Bridion (sugammadex) / Merck (MSD) - LARVOL DELTA

The SNaPP Study: Sugammadex, neostigmine and postoperative pulmonary complications (SNaPP): a randomised controlled trial (ANZCTR) - P4 | N=3500 | Completed | Sponsor: University of Melbourne | Active, not recruiting ➔ Completed

Trial completion • Acute Respiratory Distress Syndrome • Anesthesia • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Sugammadex vs. neostigmine: the train-of-four counts too. (PubMed, Anaesthesia) - No abstract available

Journal

REMI-MEP: REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring (clinicaltrials.gov) - P4 | N=316 | Not yet recruiting | Sponsor: Mayo Clinic

Intubation • New P4 trial • Orthopedics

Sudden, Severe, Refractory Hypotension Following Sugammadex Administration During Low-Risk Orthopedic Surgery in a Healthy Young Adult: A Case Report. (PubMed, Case Rep Anesthesiol) - "Although causality cannot be definitively established, the temporal relationship raises concern for sugammadex-associated hypotension without bradycardia, possibly related to an atypical hypersensitivity reaction. This case highlights that severe hypotension may occur even in low-risk patients in the absence of bradycardia or other classic features of anaphylaxis, requiring prompt recognition and early potent vasopressor support."

Journal • Cardiovascular • Hypotension • Immunology • Orthopedics

Clinical application of sugammadex in renal impairment: pharmacokinetics and pharmacodynamics. (PubMed, Front Pharmacol) - "Sugammadex, a modified γ-cyclodextrin, rapidly and predictably reverses aminosteroid neuromuscular blockade by directly encapsulating rocuronium and vecuronium, thereby avoiding the cholinergic adverse effects associated with acetylcholinesterase inhibitors. Overall, sugammadex may serve as an effective and generally well-tolerated reversal agent in carefully selected patients with severe renal impairment. Additional prospective studies are required to establish its long-term safety and guide clinical recommendations."

Journal • PK/PD data • Review • Chronic Kidney Disease • Nephrology • Renal Disease

Prospective, randomized comparison of electromyographic neuromuscular responses from the adductor pollicis and abductor digiti minimi muscles during rocuronium-induced neuromuscular block. (PubMed, Anesthesiology) - "The present study underscores the equivalency between ADM and AP muscles for routine neuromuscular monitoring during surgery. When monitoring the non-dominant arm, the ADM and AP muscles have similar recoveries. In the dominant arm, the ADM muscle recovery is significantly faster than that of the AP muscle."

Journal • Anesthesia

Application of sugammadex sodium in the recovery period of general anesthesia in patients with uvulopalatopharyngoplasty (ChiCTR) - P=N/A | N=80 | Completed | Sponsor: The Second Norman Bethune Hospital of Jilin University; The Second Norman Bethune Hospital of Jilin University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Effect of Sugammadex Sodium on Neuromuscular Blockade Reversal and Postoperative Recovery in Elderly Patients Undergoing Thoracoscopic Lung Surgery: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University

New trial

Turning over new stones and discovering new questions in the contributions of anaesthetic drugs to perioperative cardiac arrest. (PubMed, Br J Anaesth) - "Using data from VigiBase, Perez and Fettiplace established a Risk of Reporting (RoR) metric for each common anaesthetic agent, comparing the occurrence of cardiac arrest associated with a given agent relative to its reported use in the database with propofol as the reference agent. This 'RoR' metric can inform future research into the association between specific anaesthesia medications and the risk for perioperative cardiac arrest."

Journal • Review • Anesthesia • Cardiovascular

Impact of Sugammadex on Clinical and Patient-Centered Outcomes: Beyond Neuromuscular Recovery. (PubMed, J Clin Med) - "Sugammadex provides rapid and predictable reversal of rocuronium- and vecuronium-induced blockade and reduces residual neuromuscular blockade more effectively than conventional anticholinesterase-based reversal. Sugammadex may be associated with favorable selected postoperative outcomes, but it should not be regarded as an independent determinant of recovery. Its clinical effects must be interpreted as part of optimized neuromuscular management incorporating quantitative monitoring, blockade-depth-appropriate dosing, confirmation of recovery, and comprehensive perioperative care."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Immunology • Pain • Renal Disease

Era of Sugammadex: Reply. (PubMed, Anesthesiology) - No abstract available

Journal

Era of Sugammadex: Comment. (PubMed, Anesthesiology) - No abstract available

Journal

Era of Sugammadex: Comment. (PubMed, Anesthesiology) - No abstract available

Journal

Era of Sugammadex: Comment. (PubMed, Anesthesiology) - No abstract available

Journal

Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA): protocol for an embedded mixed-methods process evaluation. (PubMed, BJA Open) - "ISRCTN.com ISRCTN15109717. Registered on 21 December 2022."

