ceftazidime / Generic mfg. - LARVOL DELTA

A second occurrence of intravitreal injection-associated endophthalmitis 2 years apart. (PubMed, Am J Ophthalmol Case Rep) - "The patient underwent vitreous tap and injection with intravitreal vancomycin, ceftazidime, and dexamethasone...Endophthalmitis is a rare complication of intravitreal injection. The current report describes a patient who developed a second occurrence of endophthalmitis associated with an intravitreal injection 2 years later."

Journal • Age-related Macular Degeneration • Diabetes • Inflammation • Macular Degeneration • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Wet Age-related Macular Degeneration

Meropenem, Ceftazidime, and Polymyxin B combination therapy: a novel approach to combat antimicrobial resistance in MDR, XDR and PDR Escherichia coli. (PubMed, J Antibiot (Tokyo)) - "Dual and triple combination regimens were found to be effective for treating MDR, XDR, and PDR isolates. The present study suggested a promising strategy in in vitro conditions, but its effectiveness still requires further in vivo validation considering pharmacokinetics/pharmacodynamics (PK-PD) modeling and dynamic dosing regimens."

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Comparison of clinical and microbiological features between mucoid and non-mucoid Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis. (PubMed, Microbiol Spectr) - "Time-kill assays revealed a higher tolerance of mucoid isolates to ceftazidime, ciprofloxacin, and tobramycin, with comparable killing observed only for colistin. Our findings also suggest that conventional antimicrobial susceptibility testing may not fully reflect the clinical challenges posed by mucoid strains. These results highlight the need for improved diagnostic and therapeutic strategies tailored to the distinctive characteristics of mucoid P. aeruginosa in bronchiectasis."

Journal • Bronchiectasis • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Non‐Cystic Fibrosis Bronchiectasis • Pulmonary Disease • Respiratory Diseases

Secondary orbital abscess from hypervirulent Klebsiella pneumoniae panophthalmitis with scleral necrosis. (PubMed, Orbit) - "She showed no visual improvement with intravitreal ceftazidime/vancomycin. This case exemplifies hmvKp with the defining clinical features of hvKp. To our knowledge, this is a unique case of scleral melt with these devastating corollaries."

Journal • Diabetes • Hepatology • Infectious Disease • Metabolic Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Pneumonia

Emergence of Hypervirulent, Multidrug-Resistant Klebsiella pneumoniae Harboring magA in Coastal Water Sources: A Public Health Threat in Flood-Prone Communities. (PubMed, Water Environ Res) - "Resistance was observed against critically important antibiotics, including carbapenems and colistin, with the highest Minimum inhibitory concentration (MIC) values against ceftazidime and ampicillin (> 256 μg/mL). Both phenotypes harbored key resistance genes (blaTEM, blaSHV, and blaOXA), indicating a high potential for severe hard-to-treat infections. These findings underscore the urgent need for continuous environmental surveillance and One Health interventions to combat the rise of environmental hypervirulent K. pneumoniae and protect public health in flood-prone regions."

Journal • Gene Therapies • Infectious Disease • Pneumonia

Evaluating the antibacterial activity of ceftazidime/avibactam and aztreonam combinations against multidrug-resistant Stenotrophomonas maltophilia complex isolates in a hollow fiber infection model. (PubMed, Clin Microbiol Infect) - "Smc infections remain challenging due to intrinsic resistance mechanisms. These findings demonstrate the therapeutic potential of ATM+CZA, and support further evaluation using murine pneumonia and bacteremia models of S. maltophilia."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Severe respiratory syncytial virus bronchiolitis complicated by profound hyponatremia and seizures in an infant: a case report. (PubMed, AME Case Rep) - "Hyponatremia was managed with 3% hypertonic saline, and she received empiric antibiotics, later tailored to ceftazidime and amikacin, along with supportive therapy. Routine monitoring of serum sodium at admission, cautious use of intravenous fluids, and early recognition of neurological symptoms are essential to avoid serious outcomes. Awareness of this potential complication can help clinicians initiate timely management and prevent life-threatening consequences."

