itraconazole / Generic mfg. - LARVOL DELTA

Itraconazole Therapy In Bronchiectasis With Airway Mold (clinicaltrials.gov) - P4 | N=30 | Recruiting | Sponsor: Mayo Clinic | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2025 ➔ Mar 2026

Enrollment open • Trial initiation date • Bronchiectasis • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Disseminated Histoplasmosis in a Patient With HIV Infection Untreated for 23 Years. (PubMed, Cureus) - "Biopsy of a retroperitoneal lymph node revealed granulomas containing fungal organisms consistent with disseminated histoplasmosis. The patient was initially treated with empiric broad-spectrum antibiotics and intravenous amphotericin B, followed by long-term itraconazole therapy and initiation of antiretroviral treatment, resulting in clinical and immunologic improvement. This case highlights the direct relationship between prolonged untreated HIV infection, advanced immunosuppression, and disseminated histoplasmosis, while underscoring the impact of stigma and barriers to care on delayed diagnosis and disease severity. Early HIV diagnosis, timely linkage to care, and sustained patient engagement remain essential to preventing severe opportunistic infections."

Journal • Cardiovascular • Heart Failure • Human Immunodeficiency Virus • Infectious Disease • CD4

A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults (clinicaltrials.gov) - P1 | N=54 | Not yet recruiting | Sponsor: Astellas Pharma Global Development, Inc.

New P1 trial • KRAS

Mixed mycotic infection in an immunocompromised host with advanced HIV diagnosed with the assistance of a Karius test. (PubMed, Med Mycol Case Rep) - "She was treated with a 21-day course of trimethoprim-sulfamethoxazole followed by primaquine and clindamycin for PJP. She clinically improved with over 3 weeks of IV amphotericin B to cover for histoplasmosis and coccidioidomycosis, which was later de-escalated to oral itraconazole. She was instructed to follow up in clinic where bictegravir/emtricitabine/tenofovir alafenamide was initiated. This case highlights the utility of building a broad differential diagnosis as mixed mycotic infections can coexist in an immunocompromised host, and of utilizing a Karius test early in the course of illness in an immunocompromised patient to expedite a diagnosis. This case also demonstrates the need to recognize the changing geographic distribution of fungal infections."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Mycosis Fungoides • Pneumonia • Postpartum Depression • Psychiatry • Respiratory Diseases

Persistent Undocumented Meningoencephalitis due to Histoplasmosis in an HIV-Infected Patient in Brazil. (PubMed, Am J Trop Med Hyg) - "Repeated lumbar punctures for mycological culture and Histoplasma polymerase chain reaction test were necessary to confirm the diagnosis. After 6 weeks of liposomal amphotericin B followed by itraconazole and intensification of her antiretroviral therapy, she improved clinically and biologically."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

BNT326-01: A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors (clinicaltrials.gov) - P1/2 | N=980 | Recruiting | Sponsor: BioNTech SE | N=550 ➔ 980 | Trial completion date: Feb 2030 ➔ Oct 2029 | Trial primary completion date: May 2028 ➔ Feb 2028

Enrollment change • Monotherapy • Trial completion date • Trial primary completion date • Breast Cancer • Cholangiocarcinoma • Colorectal Cancer • Endometrial Cancer • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Hepatocellular Cancer • Lung Cancer • Melanoma • Mucosal Melanoma • Non Small Cell Lung Cancer • Oncology • Pancreatic Ductal Adenocarcinoma • Renal Cell Carcinoma • Solid Tumor • Triple Negative Breast Cancer • ALK • BRAF • HER-2

OPEN WIDE: EXPLORING SALIVA AS A NON-INVASIVE TOOL FOR POSACONAZOLE LEVELS IN CHILDREN (EBMT 2026) - "This is the first prospective study assessing salivary detection of posaconazole in children. Our findings indicate that saliva sampling is unsuitable for posaconazole TDM in immunocompromised children. The minimal detection is possibly related to its high protein binding (>98%) similar to itraconazole and in contrast to voriconazole (~58%) and fluconazole (~10%), which have demonstrated reliable salivary penetration."

Clinical • Non-invasive • Infectious Disease • Mucositis • Stomatitis

Telemedicine visits for new onychomycosis diagnoses result in fewer antifungal prescriptions than in-person care: A retrospective cohort study. (PubMed, JAAD Int) - No abstract available

Journal • Retrospective data • Infectious Disease

Characteristics of individual cyp51A SNPs and combinations thereof impacting the azole phenotype in TR34-mediated resistance genotypes of Aspergillus fumigatus. (PubMed, Antimicrob Agents Chemother) - "The MICs of all four azoles against the mutated cyp51A strains, which harbored combination mutations, were higher than those of the wild type, with highly elevated MICs of itraconazole, voriconazole, and isavuconazole. Genotypes TR34/L98H/T289A/I364V/G448S mutant showed a consistent phenotype to the clinical strains, which are highly resistant to voriconazole but susceptible to itraconazole. In this study, we show that molecular dynamics simulations of amino acid substitutions in the cyp51A gene correlate to the structure-function relationship of in vitro phenotype."