Clinical • Journal • Anesthesia • Critical care

Era of Sugammadex: Comment. (PubMed, Anesthesiology) - No abstract available

Journal

Bradycardia at Emergence after Percutaneous Pulmonary Valve Implantation in an Adult with Repaired Transposition of the Great Arteries and Pulmonary Atresia. (PubMed, J Cardiothorac Vasc Anesth) - No abstract available

Journal • Cardiovascular

Serial Fetal Heart Rate Monitoring During Electroconvulsive Therapy in Late Pregnancy: A Case Report of Transition From Succinylcholine to Rocuronium Reversed With Neostigmine. (PubMed, Neuropsychopharmacol Rep) - "Postpartum ECT was resumed for five additional sessions using rocuronium reversed with sugammadex, and the patient achieved clinical remission. This case suggests the feasibility of rocuronium with neostigmine reversal as an alternative to succinylcholine for ECT during late pregnancy when succinylcholine is unavailable, provided that multidisciplinary management and fetal monitoring are available."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Respiratory Diseases • Suicidal Ideation

Safety and Efficacy of Using Sugammadex in Pediatric Patients: A Narrative Review. (PubMed, J Pain Res) - "Overall, sugammadex provides a promising alternative to current therapies with vast implications for clinical anesthesia practice in pediatrics. Further studies are needed to investigate optimal practices in dosing, safety, and cost-effectiveness in pediatric subgroups."

Journal • Review • Anesthesia • Cardiovascular • Hypotension • Pediatrics

Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=80 | Recruiting | Sponsor: Dr. Nguyen Thi Thu Hang

New trial • Cardiovascular • Pediatrics

Urinary Difficulty After General Anesthesia for Otolaryngology Head and Neck Surgery. (PubMed, Ear Nose Throat J) - "No patients with rocuronium plus sugammadex had POUD.ConclusionsPOUD is common following otolaryngology head and neck surgery, particularly in older male patients and with prolonged operation time. It is essential to develop targeted interventional strategies to prevent and manage POUD in these high-risk groups."

Journal • Anesthesia • Otorhinolaryngology

Total Rocuronium Requirement During Intermittent Bolus Versus Continuous Infusion for Deep Neuromuscular Block in Elective Abdominal Cancer Surgery: A Randomized Equivalence Trial. (PubMed, J Clin Med) - " This prospective, single-center, randomized equivalence trial enrolled 72 adults undergoing elective abdominal cancer surgery under sevoflurane-remifentanil anesthesia...Deep NMB duration (127 ± 43 vs. 132 ± 65 min; p = 0.687) and recovery after sugammadex did not differ significantly...Recovery outcomes did not differ significantly; however, the infusion protocol required rescue boluses in some patients. PTC-guided individualization is therefore needed."

Journal • Anesthesia • Oncology

Comparison of kinemyography and electromyography during onset of and recovery from non-depolarising neuromuscular blockade: prospective observational study. (PubMed, Anaesthesiol Intensive Ther) - "KMG and EMG are not interchangeable for perioperative neuromuscular monitoring; the observed disagreement suggests that KMG may overestimate neuromuscular block, whereas EMG-based monitoring may provide a safer approach. The EMG-derived parameter T1% appears promising but requires further validation before routine clinical use."

Clinical • Journal • Observational data • Anesthesia

Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection (clinicaltrials.gov) - P4 | N=132 | Completed | Sponsor: University of California, Irvine | Recruiting ➔ Completed | Trial primary completion date: Jul 2026 ➔ Mar 2026

Trial completion • Trial primary completion date • Gastrointestinal Disorder

Does Sugammadex Decrease Length of Stay in Bariatric Surgery? Experience from an MBSAQIP Comprehensive Bariatric Center. (PubMed, Obes Surg) - "Sugammadex use was associated with significantly lower odds of prolonged hospital stay following elective bariatric surgery. Procedure complexity and higher BMI were also independent predictors. Further prospective studies are warranted to confirm these findings."

Journal • Anesthesia