Akis (diclofenac injection) / IBSA Institute Biochemical SA - LARVOL DELTA

Advancing relational methods in agri-food governance research and beyond: Introducing the Socio-Material Actor-Network Analysis (SMANA) methodology. (PubMed, Open Res Eur) - "This paper contributes to this agenda by presenting the Socio-Material Actor-Network Analysis (SMANA) methodology developed in the context of the research project AETERAKIS - A territorialised Agricultural Knowledge and Innovation Systems (AKIS) framework for agroecological transitions...This approach enables collective reflection throughout its application and subsequent analysis, supporting local transformation processes. Beyond the immediate purpose of guiding data collection and analysis within the AETERAKIS project, the proposed methodology can assist researchers working on other components or relational aspects of complex, territorial and multi-actor governance processes."

Journal

Epidemiology and Maternal-Fetal Outcomes of Pregnancy-Related Acute Kidney Injury: A Prospective Observational Study of a Predominantly Dialysis-Requiring Cohort at a Tertiary Care Center in Northern India. (PubMed, Cureus) - "Dialysis-requiring PRAKI is associated with high maternal mortality, fetal morbidity, and significant progression to CKD/end-stage renal disease. Puerperal sepsis remains the commonest cause, followed by septic abortion. Early sepsis management could reduce morbidity. The study underscores the need for improved obstetric care and timely intervention in resource-limited settings to mitigate the impact of PRAKI on maternal and fetal health."

Journal • Observational data • Acute Kidney Injury • Chronic Kidney Disease • Critical care • Genetic Disorders • Glomerulonephritis • Hematological Disorders • IgA Nephropathy • Infectious Disease • Long-acting Reversible Contraceptives • Nephrology • Obstetrics • Postpartum Hemorrhage • Renal Disease • Septic Shock

Size Effect of Nanoparticles on Targeting Injured Kidneys for Enhanced Intervention in Acute Kidney Injury. (PubMed, ACS Nano) - "Nanoparticles show great potential for the management of acute kidney injuries (AKIs)...After loading curcumin, a natural antioxidant, into 5, 16, and 60 nm AuNPs to compare their efficacies against AKI, we found that 5 and 16 nm AuNPs both effectively delivered drugs into renal tubules, resulting in their equal therapeutic performance and significantly better efficacy than 60 nm ones, further validating the enlarged KFT under AKI. Our results provide valuable insights for size engineering of nanomedicine for better AKI management and enable a deeper understanding of AKI renal physiology at the nanoscale."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Differential impact of pre-operative tirzepatide compared to glucagon-like-peptide-1 single receptor agonists on outcomes of spinal fusion surgery in obese patients. (PubMed, Eur Spine J) - "In a propensity-matched analysis, obese spinal fusion patients treated with Tirzepatide compared to srGLP-1 agonists, had lower rates of early postoperative thrombotic and embolic events, UTIS, and AKIs. Additionally, the Tirzepatide fusion cohort had significantly lower rates of pseudarthrosis, revision surgery, and post-laminectomy syndrome 2 years after surgery. These findings support the potential protective physiological impact of Tirzepatide over srGLP-1s in obese patients undergoing spinal fusion."

Journal • Obesity • Osteoarthritis

Exploring large language model applications in dance education from an educational psychology perspective. (PubMed, Front Psychol) - "To address the limited personalization of traditional dance instruction and its insufficient adaption to learners' cognitive and emotional characteristics, a conceptual methodology is introduced with three components: Preliminaries, the DanceGPT, and Adaptive Knowledge Integration Strategy (AKIS)...The reliance on multimodal modeling introduces non-trivial computational cost. These limitations indicate that future research should further validate the framework through real learner studies, interactive tutoring scenarios, and longitudinal evaluations in authentic dance education settings."

Journal

Morphological and Cyto-Nuclear Conflicting Signals Across Non-Sister Lineages in Darkling Beetles (Tenebrionidae: Akis). (PubMed, Genes (Basel)) - "The geographic location of the problematic specimens, limited to a narrow marginal contact zone between the two non-sister species, suggests that local hybridisation may occur. Our results indicate that cyto-nuclear discordances between mitochondrial and nuclear markers, even across morphologically well-differentiated non-sister lineages, may be more frequent than previously assumed in darkling beetles, highlighting both their evolutionary relevance and the need for caution when relying solely on mitochondrial data for species identification."

Journal

Lower Risk of Acute Kidney Injury in Hospitalized Patients Treated With SGLT-2 Inhibitors: A Retrospective Matched Cohort Study. (PubMed, Am J Nephrol) - "We observed a 32% lower risk of AKI in hospitalized patients using SGLT-2i at admission. This suggest a protective effect of SGLT-2i against AKI, which remained when SGLT-2i was continued during hospitalization."

Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Serial Combination of Toxic and Ischemic Renal Damages Causes Subsequent Chronic, Irreversible, and Progressive Renal Disease in Rats. (PubMed, Int J Mol Sci) - "In this study, we developed a rat model of 3 serial AKIs leading to CKD, in which renal function, kidney structure and fibrosis, and urinary injury biomarkers were studied over a period of 9 months, alongside a traditional model of CKD caused by renal mass reduction...Finally, a clear dissociation in the evolution of interstitial fibrosis (progressively increasing) and of glomerular filtration (mainly stable) was observed in both models. This questions the consuetudinary paradigm ascribing an etiological role to fibrosis in progressive renal dysfunction."

Biomarker • Journal • Preclinical • Acute Kidney Injury • Chronic Kidney Disease • Fibrosis • Immunology • Nephrology • Renal Disease • KIM1 • LCN2 • RBP4

AI-driven preoperative risk assessment in kidney cancer surgery: A comparative feasibility study of machine learning models. (PubMed, BJUI Compass) - "This study suggests that NNs are the most appropriate models to stratify patients regarding the occurrence of MCs and AKIs, respectively. The models are made publicly available for reproducibility."

Journal • Acute Kidney Injury • Genito-urinary Cancer • Kidney Cancer • Nephrology • Oncology • Renal Cell Carcinoma • Solid Tumor

The Role of Other Major Postoperative Complications in Determining Outcomes of Acute Kidney Injury After Coronary Artery Bypass Surgery. (PubMed, Acta Anaesthesiol Scand) - "AKI following CABG was not associated with short- and long-term mortality in the absence of major complications but predicted a higher risk of MACCE and postoperative chronic kidney disease. These results highlight AKIs role in progressive renal dysfunction and long-term cardiovascular morbidity, while its association with short-term mortality may be mediated by other major complications."

Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Nephrology • Renal Disease

Physiological Responses to Heat Stress in Groundskeepers: An Observational Field Study. (PubMed, Appl Physiol Nutr Metab) - "While hyperthermia was not prevalent, subjects began and ended the workday with concentrated urine. Hypertension, obesity, and low water intake may have contributed to the overall low kidney function and AKIs observed."

Journal • Acute Kidney Injury • Cardiovascular • Genetic Disorders • Hypertension • Nephrology • Obesity • Renal Disease

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Purine Metabolism in Acute Kidney Injury after On-Pump Coronary Artery Bypass Graft. (PubMed, J Proteome Res) - "Our research suggests that the panel could play a significant role in distinguishing AKIs from non-AKIs prior to surgery. We propose targeting purine metabolism pathways that may help to identify potential renal protective approaches in acute kidney injury. This study helps to reveal changes in urinary metabolomics and proteomics after CABG and may provide diagnostic clues for patients with postoperative renal injury."

Journal • Acute Kidney Injury • Nephrology • SOD2

Aurora kinases signaling in cancer: from molecular perception to targeted therapies. (PubMed, Mol Cancer) - "Researchers are also exploring combination therapies that use Aurora kinase inhibitors alongside other targeted treatments to overcome resistance and improve patient outcomes. Additionally, advancements in biomarker discovery are expected to facilitate the identification of patients most likely to benefit from Aurora kinase-targeted therapies, paving the way for more personalized approaches to cancer treatment."

Journal • Review • Oncology • AURKA • AURKB

Aurora kinases, emerging critical targets for cancer treatment and related new therapeutic strategies. (PubMed, Bioorg Chem) - "Furthermore, we reviewed the current development of a new generation of AKI, such as PROTAC degrader. Further understanding the mechanism underlying the responsiveness of AKIs could help evaluate their effect and improve them as potential therapeutic targets."

Journal • Review • Breast Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Targeted Protein Degradation • Triple Negative Breast Cancer

Attention to early stages: predicting acute kidney injury in a post cardiosurgical ICU setting using an inclusive time-to-event model. (PubMed, Comput Biol Med) - "We demonstrated the importance of early-stage AKI predictions and presented a novel approach to achieve this. Under similar assumptions, our results showed improvement and approached outcomes comparable to the literature. While practical validation is pending, we are confident that our approach proves useful in assisting physicians to prevent AKI development."