Journal

Necrotizing pneumonia due to blastomycosis: Diagnostic challenges and the emerging role of cell-free DNA testing. (PubMed, IDCases) - "He was admitted for community acquired pneumonia and initially treated with ceftriaxone and azithromycin...Initial treatment with Itraconazole was suspended due to suspected pulmonary toxicity and was transitioned to Isavuconazonium after completion of lipid amphotericin. He was successfully extubated after 8 days and was discharged on day 51 of admission without any supplemental oxygen requirements. This case underscores the value of rapid, noninvasive diagnostics like cfDNA testing for non-resolving pneumonia and raises the question if fungal surveillance in those who required lobectomy from prior fungal infection would mitigate future severe infections."

Journal • Acute Respiratory Distress Syndrome • Dermatology • Diabetes • Follicular Lymphoma • Genito-urinary Cancer • Hematological Malignancies • Infectious Disease • Lymphoma • Metabolic Disorders • Non-Hodgkin’s Lymphoma • Oncology • Pneumonia • Pulmonary Disease • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases • Septic Shock • Solid Tumor • Type 2 Diabetes Mellitus

A Study in Healthy People to Test How Itraconazole Influences the Amount of BI 3031185 in the Blood (clinicaltrials.gov) - P1 | N=14 | Completed | Sponsor: Boehringer Ingelheim | Active, not recruiting ➔ Completed

Trial completion

Variability of clinical presentation and diagnostic challenges in osteoarticular sporotrichosis: a case series. (PubMed, Rev Inst Med Trop Sao Paulo) - "All patients received antifungal therapy with itraconazole and/or amphotericin B. Relapses were recorded in two patients, and there were irreversible sequelae such as chronic arthritis, joint stiffness, or deformity in all cases. Osteoarticular sporotrichosis should be considered in the differential diagnosis of chronic musculoskeletal conditions, including arthritis, osteomyelitis, synovitis, bursitis, and tenosynovitis, particularly in endemic regions. Early recognition and prolonged antifungal therapy are essential to achieve cure and prevent complications."

Journal • Immunology • Inflammation • Musculoskeletal Diseases • Rheumatology

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in Candida Species Isolated From Diaper Rash of Neonates. (PubMed, Health Sci Rep) - "Nystatin, posaconazole, voriconazole, amphotericin B, ketoconazole, and clotrimazole showed high activity against all species (Minimum Inhibitory Concentration ≤ 0.125 µg/mL). The treatment of recurrent invasive candidiasis, needing repeated course of fluconazole or itraconazole, could be a risk factor for selecting resistant isolates. In addition, as the liposomal amphotericin B is no more commercialized in our country, a higher drug selection pressure for azoles may be expected in the future."

Journal • Candidiasis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pediatrics

A Case Report on Tinea Imbricata. (PubMed, Cureus) - "The patient was managed with oral itraconazole (200 mg, pulse therapy) in combination with topical miconazole cream, resulting in complete resolution of lesions. To the best of our knowledge, this is the first reported case of tinea imbricata in Saudi Arabia."

Journal • Dermatology • Infectious Disease

Liposomal amphotericin B in the treatment of pediatric gastrointestinal basidiobolomycosis. (PubMed, J Med Case Rep) - "This case highlights the diagnostic challenges of pediatric gastrointestinal basidiobolomycosis and demonstrates successful management with liposomal amphotericin B followed by itraconazole. It underscores the ongoing gap in establishing standardized treatment and supports further prospective studies to define optimal antifungal and surgical strategies for this rare entity."

