bromocriptine / Generic mfg. - LARVOL DELTA

Case Report: Paralytic ileus as an early manifestation of evolving neuroleptic malignant syndrome in a patient receiving anti-psychotics. (PubMed, Front Med (Lausanne)) - "This atypical and underreported presentation highlights the importance of maintaining a high index of suspicion for NMS in patients receiving antipsychotic therapy who develop unexplained gastrointestinal dysmotility. Prompt recognition, immediate discontinuation of the offending antipsychotic agent, and early initiation of treatment with dantrolene and bromocriptine resulted in a favorable clinical outcome."

Journal • CNS Disorders

Therapeutic effects of bromocriptine on pulmonary arterial hypertension (ERS 2026) - "Bromocriptine ameliorates hemodynamic impairment and vascular remodeling in MCT-induced PAH rats by inhibiting VEGF-driven endothelial proliferation and migration, suggesting a novel therapeutic strategy for PAH."

Cardiovascular • Inflammation • Pulmonary Arterial Hypertension • Respiratory Diseases

Left Ventricular Recovery Following Bromocriptine Initiation at Different Stages of Peripartum Cardiomyopathy: A Report of Two Cases. (PubMed, Cureus) - "Her LVEF improved to 39% by hospital day 15 and ultimately recovered to 61%. These cases demonstrate a temporal association between bromocriptine initiation and subsequent improvement in left ventricular systolic function at different stages of the clinical course of PPCM."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Thrombosis

Drugs associated with retroperitoneal fibrosis: assessment of the 1969-2025 Food and Drug Administration (FDA) pharmacovigilance database. (PubMed, Pharmacol Rep) - "This pharmacovigilance analysis identified multiple medications, spanning different therapeutic classes, that demonstrated a disproportionate association with reports of RPF. Notably, some drugs with well-established safety profiles also emerged as potential signals, warranting increased clinical awareness. While this analysis reveals pharmacovigilance signals suggestive of drug-induced RPF, the observational nature of FAERS data limits causal inference. These findings underscore the need for further clinical research and mechanistic studies to better understand the etiopathogenic role of these agents in RPF development."

Adverse events • Journal • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease

Alterations of Telomere-Associated Genes and Underlying Mechanisms in Hypoxic-Ischemic Encephalopathy. (PubMed, Neuropharmacology) - "The study systematically identified Telomere-DEGs in neonatal HIE, characterized the disease's inflammatory immune microenvironment, and predicted potential targeted therapeutic agents. SOCS3 upregulation in HIE was confirmed both in vivo and in vitro. In vitro mechanistic studies suggest that SOCS3 aggravates telomere damage and oxidative stress through NF-κB activation, leading to neuronal injury, thus providing experimental evidence for HIE mechanism research and targeted therapy."

Journal • CNS Disorders • Inflammation • SOCS3 • TERF2

Acute Peripartum Cardiomyopathy With Cardiogenic Shock Requiring Venoarterial Extracorporeal Membrane Oxygenation: A Case Report Of Complete Ventricular Recovery (HFSA 2026) - "With disease progression, VA-ECMO provides temporary biventricular support as a bridge to recovery, leveraging the myocardial regeneration potential unique to PPCM.Case Presentation: A 35-year-old G1P0 woman with a history of Hodgkin lymphoma treated with doxorubicin-based chemotherapy and IVF-conceived dichorionic diamniotic twin pregnancy presented for delivery...Bromocriptine was initiated for lactation suppression and cardioprotection...VA-ECMO provided essential biventricular support; concurrent bumetanide and clevidipine addressed LV afterload elevation from retrograde ECMO flow... This case reinforces the importance of early mechanical circulatory support as a bridge-to-recovery strategy. Prospective registries examining interactions among cardiotoxic chemotherapy, assisted reproductive technology, preeclampsia, and PPCM outcomes are needed."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Gynecology • Heart Failure • Hematological Malignancies • Hodgkin Lymphoma • Hypertension • Hypotension • Lymphoma

Synergistic effect of GLP-1 and dopamine receptors agonists in adipose tissue and liver metabolism in obese-diabetic rats (EASD 2026) - "These findings indicate that the combination of liraglutide and bromocriptine provides additional benefits, supporting its therapeutic potential for metabolic disorders."

Preclinical • Diabetes • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • SLC2A4

Massive Bilateral Breast Hypertrophy in Pregnancy Due to Gestational Gigantomastia: A Case Report and Review of the Literature. (PubMed, Cureus) - "Cabergoline was then administered to suppress lactation. In severe cases, surgical treatment (reduction mammoplasty or bilateral mastectomy with delayed reconstruction) is the mainstay of treatment, and bromocriptine is the best-established medical alternative, but with variable success. Coordinated multidisciplinary care is essential to optimise patient outcomes and minimise life-threatening complications."

