Bridion (sugammadex) / Merck (MSD) - LARVOL DELTA

Use of sugammadex to reverse alfaxalone anesthesia in rats. (PubMed, Vet Anaesth Analg) - "Sugammadex can be used to reverse anesthetic effects from alfaxalone in rats. Recovery speed from alfaxalone anesthesia is dependent on sugammadex dose and sex."

Journal • Preclinical • Anesthesia

Bibliometric analysis of sugammadex sodium literature based on the Web of Science database. (PubMed, Medicine (Baltimore)) - "Research on sugammadex sodium has received significant scholarly attention, with strong potential for future collaborative studies. The impact of sugammadex sodium on postoperative complications remains a promising area for in-depth analysis and a topic for future research."

Journal • Anesthesia

Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery (clinicaltrials.gov) - P3 | N=560 | Not yet recruiting | Sponsor: Xijing Hospital

New P3 trial

Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications: A retrospective cohort study. (PubMed, Anesthesiology) - "Sugammadex introduction was followed by a 45.1% increase in rocuronium doses. While sugammadex attenuated the risk of postoperative respiratory complications, it was only completely abolished with quantitative neuromuscular monitoring."

Journal • Retrospective data • Anesthesia

Respiratory Failure Due to Bilateral Vocal Fold Paralysis Following Laparoscopic Cholecystectomy: A Rare Presentation of Myasthenia Gravis. (PubMed, Cureus) - "A 50-year-old woman with well-controlled MG developed stridor and respiratory failure on the first postoperative day after undergoing laparoscopic cholecystectomy with total intravenous anesthesia and sugammadex reversal...The patient improved with optimized MG management and was discharged after three weeks. This rare MG manifestation emphasizes the importance of early stridor recognition, difficult airway preparedness, and adherence to American Society of Anesthesiologists guidelines for airway management and bronchoscopy."

Journal • Anesthesia • CNS Disorders • Immunology • Myasthenia Gravis • Respiratory Diseases

Remote diffuse multi-coronary artery spasm following pulmonary vein and posterior wall isolation, using a focal monopolar pulsed field ablation catheter. (PubMed, HeartRhythm Case Rep) - No abstract available

Journal • Cardiovascular

Rocuronium for Treatment of Sugammadex Anaphylaxis: A Case Report. (PubMed, Case Rep Anesthesiol) - "We present a case suggesting the converse might also be efficacious. In a critically ill patient with refractory anaphylaxis apparently triggered by sugammadex, administration of rocuronium rapidly restored hemodynamic stability."

Journal

Optimization and Validation of a Green Shelf Life HPLC Technique for Testing Sugammadex Sodium in Raw Material and Parenteral Medications. (PubMed, Biomed Chromatogr) - "An intravenous drug called sugammadex is used to counteract the adverse reactions of the relaxation medications rocuronium and vecuronium, which are given during operations to provide full anesthesia. It includes the eluting phase that comprises of 7 mL/L aqueous solution of triethylamine adjusted at pH 3.0 with phosphoric acid: ethanol (750:250) (V:V). The positive environmental impacts of the LC technique are demonstrated by the combined AES grade of 87, CACI rating of 78, AGSA rating of 75, MoGAPI rating of 80, BAGI rating of 82.5, and final whiteness rating of 96.7."

Journal • Anesthesia • Cerebral Hemorrhage

Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study. (PubMed, Acta Anaesthesiol Scand) - P4 | "Time to TOF ≥ 0.9 was shorter after reversal with sugammadex 2 mg kg-1 compared to neostigmine/glycopyrrolate 50/10 μg kg-1 in elderly patients administered rocuronium during total intravenous anaesthesia. For neostigmine a large variation in time to recovery was detected. No significant difference in clinical signs of residual NMB was found."

Clinical • Journal • Anesthesia

Perioperative Management of Patients Undergoing Kidney Transplantation in the United States-A National Survey. (PubMed, Clin Transplant) - "This survey demonstrated significant heterogeneity in the perioperative management of kidney transplant recipients in the U.S. There is an urgent need for further research on how perioperative management strategies affect postoperative outcomes after kidney transplantation to better guide evidence-based practice."

Journal • Anesthesia • Transplantation

General Anesthesia Management Using Remimazolam and Dexmedetomidine in a Patient Undergoing Palatal Fistula Closure With a Tongue Flap. (PubMed, Cureus) - "Anesthesia was induced and maintained with remimazolam and remifentanil, followed by the administration of dexmedetomidine toward the end of the surgery. After thorough oral suctioning, sugammadex was administered to reverse neuromuscular blockade, and flumazenil was used to counteract remimazolam-induced sedation...Mild postoperative bleeding was observed but was effectively managed with temporary re-sedation using sevoflurane...This combination of remimazolam and dexmedetomidine offers an effective anesthetic strategy for safe emergence and extubation in patients undergoing palatal fistula closure with a tongue flap. It may also apply to other cases requiring cautious extubation and difficult airway management."

