itraconazole / Generic mfg. - LARVOL DELTA

Therapeutic Advances in Head and Neck Dermatitis (HND): A Clinical Update (AAD 2026) - " Selective JAK1 inhibitors, including upadacitinib and abrocitinib, achieve rapid and sustained clearance in dupilumab-refractory cases, while topical delgocitinib and roxolitinib have shown benefits without local adverse effects. IL-13 antagonists such as tralokinumab and lebrikizumab provided head-to-neck symptomatic and quality-of-life improvement in patients unresponsive to dupilumab or JAK inhibitors, with a favorable safety profile...Topical agents like ketoconazole and ciclopirox showed good tolerability and clinical improvement in mild cases. Oral itraconazole, while favored for its lipophilic properties and ability to reduce Malassezia-specific IgE, was often followed by relapse upon discontinuation... HND represents a distinct, treatment-resistant AD phenotype requiring strategic multimodal care. Immunomodulators and antifungal therapies, often combined with topical agents, offer promising results, though larger long-term trials are needed to define optimal..."

Clinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • IL13

Dual CARD9/GATA2 Mutations Promote Refractory Neoscytalidium dimidiatum Subcutaneous Infection: Synergistic Clearance by Voriconazole and Targeted Hyperthermia (AAD 2026) - "Initial oral itraconazole treatment (200-400 mg/d) showed transient improvement over 3 months but resulted in relapse with drug resistance after discontinuation...Successful management involved voriconazole (400 mg/d) combined with luliconazole cream and localized hyperthermia (42°C/d) based on antifungal susceptibility testing (MIC 0.06 μg/ml) and thermotolerance data showing no growth at 42°C, achieving significant lesion regression within 8 weeks without recurrence during follow-up. Notably, dermoscopic examination identified a "black-red dot sign" on erythematous bases with yellowish scales that resolved alongside clinical improvement, suggesting potential as a fungal subcutaneous infection biomarker. This case highlights CARD9/GATA2 mutations as possible contributors to chronic fungal infections and drug resistance mechanisms in immunocompetent individuals while demonstrating the therapeutic value of combined antifungal and thermotherapy..."

Cardiovascular • Hypertension • Infectious Disease • Inflammation • CARD9 • GATA2

A Review of Hedgehog Pathway Inhibitors in Combination Therapy for Basal Cell Carcinoma (AAD 2026) - "A total of nine studies were included, involving either vismodegib or sonidegib combined with concomitant therapy of either itraconazole, radiation therapy, photodynamic therapy (PDT), pembrolizumab, intratumoral immunotherapy ASN-002, or surgical debulking. Lastly, 75% of combination therapy studies reported a more tolerable AE when compared to monotherapy. Combination strategies represent a promising avenue to optimize efficacy, improve tolerability, and expand therapeutic options for patients with BCC."

Combination therapy • Review • Basal Cell Carcinoma • Non-melanoma Skin Cancer • Oncology

Countering an Emerging Threat: Terbinafine-resistant and Itraconazole-resistant Trichophyton indotineae Strains are Highly Susceptible to a Novel Antifungal Nitric Oxide Releasing Gel (AAD 2026) - "Strat-M synthetic dermal membranes were placed on SDA plates seeded with fungal lawns and treated with NORS-gel, terbinafine, efinaconazole, or placebo, and zones of inhibition were measured. NORS-gel represents a promising strategy for the management of resistant dermatophytoses. Further clinical studies are needed to confirm efficacy and safety in patients."

Infectious Disease

A rare "Roman Helmet" presentation of Paracoccidioidomycosis (AAD 2026) - "The patient received itraconazole 200 mg/day for 12 months, achieving complete remission of skin lesions and clinical recovery...This case illustrates that PCM can present with unusual cutaneous manifestations even in patients without rural exposure, underscoring the importance of including PCM in the differential diagnosis of chronic ulcerative facial and scalp lesions in endemic regions. Early recognition and antifungal therapy are critical to achieving cure and preventing complications."

Alopecia • Dermatitis • Immunology • Infectious Disease • Respiratory Diseases

A case of primary localised oral histoplasmosis in an immunocompetent host: An unusual presentation (AAD 2026) - "Treatment with itraconazole was initiated, and improvement was seen. This case illustrates an unusual presentation of primary histoplasmosis without dissemination in immunocompetent hosts. This further highlights the importance of keeping histoplasmosis as a differential even in the absence of systemic symptoms in immunocompetent persons, aiding prompt diagnosis, preventing complications and avoiding mortality."

Clinical • Infectious Disease

Something Old Brings New Insights: Activity of Cerivastatin Against Thermally Dimorphic Fungi and Its Potential as an Antifungal Scaffold. (PubMed, Pharmaceuticals (Basel)) - " These findings highlight the potential of cerivastatin as an antifungal agent when used in combination with itraconazole. Furthermore, the chemical scaffold of cerivastatin warrants further investigation as a basis for the development of novel statins with antifungal activity."

