ceftazidime / Generic mfg. - LARVOL DELTA

Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic. (PubMed, Front Cell Infect Microbiol) - "coli) showed a numerical increase in ceftazidime resistance...faecium) remained susceptible to vancomycin and linezolid...coli maintained favorable susceptibility to carbapenems and piperacillin-tazobactam, whereas K. pneumoniae showed a fluctuating carbapenem resistance trend that initially increased then declined, though it remained susceptible to tigecycline...Enhanced hand hygiene and contact isolation are consistent with a sustained decline in CoNS, but show limited association with changes in Gram-negative bacilli. Routine surveillance and optimized empirical therapy remain crucial for improving neonatal sepsis outcomes."

Journal • Observational data • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Septic Shock

Culture-Proven Haemophilus influenzae Endophthalmitis After Intravitreal Topotecan for Retinoblastoma. (PubMed, J Vitreoretin Dis) - "Urgent 23-gauge pars plana vitrectomy was performed to clear dense vitritis and maintain oncologic control using a closed-system approach, melphalan irrigation (5 µg/mL), IVT topotecan, port-site cryotherapy, and silicone oil tamponade. The patient also received IVT vancomycin, ceftazidime, and voriconazole...The infection resolved, the tumor continued to regress, and no extraocular tumor spread was observed during 24 months of follow-up. Early, tailored vitrectomy may help preserve vision in severe endophthalmitis after IVT chemotherapy for retinoblastoma when strict oncologic precautions are maintained, with long-term follow-up required to monitor for tumor recurrence or extraocular spread."

Journal • Eye Cancer • Infectious Disease • Influenza • Ocular Infections • Ocular Inflammation • Ocular Melanoma • Oncology • Ophthalmology • Respiratory Diseases • Retinal Disorders • Retinoblastoma • Solid Tumor

Cohort profile: Infant Gut Bacterial Study in Pakistan (INBUGS-P) longitudinal birth cohort. (PubMed, BMJ Open) - "Antibiotics were prescribed to almost all mothers following delivery, and 19 infants received antibiotics during follow-up, most commonly amikacin combined with ceftazidime. Shotgun metagenomic sequencing of infant stool samples is underway to enable species-level and plasmid-level profiling of microbial communities and ARGs. Subject to funding, hybrid long- and short-read sequencing and extended follow-up to 24 months are planned."

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Multifunctional calcium phosphate-bioactive glass composite cement with controlled degradation and local antibiotic delivery for bone regeneration. (PubMed, J Mater Chem B) - "The incorporation of mesoporous BG was associated with sustained, pseudo-Fickian release of vancomycin and ceftazidime over 28 days. Finally, an in vivo critical-sized rat cranial defect model confirmed that the composite achieves uniform, accelerated bone regeneration and substantial defect closure within 8 weeks. Together, these findings demonstrate that this degradation-associated delivery framework represents a promising strategy for managing complex, infection-prone bone defects."

Journal • Infectious Disease • ALPL

Pseudomonas antimicrobial resistance profile in cystic fibrosis: a 30-year report (ERS 2026) - "Looking at AMR data, cumulative prevalence of AMR in our dataset was 67.7% aminoglycosides, 24.8% fluoroquinolones, 45.7% carbapenems, 40.3% beta-lactams.Logistic regression odds ratio showed an increasing risk of developing resistance to aminoglycosides (+2.8%/year), fluoroquinolones (+5.0%/year), carbapenems (+3.4%/year) while beta-lactams showed a negative trend (-1.0%/year), all with p-values 0.3) correlate with carbapenem resistance...CONCLUSIONAMR prevalence in pwCF is increasing, constant epidemiological monitoring is necessary. AMR mechanisms should be studied with molecular techniques to better characterize their epidemiology and tailor antimicrobial stewardship accordingly."

Cough • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Respiratory Diseases

Survey of Antibiotic Resistance of Acinetobacter Baumannii and Pseudomonas Aeruginosa at Ninh Thuan Province General Hospital in Vietnam in 2023. (PubMed, Endocr Metab Immune Disord Drug Targets) - "The high prevalence of antimicrobial resistance in hospitals and the general population highlights the urgent need for effective control programs. Future regional epidemiological data on ABR and AMR patterns will be essential for implementing rigorous national antibiotic policies aimed not only at limiting the spread of resistant bacteria but also at identifying more effective solutions, both in Vietnam and in Italy."

Journal • Infectious Disease

An AI-Driven Chemogenomics Knowledgebase for Human-Transmissible Pathogens: A Platform for Antimicrobial Drug Discovery. (PubMed, J Chem Inf Model) - "In wet-lab validations, four approved drugs (cefixime, ceftazidime, saquinavir, and rilapladib) identified via virtual screening show binding activity to SARS-CoV-2 nucleoprotein in affinity assays and inhibit SARS-CoV-2 replication in Vero E6 cells, demonstrating HPM-CKB's potential in drug repurposing. Meanwhile, two anti-Staphylococcus aureus lead compounds with novel scaffolds (CYC-HXL-9124 and CYC-HXL-9126) are identified via deep learning, and the potential target protein, cell division protein FtsZ, is subsequently prioritized using HPM-CKB (http://cgai.asia/g/pathogenDB) and experimentally validated by affinity assays. Collectively, these findings establish HPM-CKB as both a chemogenomic knowledgebase and a systematic drug development platform against EIDs."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CKB

Comparable Allergic Reaction Rates After Ceftazidime vs Penicillin in Aztreonam-Allergic Patients— United States, 2000–2025 (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Genomic diversity, antimicrobial resistance, and virulence-associated characteristics of Escherichia coli recovered from poultry hatchery-box material. (PubMed, Poult Sci) - "Following within-sample reduction based on antimicrobial susceptibility profiles and PCR screening for selected APEC-associated virulence genes, 91 isolates enriched for cefotaxime-medium recovery or APEC-associated gene profiles were selected for Illumina whole-genome sequencing...Seventeen isolates were resistant to ceftazidime; eight carried ESBL or plasmid-mediated AmpC determinants, while eight additional isolates had the chromosomal ampC promoter substitution C-42T as the only identified determinant associated with this phenotype...These findings document genomically diverse, resistance- and virulence-associated E. coli in hatchery-box material and identify genetically related isolates that warrant investigation through structured longitudinal sampling. Because sampling was unequal and isolates were purposively selected, the findings do not provide prevalence estimates or demonstrate source, transmission, persistence, or pathogenicity."

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Disseminated Melioidosis Complicated by Dural Venous Sinus Thrombosis: A Case Report. (PubMed, Cureus) - "The patient was initially treated with intravenous meropenem, followed by ceftazidime and oral trimethoprim-sulfamethoxazole as part of eradication therapy. Therapeutic anticoagulation with enoxaparin was also initiated. Follow-up imaging demonstrated significant resolution of the visceral abscesses and pulmonary lesions."

Journal • Back Pain • Cardiovascular • Diabetes • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Pain • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Thrombosis

Endogenous Klebsiella pneumoniae Endophthalmitis With Iris Abscess and Discordant Systemic and Ocular Culture Susceptibilities. (PubMed, J Vitreoretin Dis) - "Initial treatment included intravitreal (IVT) vancomycin and ceftazidime with anterior chamber paracentesis. Postoperatively, weekly IVT moxifloxacin injections were administered for 3 weeks, resulting in resolution of infection. This case demonstrates rare iris abscess formation in K. pneumoniae endogenous endophthalmitis and underscores the importance of intraocular cultures in guiding targeted antimicrobial therapy."

Journal • Diabetes • Hepatology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumonia • Septic Shock

Genomic surveillance reveals escalating antimicrobial resistance and plasmid diversity in clinical Salmonella 1,4,[5],12:i:- ST34 isolates from Guizhou Province, China. (PubMed, Front Microbiol) - "The isolates exhibited resistance to first-line antibiotics, with 22.4% for ciprofloxacin, 11.4% for azithromycin, 18.5% for ceftazidime, and 39.1% for cefotaxime. ARGs showed substantial agreement with phenotypes for tetracycline, macrolides, third-generation cephalosporins (3GCs), carbapenems, and colistin (80.8-100.0% consistency; Kappa: 0.50-1.00)...Gene-content analysis revealed that isolates in Clades 4 and 5 harbored the largest mean gene complements, and cgST52428 isolates also harbored the largest among dominant cgSTs. This study presents a comprehensive genomic profile of Salmonella 1,4,[5],12:i:- ST34 in Guizhou, providing essential data for exploring the resistance characteristics and investigating the molecular epidemiology of Salmonella 1,4,[5],12:i:-."

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Esculentin-1a Derived Peptides Potentiate Ceftazidime Activity against Multidrug-Resistant KPC-Producing Klebsiella pneumoniae. (PubMed, ACS Infect Dis) - "Importantly, no outer membrane perturbation was observed in a strain lacking a synergistic response, suggesting that membrane susceptibility is a key determinant of this cooperative interaction. Overall, these results highlight the potential of Esc-derived peptides as adjuvants capable of restoring β-lactam efficacy against multidrug-resistant carbapenemase-producing Klebsiella pneumoniae, offering a promising strategy to combat antimicrobial resistance."