Journal • Anesthesia

The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction (clinicaltrials.gov) - P4 | N=184 | Completed | Sponsor: Clayton Petro | Active, not recruiting ➔ Completed

Trial completion • Gastroenterology

Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease (clinicaltrials.gov) - P4 | N=490 | Recruiting | Sponsor: The University of Texas Medical Branch, Galveston | Trial primary completion date: Sep 2025 ➔ Dec 2026

Trial primary completion date • Anesthesia • Chronic Kidney Disease • Nephrology • Renal Disease

Sugammadex and Menstrual Cycle in Postoperative Nausea and Vomiting (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: Sakarya University

New trial

Reversal effect of sugammadex sodium on rocuronium-induced neuromuscular blockade in patients undergoing painless tracheoscopy. (PubMed, Am J Transl Res) - "In painless tracheoscopy, sugammadex sodium provides rapid and complete reversal of rocuronium, lowers postoperative complications, and improves perioperative efficiency."

Journal • Anesthesia • Cardiovascular • Pain

Sugammadex for reversing neuromuscular blockade in infants and children. (PubMed, Cochrane Database Syst Rev) - "The objectives are as follows: The primary objective of this review is to evaluate the benefits and harms of sugammadex compared to other neuromuscular blockade reversal agents (neostigmine and pyridostigmine) in infants and children undergoing surgical procedures. A secondary objective is to assess whether these outcomes differ by age group, comorbidities, co-medications, or type of neuromuscular blocking agent."

Journal • Review

Comment on Koo et al.'s observational study. (PubMed, Anaesth Crit Care Pain Med) - No abstract available

Journal • Observational data

Sugammadex hypersensitivity: a national retrospective cohort study from the French pharmacovigilance database. (PubMed, Anaesthesia) - No abstract available

Adverse events • Journal • Retrospective data • Immunology

Risk of postoperative urinary retention after sugammadex use in laparoscopic hernia repair: A matched cohort study of 23,444 cases. (PubMed, PLoS One) - "Sugammadex use is associated with a 77% reduction in POUR and 24% fewer ED visits than neostigmine following hernia repair, suggesting that it may be the preferred reversal agent, particularly for older adults who gain the most benefit."

Journal • Retrospective data • Benign Prostatic Hyperplasia • Gastroenterology • Infectious Disease • Pneumonia • Respiratory Diseases

Sugammadex Versus Neostigmine in Return to Intended Oncological Therapy After Gastrointestinal Cancer Surgery: A Retrospective Study. (PubMed, Cancers (Basel)) - " Sugammadex and neostigmine showed similar RIOT rates, with only a modest difference in radiotherapy resumption. Larger studies are needed to elucidate the potential benefits of sugammadex, particularly regarding long-term oncological outcomes and treatment continuity."

Journal • Retrospective data • Anesthesia • Biliary Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Sugammadex and emergence-related respiratory adverse events in pediatric tonsillectomy: a randomized controlled trial. (PubMed, Anesth Pain Med (Seoul)) - "Sugammadex provides significantly faster neuromuscular blockade reversal compared to neostigmine but does not shorten the time to extubation or reduce the incidence of emergence-related respiratory adverse events in children undergoing tonsillectomy. Moreover, its use may be associated with an increased risk of emergence delirium."

Adverse events • Journal • Allergy • Cardiovascular • CNS Disorders • Pediatrics

Density Spectral Array in Sugammadex-Induced Bradycardia. (PubMed, Asian J Anesthesiol) - No abstract available

Journal • Cardiovascular

Effect of sugammadex on pulmonary function after abdominal surgery in elderly patients (ChiCTR) - P4 | N=174 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

Head-to-Head • New P4 trial

Comparing sugammadex to neostigmine and their effects on delirium and postoperative cognitive function: A systematic review. (PubMed, J Perioper Pract) - "This systematic review suggests the possibility of a very limited neurological protective role of sugammadex compared to neostigmine, but no clinical significance was reported. Only a limited number of studies were available, suggesting the need for further research."

Journal • Review • Anesthesia • CNS Disorders • Cognitive Disorders

Glossoptosis After Tracheal Extubation in a Patient With Oculopharyngeal Muscular Dystrophy: A Case Report. (PubMed, Cureus) - "Total intravenous anesthesia was administered, followed by intravenous rocuronium (0.5 mg/kg), and tracheal intubation was performed...However, glossoptosis and hypoxia developed, necessitating sugammadex administration...Complete recovery of the adductor pollicis train-of-four ratio does not necessarily ensure safe extubation. Since current guidelines provide no recommendations for such cases, further discussion and the development of management strategies, including the consideration of routine reversal, are warranted."

Journal • Anesthesia • Gastrointestinal Disorder • Genetic Disorders • Muscular Dystrophy