Eticovo (etanercept-ykro) / Biogen, Organon, Samsung, Ewopharma, Yuhan Corp, Mundipharma, Bionovis - LARVOL DELTA

Peptide ligands targeting GP64 for the purification of Baculovirus from insect cell lysates. (PubMed, J Chromatogr A) - "Eight candidate peptides (SB1-SB8) were evaluated on Toyopearl and POROS chromatographic resins, demonstrating that matrix chemistry, pore size, and ligand density govern purification performance. The SB4-POROS resin demonstrated storage stability and ∼80% retention of binding capacity over ten purification-regeneration cycles with caustic cleaning. Integration into a three-step downstream process (clarification, affinity capture, and polishing) raised product purity 1,528-fold, from 6.22 × 106 to 9.50 × 109 viral genomes per µg of HCP, while reducing the total HCP burden 1,698-fold, at a cumulative transducing-unit yield of ∼69% relative to the feedstock, establishing SB4-POROS as a promising technology with a favorable projected cost structure for Baculovirus purification."

Journal

Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions. (PubMed, Nat Commun) - "In LRRC8A/D heteromers, the two D subunits weaken the arrangement of A subunits and thus enhance the activation properties of the channel. This channel conformation is strongly perturbed upon binding of the potentiating sybody Sb4, which disrupts the packing of the cytoplasmic domains linking their mobility to pore opening."

Journal • Oncology • LRRC8A

AMOTL2 inhibits lymph node metastasis in gastric cancer by suppressing TGF-β/Smad signaling and is destabilized by the E3 ubiquitin ligase SMURF1. (PubMed, Int J Biol Sci) - "Notably, pharmacological Smad1/5/9 activation by SB4 partially reversed the suppressive phenotypes of AMOTL2 in vitro and in vivo...AMOTL2 restoration counteracted SMURF1-driven malignant phenotypes. Collectively, these findings define AMOTL2 as a potential suppressor of GC progression that is destabilized by SMURF1, suggesting that the SMURF1-AMOTL2-Smad signaling axis may contribute to GC progression and lymphatic dissemination, representing a candidate therapeutic target that warrants further validation."

Journal • Gastric Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • BMP2 • SMAD1 • SMURF1 • TGFB1

Single-Atom Control of Aromaticity and Excited-State Dynamics in Endohedral Zirconium-Antimony Zintl Clusters. (PubMed, Angew Chem Int Ed Engl) - "Structural and bonding analyses reveal that [Zr@Sb12]2- behaves as an integrated Sb12 framework rather than three discrete Sb4 fragments coordinated to Zr...Femtosecond transient absorption (fs-TA) spectroscopy further reveals that the aromatic [Zr@Sb12]2- cluster exhibits markedly longer-lived excited-state species than [Zr@Sb13]3-. These findings establish a direct structure-aromaticity-dynamics relationship, demonstrating that single-atom control of cluster nuclearity can regulate not only ground-state aromatic stabilization but also excited-state robustness in all-metal superatoms."

Journal

The Development of Green Schiff Base-Coated Papers Using Empty Palm Fruit Bunch Biomass for Enhanced Wet Strength. (PubMed, ACS Omega) - "Cellulose isolated from EPFB was oxidized using sodium periodate to produce dialdehyde cellulose (DAC), which was subsequently reacted with six different amine precursors, methylamine (SB-1), ethylenediamine (SB-2), ethylamine (SB-3), diethylamine (SB-4), ethanolamine (SB-5), and diethanolamine (SB-6), to form cellulose-based Schiff base derivatives...Biodegradability studies confirmed rapid degradation of all Schiff base samples, achieving nearly complete degradation within 20 days, outperforming conventional synthetic agents. These findings demonstrate that EPFB-derived Schiff base materials offer a promising, biodegradable, and biobased alternative to synthetic wet strength agents in paper applications."

Journal

Aberrant expression of Gremlin1 induces trophoblast senescence in the placenta of advanced maternal age pregnancy. (PubMed, J Transl Med) - "This work elucidates GREM1/BMP4 imbalance-driven trophoblast senescence as one of the mechanisms underlying AMA-related placental dysfunction, mediated through impaired BMP-SMAD signaling. While targeting this axis effectively mitigates molecular aging markers, the multifaceted nature of clinical AMA suggests that fully reversing macroscopic outcomes may require integrated, multi-pathway interventions. Nevertheless, targeted modulation of the BMP-SMAD pathway or anti-GREM1 strategies holds significant clinical intervention potential."

