Bridion (sugammadex) / Merck (MSD) - LARVOL DELTA

Association Between Neuromuscular Blockade and Its Reversal With Postoperative Delirium in Older Patients: A Hospital Registry Study. (PubMed, Anesth Analg) - "Neuromuscular blockade during general anesthesia is dose-dependently associated with a higher risk of postoperative delirium. The administration of reversal agents mitigates this risk and might help reduce the occurrence of delirium after surgery."

Journal • Anesthesia • CNS Disorders • Transplantation

Risk factors for administration of additional neuromuscular block reversal in adults undergoing general anaesthesia: a single centre retrospective case-control study. (PubMed, BMC Anesthesiol) - "Reversing neuromuscular block with sugammadex in patients at higher risk of incomplete reversal with neostigmine can improve outcomes and reduce costs, especially in cases where qualitative assessment is utilized or when quantitative monitoring is unavailable."

Journal • Retrospective data • Anesthesia

Anesthesia management for patients with Prader-Willi syndrome undergoing bariatric surgery: a single-center retrospective case series study. (PubMed, BMC Anesthesiol) - "We advocate the use of sugammadex as the neuromuscular blockade reversal agent, the implementation of neuromuscular monitoring, progressive respiratory exercises, and multimodal analgesia in PWS patients undergoing bariatric surgery."

Journal • Retrospective data • Anesthesia • CNS Disorders • Developmental Disorders • Genetic Disorders • Obesity • Obstructive Sleep Apnea • Prader–Willi syndrome • Psychiatry • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Developing novel drugs to reverse neuromuscular block: do we need them? (PubMed, Br J Anaesth) - "In the last 5 yr, rocuronium followed by reversal with sugammadex has become the most common combination of neuromuscular blocking drug and neuromuscular block antagonist in use during anaesthesia in the developed world. This includes development of new gamma cyclodextrins such as adamgammadex, and unrelated compounds such as calabadion 2 and Pillar[6]MaxQ, that not only sequestrate rocuronium, but also opioids such as fentanyl. The reasons for such work are questioned with the acknowledgement that, as in all areas of anaesthetic practice, the search for perfect drugs continues despite the limited clinical demand."

Journal • Anesthesia

The effect of bilateral rectus sheath and oblique subcostal transversus abdominis plane blocks on mechanical power in patients undergoing laparoscopic cholecystectomy surgery: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "Bilateral RSB and OSTAP blocks significantly reduce mechanical power during surgery. Moreover, they significantly decrease postoperative pain and analgesic consumption and increase patient recovery scores."

Journal • Anesthesia • Pain

Guideline on the safe use of neuromuscular blocking agents (PubMed, Orv Hetil) - No abstract available

Journal

Impact of Drugs Used in Intensive Care on Routine Coagulation Testing. (PubMed, Diagnostics (Basel)) - "In this review, we have conducted a critical analysis of the literature to define: (1) the impact of hydroxocobalamin, intravenous lipid emulsion, and propofol on chromogenic assays; (2) the impact of PEGylated compounds, emicizumab, recombinant activated factor VII, antibiotics, and sugammadex on chronometric assays; (3) the challenges associated with bridging anticoagulation in the ICU as well as the effect of N-acetylcystein, serotonin reuptake inhibitors, and tramadol on the hemostasis system. For each drug, we specify the routine coagulation assay that is impacted, whether this is linked to an in vitro interference or an in vivo effect, and the potential consequences on patient management."

Journal • Review • Critical care

Role of Curarization During Anesthesia for Laparoscopic Hysterectomy (clinicaltrials.gov) - P2 | N=238 | Completed | Sponsor: Campus Bio-Medico University | Unknown status ➔ Completed | N=100 ➔ 238 | Trial completion date: Jan 2019 ➔ Dec 2024 | Trial primary completion date: Sep 2018 ➔ Dec 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Anesthesia • Gynecology • Pain

Is there still a place for fast-acting neuromuscular blockade agents: fast onset or safe and prompt reversal? (PubMed, Curr Opin Anaesthesiol) - "The emerging data suggest that these novel agents could significantly enhance clinical outcomes by improving the precision and safety of neuromuscular blockade management during surgery. Further research is warranted to optimize dosing protocols and verify long-term safety, potentially leading to refined anesthetic practices and better postoperative recovery."

Journal • Anesthesia

Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children (clinicaltrials.gov) - P=N/A | N=73 | Completed | Sponsor: Seoul National University Hospital | Recruiting ➔ Completed | Trial completion date: Apr 2025 ➔ Jun 2024 | Trial primary completion date: Feb 2025 ➔ Jun 2024

Trial completion • Trial completion date • Trial primary completion date

The effect of neuromuscular blocking reversal agents on perioperative neurocognitive function after general anaesthesia: a systematic review and meta-analysis. (PubMed, BMC Anesthesiol) - "This meta-analysis demonstrated that the use of sugammadex was associated with improved early perioperative neurocognitive function compared to neostigmine when used to reverse neuromuscular blockade, without an increase in the incidence of adverse events."

