zaloglanstat (ISC 27864) / Glenmark - LARVOL DELTA

Microsomal prostaglandin E synthase-1 and its inhibitors: molecular mechanisms and therapeutic significance. (PubMed, Pharmacol Res) - "After 20 years of in-depth research on mPGES-1 and its inhibitors, ISC 27864 have completed phase II clinical trial. In this review, we intend to summarize mPGES-1 inhibitors focused on their inhibitory specificity with perspectives for future drug development."

Journal • Review • Cardiovascular • Gastrointestinal Disorder • Immunology • Inflammation • Metabolic Disorders

Ichnos Sciences announces completion of enrollment of phase 2b trials for two investigational therapies - ISB 830 and ISC 27864 (PRNewswire) - "Ichnos ('īk-nōz) Sciences today announced that it has completed enrollment of two Phase 2b clinical trials for two candidates in clinical development: ISB 830, an OX40 antagonist monoclonal antibody currently in development for the treatment of atopic dermatitis, and ISC 27864...currently in development for osteoarthritic pain....Topline results are expected in the 1st half of 2020 and will be submitted for presentation at scientific meetings."

Enrollment closed • P2b data