Journal • Breast Cancer • Dermatology • Immunology • Infectious Disease • Inflammatory Breast Cancer • Musculoskeletal Pain • Oncology • Pain • Rare Diseases • Solid Tumor

Neurostimulants for disorders of consciousness in the intensive care unit: A systematic review. (PubMed, Gen Hosp Psychiatry) - "Neurostimulants were associated with short-term improvements in measures of arousal and recovery, although evidence remains heterogeneous and largely observational. Amantadine has the largest ICU evidence base; methylphenidate has been studied as monotherapy and augmentation; modafinil has primarily been evaluated for hypersomnolence. Further placebo-controlled trials are needed to establish efficacy across different causes of DoC; head-to-head studies are needed to clarify comparative effectiveness among available neurostimulants."

Journal • Review • Critical care

Neuromodulation to Promote Recovery Following Traumatic Brain Injury: A Narrative Review of Current Pharmacologic and Non-Pharmacologic Approaches. (PubMed, Brain Sci) - "This narrative review summarizes current evidence supporting pharmacologic neuromodulatory therapies, including central nervous system stimulants (methylphenidate and modafinil), dopaminergic agents (amantadine and bromocriptine), acetylcholinesterase inhibitors (donepezil and rivastigmine), and selective serotonin reuptake inhibitors (sertraline and fluoxetine). However, current evidence is limited by heterogeneous study populations, small sample sizes, inconsistent outcome measures, and a paucity of long-term randomized controlled trials. Future research should prioritize adequately powered comparative studies, standardized outcome measures, biomarker-guided patient selection, and multimodal treatment strategies to optimize neurological recovery following TBI."

Journal • Review • CNS Disorders • Fatigue • Vascular Neurology

Neuroleptic Malignant Syndrome (PubMed, Medicina (B Aires)) - "Management relies on immediate discontinuation of the offending agent, intensive supportive care, and, in moderate to severe cases, pharmacological treatment with benzodiazepines, dopaminergic agents such as bromocriptine or amantadine, and muscle relaxants such as dantrolene. Early recognition and timely treatment are crucial to ensure favorable outcomes and reduce morbidity and mortality."

Journal • Review • CNS Disorders • DRD2

Dopaminergic fronto-striatal connectivity underlies schema-dependent learning. (PubMed, J Psychopharmacol) - "Our findings give novel insights by showing that schema-dependent learning is modulated by dopamine, and they suggest that this relates to fronto-striatal connectivity."

Journal

Management of Peripartum Cardiomyopathy With and Without Bromocriptine: A Comparative Study. (PubMed, Cureus) - "Both groups showed improvement in left ventricular function. Low-dose one-week bromocriptine was associated with greater one-month LVEF in this cohort, but the non-randomized design, baseline imbalances, limited documentation of background therapy and anticoagulation, and short follow-up preclude causal claims. The findings should be interpreted as hypothesis-generating and require confirmation in larger protocolized studies with adjustment for confounding and longer follow-up."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Critical care • Heart Failure

Pharmacokinetics of oral bromocriptine in postpartum patients. (PubMed, Pregnancy (Hoboken)) - "In this modest sample, several PK parameters of oral bromocriptine in healthy postpartum participants differed from those reported in the literature, which may be due to physiological changes in pregnancy. The association between PK parameters and clinical outcomes in patients with PPCM warrants further evaluation."

Journal • PK/PD data • Cardiomyopathy • Cardiovascular

A Rare Constellation of Peripartum Cardiomyopathy Manifesting With Multiple Thromboembolic Phenomena in a 15-Year-Old. (PubMed, Clin Case Rep) - "Diagnostics confirmed concurrent cardioembolic stroke and pulmonary embolism secondary to peripartum cardiomyopathy (ejection fraction 29%). Managed successfully without thrombolysis using low-molecular-weight heparin, bromocriptine, heart failure therapy, and multidisciplinary care, achieving near complete neurological recovery."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ischemic stroke • Pain • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Reproducible Generalized Thermal Sensation Triggered by Levodopa in a Patient With Parkinson's Disease. (PubMed, J Med Cases) - "The phenomenon was subsequently reproduced during supervised medication rechallenge, but did not occur during monotherapy or combination therapy with dopamine agonists (pramipexole, rotigotine, and bromocriptine) and selegiline. The described phenomenon may represent a rare or underrecognized adverse effect of levodopa. As a part of comprehensive follow-up on patient's health and wellbeing after treatment for PD, careful attention to emergent unusual thermal phenomena can constitute good clinical practice."

Journal • CNS Disorders • Movement Disorders • Pain • Parkinson's Disease

Multiple endocrine neoplasia presenting initially as acute pulmonary thromboembolism: a case report (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "Oral bromocriptine was continued for the pituitary adenoma, and parathyroidectomy was performed after correction of the hypercalcemic crisis...Through a brief literature review, we explored how MEN1 may contribute to a hypercoagulable state. The case highlighted the importance of endocrine and genetic screening in patients with unexplained pulmonary embolism."

Journal • Cardiovascular • Endocrine Disorders • Gastrointestinal Neuroendocrine Tumor • Neuroendocrine Tumor • Oncology • Pancreatic Cancer • Pituitary Gland Carcinoma • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • MEN1

Functioning pituitary adenomas in pregnancy: updates and controversies. (PubMed, Curr Opin Endocrinol Diabetes Obes) - "Owing to the relative rarity of functioning pituitary adenomas in pregnancy, current clinical practice and guidelines rely largely on limited retrospective evidence regarding the disease course and outcomes. Although new medical therapies for acromegaly and Cushing's disease are now available, data to support their use in pregnancy are lacking. Management therefore remains individualized and emphasizes shared decision-making."

Journal • Acromegaly • Cushing’s Disease • Endocrine Disorders • Pituitary Gland Carcinoma

Ex Vivo drug sensitivity in patient-derived 3D cultures in acromegaly and its association with clinical predictors. (PubMed, Pituitary) - "Spheroid-based Pd3D ex vivo viability assays revealed modest but significant cohort-level effects and sample-level concordance with clinical predictors, suggesting its potential utility as an exploratory model. Additionally, AI-based quantification of SSTR2 dynamics captured functional receptor shifts."

Journal • Preclinical • Acromegaly • Endocrine Disorders • Oncology • Pituitary Gland Carcinoma • SSTR2

Depressive Burden and Interoceptive Disturbance Improve After Bromocriptine Treatment in Women with Microprolactinomas. (PubMed, Endocr Pract) - "Women with microprolactinomas showed improvements in both emotional symptoms and interoceptive awareness following bromocriptine treatment. Emotional disturbances in these patients may be more closely associated with altered interoceptive processing than with prolactin levels themselves."

Journal • CNS Disorders • Depression • Psychiatry

Cardiovascular pharmacology of dopaminergic agents in humans: a review. (PubMed, Clin Auton Res) - "The cardiovascular response to dopaminergic agents depends on receptor selectivity, intrinsic activity, and baroreflex integrity. The discrepancy between murine-knockout-predicted hypertension and human pharmacological neutrality with antagonists, and the hypertensive effects of dopamine D1 positive allosteric modulators, represent key unresolved questions."

Journal • Review • Cardiovascular • CNS Disorders • Hypertension • Hypotension • Mental Retardation • Movement Disorders • Parkinson's Disease • Psychiatry

Association Between Ergot-Derived Dopamine Agonists and Valvular Heart Disease: A Systematic Review and Meta-Analysis. (PubMed, Cardiol Rev) - "The pooled risk ratio of VHD was significantly elevated in patients treated with pergolide [risk ratios (RR) 2.29, 95% confidence interval (CI): 1.62-3.24], cabergoline (RR 1.68, 95% CI: 1.21-2.34), and bromocriptine (RR 1.52, 95% CI: 1.02-2.27). Ergot-derived DAs are significantly associated with an increased risk of VHD. Close echocardiographic monitoring should be emphasised for patients receiving ergot-derived DAs, particularly those on long-term or high-dose therapy."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Heart Failure • Movement Disorders • Parkinson's Disease

Neuroleptic malignant syndrome precipitated by chlorpromazine: a case report. (PubMed, J Med Case Rep) - "This case highlights that NMS may occur rapidly following a single lowtherapeutic dose of chlorpromazine. Early recognition and timely management are essential for favorable outcomes. To our knowledge, this is the first reported case of chlorpromazine-induced NMS from Somalia."

Journal • CNS Disorders

Long-term survival in glioblastoma patients treated with dopamine agonists: A report of two cases and implications for drug repurposing. (PubMed, Surg Neurol Int) - "The first patient, treated with the ergot derivative bromocriptine for a prolactinoma, presented with multifocal disease and underwent subtotal resection...The second patient, a 70-year-old male with Parkinson's disease treated with the non-ergot dopamine agonist pramipexole and with Sinemet, which increases the amount of available dopamine...These observational cases suggest a hypothetical association between dopamine agonist therapy and improved survival outcomes in GBM, challenging the current paradigm that favors receptor antagonism. Given the safety, low cost, and blood-brain barrier penetrance of these Food and Drug Administration-approved drugs, we propose that dopamine agonists warrant further investigation as repurposed adjuvant agents in GBM treatment."

Journal • Brain Cancer • CNS Disorders • Glioblastoma • Movement Disorders • Oncology • Parkinson's Disease • Solid Tumor • DRD2

Neuroleptic Malignant Syndrome in a Young Male on Clozapine: A Diagnostic and Therapeutic Challenge. (PubMed, Ann Afr Med) - "This case highlights the importance of early recognition of NMS in patients receiving antipsychotic therapy. Prompt diagnosis, withdrawal of the offending drug, and aggressive supportive treatment are essential to improve outcomes and reduce mortality."

Journal • CNS Disorders • Mental Retardation • Psychiatry