Infectious Disease • Inflammation

Untargeted Metabolomic and Phytochemical Profiling of Berberis crataegina DC. Plant Parts: Antidiabetic Potential and Cytoprotection in High-Glucose-Exposed SH-SY5Y Cells. (PubMed, Pharmaceuticals (Basel)) - "Chlorogenic acid, rutin, caffeic acid, protocatechuic acid, quercetin, and quercetin-3-O-glucoside were detected and quantified in the fruit extract by HPLC-DAD...The findings suggest that these effects may arise from the combined contribution of multiple constituents within a polyphenolic matrix rather than from a single compound; however, synergistic interactions were not experimentally demonstrated. These results support further evaluation of the fruit extract through mechanistic, in vivo, and standardization studies."

Journal • Diabetes • Diabetic Neuropathy • Pain

Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction. (PubMed, Antioxidants (Basel)) - "Targeted LC-MS/MS quantified five phenolic constituents, with p-coumaric acid (1599.71 µg/g), chlorogenic acid (871.43 µg/g), and ferulic acid (285.50 µg/g) being the most abundant. Overall, these findings support the further investigation of silkworm feeding waste as a feedstock for thermochemical valorization into chemically and biologically evaluable bio-based fractions."

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Effects of Chlorogenic Acid-Rich Eucommia ulmoides Extract Supplementation During Late Gestation and Lactation on Maternal Health, Colostrum Composition, and Neonatal Intestinal Development. (PubMed, Antioxidants (Basel)) - "These findings suggest that maternal CAE supplementation enhances maternal antioxidant status, alters placental microvascular morphology, modifies colostrum composition, and improves neonatal metrics and postnatal intestinal development. Because CAE supplementation spanned both late gestation and lactation, the relative contributions of gestational versus lactational exposure cannot be isolated; the functional significance of observed microbiota and metabolomic shifts requires further investigation through temporally partitioned experimental designs."

Journal • CAT

Organ-Specific Phenolic Profiles, Antioxidant Capacity, and Enzyme-Inhibitory Activities of the Turkish Endemic Origanum bilgeri. (PubMed, Pharmaceuticals (Basel)) - "Under the present assay conditions, all organ extracts yielded lower α-glucosidase IC50 values (0.97-1.10 mg/mL) than acarbose (1.16 mg/mL). The root was particularly characterized by high verbascoside and chlorogenic acid contents, elevated total phenolic content, strong antioxidant performance across several assays, and α-glucosidase inhibitory activity. These findings support further investigation of O. bilgeri, particularly its root, using independent biological replicates and complementary phytochemical and biological approaches."

Journal • Tyrosinase

Synergistic Antimicrobial and Antibiofilm Activity Optimization of a Thymus vulgaris-Moringa oleifera-Echinacea purpurea Ternary Ethanolic Extract Blend Against Candida albicans and Streptococcus mutans Using L-Optimal Mixture Design. (PubMed, Microorganisms) - "Through HPLC, apigenin, chlorogenic acid, resorcinol, and ferulic acid were identified as dominant constituents...oleifera-E. purpurea blend as a synergistic, multi-target antimicrobial candidate with a favorable preliminary safety profile, supporting further development and evaluation against clinical isolates for oral fungal and bacterial infections."

Journal • Infectious Disease

Carboxyl Amidation of Chlorogenic Acid Improves Anti-Inflammatory Activity and Biosafety via Potent AKR1B1 Inhibition in LPS-Induced Macrophages. (PubMed, Molecules) - "Molecular docking revealed that the newly introduced amide forms an additional hydrogen bond with ILE-260, enhancing ligand-target affinity. This carboxyl-amidation strategy simultaneously improves the cellular safety and AKR1B1 inhibitory potency of CGA, providing a rational approach for developing low-toxicity polyphenol-based anti-inflammatory leads."

Journal • Inflammation • AKR1B1 • IL6 • TNFA

Effects of Colchicine Treatment on Bioactive Compounds and Structural Characteristics of the Epidermis and Cortex of Edible Cactus [Opuntia ficus-indica (L.) Mill.] Cladodes at Different Maturity Stages. (PubMed, Foods) - "HPLC analysis further revealed marked increases in chlorogenic acid (6.25-fold), gentisic acid (3.47-fold), and gallic acid (63.9%), while rutin and apigenin were the predominant flavonoids. Pearson's correlation and heatmap analyses further revealed positive associations among phenolic compounds, flavonoids, and antioxidant activities. These findings indicate that colchicine concentration and maturity stage were associated with distinct patterns of metabolite accumulation and antioxidant activity in edible cactus cladodes, supporting their potential application as functional food ingredients."