Journal

Diversity and Antifungal Susceptibility of Malassezia spp. Isolated From Brazilian Patients With Pityriasis Versicolor and Seborrheic Dermatitis. (PubMed, Mycoses) - "This study showed the diversity of Malassezia species causing PV and SD in Brazil, including the rare species M. yamatoensis and M. japonica. These findings highlight the importance of antifungal susceptibility testing for these species to guide appropriate therapy."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Psoriasis • Seborrheic Dermatitis

Feline Cryptococcosis: Two Case Reports and a Literature Review. (PubMed, Pathogens) - "Based on cytological findings, both patients were treated with oral itraconazole, resulting in favorable clinical outcomes...Early diagnosis and antifungal therapy are crucial for successful management. From a One Health perspective, feline cryptococcosis may indicate shared environmental exposure risks relevant to both animal and human health."

Journal • Review • Dermatology • Infectious Disease • Oncology

PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example. (PubMed, AAPS J) - "This model effectively captured plasma drug concentration-time profiles reported for preclinical and clinical studies, including studies involving impact of food and drug-drug interactions with itraconazole and esomeprazole. Following administration of a single dose (280 mg) of ARV-110, the observed vs. predicted AUC0-inf for high fat, medium fat and low fat studies were 13563.0 vs. 7646.0 ng.h/ml, 4358.0 vs. 4618.3 ng.h/ml and 1919.0 vs. 1403.3 ng.h/ml. This work provides a translational PBPK framework for predicting human oral PK of PROTACs and emphasizes challenges in generating robust preclinical data to enhance prediction accuracy."

Journal • Oncology • Targeted Protein Degradation

New and Investigational Treatment Options for Dermatomycosis in the Era of Antifungal Resistance. (PubMed, J Fungi (Basel)) - "Olorofim and ME1111 represent novel drug classes that target intracellular metabolism. New agents belonging to the azole class demonstrate reduced drug-drug interactions (oteseconazole), a broader antifungal spectrum (voriconazole), and reduced pharmacokinetic complexity (fosravuconazole, super-bioavailable itraconazole)...Based on our current understanding of dermatophyte immunity, antimicrobial peptides and vaccines targeting virulence factors (e.g., subtilisins) represent novel strategies. Nanotechnology platforms also show promise in introducing new antifungal agents (e.g., metal nanoparticles, nitric oxide-releasing nanoparticles), as well as developing topical formulations to enhance the bioavailability and safety profiles of existing antifungals (amphotericin B, ketoconazole, voriconazole)."

Journal • Review • Dermatology

Letter to the Editor Regarding "The Effect of Itraconazole on the Pharmacokinetics of Vepdegestrant, a PROteolysis TArgeting Chimera Estrogen Receptor Degrader, in Healthy Adult Participants" Recently Published by Tran and Colleagues. (PubMed, Clin Ther) - No abstract available

Journal • PK/PD data • Targeted Protein Degradation • ER

A Case of Recurrent Chromoblastomycosis Treated with Multiple Surgical Management Options. (PubMed, Dermatopathology (Basel)) - "Past medical history included atrial fibrillation on apixaban, hypertension and a cardiac stent...The patient was on rosuvastatin, rendering itraconazole not a possible treatment option, and instead the patient underwent curettage and cautery with two bouts of cryotherapy freeze and thaw cycles...This case highlights multiple surgical options for the management of chromoblastomycosis in patients where medical management is contraindicated. It highlights the therapeutic challenge of this disease due to frequent recurrence of lesions and that repeat biopsy may be efficacious in monitoring for recurrence."

Journal • Atrial Fibrillation • Cardiovascular • Dermatology • Fibrosis • Hypertension • Immunology • Inflammation

Antifungal Susceptibility Assessment of Candida Isolates from Denture Stomatitis Patients to Azole Drugs. (PubMed, J Pharm Bioallied Sci) - "Antifungal susceptibility to fluconazole, itraconazole, ketoconazole, and voriconazole was evaluated using the CLSI broth microdilution method. Azole resistance, particularly to fluconazole, is notable among Candida isolates from denture stomatitis patients. Routine antifungal susceptibility testing is recommended to guide effective therapy and prevent treatment failure."

Journal • Dental Disorders • Stomatitis

Challenges in diagnosing mucocutaneous leishmaniasis caused by Leishmania (Mundinia) martiniquensis mimicking oral histoplasmosis in a patient with advanced HIV disease from Southern Thailand. (PubMed, J Infect Public Health) - "We report a case of a 53-year-old Thai man with advanced HIV disease from Southern Thailand who presented in 2020 with a chronic palate ulcer and hard palate perforation, initially diagnosed as histoplasmosis and treated with itraconazole for a year...This report documents the second case of mucocutaneous leishmaniasis caused by L. martiniquensis in Thailand, with primary mucocutaneous presentation that progressed to visceral involvement. This highlights diagnostic challenges due to morphological similarities between Leishmania amastigotes and Histoplasma capsulatum yeasts, emphasizing the need for integrative histopathological (including specific staining techniques) and molecular diagnostics for accurate diagnosis and effective treatment."