Journal • Infectious Disease • Pneumonia

Detection and antimicrobial susceptibility patterns of Salmonella enterica subsp. arizonae and Proteus spp. associated with gastrointestinal disease in rescued hedgehogs (Erinaceus europaeus). (PubMed, Comp Immunol Microbiol Infect Dis) - "isolates were susceptible to cefotaxime, nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, amikacin, gentamicin, tobramycin, aztreonam, cefoxitin, ceftazidime and fosfomycin. However, resistance was observed to amoxicillin-clavulanic acid, ampicillin, ertapenem, meropenem, trimethoprim-sulfamethoxazole, cefuroxime, piperacillin-tazobactam, colistin and nitrofurantoin, with the latter two showing resistance in all Proteus spp...from hedgehog samples may display relevant antimicrobial resistance (AMR) patterns. Therefore, continuous bacteriological monitoring and antimicrobial susceptibility testing are important in wildlife rehabilitation settings to guide treatment decisions and support One Health surveillance."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Bacterial Profile and Antibiotic Susceptibility Patterns of Urogenital Isolates Among Women With Preterm Labor at a Tertiary Hospital in Southwestern Uganda. (PubMed, Cureus) - "Staphylococcus aureus and Klebsiella spp. were the predominant urogenital bacterial isolates among women with preterm labor. Most bacterial isolates were susceptible to gentamicin, ciprofloxacin, ceftriaxone, and ceftazidime but demonstrated high resistance to ampicillin and azithromycin. These findings highlight the need for routine culture and antibiotic susceptibility testing and may inform future updates of empirical antibiotic treatment guidelines in Uganda."

Journal • Infectious Disease • Inflammation • Obstetrics • Septic Shock

Adjunctive Photoactivated Chromophore for Keratitis-Corneal Cross-Linking for Refractory Pseudomonas aeruginosa Keratitis During Pregnancy: A Case Report. (PubMed, Cureus) - "Following consultation with the obstetric team, intensive topical amikacin and vancomycin, topical atropine, and intravenous ceftazidime were administered. However, the reproductive safety of riboflavin-ultraviolet-A cross-linking has not been established. Its use during pregnancy should therefore be considered only in exceptional, sight-threatening circumstances following multidisciplinary assessment and informed evaluation of the potential maternal benefits and unknown fetal risks."

Journal • Infectious Disease • Inflammation • Keratitis • Obstetrics • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Transplantation

Comparative effectiveness of ceftolozane/tazobactam relative to ceftazidime/avibactam for the treatment of adult, hospitalized patients with pneumonia due to multidrug-resistant Pseudomonas aeruginosa in U.S. Veterans Health Administration facilities. (PubMed, Antimicrob Agents Chemother) - "In this national VHA cohort, C/T and C/A demonstrated comparable clinical, microbiologic, and healthcare utilization outcomes. These findings support consideration of either C/T or C/A for MDR-PSA pneumonia when used at appropriate doses."

HEOR • Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Pseudomonas aeruginosa develop faster ciprofloxacin and meropenem resistance in people with cystic fibrosis-related diabetes (NACFC 2026) - "No associations were observed for aztreonam, ceftazidime, colistin, piperacillin/tazobactam, or tobramycin. PwCF with and without CFRD had similar sputum sampling frequency and PA detection rates; however, CFRD was associated with higher PA growth scores and more rapid development of ciprofloxacin and meropenem resistance. These findings may suggest that hyperglycemia can enhance PA fitness, supporting cautious antibiotic selection to minimize resistance development in people with CFRD."

Cystic Fibrosis • Diabetes • Genetic Disorders • Immunology • Metabolic Disorders • Respiratory Diseases • Type 2 Diabetes Mellitus

Outcomes of patients with suspected or confirmed melioidosis:A prospective multi-national, multicenter, observational study. (PubMed, PLoS Negl Trop Dis) - "Future clinical trials aiming to reduce mortality in patients with suspected or confirmed melioidosis should consider stratification based on the severity of organ dysfunction at enrollment. Differences in mortality between study sites may reflect residual confounding and should be carefully considered in sample size calculations."

