APB-A2 / AprilBio - LARVOL DELTA

EXPANDED ASSESSMENT OF GERMLINE GENOMIC EFFECTS AND LANGERHANS CELL HISTIOCYTOSIS (SIOP 2026) - "Several clusters of variants in linkage disequilibrium were evident in ANAPC1 on chr2 and APBA2 on chr15... A mixed-model GWAS analysis of >700 LCH cases identified multiple novel risk variants not previously reported. Next steps include stratification by i) age and ii) genomic ancestry to test for differential risk loci across the age spectrum or ancestries. Future studies in our cohort are warranted to confirm and evaluate the roles of these novel variants and associated genes in relation to LCH pathogenesis."

Late-breaking abstract • Langerhans Cell Histiocytosis • PDGFA