ConstaDopa (levodopa controlled release) / APeT Holding - LARVOL DELTA

Maximizing "On" Time: Longer-Lasting Levodopa Therapy Options for Parkinson's Disease (NeurologyLive) - "'Good On' time is the sum of periods where patients experience 'On' time with no dyskinesia and 'On' time with non-troublesome dyskinesia, and is most strongly correlated with patients' perceived duration of good response to medication through the day. Unfortunately, as a patient's PD progresses, the window of LD's effectiveness is reduced, resulting in more 'Off' time and 'On' time compromised by disabling dyskinesias."

Online posting

"Brace" could optimize Parkinson's therapy: Applicator ensures fewer interruptions in levodopa/carbidopa administration [Google translation] (Medscape) - "dr Stuart Isaacson....'Novel devices that allow more sustained delivery of levodopa would be an important therapeutic advance,' said Isaacson."

Media quote

Shared Decision-Making In Parkinson Disease Care (NeurologyLive) - "Stuart H. Isaacson, MD, FAAN: I think that not everything about these treatments is painted in surgical and nonsurgical. I think about the patient and what problems they're having and how can I help those....Well, I think it's done on the basis of knowledge. And meetings like the AAN, and other meetings we have here talks and videos in trying to educate clinicians, doctors, and nurses, truly all parts of evolving care-new medications, new ways of using medications, and new strategies and paradigms of using medications to maintain as consistent dopamine as possible, limit disruptions, and maintain a true duration of benefit ON."

Video

Management of Dyskinesia and Advances in Treatment of Parkinson’s Disease : Episode 2: Use of Parkinson Disease Treatments and Identification of OFF Episodes in Clinical Practice (NeurologyLive) - "The expert panel discusses advances in formulations of carbidopa/levodopa and identification of OFF and ON time in patients with Parkinson disease....Daniel E. Kremens, MD, JD: That's a really interesting observation, because earlier this week, a patient brought in their levodopa and showed me the bottle, and I had prescribed CR, and the bottle contained CR, but it was labeled ER....Fernando Pagan, MD: I think the discussion Dr Ondo gave us about all the different medications we have is exciting with what's happened in Parkinson disease because when we just had levodopa, we had to be creative."

Video

Management of Dyskinesia and Advances in Treatment of Parkinson’s Disease : Episode 1: Treatment Options for Parkinson Disease (NeurologyLive) - "Dr William G. Ondo provides an overview of available treatments and pharmacokinetic properties of different drugs for Parkinson Disease....Daniel E. Kremens, MD, JD: Hello and welcome to this NeurologyLive Peer Exchange titled, 'Management of Dyskinesia and Advances in Treatment of Parkinson Disease.' I’m your host, Dr Daniel Kremens...And Dr Fernando Pagan...."

Video

Understanding and Managing Acute OFF Episodes in Parkinson’s Disease : Episode 5: Future Outlook for Parkinson’s Disease (NeurologyLive) - "Expert neurologist highlights ongoing research in newer mechanisms of action and modes of delivery for treatments of Parkinson's disease and OFF episodes."

Video

Understanding and Managing Acute OFF Episodes in Parkinson’s Disease : Episode 4: Current Treatment Paradigm for Management of OFF Episodes (NeurologyLive) - "Stuart Isaacson, MD, FAAN, evaluates the current treatment paradigm and highlights new, 'on-demand' medication for management of OFF episodes in Parkinson's disease."

Video

Understanding and Managing Acute OFF Episodes in Parkinson’s Disease : Episode 3: Pharmacological Basis of OFF Episodes in Parkinson's Disease (NeurologyLive) - "Stuart Isaacson, MD, FAAN, discusses the pharmacological basis of OFF episodes in patients with Parkinson's disease."

Video

Parkinson’s Disease Course 4 - "Levodopa: Facts and Myths."

Live event