Journal • Observational data • Beta-Thalassemia • Chronic Kidney Disease • Critical care • Diabetes • Genetic Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Septic Shock

Prevalence and patterns of antimicrobial resistance in Escherichia coli from Indonesian broiler chickens: Comparison of CLSI and EUCAST 2025 standards. (PubMed, J Adv Vet Anim Res) - " The highest resistance rates under both standards were observed for ampicillin (78.33% according to CLSI and 78.63% according to EUCAST), while all isolates remained susceptible to meropenem (100%) based on both references. Significant differences between CLSI and EUCAST interpretations were observed for colistin and ciprofloxacin (p 0.91)...Strengthening and harmonizing AMR surveillance reporting based on both standards is essential to support evidence-based and effective AMR mitigation policies. This approach, within a One Health framework, is to safeguard animal health, public health, and food safety in Indonesia."

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Four-year surveillance of Major Gram-negative pathogens in a Saudi tertiary hospital: clinical distribution, comorbidity profiles, and antimicrobial resistance. (PubMed, Expert Rev Anti Infect Ther) - "In P. aeruginosa, ceftazidime non-susceptibility increased from 55.2% to 78.6% (q < 0.001), meropenem decreased from 46.8% to 32.9% (q = 0.031), and tobramycin increased from 22.2% to 45.7% (q = 0.030). The single-center surveillance study shows a persistent and species-specific Gram-negative resistance burden, led by K. pneumoniae and accompanied by substantial P. aeruginosa non-susceptibility. The findings support organism-specific detections, antibiograms and continued multicenter surveillance linked to antimicrobial exposure, genomic data, and patient outcomes."

Journal • Critical care • Infectious Disease • Pneumonia

Aztreonam-avibactam therapy following surgical source control for bla NDM -positive carbapenem-resistant Klebsiella pneumoniae intra-abdominal infection in an infant: a case report. (PubMed, Front Pharmacol) - "The isolate was resistant to carbapenems and ceftazidime-AVI but was susceptible to ATM-AVI, with a minimum inhibitory concentration of ≤4 mg/L. ATM-AVI was administered at 30 mg/kg every 8 h, based on the aztreonam component, for 14 days; linezolid and fluconazole were co-administered as part of the broader anti-infective regimen...No hepatic or renal toxicity was observed during treatment. This case suggests that, when combined with adequate surgical source control, ATM-AVI may represent a valuable mechanism- and susceptibility-guided pharmacological component in a multidisciplinary treatment paradigm for severe bla NDM -positive CRKP infections in selected infants."

Journal • Critical care • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock

Acinetobacter baumannii resistance trends in an ICU from Saudi Arabia over 12 years. (PubMed, Indian J Med Res) - "Logistic regression revealed significant temporal declines in resistance to cefepime, ceftazidime, aminoglycosides, and fluoroquinolones (P<0.001). We observed significant temporal declines in resistance to selected agents, particularly cefepime, aminoglycosides, and fluoroquinolones. These findings highlight the critical role of ICU-focused antimicrobial stewardship, enhanced infection control strategies, and regional molecular surveillance to limit further spread."

Journal • Retrospective data • Critical care • Infectious Disease

Frequency and characteristics of extended-spectrum beta-lactamase-producing Escherichia coli in wastewater in Dakar, Senegal. (PubMed, BMC Res Notes) - "All the 107 isolated ESBL-producing E. coli isolates were multidrug resistant (MDR), with 100% resistance to beta-lactams (ampicillin, cefalotin, cefotaxime, ceftazidime, cefepime, aztreonam) and high resistance rates to non-beta-lactam antibiotics, including ciprofloxacin (77.6%). Phylogenetic analysis of 107 isolates revealed a diverse distribution across four phylogroups: A (37.4%), D (22.4%), B1 (14.0%), and B2 (5.7%). The predominance of phylogroup A, mainly associated with intestinal commensal carriage, suggests fecal contamination as a primary source."

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Predictive value of in vitro antimicrobial susceptibility testing for outcomes of Burkholderia cepacia complex infection: a single-center retrospective study. (PubMed, Front Med (Lausanne)) - "Over the 10-year period, Bcc isolates maintained high and stable in vitro susceptibility to trimethoprim-sulfamethoxazole (95.6%), minocycline (95.7%), and ceftazidime (91.1%). Although Bcc isolates remained highly susceptible to first-line agents, in vitro AST results alone were insufficient to predict clinical outcomes, which were driven predominantly by host factors, particularly advanced age. In the absence of current CLSI breakpoints, AST results should be interpreted cautiously and integrated with host risk assessment, source control, and overall clinical status rather than used in isolation."

Journal • Preclinical • Retrospective data • Infectious Disease • Respiratory Diseases