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Synergistic Orchestration of Chlorogenic Acid Analogs in Sugarcane Molasses Polyphenols for Sucrase Inhibition: Insights into a Multilevel Inhibitory Mechanism. (PubMed, Foods) - "Mechanistically, CA and NA exhibited competitive inhibition, whereas MC and SMPE showed mixed-type inhibition; fluorescence, CD, and thermal stability analyses revealed compound-dependent changes in aromatic residue microenvironments, secondary structure, and protein stability, while molecular modeling predicted peripheral binding of CA/NA and catalytic-region interactions of MC, suggesting distinct but complementary routes for perturbing substrate recognition and catalysis. This study provides mechanistic insight into the synergistic inhibition of sucrase by SMPE and supports its potential development as a natural agent for modulating postprandial glycemia."

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Comparative Elicitation of Phenolic Accumulation in Salvia officinalis Hairy-Root Cultures Using Salicylic Acid, Silver Nitrate, LED Spectra, and Microbial Preparations. (PubMed, Biology (Basel)) - "Within the chemical-elicitation series, AgNO3 produced the strongest response, increasing total phenolic content by 39.2% after 7 days compared with the untreated control and inducing an approximately three-fold increase in rosmarinic acid, together with elevated levels of caffeic, syringic, and chlorogenic acids...These results demonstrate that elicitor type, dose, and exposure time critically determine phenolic accumulation specificity. AgNO3, blue and red LED illumination, and B. velezensis cell-free supernatant were identified as promising individual treatments in their respective experimental series; however, combined-treatment effects and possible synergism require confirmation in a factorial experiment."

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Phytochemical Profiling (Phenolics and Carotenoids) and Antioxidant Potential of Apple, Plum, Carrot, and Beetroot Juice Pomaces: Towards Sustainable Food Ingredients. (PubMed, Foods) - "Apple pomace provided a carbohydrate-rich matrix (77.71 ± 0.65% dw) featuring positively identified chlorogenic acid (463.16 ± 0.35 μg/g dw) and tentatively identified dihydrochalcones. These findings support the targeted valorization of these pomaces as functional food ingredients within a circular bioeconomy framework."

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Gaultheria Berries as Potential Functional Foods: Phytochemical Composition, Health-Promoting Properties, and Nutritional Potential. (PubMed, Nutrients) - "Current evidence suggests that Gaultheria berries represent underutilised sources of structurally diverse bioactive compounds that warrant further investigation as potential food and nutraceutical ingredients. However, their health-promoting effects in humans remain unestablished. Future research should prioritise comprehensive metabolomic profiling, standardisation of phytochemical composition, bioavailability and safety assessment, in vivo validation, and controlled human studies before specific health benefits or therapeutic applications can be substantiated."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Inflammation • Pain

Solvent-Dependent Phenolic Profiling and Bioactivities of Medicago marina L.: An Ultrasound-Assisted Extraction Approach. (PubMed, Molecules) - "LC-MS/MS profiling showed distinct phenolic compositions between the investigated extraction batches: the water extract contained higher levels of ferulic acid, apigenin, and several hydroxybenzoic acid derivatives, whereas the methanol extract was enriched in hyperoside, hesperidin, chlorogenic acid, and other flavonoid derivatives...Yield normalization to the initial dry plant material altered the relative performance of the two extraction batches in several assays because of the higher water extraction yield. These findings show that extract-level enrichment and yield-normalized activity provide complementary perspectives on the phytochemical and biological characteristics of the specific M. marina extraction batches investigated."

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Polyphenolic Fingerprint, Inter-Population Variability and Botanical Authentication of Wild Polygonum aviculare L. from Northwestern Romania. (PubMed, Molecules) - "Chlorogenic acid and rutin were confirmed using authentic reference standards, whereas the remaining compounds were tentatively annotated...Exploratory analysis indicated a general tendency toward lower phenolic content along a lowland-to-mountain environmental gradient characterized by increasing altitude and precipitation and decreasing mean annual temperature, although the total content was not significantly correlated with altitude. This pronounced inter-population variability underlines that wild-harvested PAV cannot be assumed uniform, highlighting the need for standardized extracts and site-specific phytochemical documentation in its pharmaceutical use."

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Integrated Phytochemical Profiling, In Vitro Bioactivity, Molecular Docking, and Pharmacokinetic-Toxicity Evaluation of Ficus carica Leaf Extracts. (PubMed, Life (Basel)) - "Major contributors to bioactivity included hesperidin, rutin, chlorogenic acid, cynarin, naringenin, and 4-hydroxyresorcinol...ADMET predictions suggested favorable oral drug-likeness for selected compounds, whereas others may require further optimization. Overall, these findings indicate that F. carica leaves represent a promising source of natural phenolics with multifunctional bioactivity."