Journal • BMP4 • GREM1

Unique Defect Characteristics of Antimony Chalcogenide Photovoltaic Materials. (PubMed, Acc Chem Res) - "Different from all the previous solar cell materials, the crystal structures of this class of semiconductors are composed of quasi-one-dimensional ribbons, which renders efficient directional carrier transport along the one-dimensional Sb4(S/Se)6 ribbon...Together, these directions have enabled the power conversion efficiency to exceed 11%. By establishing a unified chemical framework for understanding and controlling point defects, this Account provides guiding principles for advancing Sb2(S,Se)3 materials in terms of sophisticated defect-engineering."

Journal

Effects of Bone Morphogenetic Protein Agonist Small Molecule, SB4, on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells. (PubMed, J Bone Metab) - "These results indicate that SB4, with potential BMP-like activity, induces OS differentiation of ADMSCs, leading it to serve as a cost-effective BMP agonist for osteogenesis-related research as well as a potential therapeutic agent for bone repair and regeneration."

Journal • BMP2 • RUNX2 • SPP1

Shaping Antimalarials: A Geometry-First Approach to PfCLK3 Covalent Inhibitors. (PubMed, J Med Chem) - "Herein, we describe a geometry-first approach to optimize covalent PfCLK3 inhibitors, starting from the highly reactive chloroacetamide SB4-17 (2)...Notably, the methyl sulfamate analogue SB5-171 (14) showed potent antiparasitic activity (EC50 = 104 nM) and improved metabolic stability (t1/2 = 35 min in mouse hepatocytes). These findings demonstrate that geometric optimization can decouple covalent engagement from high intrinsic reactivity, providing a rational framework for designing selective, drug-like CKIs."

Journal • Infectious Disease

Genome-wide association and haplotype analyses reveal genetic architecture of seed dormancy in grain sorghum with implications for preharvest sprouting tolerance. (PubMed, Plant Genome) - "Notably, clusters of ArcG%-associated QTL on chromosomes Sb4 and Sb5 represented major genetic hotspots enriched for dormancy-related variation...Several QTLs also colocalized with known sorghum dormancy genes (e.g., SbVP1, SbABI1, SbGA2ox1, SbPKABA1) and orthologs of cereal dormancy regulators (e.g., TaAFP, TaMYB10, TaPYL5, Sdr4, ABI5), suggesting conserved mechanisms across cereals. Collectively, these findings identify key genomic regions, favorable haplotypes, and high-priority candidate genes associated with seed dormancy and germination response, providing valuable genomic resources for breeding sorghum cultivars with improved PHS tolerance."

Journal

Clinical and Real-World Evidence on Etanercept Biosimilar Switching: A Narrative Literature Review of Efficacy and Safety. (PubMed, Adv Ther) - "This review examines clinical and real-world data on the effects of switching between reference and biosimilar (SDZ-ETN, SB4, LBEC0101, YLB113) etanercept on treatment efficacy and safety in patients with inflammatory rheumatic and musculoskeletal diseases. These findings support broader biosimilar adoption to improve patient access and reduce healthcare costs. However, published data on multiple biosimilar switches and patient-reported outcomes remain limited, warranting further research efforts in these areas."

Clinical • HEOR • Journal • Real-world evidence • Review • Ankylosing Spondylitis • Dermatology • Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Psoriasis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis

Synthesis, Physicochemical Characterization, and Biocidal Evaluation of Three Novel Aminobenzoic Acid-Derived Schiff Bases Featuring Intramolecular Hydrogen Bonding. (PubMed, Int J Mol Sci) - "We synthesized three derivatives (SB-3/Cl, SB-4/Br, and SB-5/I) and confirmed their structures using FTIR, 1H- and 13C-NMR, UV-Vis, and HRMS...In mammalian cells (HeLa), the compounds displayed clear concentration-dependent behavior. Overall, halogenation, particularly iodination, emerges as a powerful tool to couple redox tuning with selective Gram-positive activity and a favorable cellular tolerance window, nominating SB-5 as a promising scaffold for further antimicrobial optimization."

Journal • Infectious Disease

Multifunctional lactic acid bacteria isolated from traditional Makdous. (PubMed, Antonie Van Leeuwenhoek) - "plantarum SB14 showed the highest radical scavenging activity, while SB4 demonstrated potent inhibition against Listeria monocytogenes ATCC 13932 and Staphylococcus aureus ATCC 43300. These findings suggest that SB4 and SB14 are strong candidates as multifunctional starters to enhance the safety, quality, and health-promoting potential of fermented vegetable products and other functional food applications."

Journal

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism. (PubMed, MedComm (2020)) - "Notably, they reversed cetuximab-induced cancer stemness in colorectal adenocarcinoma-enriched stem cells. In a CT26/near-infrared fluorescent protein tumor model, SB4 markedly inhibited tumor growth and modulated key markers of stemness, motility, metabolism, and apoptosis in tumor tissues. Collectively, these findings demonstrate that SB4 and SB5 are promising candidates for colorectal cancer therapy by targeting VDAC1/PHB/MMP9."

Journal • Colorectal Adenocarcinoma • Colorectal Cancer • Oncology • Solid Tumor • MMP9 • VDAC1

Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Bacterial Viruses Subcommittee, 2025. (PubMed, J Gen Virol) - "Key updates include the creation of new orders and families that include existing taxa to better reflect genomic and evolutionary relationships. As sequencing and bioinformatics approaches continue to advance, further expansion and refinements in viral taxonomy can be anticipated in the coming years."

Journal • Infectious Disease

SbIV, an Unusual Player in 2D Spintronic Devices. (PubMed, ACS Nano) - "Density-functional theory calculations combined with Bader charge analysis show that antimony adopts the Sb4+ oxidation state, and density-functional perturbation theory confirms structural stability for multilayer configurations...As the number of layers increases, charge disproportionation arises, with Sb(III) localized at the surface and Sb(V) in inner layers. These results relate structural stability, charge localization, and reduced dimensionality in Rb-terminated Rb2SbCl6 multilayers and indicate inverse-sign thermoelectric and spin Hall responses relevant for spin-charge interconversion in spin-based transistors and nonvolatile memory devices."

Journal

Inclusion of endophytes in hydroponic cultivation of basils enhances hydroxycinnamic acid levels and antioxidant capacity. (PubMed, J Food Sci Technol) - "The endophytes that had the greatest effects were Curtobacterium flaccumfaciens (SB3), Methylobacterium oryzae (SB4), Rizhobium selenireductens (SB7), and Bacillus toyonensis (SB9). In the antioxidant assay, two of the best endophytes (SB7 and SB9) scavenged hydroxyl radicals by 87.6% and 82.9%, respectively. Additionally, inoculation increased iron-chelating capacity by 40% and fully inhibited lipid oxidation, indicating, overall, the benefits of the inoculation of endophytes during the hydroponic growth of basils."

Journal • Review

Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury. (PubMed, Nat Commun) - "We reveal that BMP4 signaling in HSPCs confers IR resistance, and a single administration of BMP4 or SB4 can rescue mice from the IR-induced mortality...In Nrf2 knockout mice, we demonstrate that Nrf2 is a critical downstream functional gene for BMP4-BMPR2 signaling on HSCs to resist IR-induced damage. Collectively, we provide insights into the molecular intricacies underlying HSPC heterogeneity and BM niche after radiation exposure, and we uncover that BMP4-BMPR2 signaling may serve as a promising target for developing innovative and effective intervention strategies to mitigate IR-induced hematopoietic injury."

Journal • BMP4 • NFE2L2

Compressive Force Inhibits Osteogenic Differentiation of Dental Follicle Stem Cells Through Biglycan/Bone Morphogenetic Protein2/Smad1 Signaling Pathway. (PubMed, Stem Cells Dev) - "Furthermore, activation of the BMP2/Smad1 signaling pathway using sb4 also reversed the compressive force-induced decline in osteogenic differentiation of hDFSCs. In vivo, the expression levels of the BGN/BMP2/Smad1 signaling axis and the osteogenic markers were significantly reduced on the compressive side of periodontal tissue compared with the control group (P < 0.01). BGN plays a crucial role in the osteogenic differentiation of hDFSCs under compressive force via the BMP2/Smad1 signaling axis and may contribute to the occurrence of OIIRR in mice."

Journal • BGN • BMP2 • MAD1L1 • RUNX2 • SMAD1

Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins. (PubMed, Biol Direct) - "We further explore the role of topology in folding commitment using the metamorphic mutant Sb4, which can populate both conformations. By analyzing folding and unfolding behaviors under varying experimental conditions, our findings suggest that topology dictates folding mechanisms at an early stage. These results demonstrate that folding landscapes are primarily shaped by final native structures rather than sequence composition."

Clinical • Journal

Stabilization of Sb4 Tetrahedra in Paramagnetic Transition Metal Carbonyl Complexes. (PubMed, J Am Chem Soc) - "Complex 1 exhibited versatile reactivities toward groups 7-9 metal carbonyls, dioxygen, or [Cu(MeCN)4][BF4] to form selective orbital-controlled Sb4-based products, including transmetalated paramagnetic complexes [Et4N]4[Sb4Cr5Mn(CO)28]Br ([Et4N]4[1-Mn]Br), [Et4N]4[Sb4Cr2Fe6(CO)30] ([Et4N]4[1-Fe]), and [Et4N]2[Sb4Cr4Co4(CO)31] ([Et4N]2[1-Co]), the dioxygen-activated paramagnetic cluster [Et4N]4[O2Sb4Cr6(CO)28] ([Et4N]4[1-O2]), or the spin-quenched complex [Et4N]2[Sb4Cr6(CO)28] ([Et4N]2[2]), respectively. The structural nature, bonding properties, paramagnetism, and semiconductivity of these unprecedented transition metal carbonyl-protected Sb4-based clusters were further realized with DFT calculations."

Journal

Atomic Structure, Dynamics, Changes in Chemical Bonding and Semiconductor-Metal Transition in Sb2Se3: A Remarkable Material for Quantum Networks and Energy Applications. (PubMed, ACS Appl Mater Interfaces) - "Unlike benchmark telluride PCMs, Sb2Se3 features a quasi-one-dimensional (1D) crystalline structure consisting of (Sb4 Se6)∞ ribbons, lacks the typical PCM chemical bonding, and undergoes an extended semiconductor-metal transition above the melting point...Liquid Sb2Se3 also appears to be strongly fragile, with a nonmonotonic change in viscosity and higher atomic mobility in the metallic liquid. These results explain extraordinary functionalities of Sb2Se3 for photonic and energy applications."

Journal

Formulation and Characterization of Etoricoxib Suppositories for the Management of Hemorrhoids. (PubMed, Turk J Pharm Sci) - "The SB3 gave 91.47±17.74% drug release in 6 h, whereas the SB1 gave 99.08±3.40% drug release in 12 h. Drug release from all formulations of suppositories was supported by zero-order, first-order, and Higuchi plots, except for SB4. The SB2 results were found to be more appropriate than those of the other batches. These results confirm that the prepared formulation has a future scope and should be further explored in in vitro cell lines and animal studies."

Journal • Gastroenterology • Gastrointestinal Disorder

The Effect of the Central Post and Screw Constructs on the Univers Revers Total Shoulder System. (PubMed, J Shoulder Elbow Surg) - "With a non-augmented glenoid baseplate and 4 to 8 mm of lateralization, central posts within the vault, central posts exiting the vault, and bicortical screw fixation were equivocal in terms of micromotion. Load to failure was highest with 4 mm of lateralization and a central post contained within the glenoid vault or a bicortical screw. With 8 mm of lateralization and the use of 4 peripheral screws there is no difference between a central post exiting the vault, post within the vault and bicortical screw fixation."

Journal • Musculoskeletal Diseases • Orthopedics

Schiff bases of cellulose: Synthesis, characterization, and anticancer potency against hepatocellular carcinoma. (PubMed, Int J Biol Macromol) - "Interestingly, SB4 could act as a pro-oxidant by inducing reactive oxygen species and oxidative stress with notable decline in the antioxidant system within Hep G2 cells. The results displayed that cellulose-based Schiff bases may offer a new strategy for liver cancer therapy."

Journal • Hepatocellular Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor