FML (fluorometholone ophthalmic ointment) / AbbVie - LARVOL DELTA

First case of Phthirus pubis and Demodex co-infestation of the eyelids: a case report. (PubMed, BMC Ophthalmol) - "Our report shows the importance of an early and comprehensive diagnosis, because both phthiriasis palpebrarum and demodicosis can be confused with blepharitis."

Clinical • Journal • Dry Eye Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations. (PubMed, Pharm Res) - "This initial model for ointment ophthalmic formulations is a first step to better understand the interplay between physiological factors and ophthalmic formulation physicochemical properties and their impact on in vivo ocular drug pharmacokinetic performance in rabbits."

Journal • PK/PD data • Ophthalmology

[VIRTUAL] Diagnosis and Management of Dupilumab-Associated Conjunctivitis in a Patient with Atopic Dermatitis (AAOPT 2020) - "I prescribed Fluorometholone 0.1% 6x/day OU x 5 days, and recommended preservative-free artificial tears q2hours OU. It is interesting that both the disease (AD) and the treatment (Dupilumab) can have ocular manifestations. Optometrists should be aware of Dupilumab’s potential to cause conjunctivitis and be comfortable with its treatment options; the goal is to manage Dupilumab’s ocular side effects so that the patient can continue to enjoy its anti-eczema benefits."

Clinical • Conjunctivitis • Ocular Inflammation • Ophthalmology

Core-interlayer-shell Fe3O4@mSiO2@lipid-PEG-methotrexate nanoparticle for multimodal imaging and multistage targeted chemo-photodynamic therapy. (PubMed) - "Herein, we have elaborately developed a core-interlayer-shell structure Fe3O4@mSiO2@lipid-PEG-methotrexatenanoparticle(FMLM), in which the Fe3O4 core could be used for magnet-stimulate-response drug release, magnetic resonance imaging, and early-phase magnet targeting ability; the mSiO2 layer could encapsulate anticancer drug doxorubicin (Dox) for chemotherapy; and the protective shell of lipid-PEG and lipid-PEG-methotrexate offered later-phase specific cellular targeting ability, good water dispersibility, and loading of photosensitizer zinc phthalocyanine (ZnPc) for simultaneous near-infrared fluorescence imaging and photodynamic therapy. Both in vitro and in vivo studies indicated that the both Dox and ZnPc-loaded FMLM (Dox/ZnPc-FMLM) exhibited the enhanced tumor accumulation, increased cellular uptake, improved anticancer activity, and weaked side effects compared with Dox/ZnPc-Fe3O4@mSiO2@lipid-PEG nanoparticle (Dox/ZnPc-FML) and free drug. For the first time, magnet...&quo

Journal • Biosimilar • Oncology

Fracto-mechanoluminescence induced by impulsive deformation of II-VI semiconductors. (PubMed, Luminescence) - "In the proposed mechanism, expressions are derived for the rise, the time tm corresponding to the ML intensity versus time curve, the ML intensity Im corresponding to the peak of ML intensity versus time curve, the total fracto-mechanoluminescence (FML) intensity IT , and fast and slow decay of FML intensity of II-VI semiconductors. The FML plays a significant role in understanding the processes involved in biological detection, earthquake lights and mine failure."

Journal • Biosimilar

Fracto-mechanoluminescence and thermoluminescence properties of UV and γ-irradiated Ca2 Al2 SiO7 :Ce(3+) phosphor. (PubMed) - "The TL and ML emission spectra of Ca2 Al2 SiO7 :Ce(3+) phosphor showed maximum emission at 400 nm. The possible mechanisms involved in the TL and ML processes of the Ca2 Al2 SiO7 :Ce(3+) phosphor are also explained."

Journal • Biosimilar

Effect of Topical Periocular Steroid Use on Intraocular Pressure: A Retrospective Analysis. (PubMed, Ophthalmic Plast Reconstr Surg) - "Periocular steroid treatment causes a statistically significant rise in IOP in eyes with higher baseline IOP measurements, the risk of which increases with follow up. While this change is not always correlated with a clinically significant rise in IOP, clinicians should monitor more closely patients at greatest risk of steroid response."

Journal • Retrospective data