nebulized fentanyl citrate / Boehringer Ingelheim - LARVOL DELTA

Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators (clinicaltrials.gov) - P4 | N=20 | Completed | Sponsor: Queen's University | Suspended ➔ Completed | Trial completion date: Dec 2022 ➔ Mar 2023

Metastases • Trial completion • Trial completion date • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea (clinicaltrials.gov) - P3 | N=21 | Completed | Sponsor: Queen's University | Suspended ➔ Completed

Trial completion • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators (clinicaltrials.gov) - P4 | N=17 | Suspended | Sponsor: Queen's University | Trial completion date: Aug 2022 ➔ Dec 2022 | Trial primary completion date: Sep 2021 ➔ Sep 2022

Trial completion date • Trial primary completion date • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators (clinicaltrials.gov) - P4; N=17; Suspended; Sponsor: Queen's University; Trial primary completion date: Mar 2021 ➔ Sep 2021

Trial primary completion date • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

[VIRTUAL] Exertional dyspnea in COPD: the dominant role of increased diaphragmatic activation (ERS 2020) - " This double-blind crossover study compared combined supplemental O2 (Fi­O2=0.6) and nebulized fentanyl (100mcg) with nebulized bronchodilator (0.5mg ipratropium bromide+2.5mg salbutamol). The strong relationship between dyspnea intensity and diaphragm activation during exercise in COPD was not altered by selective therapeutic manipulation of central medullary or cortical motor centers which introduced significant differences in ventilation, and resting and dynamic respiratory mechanics."

Chronic Obstructive Pulmonary Disease

Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators (clinicaltrials.gov) - P4; N=17; Suspended; Sponsor: Queen's University; Trial primary completion date: Oct 2020 ➔ Mar 2021

Trial primary completion date • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea (clinicaltrials.gov) - P3; N=21; Suspended; Sponsor: Queen's University; Trial completion date: Aug 2020 ➔ Aug 2022; Active, not recruiting ➔ Suspended

Clinical • Trial completion date • Trial suspension • Interstitial Lung Disease • Respiratory Diseases

Inspiratory neural drive and dyspnea in interstitial lung disease: Effect of inhaled fentanyl. (PubMed, Respir Physiol Neurobiol) - "IND rose sharply during constant work rate exercise in association with dyspnea intensity in mild to moderate ILD but was not different after nebulized fentanyl compared with placebo."

Journal • Interstitial Lung Disease • Respiratory Diseases

[VIRTUAL] Aggregated n-of-1 randomized controlled trial of nebulized fentanyl or nebulized furosemide in palliative care patients with refractory breathlessness. (ASCO 2020) - "Adjunctive treatment nebulizer drugs with fentanyl, furosemide and sterile water significantly improve breathlessness symptoms. No significant different in efficacy, adverse events in nebulized fentanyl, furosemide and sterile water. N-of-1 trials may provide a rational and effective method to best choose drugs for individuals with breathlessness."

Clinical • Oncology • Palliative care

Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea (clinicaltrials.gov) - P3; N=21; Active, not recruiting; Sponsor: Queen's University; Recruiting ➔ Active, not recruiting

Clinical • Enrollment closed • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

Comparison of efficacy nebulized fentanyl with intravenous ketorolac for renal colic in patients over 12 years old. (PubMed, Am J Emerg Med) - "Intravenous ketorolac had better analgesic effects in renal colic patients compared with nebulized fentanyl. Further studies that include complications and combinational therapy are required."

Clinical • Journal • CNS Disorders • Pain

Nebulized Fentanyl in Patients With Mild to Moderate Idiopathic Pulmonary Fibrosis and Chronic Dyspnea (clinicaltrials.gov) - P3; N=20; Recruiting; Sponsor: Queen's University; Trial completion date: Jul 2019 ➔ Jul 2020; Trial primary completion date: Jul 2019 ➔ Mar 2020

Clinical • Trial completion date • Trial primary completion date

Comparison of Nebulized Fentanyl, Midazolam and Dexmedetomidine as a Premedication in Pediatric Dental Surgeries (clinicaltrials.gov) - P=N/A; N=39; Recruiting; Sponsor: Zagazig University

Clinical • New trial

Nebulized Fentanyl for Dyspnea: A Retrospective Chart Review. (PubMed, J Pain Palliat Care Pharmacother) - "Our preliminary data suggest that nebulized fentanyl has limited side effects and may have a role in the treatment of dyspnea. Further research is necessary to determine its efficacy."

Journal • Retrospective data

Impact of nebulized fentanyl on exertional dyspnea in interstitial lung disease (ERS 2019) - "Conclusions : In ILD exertional dyspnea increases in tandem with IND as IRV decreases. Nebulized fentanyl had no effect on dyspnea, IND, dynamic respiratory mechanics or their inter-relationships during exercise."

Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: A randomized, double-blind, clinical trial. (PubMed, Afr J Emerg Med) - "Multiple comparison analysis showed that pain scores were significantly higher in the patients of Group I. Moreover, patients in Group I required additional treatment. Ketamine can be used as an alternative non-invasive treatment to successfully relieve pain in patients with limb fractures."

Clinical • Journal

Effect of Inhaled Fentanyl on Dyspnea and Exercise Tolerance in Chronic Obstructive Pulmonary Disease (COPD) (clinicaltrials.gov) - P=N/A; N=16; Completed; Sponsor: Queen's University; Recruiting ➔ Completed

Clinical • Trial completion