Clinical • Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Cognitive Disorders • Developmental Disorders

Impact of Sugammadex on Pulmonary Complications After Neuromuscular Blockade Reversal in Older Adults Following Non-Cardiac Major Surgery: A Multicenter, Prospective, Observational Study (ChiCTR) - P4 | N=2470 | Not yet recruiting | Sponsor: Nanjing Drum Tower Hospital; Nanjing Drum Tower Hospital

New P4 trial

Effects of neostigmine versus sugammadex on postoperative nausea and vomiting after laparoscopic gynecologic surgery: a randomized controlled trial (ChiCTR) - P=N/A | N=300 | Not yet recruiting | Sponsor: Womens' Hospital, School of Medicine, Zhejiang University; Womens' Hospital, School of Medicine, Zhejiang University

New trial • Gynecology

Effectiveness and Safety of Jianlisu sugammadex on the Reversal of Postoperative Residual Neuromuscular Blockade in Pediatric Patients (ChiCTR) - P4 | N=74 | Recruiting | Sponsor: Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University of Medicine; No.1678,Dongfang Road,Pudong New Area,Shanghai

New P4 trial • Pediatrics

The impact of sugammadex sodium on postoperative residual neuromuscular blockade and early recovery quality in asthma patients (ChiCTR) - P=N/A | N=70 | Not yet recruiting | Sponsor: Fourth Military Medical University Tangdu Hospital /The Second Affiliated Hospital of Air Force Military Medical University; The Second Affiliated Ho

New trial • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

SECURE: An Observational Study to Analyze the Prescription Pattern of Sugammadex and Its Effectiveness and Safety (clinicaltrials.gov) - P=N/A | N=7000 | Recruiting | Sponsor: Boryung Pharmaceutical Co., Ltd | Trial primary completion date: Mar 2025 ➔ Jun 2025

Trial primary completion date • Anesthesia

Effect of Sugammadex Sodium on postoperative recovery in patients undergoing short surgery - a single-center, prospective, randomized controlled study (ChiCTR) - P1 | N=204 | Recruiting | Sponsor: Affiliated Traditional Chinese Medicine Hospital of Xi'nan Medical University; Affiliated Traditional Chinese Medicine Hospital of Xi'nan Medical Univ

New P1 trial

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis (clinicaltrials.gov) - P=N/A | N=62 | Completed | Sponsor: Beijing Tongren Hospital | Recruiting ➔ Completed | Trial completion date: Dec 2025 ➔ Mar 2025

Trial completion • Trial completion date • CNS Disorders • Myasthenia Gravis

Sugammadex Reduces Antiemetic Effect of Dexamethasone (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Augusta University

New trial

Speed of reversal by sugammadex or neostigmine after vecuronium-induced neuromuscular block in dogs: Randomized clinical trial and pharmacological modeling. (PubMed, Vet Anaesth Analg) - "Recovery from vecuronium-induced neuromuscular block with sugammadex was dose dependent and faster than neostigmine. Substantial variation in recovery times is expected with low-dose sugammadex and neostigmine, highlighting the importance of monitoring."

Clinical • Journal • Ophthalmology

Next generation of neuromuscular blockade reversal agents. (PubMed, Curr Opin Anaesthesiol) - "Emerging NMBA reversal agents offer potential improvements in safety, efficacy, and broader NMBA compatibility. These alternatives to sugammadex and neostigmine show promise in preclinical and early clinical trials. Further studies are necessary to confirm their clinical applicability and regulatory approval."

Journal • Immunology

Placental Transfer of Sugammadex in the Human Placental Perfusion Model (clinicaltrials.gov) - P=N/A | N=16 | Enrolling by invitation | Sponsor: Universitaire Ziekenhuizen KU Leuven | Not yet recruiting ➔ Enrolling by invitation | Initiation date: Dec 2024 ➔ Mar 2025 | Trial primary completion date: Feb 2025 ➔ Sep 2025

Enrollment open • Trial initiation date • Trial primary completion date

Response to the Letter to the Editor Regarding Our Research Article on "Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy". (PubMed, Medeni Med J) - No abstract available

Journal

Correspondence on Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy. (PubMed, Medeni Med J) - No abstract available

Journal • Anesthesia

Use and Outcomes of Sugammadex for Neurological Examination after Neuromuscular Blockade in the Emergency Department. (PubMed, West J Emerg Med) - "Non-depolarizing agents such as rocuronium and vecuronium are frequently used in the emergency department (ED) to facilitate intubation but may lead to delay in neurologic examination and intervention. Patients who received sugammadex in the ED to facilitate neurologic examination during the study period had rare associated adverse effects, high rates of procedures within 24 hours of administration, and significant in-hospital mortality. Prospective data is needed to assess the impact of sugammadex on decision-making."

Journal • Retrospective data • Cardiovascular • Hypotension