Journal • Anorexia • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Pain • Pediatrics

Prospective evaluation of itraconazole for the treatment of Jorge Lobo's Disease (Lobomicose) (ESCMID Global 2026) - No abstract available

Clinical

A Study to Investigate the Impact of Multiple Doses of Itraconazole on AZD5004 in Healthy Participants and Multiple Doses of AZD5004 on Combined Oral Ethinyl Oestradiol and Levonorgestrel in Healthy Female Participants (clinicaltrials.gov) - P1 | N=51 | Completed | Sponsor: AstraZeneca | Active, not recruiting ➔ Completed

Trial completion

Unique genetic clades and frequent zoonotic transmission of Sporothrix brasiliensis with reduced itraconazole susceptibility (ESCMID Global 2026) - No abstract available

Endocrine consequences of antifungal therapy: A missed entity. (PubMed, World J Clin Cases) - "Adrenal and gonadal dysfunctions with ketoconazole, and mineralocorticoid excess with posaconazole and itraconazole, are well-documented. Uncommon manifestations, such as voriconazole-induced syndrome of inappropriate antidiuretic hormone secretion or salt-losing nephropathy, and fluoride-related periostitis associated with voriconazole and itraconazole, have also been reported...Echinocandins differ from azoles and polyenes in that they rarely affect endocrine pathways, making them a safer option when endocrine toxicity is a concern. Clinicians must remain vigilant to the endocrine adverse effects and pharmacological interactions of antifungal agents to enable timely recognition and management."

Journal • Review • Endocrine Disorders • Infectious Disease • Nephrology • Renal Disease

A Case Report of Cutaneous Scedosporium apiospermum Presenting with Cellulitis-like Cutaneous Findings and A Review of the Literature (PubMed, Mikrobiyol Bul) - "The minimum inhibition concentration was defined as 1 µg/mL for amphotericin B; 16 µg/mL for fluconazole; 0.25 µg/mL voriconazole, 4 µg/mL for caspofungin, 1 µg/mL for itraconazole and 0.125 µg/mL for posaconazole on 48 h of incubation. The patient died of severe septic shock and multiorgan failure. We also reviewed the literature presenting similar cutaneous scedosporiosis cases and discussed the results."

Journal • Review • Asthma • Critical care • Dermatitis • Dermatology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Pulmonary Disease • Respiratory Diseases • Septic Shock • Thrombocytopenia

An adolescent male presenting with fever and pulmonary opacities (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "His symptoms resolved with treatment of trimethoprim-sulfamethoxazole, itraconazole and glucocorticoids. Significant radiographic improvement was documented at 3-month follow-up."

Journal • Immunology • Infectious Disease • Inflammation • Pneumonia • Primary Immunodeficiency • Respiratory Diseases

Cutaneous and subcutaneous nodular scedosporiosis in a cat. (PubMed, J Mycol Med) - "Despite targeted antifungal treatment with itraconazole and topical ciclopirox olamine, the cat developed systemic complications and died. This case emphasizes the challenges associated with diagnosing and managing opportunistic fungal infections in companion animals. It is, to the authors' knowledge, the first case of infection caused by S. sphaerospermum."

Journal • Dermatitis • Dermatology • Immunology • Infectious Disease • Pain

A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole-A Single-Institution Randomized Placebo-Controlled Trial. (PubMed, Curr Oncol) - "Purpose: This study aims to evaluate the effects of itraconazole as a supplementary treatment with paclitaxel and carboplatin on malignancy response and in preventing the initial development of chemoresistance in chemotherapy-naïve patients with advanced ovarian epithelial cancer. Itraconazole was safe and its use was associated with a significant improvement in the quality of life (QOL). Itraconazole could represent a promising add-on therapy to enhance tumor response to chemotherapy in patients with ovarian cancer."

Clinical • Journal • Platinum resistant • Oncology • Ovarian Cancer • Solid Tumor • KDR • MUC16

Risk factors for Poor Response to Itraconazole in Onychomycosis Patients: A Prospective, Observational Study in China. (PubMed, Mycopathologia) - "First, this study validated that multiple factors are associated with the prognosis of itraconazole pulse therapy for onychomycosis, suggesting that early treatment of the disease and attention to bathing habits can lead to better therapeutic outcomes. Second, based on the contribution of representative variables to the predictive power of the binary multivariate logistic regression model, it can help clinicians better understand the characteristics of patients with onychomycosis who experience treatment failure. These characteristics mainly include a longer disease duration, non-dermatophyte infections, multiple nail involvement, and significant psychological impact. Based on these features, it provides a reliable basis for determining the optimal treatment course of itraconazole pulse therapy for onychomycosis and whether additional treatment is needed."

Journal • Observational data • Infectious Disease

Antifungal and molecular analysis of gene expression caused by haloperidol in Candida spp. (PubMed, Microb Pathog) - "Synergistic interactions were identified between haloperidol and the azoles fluconazole and itraconazole, alongside a 2.5% synergy rate with amphotericin B. Additionally, mechanistic assays confirmed that haloperidol induces programmed cell death (apoptosis) in C. albicans and C. auris strains. It reduced mitochondrial depolarization and decreased the reduction of glutathione (GSH), causing morphological alterations. The results suggest the apoptotic pathway as the main antifungal mechanism of haloperidol."

Biomarker • Journal • Candidiasis