Journal • Review • Acute Kidney Injury • Cardiovascular • Critical care • Nephrology • Renal Disease

Accuracy of Diagnostic Coding for Acute Kidney Injury in Japan-Analysis of a Japanese Hospital-Based Database. (PubMed, Pharmacoepidemiol Drug Saf) - "The ICD-10 codes for AKI showed poor positive predictive values for AKI as defined by the KDIGO criteria, suggesting that it may be difficult to identify AKI using ICD-10 codes alone in the Japanese context."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Cost-Effectiveness of Team-Based Coaching With Surveillance for Prevention of Acute Kidney Injuries. (PubMed, JAMA Netw Open) - "More than 10% of US patients undergoing endovascular procedures experience contrast-associated acute kidney injuries (AKIs), resulting in increased costs and health deficits...In this economic evaluation of implementation strategies for AKI prevention, virtual learning collaborative with automated surveillance reporting was the economically preferred intervention and was estimated to decrease AKI likelihood, permanent kidney disease, and their associated costs after undergoing cardiac catheterization. These results may be generalizable to other endovascular procedures and practice-changing protocols or checklists implementation efforts."

Clinical • HEOR • Journal • Acute Kidney Injury • Nephrology • Renal Disease

Not "a cute" complication: phenotypic analysis of acute kidney injury in Staphylococcus aureus bacteraemia. (PubMed, Clin Microbiol Infect) - "AKI is a frequent complication of SAB and is associated with 30-day mortality. Some AKI phenotypes have rapid resolution, which supports the consideration of delayed antimicrobial dose reduction."

Journal • Retrospective data • Acute Kidney Injury • Nephrology • Renal Disease

Advances in the Design, Discovery, and optimization of aurora kinase inhibitors as anticancer agents. (PubMed, Expert Opin Drug Discov) - "The integration of artificial intelligence and computational approaches is poised to accelerate the development of AKIs as anticancer agents. However, the associated challenges currently hindering its impact in drug development must be overcome before drugs can successfully translate from early drug development into clinical practice."

Journal • Review • Oncology

Quantifying the potential contribution of drugs to the occurrence of acute kidney injury in patients with chronic kidney disease. (PubMed, Clin Kidney J) - "AKIs and adverse drug reactions (ADRs) were prospectively identified from hospital reports, medical records, and patient interviews...Drug-related AKI is prevalent among patients with CKD. Even though a substantial proportion of these events were classified as stage 1, our findings point to a poor prognosis."

Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Metabolic Disorders • Nephrology • Renal Disease

Understanding rhabdomyolysis induced acute kidney injury in patients with COVID-19. (PubMed, World J Virol) - "It is clear from these findings that clinicians must closely monitor and assess for the presence of rhabdomyolysis in COVID-19 patients who have developed AKIs. Moreover, additional research is required to further understand the mechanisms behind the development of RIAKI in COVID-19 patients in order to better inform treatment guidelines and protocols."

Journal • Acute Kidney Injury • Infectious Disease • Musculoskeletal Pain • Nephrology • Novel Coronavirus Disease • Pain • Renal Disease • Respiratory Diseases • CRP • MB

A cost effectiveness analysis of a quality improvement intervention to increase preferential balanced fluid prescribing. (PubMed, BMC Health Serv Res) - "The QI intervention was predicted to improve patient outcomes while yielding significant cost-savings. The marginally increased cost of balanced fluids should not discourage implementation of interventions aimed at increasing evidence-supported balanced fluid prescribing."

Cost effectiveness • HEOR • Journal • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Acute Kidney Injury Secondary to Hypertension-Related Thrombotic Microangiopathy: A Case Report and Literature Review. (PubMed, Cureus) - "The presence of acute kidney injuries (AKIs) in adults with microangiopathic hemolytic anemia and thrombocytopenia poses diagnostic and therapeutic challenges, as there are numerous causes that cannot always be rapidly differentiated...We report a case of AKI secondary to hypertension-related thrombotic microangiopathy and describe the clinical course from presentation to diagnosis and treatment. The patient remained hemodialysis-dependent despite attempts to control the blood pressure and administer anticomplement treatment."

Journal • Review • Acute Kidney Injury • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Hypertension • Nephrology • Renal Disease • Thrombocytopenia

Drug-induced acute kidney injury: a cohort study on incidence, identification of pathophysiological mechanisms, and prognostic factors. (PubMed, Front Med (Lausanne)) - "Most nephrotoxic drugs caused type A reactions, with Vancomycin being the primary nephrotoxin. Although the mortality rate is lower among DI-AKIs compared to other AKI etiologies, the need for AKST was similar. Therefore, it is recommended that DI-AKI be recognized early to enable dose reduction or even drug suspension, depending on the type of reaction, to reduce healthcare costs and improve clinical outcomes for patients."

Biomarker • Journal • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Prevalence of acute kidney injury and outcome in cats treated as inpatients versus outpatients following lily exposure. (PubMed, J Am Vet Med Assoc) - "Results of our study suggested that IP cats have a superior outcome than OP cats; however, cats treated as OPs may still have favorable outcomes."

Journal • Acute Kidney Injury • Nephrology • Renal Disease