Journal • Cardiovascular • CNS Disorders • Cough • Critical care • Epilepsy • Heart Failure • Infectious Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Distribution of Isolated Pathogens and Resistance Patterns in Non-Ventilator Hospital-Acquired Pneumonia at King Hamad University Hospital (KHUH), Bahrain: A Retrospective Study. (PubMed, Cureus) - "Resistance to ceftazidime, cefuroxime, levofloxacin, meropenem, and piperacillin-tazobactam increased significantly over time. Conclusion NV-HAP in Bahrain is characterized by a high burden of MDR K. pneumoniae, particularly among elderly patients, and increasing resistance to commonly used agents. These findings highlight the need to revise empiric treatment strategies and strengthen antimicrobial stewardship, providing baseline data to guide NV-HAP management and regional surveillance."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Two Cases of Catheter-Related Bloodstream Infection: A Previously Unreported Complication of Long-Term Ritodrine Tocolysis. (PubMed, Cureus) - "The second case involved Achromobacter xylosoxidans bacteremia, treated successfully with ceftazidime, resulting in favorable maternal and neonatal outcomes. Both pathogens are opportunistic, typically affecting immunocompromised hosts or patients with indwelling devices, and their occurrence in otherwise healthy pregnant women underscores the risks of long tocolysis. These cases highlight CRBSI as a potentially life-threatening complication of long-term intravenous RT and emphasize the need to carefully balance its use against adverse outcomes."

Journal • Infectious Disease

Prevalence, Demographic Distribution, and Antimicrobial Resistance Patterns of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Urinary Tract Infections: A Cross-Sectional Study in a Tertiary Care Hospital in Manipur, India. (PubMed, Cureus) - "This study demonstrates a high prevalence of ESBL-producing E. coli in both community and hospital settings in Manipur, underscoring the urgent need for routine screening, enhanced antimicrobial stewardship, ongoing surveillance, and evidence-based empirical therapy guidelines to curb escalating resistance and improve patient outcomes."

Journal • Observational data • Infectious Disease • Nephrology

A Case of Severe Neonatal Neutropenia Secondary to Late-Onset Sepsis From E. coli Omphalitis. (PubMed, Cureus) - "The patient was managed with targeted intravenous ceftazidime and a short course of granulocyte colony-stimulating factor (G-CSF). A comprehensive workup, including a bone marrow aspirate and whole exome sequencing (WES), was performed to rule out congenital etiologies; WES returned negative, supporting the diagnosis of acquired, sepsis-induced neutropenia. On follow-up at two months of age, the infant was asymptomatic and thriving well and had a normal complete blood count with differential (CBCD). This case underscores the importance of a systematic diagnostic approach to neonatal neutropenia, highlighting the differential diagnosis and the evolving role of advanced genetic testing such as WES in providing definitive diagnostic and prognostic clarity, thereby guiding appropriate management."

Journal • Hematological Disorders • Infectious Disease • Neutropenia • Septic Shock • CRP

A novel green synthesized ZnO-based antimicrobial nanocomposite: synergistic action, in vitro cytotoxicity, and molecular docking studies of ceftazidime, metformin, and chitosan against multidrug-resistant Salmonella enterica. (PubMed, Microb Cell Fact) - "The present study demonstrates the novelty of a ZnO-based multicomponent nanocomposite that uniquely integrates CAZ, MTF, and CS. This novel formulation exhibited synergistic antibacterial effects against multidrug-resistant Salmonella enterica alongside acceptable in vitro safety. The findings underscore the potential of microbially synthesized nanocomposites as promising candidates for combating antibiotic-resistant bacterial infections and support further preclinical investigations."

Journal • Preclinical • Infectious Disease

Limb Salvage in Methicillin-Resistant Staphylococcus aureus (MRSA)-Complicated Necrotic Loxoscelism Through Lifotronic® Negative Pressure Wound Therapy and Wolfe-McGregor Reconstruction. (PubMed, Cureus) - "The patient received broad-spectrum antimicrobial therapy with linezolid, ceftazidime, and metronidazole, followed by vacuum-assisted closure therapy using the Lifotronic® Negative Pressure Wound Therapy System and a Wolfe-McGregor skin graft, achieving full recovery of the limb. This case highlights the efficacy of a multimodal approach combining targeted anti-MRSA therapy, negative pressure wound therapy, and reconstructive grafting in achieving limb salvage and preserving functional mobility in high-risk patients with complicated necrotic loxoscelism."

Journal • Cardiovascular • Chronic Kidney Disease • Genito-urinary Cancer • Hypertension • Infectious Disease • Nephrology • Oncology • Prostate Cancer • Solid Tumor • CRP

An insight into the characterization of multidrug resistant Salmonella Minnesota isolated from poultry in Brazil. (PubMed, Infect Genet Evol) - "High resistance rates were observed against ciprofloxacin (100%), ceftazidime (95%), and gentamicin (70%). While SISTR identified all strains as S. Minnesota, SeqSero identified one as S. Minnesota and 19 as S. Rochdale, a difference that highlights the limitations of serological and in-silico methods for closely related serovars. These results emphasize the spread of MDR S. Minnesota in poultry and the necessity of genomic surveillance for accurate resistance monitoring and public health protection."

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Ischial Tuberosity Osteomyelitis: A Rare Complication Following Platelet-Rich Plasma Injection: A Case Report. (PubMed, JBJS Case Connect) - "This first reported case of PRP-associated ischial osteomyelitis highlights the role of minimally invasive pelvic bone biopsy and the importance of postinjection vigilance."

Journal • Immunology • Inflammation • Musculoskeletal Pain • Pain • CRP

Antimicrobial resistance and real-time PCR detection of blaKPC in Klebsiella pneumoniae isolated from wound infections in a tertiary care hospital. (PubMed, Front Antibiot) - "Out of 560 K. pneumoniae isolates, 110 (19.6%) were resistant to meropenem. These resistant isolates also displayed high rates of multidrug resistance, with over 90% resistant to amikacin, ceftazidime, ampicillin, and cefazolin...In conclusion, K. pneumoniae isolates exhibit a concerning rate of carbapenem resistance mediated by the blaKPC gene. Antimicrobial stewardship and molecular surveillance are crucial for the prevention of the spread of carbapenem-resistant K. pneumoniae in clinical settings."

Journal • Infectious Disease • Pneumonia

Multidrug-resistant Staphylococcus hominis endophthalmitis after cataract surgery: A case report. (PubMed, IDCases) - "A pars plana vitrectomy was performed and vancomycin and ceftazidime were administered intravitreally...The medication was modified accordingly, with topical gentamicin and oral doxycycline, under daily close monitoring. One month later, cystoid macular edema appeared, which was successfully treated with acetazolamide, topical corticosteroids, and bromfenac. Three months after surgery, the patient's vision had returned to 9/10 without any permanent damage. Early surgical intervention, culture-guided therapy, and intensive follow-up can preserve vision even in postoperative endophthalmitis due to multidrug-resistant organisms."

Journal • Cataract • Inflammation • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology

Antibiotic susceptibility of Gram-negative bacteria in cerebrospinal fluid compared to Mueller-Hinton broth and artificial cerebrospinal fluid. (PubMed, Int J Antimicrob Agents) - "In CNS infections, when antimicrobial susceptibility testing in standard media does not result in adequate therapeutic options, we suggest to test the antimicrobial susceptibility of the causative bacterium in human CSF."

Journal • Infectious Disease

Posterior Nodular Scleritis in a Leukemic Patient: A Case Report. (PubMed, Case Rep Ophthalmol) - "Topical corticosteroids, intravitreal injections of vancomycin and ceftazidime, oral trimethoprim-sulfamethoxazole, and intravenous tazocillin were administered. NPS is a rare pathology, most commonly idiopathic. A systemic checkup and vitrectomy with subretinal biopsy should be considered in immunosuppressed leukemic patients when the etiology of the nodule remains uncertain."

Journal • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Leukemia • Neutropenia • Ocular Inflammation • Oncology • Ophthalmology • Pain • Retinal Disorders • Scleritis

Endophthalmitis After Dexamethasone Implant. (PubMed, Clin Exp Ophthalmol) - "The rate of dexamethasone implant-related endophthalmitis is 0.16% which is higher than other intravitreal injections reported in the literature, with considerably poor visual outcomes. The vitreous diagnostic samples are culture-positive in 87% of cases (13/15), with 46.7% (7/15) isolating Staphylococcus epidermidis."

Journal • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

Biochemical and structural analyses of metallo-β-lactamase VIM-28: impact of substitutions at residues 224 and 228 on substrate profile, stability, and zinc affinity. (PubMed, Microbiol Spectr) - "Compared with VIM-26 (R228S), VIM-28 displayed decreased Km (12.5 for VIM-28 vs 513 μM for VIM-26; 9.66 vs 150 μM) and increased kcat/Km(15.3 vs 1.81 μM-1s-1; 28.6 vs 5.89 μM-1s-1) for ampicillin and cephalothin, respectively...The combined L224H/R228S substitutions in VIM-1 increased the catalytic efficiency of the enzyme for ceftazidime by more than one order of magnitude...Notably, the R228S substitution improved zinc binding and thermal stability, supporting enzyme function under zinc-limited host conditions. These findings reveal mechanisms driving MBL diversity and highlight evolutionary strategies sustaining antibiotic resistance."

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Unusual Sternoclavicular Joint Infection With Pseudomonas in a Young Adult With Hidradenitis Suppurativa: A Case Report. (PubMed, Cureus) - "He showed clinical improvement and normalization of inflammatory markers with intravenous ceftazidime for two weeks, and he was discharged home on oral ciprofloxacin for four weeks. In this context, we underscore the need to consider uncommon pathogens in atypical infection sites."

Journal • Dermatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation

Neonatal Sepsis: Etiology, Antimicrobial Susceptibility, and Treatment Outcomes in a Tertiary Hospital in Jos, Nigeria. (PubMed, Am J Trop Med Hyg) - "More organisms were sensitive to piperacillin-tazobactam (19/19; 100%), gentamicin (21/27; 78%), imipenem (4/8; 50%), and ceftazidime (17/28; 61%) than to the other antibiotics tested. Neonatal sepsis-related mortality is high in the study center in Jos, Nigeria. Additional work is needed to mitigate NNS mortality and the rising problem of antimicrobial resistance."

Journal • Retrospective data • Infectious Disease • Pneumonia • Septic Shock

Catastrophic Consequences of Bacillus Cereus–Contaminated Hematopoietic Stem Cells: Hemolytic Transfusion Reaction, Septic Shock, and Adaptive GVHD Prophylaxis in a Pediatric Allogeneic Transplant (TCT-ASTCT-CIBMTR 2026) - " An 18-year-old female with severe aplastic anemia underwent conditioning with fludarabine, cyclophosphamide, total-body irradiation, and rATG before matched unrelated donor HCT...Empiric vancomycin and ceftazidime were escalated to meropenem for 14 days. Methotrexate was withheld due to AKI, and mycophenolate mofetil (MMF) was substituted from day +2 to +45... B. cereus contamination of HCT products constitutes a medical emergency with life-threatening consequences. Prompt recognition, aggressive supportive care, and predefined institutional protocols are essential to improve outcomes. This case illustrates the feasibility of tailoring GVHD prophylaxis when standard agents are contraindicated by organ dysfunction and underscores the importance of coordinated multidisciplinary management in these rare but catastrophic scenarios."

Clinical • Acute Graft versus Host Disease • Acute Kidney Injury • Aplastic Anemia • Graft versus Host Disease • Hematological Disorders • Immunology • Nephrology • Pediatrics • Septic Shock • Transplantation

Eco-Friendly Synthesis of Magnesium Oxide Nanoparticles Using Citrullus colocynthis and their Synergistic Antimicrobial Activity against Drug-Resistant Pathogens. (PubMed, Curr Microbiol) - "Remarkably, MgO-NPs restored susceptibility to β-lactam antibiotics (ceftazidime and penicillin) in resistant strains, demonstrating synergistic effects...Phytochemical analysis revealed solvent-dependent bioactive constituents in C. colocynthis, with aqueous extracts rich in tannins/phenolics and methanolic extracts rich in flavonoids/terpenoids. This is the first report demonstrating the restoration of antibiotic susceptibility by MgO-NPs synthesized from C. colocynthis extract."

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