Journal • PK/PD data • Preclinical • Pain • Tyrosinase

Emulsion Gels Stabilized Using Sweet Almond Expeller Globulin Modified by Ultrasonication Assisted with Chlorogenic Acid Conjugation: Preparation, Characterization, Stability, and Applications in Curcumin. (PubMed, Foods) - "Additionally, the SAEG-UCA-emulsion gel improved the photostability, encapsulation and loading capacities, and bioaccessibility of curcumin (p < 0.05). However, more specific mechanisms should be investigated in future research."

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Dasiphora parvifolia: Pharmacognostic Standardization and Antimicrobial Potential. (PubMed, Pharmaceuticals (Basel)) - " D. parvifolia can be considered a relevant source of phenolic compounds. The high levels of gallic and chlorogenic acids, together with hyperoside and cynaroside, indicate a substantial phenolic profile and may contribute to the antioxidant and antimicrobial activities of the extracts."

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Harvest-Time-Dependent variations in phytochemistry and in vitro bioactivities of Vitis vinifera Leaves. (PubMed, BMC Complement Med Ther) - "Harvest time substantially influences the accumulation of bioactive constituents and the in vitro biological potential of V. vinifera leaves. Among the investigated periods, May appeared to be the most favorable harvest time for obtaining grape leaves enriched in bioactive phytochemicals with promising biological activities, supporting their potential valorization as a value-added viticultural by-product."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders

Phytochemical Characterization and Antipyretic and Antinociceptive Activities of Echinops orientalis Trautv. Methanolic Flower Extract: Evidence from In vivo Studies, Network Pharmacology and Molecular Docking. (PubMed, J Ethnopharmacol) - "Echinops orientalis MFE shows antipyretic and antinociceptive potential, supporting its traditional use. Computational predictions suggest modulation of cyclooxygenase (COX-2), prostaglandin E2 receptor (EP2), thromboxane synthase (TBXAS1) and interconnected inflammatory pathways, a hypothesis requiring experimental validation and further preclinical investigation."

Journal • Preclinical • Pain • AKT1 • EGFR • IL6 • STAT3

Phytochemical Profile and Long-Term Physiological Effects of Green Coffee Bean Extract on Body Composition, Hematological Indices, and Liver Integrity in Experimental Rats. (PubMed, Chem Biodivers) - "GC-MS identified caffeine, quinic acid, 2-hydroxy-6-methylbenzaldehyde, and n-hexadecanoic acid. Overall, 90-day exposure was associated with reduced weight gain and alterations in selected hematological indices, while no major structural hepatic damage was observed under the experimental conditions."

Journal • Preclinical • Hematological Disorders • Sinusitis

Integrated Transcriptomics and Metabolomics to Reveal the Regulatory Mechanisms of Flavonoid Biosynthesis in Persicaria capitata Under Different Nitrogen Fertilization Levels. (PubMed, Metabolites) - "Nitrogen supplementation increases the yield of P. capitata but inhibits flavonoid biosynthesis. Downregulated expression of key genes in flavonoid metabolism is responsible for the decreased flavonoid content. This study provides theoretical support for optimized nitrogen management to coordinate yield formation and quality improvement in planting practices for P. capitata."

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Chlorogenic acid attenuates LPS-induced hepatic oxidative stress in broilers by regulating cyclooxygenase-2 expression. (PubMed, Poult Sci) - "Immune stress can impair growth performance and induce hepatic oxidative injury; however, the protective potential and underlying mechanisms of the dietary phenolic compound chlorogenic acid (CGA) remain unclear. Celecoxib partially reproduced the effects of CGA by reducing PTGS2 and NOX1 expression and increasing FoxO3 expression. Collectively, CGA alleviates LPS-induced hepatic oxidative stress and partially improves growth performance, potentially by suppressing a COX-2-associated NOX1-mediated pro-oxidant response and enhancing Nrf2/FoxO3/GPX1-dependent antioxidant defenses."

Journal • FOXO3 • GPX1 • PACERR • PTGS2

Chitosan-based multifunctional hydrogel coatings with dual antibacterial and antioxidant properties are used for preservation and anti-corrosion. (PubMed, RSC Adv) - "Herein, a chitosan-based multifunctional hydrogel coating (CTS-ZnO&CA) integrating ZnO nanoparticles and chlorogenic acid (CA) extracted from honeysuckle was rationally constructed to simultaneously address microbial growth and oxidative instability in fruits...Preservation performance was validated using fresh produce models, where CTS-ZnO&CA significantly reduced water loss and maintained the appearance quality of intact tomatoes, while effectively suppressing pathogen proliferation and delaying lesion expansion in wound-infected citrus fruits. This study highlights a hydrogel-coating strategy that integrates antimicrobial and antioxidant functions, providing a promising and practical approach for postharvest fruit preservation and anti-corrosion applications."

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