COV2-2381 / IDBiologics, Twist Biosci, Vanderbilt University - LARVOL DELTA

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques. (PubMed, Med (N Y)) - "The Fc-region of two neutralizing mAbs (COV2-2130 and COV2-2381) targeting non-overlapping epitopes on the receptor-binding domain of SARS-CoV-2 spike protein was engineered to extend their persistence in humans and reduce interactions with Fc gamma receptors. These results support clinical development of ADM03820 for COVID-19 prevention. This research was supported by a contract from the JPEO-CBRND (W911QY-20-9-003), 20-05, the Joint Sciences and Technology Office and the Joint Program Executive Office (MCDC-16-01-002 JSTO, JPEO), DARPA grant (HR0011-18-2-0001), NIH grant (R01 AI157155), and the 2019 Future Insight Prize from Merck KGaA."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases