STRIKE2001 / Strike Pharma - LARVOL DELTA

Optimizing immune responses through targeted delivery of neoantigens: A study on the dual-function STRIKE2001 antibody and peptide tag variants (CRI-ENCI-AACR ICIC 2024) - "Additional experiments will focus on the intracellular routing of the tagged cargo using the tag variants. Elucidating this mechanism would allow us to steer the desired immune response by selecting the appropriate pTag along with considerations of processing elements to improve immune responses when coupled to the targeted delivery platform known as Adaptable Drug Affinity Conjugate (ADAC™) technology."

IO biomarker • Tumor-specific neoantigens • Oncology • CD40 • CD8

Modular peptide cargo delivery by targeting CD40 enables ligandome driven, precision immunotherapy via the Adaptable Drug Affinity Conjugate (ADAC™) technology (AACR 2023) - "Data suggest that the novel candidate drug (STRIKE2001), now developed based on the ADAC concept[2], retains similar agonistic activity in its bispecific, IgG2 format and does not inhibit CD40L binding to the CD40 protein...Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial...Cancer Immunol Res 1 January 2014; 2 (1): 80-90. https://doi.org/10.1158/2326-6066.CIR-13-0067"

Bladder Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Pancreatic Cancer • Solid Tumor • Urothelial Cancer • CD40 • CD40LG