Journal • Dermatology • Dermatopathology • Human Immunodeficiency Virus • Infectious Disease

Knufia epidermidis Infection: A Case Report and Literature Review. (PubMed, Am J Trop Med Hyg) - "epidermidis) infection and successfully treated with itraconazole at a dosage of 200 mg/day and acitretin at a dosage of 20 mg/day for 2 weeks. It is worth noting that K. epidermidis is a pathogen that can cause cutaneous infections. Doctors should be aware of this disease to avoid misdiagnosis."

Journal • Infectious Disease

Сlinical Study Aiming to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of ZE63-0302 in Healthy Volunteers (clinicaltrials.gov) - P1 | N=82 | Completed | Sponsor: Eilean Therapeutics | Recruiting ➔ Completed

First-in-human • Trial completion

OPEN WIDE: EXPLORING SALIVA AS A NON-INVASIVE TOOL FOR POSACONAZOLE LEVELS IN CHILDREN (EBMT 2026) - "This is the first prospective study assessing salivary detection of posaconazole in children. Our findings indicate that saliva sampling is unsuitable for posaconazole TDM in immunocompromised children. The minimal detection is possibly related to its high protein binding (>98%) similar to itraconazole and in contrast to voriconazole (~58%) and fluconazole (~10%), which have demonstrated reliable salivary penetration."

Clinical • Non-invasive • Infectious Disease • Mucositis • Stomatitis

Isolated hepatic histoplasmosis in an immunocompetent patient. (PubMed, BMJ Case Rep) - "Treatment with Amphotericin B and Itraconazole resulted in complete recovery, and Urinary Histoplasma antigen was negative 6 weeks after treatment initiation...Also, the rare presentation of histoplasmosis with isolated hepatic involvement is discussed. This case adds to the growing body of evidence on histoplasmosis in India, a region traditionally considered non-endemic for the disease."

Journal • Gastrointestinal Disorder • Hepatology • Infectious Disease • Inflammation • Liver Failure

Chronic pulmonary aspergillosis and pulmonary embolism/venous thromboembolism: a case series and systematic review of the literature. (PubMed, Ther Adv Infect Dis) - "All patients received itraconazole and anticoagulation with rivaroxaban. CPA may coexist with PE/DVT due to fungal angioinvasion, chronic inflammation, or immobilization from advanced lung disease. Management requires individualized balancing of antifungal and anticoagulation therapy, with heightened vigilance for bleeding."

Journal • Cardiovascular • Chronic Obstructive Pulmonary Disease • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammation • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Tuberculosis • Venous Thromboembolism • CD4

Copper-based fungicide induces azole resistance in Aspergillus fumigatus at environmental concentrations. (PubMed, Pest Manag Sci) - "These findings demonstrated stable triazole resistance in A. fumigatus associated with agricultural copper hydroxide exposure. Copper-based fungicide should be applied strictly at dosage recommended by good agricultural practices and alternated with fungicides of different modes-of-action to mitigate resistance risk."

Journal • ABCB1

Filamentous fungi, and their antifungal susceptibilities, isolated from patients at an oncology hospital in Turkey. (PubMed, Rev Iberoam Micol) - "The filamentous fungi recovered from the patients showed high antifungal MIC/MEC values, and some isolates had high amphotericin B MICs. Voriconazole was effective in vitro against A. fumigatus."

Journal • Review • Infectious Disease • Oncology

Six-month open-label clinical study of a novel topical solution for mild distal lateral subungual onychomycosis. (PubMed, Eur J Dermatol) - "Systemic antifungals such as terbinafine and itraconazole are often limited by drug interactions and side effects in the treatment of onychomycosis...This topical "barrier-effect" treatment was associated with improvements in nail appearance and fungal resolution after only 12 weeks, with further benefit at six months, and was safe, well tolerated, and easy to use. Also, concomitant use with systemic antifungals may be possible subject to further studies."

Clinical • Journal • Dermatology • Infectious Disease

A deep dive into the diversity of the Aspergillus community in the lakes of northern Iran. (PubMed, Front Public Health) - "Elevated minimum inhibitory concentrations (MICs) against itraconazole and voriconazole were observed in 3.22 and 1% of isolates, respectively. Therefore, prioritizing microbial contamination control and improving hygienic awareness among visitors remain vital. However, seasonal sampling and section-level identification represent limitations that should be addressed in future studies."

Journal

The Evolving Landscape of Dermatophytosis in the UAE: Trichophyton indotineae and Related Genotypes. (PubMed, Mycoses) - "This study provides baseline evidence of endemic terbinafine-resistant T. indotineae in the UAE, underscoring urgent needs for molecular diagnostics, routine susceptibility testing and antifungal stewardship programs to guide effective management strategies."

Journal • Dermatology • Infectious Disease • SQLE