Ossmax (alendronate) / Sun Pharma - LARVOL DELTA

Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction. (PubMed, J Biol Chem) - "Furthermore, we investigate OsKAI2-mediated signaling by examining its ability to form a complex with its binding partner, the F-box protein DWARF3 (D3) ubiquitin ligase and subsequent degradation of the target substrate OsSMAX1, demonstrating the significant role of hydrophobic interactions in the OsKAI2-D3 interface. This study provides new insights into the diverse and pivotal roles of the OsKAI2 signaling pathway in the plant kingdom, particularly in grasses."

Journal • Targeted Protein Degradation

New data from amgen’s prolia (denosumab) demonstrates significant reduction in osteoporotic fracture risk compared to alendronate (Amgen) - "'Although comparative trials between Prolia and bisphosphonates showed superior bone mineral density increases with Prolia at key skeletal sites, direct comparative studies with fracture as an endpoint are lacking. These findings from nearly half a million patients provide evidence that Prolia is associated with greater fracture risk reduction than with alendronate,' said Jeff Curtis...'This comparative effectiveness research employs rigorous methodology that provides important insights that are relevant to the care of women living with osteoporosis.'"

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Treatment sequence key for optimal management of osteoporosis (Healio) - "'All osteoanabolic agents have been shown to reduce fractures and to increase bone mass and calculated hip bone strength. However, after they are used, both bone mass and bone strength rapidly deteriorate unless an antiresorptive agent is administered,' Lane told Endocrine Today...."

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Karrikin Signaling Acts Parallel to and Additively with Strigolactone Signaling to Regulate Rice Mesocotyl Elongation in Darkness. (PubMed, Plant Cell) - "Moreover, we showed that the GR24 enantiomers GR245DS and GR24ent-5DS specifically inhibit mesocotyl elongation and regulate downstream gene expression in a D14- and D14L-dependent manner, respectively. Our work revealed that karrikin and SL signaling play parallel and additive roles in modulating downstream gene expression and negatively regulating mesocotyl elongation in the dark."

Journal • Targeted Protein Degradation

Reassessing CVD Risk in Rheumatic Disease (Rheumatology Network) - "'There are a lot of drugs we use that affect our patients' CVD risk,' said Jeffrey Curtis, M.D...Dr. Curtis recently spoke on this issue at the Congress of Clinical Rheumatology East 2020 annual meeting held earlier this month. 'How to communicate risk...I think may be the next wave.'...'Even when compared to alendronate, there is still a significant benefit for vertebral fractures. It reduced vertebral fractures by half compared to alendronate,' Dr. Curtis said. 'The warning caused some concern. But it's less than one out of 100 people who had a [cardiovascular] event. Only more time and safety studies will tell, but it informs [how to] consider the risks and benefits.'"

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Karrikin Signaling Acts Parallel to and Additively with Strigolactone Signaling to Regulate Rice Mesocotyl Elongation in Darkness. (PubMed, Plant Cell) - "Moreover, we showed that the GR24 enantiomers GR245DS and GR24ent-5DS specifically inhibit mesocotyl elongation and regulate downstream gene expression in a D14- and D14L-dependent manner, respectively. Our work revealed that karrikin and SL signaling play parallel and additive roles in modulating downstream genes expression and negatively regulating mesocotyl elongation in the dark."

Journal • Targeted Protein Degradation